Article
Chemistry, Analytical
Tadashi Nishio, Yoko Toukairin, Tomoaki Hoshi, Tomomi Arai, Makoto Nogami
Summary: Dried blood spot (DBS) sampling has become the preferred method for newborn screening and therapeutic drug monitoring worldwide. It requires only a small amount of blood and has advantages such as simple collection, low sample storage costs, and microbial deactivation. However, DBS sampling is rarely used in forensic toxicological analyses.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, Legal
Pietro Zuccarello, Giulia Carnazza, Nunziata Barbera
Summary: An LC-MS/MS method was developed and validated for the analysis of vortioxetine in postmortem samples. The method showed acceptable sensitivity, selectivity, linearity, precision, and accuracy in various matrices. The concentrations of vortioxetine found in the authentic case may provide insight into similar cases in the future.
JOURNAL OF FORENSIC SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Anna Roszkowska, Natalia Treder, Alina Plenis, Natalia Miekus, Ilona Oledzka, Piotr Kowalski, Tomasz Baczek
Summary: This study compared and optimized two microextraction strategies for the extraction of four immunosuppressants in biofluids. The results showed that one strategy exhibited better performance for the extraction of a novel immunosuppressive drug.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Biochemical Research Methods
Nadia Arbouche, Jean-Sebastin Raul, Pascal Kintz
Summary: Oral antidiabetics are drugs used to control blood sugar in diabetic subjects. The greatest risk of using these drugs is hypoglycemia, especially in individuals with no history of exposure to these medications. Hair testing for oral antidiabetics can help differentiate the cause of hypoglycemia and has a large detection window with long-term stability. A liquid-chromatography coupled to tandem mass spectrometry method has been developed and successfully applied to analyze 13 oral antidiabetics in hair samples from diabetic patients.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sunyeong Jang, Hyungju Seo, Hojin Kim, Hyoyoung Kim, Jongsung Ahn, Hyunjeong Cho, Sunghie Hong, Seunghwa Lee, Taewoong Na
Summary: A method for the rapid and quantitative analysis of 30 veterinary drugs in feed samples was developed and validated. The method showed good linearity and recovery rates, and can be used for screening residual multiclass veterinary drugs in feed samples.
Article
Biochemistry & Molecular Biology
Hassan Shikshaky, Eman Abdelnaby Ahmed, Ali Mostafa Anwar, Aya Osama, Shahd Ezzeldin, Antony Nasr, Sebaey Mahgoub, Sameh Magdeldin
Summary: This article aims to develop a novel SWATH platform for metabolite identification using accurate mass spectral library, providing new avenues for clinical diagnosis, molecular medicine, and therapeutic drug monitoring and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Kacey D. Cliburn, Marilyn A. Huestis, Jarrad R. Wagner, Philip M. Kemp
Summary: A liquid chromatography-tandem mass spectrometry method was developed and validated for quantifying cannabinoids in postmortem specimens, showing accuracy and stability in measuring various cannabinoids.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Environmental Sciences
Pawel Szpot, Olga Wachelko, Marcin Zawadzki
Summary: The study aimed to establish a method for determining methotrexate in postmortem samples and quantifying its distribution in a fatal intoxication case. The method was found to be simple, accurate, and selective, allowing for routine determination of methotrexate concentrations in postmortem specimens.
Article
Environmental Sciences
Weimin Wang, Changsheng Guo, Like Chen, Ziwen Qiu, Xingxing Yin, Jian Xu
Summary: An enantioselective method was developed to quantify amphetamine-type chiral illicit drugs in wastewater and surface water samples from a wastewater treatment plant and its effluent-receiving river in Beijing, China. The method showed excellent performance in monitoring the variations of enantiomers in the wastewater treatment process.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Analytical
Kazushi Noro, Ayana Komatsu, Miyu Moriya, Yoko Kai, Qi Wang, Yuichi Miyake, Takashi Amagai
Summary: Passive smoking is a concern due to its harmful health risks. We developed a passive sampler coupled with perforated covers to improve sampling accuracy. Furthermore, a highly sensitive nicotine analysis method was developed. The results showed that the developed passive sampler and analytical method are promising tools for monitoring nicotine.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Lea Wagmann, Aline C. Vollmer, Lucas Lauder, Felix Mahfoud, Markus R. Meyer
Summary: The study aimed to monitor adherence to antihypertensive medication by developing a quantification procedure for drug concentrations in blood plasma. Results showed that plasma concentration interpretation is more complex than urine screening but can effectively assess adherence. Further data is needed to determine if plasma quantification is superior in assessing adherence to antihypertensive medication.
Review
Pharmacology & Pharmacy
Jae Geun Song, Kshitis Chandra Baral, Gyu-Lin Kim, Ji-Won Park, Soo-Hwa Seo, Da-Hyun Kim, Dong Hoon Jung, Nonye Linda Ifekpolugo, Hyo-Kyung Han
Summary: The application of therapeutic proteins in pharmaceuticals is expanding, and efficient bioanalytical methods are crucial for their identification and clinical development. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is often used for quantitative protein analysis in complex samples due to its sensitivity, specificity, and throughput. Proper sample preparation is important to minimize interference and enhance the accuracy of LC-MS/MS assays.
Article
Public, Environmental & Occupational Health
Abdullah Al-Matrouk, Mohammed Al-Hasan, Husain Naqi, Neamat Al-Abkal, Hanan Mohammed, Meshaal Haider, Dalal Al-Shammeri, Haider Bojbarah
Summary: The data reveals that cannabis is the most commonly seized illicit substance in the Arabian Gulf region, while methamphetamine is the most abused illicit drug in Kuwait. Deaths resulting from heroin and benzodiazepine abuse were the highest, with heroin-benzodiazepine combination deaths being most frequent. The lack of information regarding illicit substances in Kuwait highlights the need for further research and enforcement efforts.
Article
Multidisciplinary Sciences
Julia Brunmair, Laura Niederstaetter, Benjamin Neuditschko, Andrea Bileck, Astrid Slany, Lukas Janker, Max Lennart Feuerstein, Clemens Langbauer, Mathias Gotsmy, Jurgen Zanghellini, Samuel M. Meier-Menches, Christopher Gerner
Summary: Metabotyping using sweat from fingertips is a promising noninvasive tool for precision medicine, overcoming limitations of traditional metabolic analysis. Dynamic metabolic patterns can be assessed through sweat sampling, which is repeatable and reliable, enabling the monitoring of individual response to stimuli.
NATURE COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Yuhui Hong, Sujun Li, Christopher J. Welch, Shane Tichy, Yuzhen Ye, Haixu Tang
Summary: 3DMolMS is a deep neural network model that predicts mass spectra from the 3D conformations of compounds. It achieved an average cosine similarity of 0.691 and 0.478 with experimental MS/MS spectra in positive and negative ion modes, respectively. The model can be fine-tuned to predict spectra acquired by different labs and instruments. Additionally, the molecular representation learned by 3DMolMS can enhance the prediction of chemical properties such as elution time and collisional cross section.
