期刊
ANALYTICAL CHEMISTRY
卷 82, 期 1, 页码 19-22出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac902102x
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资金
- NSF [CHE-0757846]
- National Center for Research Resources (NCRR), NIH [1 K99 RR023758-01]
- Direct For Mathematical & Physical Scien [0757846] Funding Source: National Science Foundation
- NATIONAL CENTER FOR RESEARCH RESOURCES [K99RR023758] Funding Source: NIH RePORTER
The scanning mass spectrometry (SMS) probe is a new electrospray ion source. Motivated by the need for untargeted chemical imaging of dynamic events, in solution, we have exploited an approach to electrospray ionization (ESI) that allows continuous sampling from a highly localized volume (similar to picoliters) in a liquid environment, softly ionizes molecules in the sample to render them amenable for mass spectrometric analysis, and sends the ions to the mass spectrometer. The key underlying concepts for our approach are (1) treating the electrospray capillary inlet as a chemical scanning probe and (2) locating the electrospray point as close as possible to the sampling point, thus providing the shortest response time possible. This approach enables chemical monitoring or imaging of Submerged interfaces, providing access to details of spatial heterogeneity and temporal changes within liquid samples. It also permits direct access to liquid/liquid interfaces for ESI-MS analysis. In this letter we report the first demonstrations of these capabilities of the SMS probe and describe some of the probe's basic characteristics.
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