Article
Endocrinology & Metabolism
Theodosia Vallianatou, Weifeng Lin, Nicholas B. Bechet, Mario S. P. Correia, Nagesh C. Shanbhag, Iben Lundgaard, Daniel Globisch
Summary: Sleep serves as a universal core function allowing for restorative biological processes. Metabolic analysis of four mouse brain regions revealed region-specific circadian variations, with metabolites linked to oxidative stress showing alterations during sleep. This provides molecular evidence of significant metabolic shifts in brain energy metabolism, including the discovery of brain metabolites not previously associated with circadian functions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Iveta Fizikova, Jozef Dragasek, Peter Racay
Summary: The complexity of the brain can lead to the development of serious neuropsychiatric disorders, such as schizophrenia. The etiopathogenesis of schizophrenia involves multiple mechanisms, highlighting its complexity and providing a new perspective for studying this disorder. This review focuses on the contribution of mitochondria, particularly oxidative damage, ROS, and energy metabolism. It also discusses the role of redox imbalance and lactate in oxidative stress, lipid peroxidation, and cognitive functions in schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
James P. Bennett, Isaac G. Onyango
Summary: The adult human brain consumes a disproportionate amount of energy substrates, with ATP being the universal energy currency. Neurodegenerative diseases may result from factors such as stress damage, genetic mutations, epigenetic modifications, and mitochondrial dysfunction. Mitochondrial therapeutics aims to correct deficiencies in energy production processes.
Review
Agriculture, Dairy & Animal Science
A. S. Marquez-Acevedo, W. R. Hood, R. J. Collier, A. L. Skibiel
Summary: Heat stress negatively affects milk production and increases disease risk in dairy cows. It alters metabolic adaptations, such as nutrient mobilization and partitioning, compromising the energy demands of lactation. Mitochondrial density and bioenergetic capacity at the cellular level play a role in meeting the changing energy requirements in response to heat stress.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Cell Biology
Julie Faitg, Clay Lacefield, Tracey Davey, Kathryn White, Ross Laws, Stylianos Kosmidis, Amy K. Reeve, Eric R. Kandel, Amy E. Vincent, Martin Picard
Summary: This study used quantitative three-dimensional electron microscopy to map mitochondrial network morphology and complexity in the mouse brain. Differences in mitochondrial morphology across different cell types and ages were identified, providing a foundation for further research on the role of neuronal mitochondria in the aging brain.
Review
Nanoscience & Nanotechnology
Yue Zhang, Meiyan Sun, Hongxiang Zhao, Zhengyan Wang, Yanan Shi, Jianxin Dong, Kaifang Wang, Xi Wang, Xingyue Li, Haiyan Qi, Xiaoyong Zhao
Summary: This review discusses the multiple pharmacological activities of DCA in neuroprotection and its therapeutic effects on different diseases. The causes and solutions of DCA's adverse effects are also explored.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Environmental Sciences
Min Li, Ling-Yu Ruan, Fei Dang, Hai-Long Liu, Dong-Mei Zhou, Bin Yin, Jun-Song Wang
Summary: Silver nanoparticles (AgNPs) in soil pose risks to soil invertebrates, but the toxicity of AgNPs at environmentally relevant concentrations is not well understood. This study investigated the effects of low-level AgNPs on the bioaccumulation, pathology, and metabolism of earthworms. The results showed that AgNPs exposure disturbed the metabolism of different body parts and induced intestinal damage in earthworms. The findings provide biochemical insights for the risk assessment of low-level AgNPs in terrestrial environments.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Biomedical
Song Xue, Xiaojun Zhou, Weilin Sang, Cong Wang, Haiming Lu, Yiming Xu, Yiming Zhong, Libo Zhu, Chuanglong He, Jinzhong Ma
Summary: A novel cartilage-targeting dual-drug delivery system was designed to effectively treat osteoarthritis by sequentially releasing two agents. The system demonstrated excellent ROS scavenging ability and anti-apoptotic effects, while also enhancing autophagy activity and chondrocyte protection. It has the potential to be a promising therapy for osteoarthritis.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Renata Candido da Silva, Bertha Furlan Polegato, Paula Shmidt Azevedo, Ana Angelica Fernandes, Katashi Okoshi, Sergio Alberto Rupp de Paiva, Marcos Ferreira Minicucci, Leonardo Antonio Mamede Zornoff
Summary: Jaboticaba attenuates cardiac remodeling after myocardial infarction by reducing oxidative stress and improving energy metabolism.
Article
Biochemistry & Molecular Biology
Kang Han, Xiaofang Jin, Xin Guo, Guoli Cao, Siyu Tian, Yiming Song, Yuanyuan Zuo, Peng Yu, Guofen Gao, Yan-Zhong Chang
Summary: Nrf2 plays a crucial role in regulating brain iron metabolism, with Nrf2 KO improving motor function in aged mice while reducing oxidative stress and neuronal apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Giuseppe Caruso, Anna Privitera, Miriam Wissam Saab, Nicolo Musso, Salvatore Maugeri, Annamaria Fidilio, Anna Provvidenza Privitera, Alessandra Pittala, Renaud Blaise Jolivet, Luca Lanzano, Giuseppe Lazzarino, Filippo Caraci, Angela Maria Amorini
Summary: The activity of microglia plays a crucial role in various physiological processes and its imbalance can lead to neurodegenerative disorders. Carnosine, a naturally occurring molecule, has antioxidant and anti-inflammatory activities, and can modulate immune cell response and energy metabolism. Understanding microglia characteristics and their response to environmental challenges is important for therapeutic strategies.
Article
Environmental Sciences
Han Zhao, Hongyu Ke, Lu Zhang, Zhongmeng Zhao, Jiansheng Lai, Jian Zhou, Zhipeng Huang, Huadong Li, Jun Du, Qiang Li
Summary: This study conducted an acute temperature stress experiment on Gymnocypris chilianensis in the Qilian Mountains, China, and identified key metabolic pathways involved in maintaining physiological balance under thermal stress, such as glucose metabolism, lipid metabolism, and amino acid metabolism. The research provides valuable insights into the mechanisms underlying responses to heat stress in G. chilianensis, and may serve as reference data for studying environmental mutations in indigenous fish in the Qinghai-Tibet Plateau and Qilian Mountains.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Kristina Wardelmann, Michaela Rath, Jose Pedro Castro, Sabine Bluemel, Mareike Schell, Robert Hauffe, Fabian Schumacher, Tanina Flore, Katrin Ritter, Andreas Wernitz, Toru Hosoi, Koichiro Ozawa, Burkhard Kleuser, Jurgen Weiss, Annette Schurmann, Andre Kleinridders
Summary: Research indicates that reduced Hsp10 expression in the brains of type 2 diabetes mice is regulated by leptin in vitro. Decreased Hsp10 in hypothalamic cells leads to mitochondrial dysfunction and insulin resistance.
Article
Biochemistry & Molecular Biology
Chunling Wang, Miaomiao Hou, Kunyu Shang, Huanshan Wang, Jianwei Wang
Summary: Microplastic exposure caused various sublethal effects on rare minnows, including cellular and tissue alterations in the liver. Transcriptomic and metabolomic analyses revealed significantly varied metabolic pathways, such as glucolipid, amino acid, and nucleotide metabolism. Results showed that microplastic exposure induced immune reaction, oxidative stress, and disturbed glycolipid and energy metabolism in rare minnows.
Article
Environmental Sciences
Yunchao Du, Jianmin Zhao, Jia Teng, Jingying Ren, Encui Shan, Xiaopeng Zhu, Wenjing Zhang, Lei Wang, Chaowei Hou, Qing Wang
Summary: Microplastics pollution and salinity variation have limited knowledge of their combined effects on marine mollusks. This study found that low salinity reduced the uptake of microplastics by oysters. Antagonistic interactions between microplastics and low salinity were mainly observed, with some synergistic effects induced by smaller particles. Smaller particles of microplastics also induced higher levels of lipid peroxidation in oysters.
MARINE POLLUTION BULLETIN
(2023)