期刊
ANALYTICAL CHEMISTRY
卷 81, 期 2, 页码 618-624出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac801919n
关键词
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资金
- Robert A. Welch Foundation [A-1176]
- U.S. Department of Energy, Division of Chemical Sciences, BES [DE-FG-04ER-15520]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0821700] Funding Source: National Science Foundation
An ion mobility-mass spectrometer (IM-MS) interface is described that can be employed to perform collisional activation and/or collision-induced dissociation (CID) with good transmission of mobility separated ions to the MS analyzer. The IM-MS interface consists of a stacked-ring ion guide design, where the field strength and pressure ratio can be operated such that structural rearrangement reactions and/or CID are achieved as a function of the effective ion temperature. The ion dynamics and collisional activation processes in the IM-MS interface are described as a function of the ion-neutral collisions, ion kinetic energies, and effective ion temperature. The applicability of the IM-CID-MS methodology to studies of peptide ion fragmentation is illustrated using a series of model peptides.
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