Article
Biophysics
Felix Hempel, Jessica Ka Yan Law, Thanh Chien Nguyen, Ruben Lanche, Anna Susloparova, Xuan Thang Vu, Sven Ingebrandt
Summary: The study investigated single-cell adhesion on organic electrochemical transistors using an impedimetric readout method, demonstrating single-cell resolution and potential future applications.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Viktoria Heine, Tom Kremers, Nora Menzel, Uwe Schnakenberg, Lothar Elling
Summary: The study presents a novel electrochemical impedance spectroscopy sensor for real-time monitoring of bacterial fucosyltransferase binding kinetics. By immobilizing a multivalent neoglycoprotein on the sensor, the researchers were able to detect glycosyltransferase activities and protein-glycan interactions, which could be valuable for detecting pathogenic bacteria and cancer cells in future biomedical applications.
Article
Engineering, Biomedical
Yi-Jie Lin, Wei-Cheng Liu, Yu-Chiao Huang, Ying-Jie Huang, Yung-Hua Yeh, Min-Hua Chang, Shu-Ping Lin, Ying-Chih Liao, Yu-Te Liao
Summary: This article presents a multimodal electrochemical sensing system-on-chip (SoC) that includes the functions of cyclic voltammetry, electrochemical impedance spectroscopy, and temperature sensing. The system achieves adaptive readout current range, high impedance resolution, extended maximum detectable load impedance, and high temperature sensing resolution.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2023)
Article
Computer Science, Hardware & Architecture
Muhammad Rizwan Khan, Rameesha Qaiser, Wala Saadeh
Summary: Diagnostic testing is crucial in modern medicine, and the electrochemical impedance spectroscopy (EIS) technique provides a sensitive method for detecting protein biomarkers in biological samples, aiding disease diagnosis and treatment decisions.
IEEE TRANSACTIONS ON VERY LARGE SCALE INTEGRATION (VLSI) SYSTEMS
(2022)
Article
Biochemistry & Molecular Biology
Chien-Chu Huang, Shao-Chih Chiu, Shih-Chi Chao, Heng-Yi Liao, Shiao-Pieng Lee, Chun-Chung Huang, Der-Yang Cho
Summary: CBD has a cytotoxic effect on oral cancer cells and induces apoptosis. It also affects the morphology and migration of OEC-M1 cells. ECIS analysis shows that CBD decreases the overall resistance and morphological parameters of the cells in a concentration-dependent manner. The study demonstrates that ECIS is more sensitive, functional, and comprehensive than traditional biochemical assays.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Anna M. Nelson, Sanaz Habibi, John O. L. DeLancey, James A. Ashton-Miller, Mark A. Burns
Summary: Urinary chloride concentration is a valuable health metric that can aid in the early detection of serious conditions. A chronopotentiometric sensor utilizing screen-printed electrodes is introduced, allowing for accurate and rapid quantification of clinically relevant chloride concentrations. This study provides a path for further development of a portable, near real-time sensor for the quantification of urinary chloride.
Article
Engineering, Electrical & Electronic
Jose Waimin, Hongjie Jiang, David A. Detwiler, Martha E. Jimenez-Castaneda, Zeynep Mutlu, Mukerrem Cakmak, Tim Filley, Rahim Rahimi
Summary: Bacteria play essential roles in soil health maintenance, and real-time monitoring of their activity levels can provide insights into soil quality, nutrient availability, and future crop yields. A non-destructive technique for monitoring cellulase activity of microorganisms in targeted ecosystems has been demonstrated using a cellulose acetate membrane. The proposed method shows potential for in-field measurements and real-time assessment of microbial activity, with implications for precision agricultural applications.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Chemistry, Analytical
Zhen Zhou, Xiaoyu Zhang, Tiean Zhou, Fushen Huang, Jinjun Chen
Summary: In this study, the adhesion and myocardial pulsation ability of rat primary cardiomyocytes were monitored in real time using a combination of electrical impedance sensing (EIS) and quartz crystal microbalance (QCM) technologies. The results showed that both EIS and QCM techniques provided consistent results and that QCM had a certain sensitivity in calculating cardiomyocyte beating. The study validates the reliability and validity of the QCM technique for measuring cardiomyocyte beating and drug testing.
Article
Engineering, Multidisciplinary
Lu Yang, Hongtao Wu, Yongnian Zhang, Hanyang Huang, Kai Liu, Bai Chen, Jiafeng Yao
Summary: A method for monitoring medaka embryo development using differential Electrical Impedance Spectroscopy (EIS) is proposed, which can extract the electrical characteristics of the embryo while eliminating the influence of electrodes and suspension. Simulation and experimental results demonstrate that this method can accurately reflect the morphological and physiological changes of the embryo.
Article
Chemistry, Multidisciplinary
Ying Yang, Friederike M. Mansfeld, Maria Kavallaris, Katharina Gaus, Richard D. Tilley, J. Justin Gooding
Summary: Impedance spectroscopy can reveal cell-to-cell heterogeneity in response to chemotherapeutic agents, while electrochemical noise reflects instantaneous responses of cells to drugs. By combining electrochemical impedance and electrochemical noise with fluorescence microscopy, information on cell susceptibility and resistance to drugs at the single cell level can be obtained.
Article
Biochemistry & Molecular Biology
Michael H. Guerra, Thangal Yumnamcha, Abdul-Shukkur Ebrahim, Elizabeth A. Berger, Lalit Pukhrambam Singh, Ahmed S. Ibrahim
Summary: This study investigated the impact of cytopathic hypoxia on the barrier functionality of RPE cells through ECIS system and seahorse technology, revealing a dose-dependent reduction in total impedance of ARPE-19 cells by CoCl2 treatment. Furthermore, CoCl2 significantly impaired mitochondrial function and decreased expression of ZO-1, a major paracellular tight junction protein, in ARPE-19 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Analytical
Sikander Ameer, Hussam Ibrahim, Muhammad Usama Yaseen, Fnu Kulsoom, Stefano Cinti, Mazhar Sher
Summary: Biofilms are complex communities of microorganisms that can form on various surfaces, and their presence can lead to infections, reduced efficiency, biofouling, and environmental damage. Electrochemical impedance sensing has emerged as a promising approach for real-time, non-destructive, and rapid monitoring of biofilms, with high sensitivity, versatility, and low cost.
Article
Chemistry, Multidisciplinary
Yu Qin, Xue-Bo Hu, Wen-Ting Fan, Jing Yan, Shi-Bo Cheng, Yan-Ling Liu, Wei-Hua Huang
Summary: A stretchable and multifunctional platform integrating 3D cell culture, mechanical loading, and electrochemical sensing has been developed for the first time, showing promising potential in exploring mechanotransduction in 3D cellular systems and engineered tissues. The platform utilizes biomimetic peptide linked gold nanotubes on porous and elastic polydimethylsiloxane to mimic articular cartilage and investigate mechanotransduction pathways in chondrocytes. The results reveal previously unclear mechanisms, such as the rapid activation of nitric oxide signaling by mechanical loading in chondrocytes.
Article
Materials Science, Ceramics
Berceste Beyribey, Hwan Kim, Joshua Persky
Summary: BaCe0.7Zr0.1Y0.16Zn0.04O3-δ perovskite shows great potential as an electrolyte in industrial steam electrolysis applications, with excellent protonic conductivity and stability, especially at elevated temperatures. The formation/degradation of secondary phases in wet atmospheres is attributed to the formation of Ba(OH)2 and CeO2 around 500 degrees C. This material is a promising candidate for industrial fuel cells and steam electrolysers.
CERAMICS INTERNATIONAL
(2021)
Review
Chemistry, Analytical
Zhao Zhang, Xiaowen Huang, Ke Liu, Tiancong Lan, Zixin Wang, Zhen Zhu
Summary: Cellular heterogeneity is important in cell-based assays, and electrical impedance sensing technology allows for rapid, non-invasive acquisition of single cell electrical parameters. These parameters are closely related to cellular properties and activities, and devices such as impedance flow cytometry and electrical impedance spectroscopy are used for cell recognition, counting, viability detection, phenotypic assay, and other cell detection. Impedance sensing technology shows promise in single-cell analysis.
Article
Engineering, Petroleum
Aobo Li, Shuo Zhang, Chicheng Xu, Xiaoguang Zhao, Xin Zhang
Summary: In this study, two-photon polymerization 3D printing technology was used to print a submicrometer resolution rock proxy of Berea sandstone. The internal structures of the 3D-printed sample were verified using SEM and CT images compared to the digital file. This method provides a way to conduct repeatable laboratory experiments without destroying natural rock samples, potentially validating numerical simulations and complementing existing laboratory measurements.
Article
Chemistry, Multidisciplinary
Ke Wu, Xiaoguang Zhao, Thomas G. Bifano, Stephan W. Anderson, Xin Zhang
Summary: Auxetics, with a negative Poisson's ratio, are utilized to design tunable metamaterials for MRI applications, enabling frequency tunability through electromagnetic interaction modification. The metamaterials fabricated using 3D printing technology show an approximate 20 MHz frequency shift during deformation, resulting in a significant boost in MRI signal-to-noise ratio.
ADVANCED MATERIALS
(2022)
Article
Optics
Chunxu Chen, Kelson Kaj, Xiaoguang Zhao, Yuwei Huang, Richard Averitt, Xin Zhang
Summary: Metasurfaces have shown great potential in controlling electromagnetic waves using arrays of subwavelength resonators. In this study, a mechanically reconfigurable metasurface based on a microelectromechanical system (MEMS) is presented for dynamic surface wave switching at terahertz frequencies. The metasurface allows for efficient conversion between plane waves and surface waves with a wide working bandwidth. This technology has applications in spatial light modulation, beam steering, focusing, and beam combining for future communication systems.
Article
Engineering, Electrical & Electronic
Ryan McNaughton, Yuda Huo, Guicai Li, Anais Di Via Ioschpe, Lei Yan, Heng-Ye Man, Xin Zhang
Summary: This study demonstrates the use of microfabrication techniques to monitor the morphological and synaptic connectivity changes of neurons in response to physical stimuli. The results show that microtopography can enhance neuron adhesion and axon growth, while inhibiting dendritic arborization and presynaptic puncta architecture.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryan McNaughton, Chris Pieper, Osamu Sakai, Julie Rollins, Xin Zhang, David N. Kennedy, Jean A. Frazier, Laurie Douglass, Timothy Heeren, Rebecca C. Fry, T. Michael O'Shea, Karl K. Kuban, Hernan Jara
Summary: This study compared the differences in brain structural parameters between adolescents born extremely preterm with autism spectrum disorder, cerebral palsy, epilepsy, or cognitive impairment and typically developing adolescents. The study found that sex played an important role in brain development, with lower white matter proton density in girls with atypical development and longer white matter T1 in boys with atypical development, which were associated with microstructural organization in white matter.
Article
Nanoscience & Nanotechnology
Yuwei Huang, Kelson Kaj, Chunxu Chen, Zhiwei Yang, Sheikh Rubaiat Ul Haque, Yuan Zhang, Xiaoguang Zhao, Richard D. Averitt, Xin Zhang
Summary: This article introduces a thin membrane silicon metasurface absorber that achieves very high absorption over a bandwidth of approximately 500 GHz. The absorber can be used in terahertz devices such as detectors, modulators, and switches.
Article
Nanoscience & Nanotechnology
Ke Wu, Guangwu Duan, Xiaoguang Zhao, Chunxu Chen, Stephan William Anderson, Xin Zhang
Summary: RFID technology is widely used in industrial applications for tracking and tracing products, assets, and material flows. The trend towards miniaturized RFID sensor tags continues to advance, but presents challenges for communication coverage area. Recent efforts have focused on using metamaterials to increase power transfer efficiency in RFID systems. Applying magnetic metamaterials and local field enhancement package to near-field RFID technology offers high power transfer efficiency and larger communication coverage area, creating new opportunities in the emerging Internet of Things era.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Samuel H. Kann, Erin M. Shaughnessey, Jonathan R. Coppeta, Hesham Azizgolshani, Brett C. Isenberg, Else M. Vedula, Xin Zhang, Joseph L. Charest
Summary: This study integrates optical-based oxygen sensors in a high-throughput organ-on-chip platform to monitor the metabolic activity of cells in membrane bilayer devices. By measuring oxygen changes in real-time and estimating cell oxygen consumption rates using a finite element analysis model, metabolic shifts in human renal proximal tubule cells following exposure to different drugs were successfully detected.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Physics, Applied
Ao Chen, Xiaoguang Zhao, Zhiwei Yang, Stephan Anderson, Xin Zhang
Summary: Ventilated acoustic insulation, based on labyrinthine metamaterials, is a promising research direction in applied acoustics. The proposed design shows potential for high-performance wide-band acoustic insulation and ventilation. The design achieves effective soundproofing in the frequency range and provides a foundation for the development of broadband ventilated acoustic insulators.
PHYSICAL REVIEW APPLIED
(2022)
Article
Physics, Applied
Yuwei Huang, Xuefei Wu, Jacob Schalch, Guangwu Duan, Chunxu Chen, Xiaoguang Zhao, Kelson Kaj, Hai-Tian Zhang, Roman Engel-Herbert, Richard D. Averitt, Xin Zhang
Summary: By integrating with dynamic quantum materials like vanadium dioxide (VO2), tunable metamaterials can be created for high-performance devices in challenging applications. The symbiotic integration of metamaterial arrays with quantum materials enhances the modulation amplitude and reveals a redshift in the resonant frequency during the insulator-to-metal transition (IMT).
PHYSICAL REVIEW APPLIED
(2022)
Article
Materials Science, Multidisciplinary
Yuwei Huang, Kelson Kaj, Chunxu Chen, Zhiwei Yang, Richard D. Averitt, Xin Zhang
Summary: Bound states in the continuum (BIC) is an exotic concept describing systems without radiative loss. This study introduces a structurally tunable BIC terahertz metamaterial fabricated using micromachining and characterized using terahertz time domain spectroscopy. The bending angle of the metamaterial is controlled by thermal actuation to modify the capacitance and achieve tuning from a quasi-BIC state to the BIC state. Temporal coupled mode theory (CMT) is used to gain additional insight into the tunable electromagnetic response of the metamaterial.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Physics, Applied
Ao Chen, Zhiwei Yang, Xiaoguang Zhao, Stephan Anderson, Xin Zhang
Summary: We propose a composite acoustic metamaterial consisting of Mie resonators and a Helmholtz resonator array, which achieves a broadband acoustic attenuation in the low-frequency regime. The wideband soundproofing effect is explained using the transfer-matrix method and the lumped-element model, and the transmission loss and transmittance are tested numerically and experimentally. By using a deep-subwavelength structure, our composite design successfully blocks over 90% of incident acoustic energy within a frequency range of 1250 Hz, offering a design paradigm for extraordinary airborne acoustic silencing in low-frequency regimes.
PHYSICAL REVIEW APPLIED
(2023)
Article
Materials Science, Multidisciplinary
Xia Zhu, Ke Wu, Stephan W. Anderson, Xin Zhang
Summary: Signal-to-noise ratio (SNR) is an important metric for assessing MRI image quality. This study proposes a Helmholtz coil-inspired volumetric wireless resonator that can significantly enhance SNR. Experimental results show that the SNR can be boosted by 5 times or more in the region covering the human knee. This research offers an efficient and practical wireless solution for improving MRI image quality, with potential applications in various imaging fields.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Analytical
Samuel H. Kann, Erin M. Shaughnessey, Xin Zhang, Joseph L. Charest, Else M. Vedula
Summary: Monitoring steady state oxygen levels in a high-throughput organ-on-chip platform with integrated optical-based oxygen sensors can evaluate drug-induced nephrotoxicity in a human microfluidic co-culture model of the kidney proximal tubule. The study demonstrates the dose and time-dependent injury responses of human PT cells to cisplatin using oxygen consumption measurements in the platform. The results highlight the utility of steady state oxygen measurements as a rapid, non-invasive, and kinetic readout of drug-induced injury in high-throughput microfluidic kidney co-culture models.
Proceedings Paper
Engineering, Electrical & Electronic
Xin Zhang, Zhiwei Yang, Yuwei Huang
Summary: Metamaterials are artificial materials that can control the propagation of electromagnetic waves through precise tailoring. Recent research aims to achieve functional and modular metamaterials that can be controlled in real-time through external stimuli. The application of microsystem technologies enhances the functionality and tunability of metamaterials.
2022 INTERNATIONAL ELECTRON DEVICES MEETING, IEDM
(2022)