Editorial Material
Oncology
Payton D. Stevens, Bart O. Williams
Summary: LGR4 is known for its role in regulating cell response to Wnt ligands and EGFR signaling. High levels of Lgr4 expression correlate strongly with EGFR signaling, challenging the understanding of the contributions of Wnt signaling and EGFR signaling in cancer.
Review
Physiology
Juan M. Saavedra
Summary: In addition to controlling blood pressure, angiotensin receptor blockers also reduce inflammation and protect various organ functions, making them useful in treating inflammatory, age-related, neurodegenerative, and metabolic disorders.
Editorial Material
Cell Biology
Annmary Paul Erinjeri, John Labbadia
Summary: Research has found that mitochondrial long-lived proteins (mitoLLPs) play a significant role in promoting respiratory capacity by facilitating supercomplex assembly within the electron transport chain, thus improving mitochondrial efficiency.
DEVELOPMENTAL CELL
(2021)
Review
Cell Biology
Anees Rahman Cheratta, Faisal Thayyullathil, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Sehamuddin Galadari
Summary: The tumor suppressor Par-4, in addition to its role as an apoptosis inducer, has new functions in regulating autophagy, senescence, and metastasis. Understanding the increasing mechanisms of Par-4 reveals how its interaction with different regulators influences cell fate. The emergence of a new secretory pathway and its clinical implications are also discussed in this review.
CELL DEATH & DISEASE
(2021)
Review
Nanoscience & Nanotechnology
Wenqian Wang, Jillian Clark, Guangzhao Mao
Summary: Neuroanatomical tract tracers (NaTTs) have a long history of application in neural circuit tracing and now have found new uses in disease diagnosis and drug/gene delivery. This Review discusses the different subclasses of NaTTs, their unique properties, recent developments in their design and performance, and their applications in neural circuit mapping, disease diagnostics, and targeted delivery to the nervous system. Incorporating NaTTs into nanomedicines offers exciting possibilities for bypassing biological barriers and delivering drugs to specific neurons, providing innovative therapeutic options for neurological diseases.
ACS APPLIED BIO MATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Wenqian Wang, Jillian Clark, Guangzhao Mao
Summary: Neuroanatomical tract tracers (NaTTs) have been widely used for neural circuit tracing and have found recent applications in disease diagnosis and drug and gene delivery targeted to the nervous system. This Review discusses the different subclasses of NaTTs, their unique properties, recent developments in improving their design and performance, and the potential for drug delivery by incorporating NaTTs into nanomedicines. NaTTs have the advantage of being readily taken up by nerve endings and efficiently transported within the central nervous system to the brain, making them a promising tool for bypassing biological barriers. This Review aims to stimulate more discussions and collaborations among neuroscientists, biomedical researchers, and nanotechnologists to develop innovative therapeutic options for treating neurological diseases.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Physical
Hongru Ding, Pavana Siddhartha Kollipara, Linhan Lin, Yuebing Zheng
Summary: Optothermal tweezers, with superior manipulation capability at low optical intensity, are limited by implicit understanding of the working mechanism. By revealing the atomistic view of opto-thermo-electro-mechanic coupling, we have developed high-performance tweezers using low-concentrated electrolytes and demonstrated their efficiency in separating colloidal particles based on surface charge differences.
News Item
Optics
Xiaohe Zhang, Bing Gu, Cheng-Wei Qiu
Summary: Researchers have proposed a new method that can measure the weak force of a single microscopic particle.
LIGHT-SCIENCE & APPLICATIONS
(2021)
Article
Cultural Studies
Alison Atkinson-Phillips
Summary: This article explores the shift in public memorialization from death to experience. Through research on Australian public memorials to loss and trauma from 1985 to 2015, the author compares the trends identified with international memorial projects. The emergence of memorials focusing on lived experiences is seen as an expansion of publicly remembered knowledge influenced by discourses on trauma, human rights, and transitional justice.
Article
Chemistry, Multidisciplinary
Hongyan Yang, Ziyang Mei, Zhenkai Li, Houquan Liu, Hongchang Deng, Gongli Xiao, Jianqing Li, Yunhan Luo, Libo Yuan
Summary: In this study, we propose an integrated 2D plasmonic optical tweezer consisting of a graphene disc array and a substrate circuit. This optical tweezer can generate optical forces on nanoparticles at a low incident intensity and dynamically transport them by controlling the excitation position.
Article
Chemistry, Multidisciplinary
Elham Babaei, Demelza Wright, Reuven Gordon
Summary: By combining fringe-field dielectrophoresis with nano aperture optical tweezers, single molecule analysis of proteins in an aqueous environment without modification is achieved. The trapping time for proteins is significantly faster when the counter electrode is positioned outside of the solution compared to the more common configuration inside the solution. These findings are a major advancement for the nanoaperture optical trapping technique for high-throughput protein analysis.
Review
Pharmacology & Pharmacy
Xiaoyu Zhu, Lili Jiang, Xuejiao Wei, Mengtuan Long, Yujun Du
Summary: Roxadustat is a newly approved hypoxia-inducible factor prolyl hydroxylase inhibitor that has shown favorable safety and efficacy in treating renal anemia. Studies have also indicated its potential for treating other hypoxia-related diseases. Although no significant adverse or off-target effects have been found in clinical studies of roxadustat, clinicians should remain vigilant about these possibilities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Ramin Jamali, Farzaneh Nazari, Azadeh Ghaffari, Sabareesh K. P. Velu, Ali-Reza Moradi
Summary: The study explores the use of speckle tweezers (ST) to manipulate low index micro-particles by repelling them from high intensity regions to lower intensity regions for local confinement. The experiments validate the method and show that ST can also manipulate nanoparticle (NP)-loaded liposomes, enabling collective manipulation of drug micro-containers.
Article
Multidisciplinary Sciences
Tobias F. Bartsch, Camila M. Villasante, Felicitas E. Hengel, Ahmed Toure, Daniel M. Firester, Aaron Oswald, A. J. Hudspeth
Summary: In high-speed single-molecule experiments, tethering proteins with force probes can avoid nonspecific interactions, but dissipate rapidly exerted forces through long linkers; due to the high frequency of mammalian hearing, short tethers are required for single-molecule experiments.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Electrical & Electronic
Kai Niu, Shangdong Zhao, Shaohua Tao, Fuliang Wang
Summary: An optical tweezers-based optofluidic conveyor has been designed to capture and transport multiple micron particles. The conveyor belts can have different shapes with phase values set as phase gradients. In this study, automatic transportation of microparticles with three different conveyor belts was achieved, and the transportation direction was variable. The system allows particles to travel along arbitrary trajectories and has the potential for other optical manipulation tasks.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
