Article
Biochemical Research Methods
Harmain Rafi, Alexander G. Zestos
Summary: The article introduces a novel carbon fiber multielectrode array technology that can record redox activity in different areas within the mouse caudate putamen and detect dopamine. This multielectrode array, coupled with multiple waveforms and a four-channel potentiostat, enables multiplexing neurochemical measurements and may help better understand brain complexity and the impact of disease states in future research.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Anntonette N. Perry, Michael T. Cryan, Ashley E. Ross
Summary: Zinc (Zn(II)) is a divalent cation that plays a role in regulating intracellular signal transduction and gene expression, and can act as a neurotransmitter in the brain. A new electrochemical waveform called extended sawhorse waveform (ESW) was developed for fast-scan cyclic voltammetry detection at carbon-fiber microelectrodes, enabling rapid and stable monitoring of Zn(II) levels. Introduction of Zn(II) using traditional waveform caused plating on the electrode surface, but using the ESW showed significant improvements in stability for monitoring Zn(II) signaling in the brain.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Physical
Manon Guille-Collignon, Frederic Lemaitre
Summary: In this article, recent important results related to the electrochemical detection of vesicular exocytosis by amperometry with microelectrodes over the past three years have been summarized. The historical carbon fiber amperometry method continues to be widely used in this scientific field, and new methodologies have emerged to expand the limits of the initial technique, demonstrating the advancement in the field. The development of exocytosis analysis techniques has become an indispensable routine experimental technique.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Chemistry, Analytical
Tiago Monteiro, Candida Dias, Catia F. Lourenco, Ana Ledo, Rui M. Barbosa, M. Gabriela Almeida
Summary: Impaired blood flow to the brain can lead to cerebral ischemia, resulting in neuronal injury or death. A new method using fast-scan cyclic voltammetry and carbon microfiber electrodes has been proposed for real-time measurement of nitrite concentration in the brain extracellular space, providing valuable insights into the role of this inorganic anion in brain redox signaling.
Article
Neurosciences
Melinda Hersey, Srimal Samaranayake, Shane N. Berger, Navid Tavakoli, Sergio Mena, H. Frederik Nijhout, Michael C. Reed, Janet Best, Randy D. Blakely, Lawrence P. Reagan, Parastoo Hashemi
Summary: This study investigates the interaction between serotonin, inflammation, and SSRIs using fast in vivo serotonin measurement tools. It reveals the significant impact of inflammation on the clinical variability of SSRIs and highlights histamine as a potentially critical player in the pathology of depression. This suggests that serotonin/histamine homeostasis may be a crucial new avenue in improving serotonin-based treatments for depression.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Electrochemistry
Alexandra L. Keller, Steven M. Quarin, Pietro Strobbia, Ashley E. Ross
Summary: This study demonstrates that the density and shape of platinum nanoparticles on carbon-fiber microelectrodes directly affect the detection of adenosine. By altering the concentration of K2PtCl6 and the electrodeposition time, the density and size of PtNPs can be manipulated, which in turn affects the adsorption behavior and sensitivity. The research also provides insights into the differences in the interaction between adenosine and dopamine on electrode surfaces.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Engineering, Electrical & Electronic
Tanoy Kumar Dey, Sara Tombelli, Palas Biswas, Ambra Giannetti, Nandini Basumallick, Francesco Baldini, Somnath Bandyopadhyay, Cosimo Trono
Summary: A long period fiber grating sensor with maximum enhancement of the evanescent field working with the lowest order cladding mode has been fabricated and analyzed in terms of dual peak resonance wavelengths and coupling conditions. The sensitivity of the sensor to surrounding refractive index was measured to be 8751 nm/SRIU with a resolution of 10(-5) within a specific SRI range.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Chao Du, Shuang Zhao, Qiuyu Wang, Bin Jia, Mingzhe Zhao, Li Zhang, Liqin Cui, Shizhe Chen, Xiao Deng
Summary: Existing methods for measuring seawater salinity have low sensitivity and accuracy. This study proposes a seawater salinity sensor based on long period fiber grating (LPFG) in the dispersion turning point (DTP), which shows good repeatability and stability. It offers a low-cost way to monitor seawater salinity in real time.
Article
Multidisciplinary Sciences
Zexuan Meng, Yuchan Zhang, Lu Yang, Shuang Zhao, Qiang Zhou, Jiajia Chen, Jiuxi Sui, Jian Wang, Lizhong Guo, Luyue Chang, Jialing He, Guixue Wang, Guangchao Zang
Summary: We constructed a composite membrane-modified carbon fiber microelectrode for ascorbic acid detection and used it to observe the process of glutamate-induced brain cytotoxic edema with AA release and reveal the mechanism. Our study is significant for monitoring neurochemicals, understanding the molecular basis of nervous system diseases, and discovering biomarkers of brain diseases.
Article
Biochemical Research Methods
Noel Manring, Muzammil M. N. Ahmed, Jessica L. Smeltz, Pavithra Pathirathna
Summary: The etiology of neurodegenerative diseases is poorly understood and the heavy metal copper has been found to play a critical role in neurotoxicity, affecting the development of these diseases. Analyzing heavy metals in the brain is challenging due to the limitations of existing metal detection tools, resulting in inadequate data for developing efficient therapeutics. This study developed a surface-modified electrode using fast-scan cyclic voltammetry to detect ultra-low concentrations of copper in the brain accurately and in real time.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Tanoy Kumar Dey, Sara Tombelli, Arpan Roy, Palas Biswas, Ambra Giannetti, Nandini Basumallick, Francesco Baldini, Somnath Bandyopadhyay, Cosimo Trono
Summary: A new methodology to enhance the sensitivity of a long period fiber grating sensor (LPFG) at the Turn Around Point (TAP) has been presented. The LPFG sensor was fabricated by etching the fiber up to 20.4 μm, until the sidelobes of dispersed LP0,2 cladding mode appeared near TAP in aqueous medium. The dual peak sensitivity of the sidelobes was found to be 16,044 nm/SRIU (surrounding refractive index units) in the RI range from 1.333 to 1.3335.
Article
Polymer Science
Lara Greiner, Manfred Doering, Sebastian Eibl
Summary: This study investigates the impact of different phosphorus-containing flame retardants on fiber degradation in carbon fiber reinforced epoxy resins during combustion. Phosphazene and phosphate have shown high flame retardant efficiency and fiber protection, with phosphazene performing best in the gas phase and phosphate showing superior performance in the condensed phase. Mechanical properties were not significantly affected by the incorporation of flame retardants, ensuring their application in components manufactured by resin transfer moulding.
POLYMER DEGRADATION AND STABILITY
(2021)
Article
Thermodynamics
Yoshinari Kobayashi, Keisuke Matsumoto, Naoki Matsukawa, Shuhei Takahashi
Summary: In this study, the combustion characteristics of carbon fiber reinforced plastic (CFRP) sheets with different carbon fiber (CF) orientations were investigated under variable opposed-flow velocity (Vg) and oxygen concentration. It was found that the limiting oxygen concentration increased with the CF orientation angle (θ) and linearly decreased with increasing Vg. The flame spread rate (Vf) was the highest when the CF orientation corresponded to the flame spread direction (θ = 0 deg.) and increased with Vg. Conductive heat transfer sideways became more significant as θ increased, leading to decreased net heat transfer rates contributing to flame spread, resulting in low flammability and weak flame spread.
PROCEEDINGS OF THE COMBUSTION INSTITUTE
(2023)
Article
Chemistry, Analytical
Luis Lopez, Nerika Hernandez, Joshua Reyes Morales, John Cruz, Krystal Flores, John Gonzalez-Amoretti, Vitmary Rivera, Lisandro Cunci
Summary: The study demonstrated the measurement of Neuropeptide Y using aptamer-modified microelectrodes by electrochemical impedance spectroscopy. The method showed high sensitivity, specificity, and a wide linear range for NPY detection without the need for a redox reaction. The immobilization and biofouling of the microelectrodes were studied and compared, with changes in impedance factors directly correlated with NPY concentrations.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Changhao Bao, Min Shi, Wenwen Ma, Jun Li, Xianju Huang, Han Cheng
Summary: In this study, a PtNPs/AuNPs modified CFME was developed to simultaneously detect aesculin and aesculetin. The modified electrode exhibited high electrocatalytic activity, and the linear ranges and detection limits achieved were the lowest reported. The electrode also showed potential for DNA detection and could be successfully applied in measuring aesculin and aesculetin in biological samples.
ANALYTICA CHIMICA ACTA
(2022)
Editorial Material
Biochemical Research Methods
B. Jill Venton, Rebecca R. Pompano
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yuanyu Chang, B. Jill Venton
Summary: Rapid adenosine signaling in the brain provides local neuromodulation but is limited in spatial resolution and regional coordination. This study used dual-channel fast-scan cyclic voltammetry to measure adenosine release in mouse brain slices, revealing localized spontaneous adenosine events and regionally extended adenosine release after mechanical stimulation.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Physical
Qizhang Jia, Cheng Yang, B. Jill Venton, Kateri H. DuBay
Summary: This study utilizes molecular dynamics simulations to investigate the surface diffusion of dopamine on graphene. The findings suggest that dopamine rapidly adsorbs to the surface and diffuses quickly, with its vertical placement influenced by charge.
Article
Chemistry, Physical
Qun Cao, Zijun Shao, Dale Hensley, B. Jill Venton
Summary: This study mass fabricates carbon nanoelectrodes by growing carbon nanospikes (CNSs) on metal wires, which have remarkable electrochemical properties and can be mass fabricated on almost any substrate without using catalysts. The CNS nanoelectrodes show excellent sensitivity for the detection of neurotransmitters like dopamine using fast-scan cyclic voltammetry.
FARADAY DISCUSSIONS
(2022)
Article
Electrochemistry
Zijun Shao, B. Jill Venton
Summary: Carbon nanotube yarn microelectrodes (CNTYMEs) exhibit different trapping effects on anions and cations, and secondary peaks can be used for dopamine identification in mixtures.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Editorial Material
Chemistry, Physical
Jordi Cabana, Thomas Alaan, George W. Crabtree, Marta C. Hatzell, Karthish Manthiram, Daniel A. Steingart, Iryna Zenyuk, Feng Jiao, Aleksandra Vojvodic, Jenny Y. Yang, Nitash P. Balsara, Kristin A. Persson, Donald J. Siegel, Christy L. Haynes, Janine Mauzeroll, Mei Shen, B. Jill Venton, Nina Balke, Joaquin Rodriguez-Lopez, Debra R. Rolison, Reza Shahbazian-Yassar, Venkat Srinivasan, Santanu Chaudhuri, Adrien Couet, Jason Hattrick-Simpers
ACS ENERGY LETTERS
(2022)
Article
Biochemical Research Methods
Scott T. Lee, Yuanyu Chang, B. Jill Venton
Summary: This study investigated the role of pannexin channels, specifically pannexinl (Panx1) channels, in rapid adenosine release. The results showed that Panx1 is a release mechanism for mechanically stimulated adenosine release, but not the only mechanism.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Zijun Shao, Yuanyu Chang, B. Jill Venton
Summary: Carbon electrodes are widely used in neurotransmitter detection due to their good electrochemical properties, high biocompatibility, and inert chemistry. Customizing the shape and nanostructuring the surface of carbon electrodes enhance their electrochemical properties, including sensitivity, selectivity, and secondary peaks. This enables new applications in neuroscience, such as distinguishing different catecholamines, detecting vesicular release in single cells, and multi-region measurements in vivo.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Kelly E. Dunham, B. Jill Venton
Summary: This study provides a detailed investigation into the effects of selective serotonin reuptake inhibitors (SSRIs) on serotonin concentration and reuptake in fruit fly larvae. The results show that different types of SSRIs have varying effects on serotonin concentration and reuptake in this model, which is valuable for future studies exploring the pharmacological effects of SSRIs with different genetic mutations in fruit flies.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qizhang Jia, B. Jill Venton, Kateri H. DuBay
Summary: This study investigates the adsorption and surface diffusion dynamics of dopamine on carbon nanotubes (CNTs) using molecular dynamics simulations. The results show that solvent affects the diffusion of adsorbates on solvated CNT surfaces, while curvature changes have minimal impact on diffusion. Furthermore, dopamine diffuses into the groove between aligned CNTs, enhancing its diffusion along the CNT axis.
Article
Chemistry, Multidisciplinary
Mimi Shin, B. Jill Venton
Summary: In this study, we developed fast-scan cyclic voltammetry (FSCV) to measure dopamine release in fruit flies during behavior. The results showed that sugar feeding induced longer dopamine release compared to acetylcholine stimulation in the mushroom body. In addition, administering dopamine transporter inhibitor or D2 receptor antagonist significantly increased sugar-evoked dopamine release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
B. Jill Venton, Zijun Shao, Leslie Wilson, Yuanyu Chang
Summary: Nanodiamonds (NDs) are a promising material for electrochemical sensing due to their large surface area, defect sites, and functional groups. Growing thin films of ND on niobium wires and oxygen plasma etching can increase sensitivity but slightly decrease fouling resistance.
Article
Biochemistry & Molecular Biology
Eduard Dumitrescu, Jeffrey M. Copeland, B. Jill Venton
Summary: This study investigates the effect of parkin knockdown on dopamine release in Drosophila. The results show that parkin knockdown causes age-dependent reduction of dopamine release in certain brain regions, leading to impaired locomotion. The findings provide insights into the mechanism of Parkinson's disease and suggest Drosophila as a useful model for studying dopamine functionality and potential therapies.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Chemistry, Physical
Yuanyu Chang, Qun Cao, B. Jill Venton
Summary: Traditional carbon electrodes made of glassy carbon or carbon fibers have limited shapes. 3D printing enables complete customization of shape and simultaneous fabrication of devices and electrodes. Additive manufacturing, the most common 3D printing method, involves adding carbon materials to make it conductive and applying treatments to enhance electrochemical activity. Another newer form, 2-photon lithography uses laser lithography to print electrodes in photoresist and then annealed to carbon. Applications of 3D printed carbon electrodes include nanoelectrode measurements, biosensor arrays, and integrated electrodes in microfluidic devices.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Article
Biochemical Research Methods
He Zhao, Kailash Shrestha, Dale K. Hensley, B. Jill Venton
Summary: Carbon nanospikes (CNSs) are a new nanomaterial that enhances the sensitivity for dopamine detection. In this study, CNS-modified electrodes (CNSMEs) were evaluated for the detection of adenosine, hydrogen peroxide ( H2O2), and histamine. The results showed that CNSMEs had higher signals compared to conventional electrodes (CFMEs), with increased sensitivity for adenosine (4.8 times), H2O2 (1.5 times), and histamine (2 times). CNSMEs also promoted the formation of secondary products for adenosine and histamine, allowing differentiation from analytes with similar oxidation potentials. CNSs selectively enhanced the sensitivity for adenosine and histamine compared to H2O2. The use of CNSMEs in brain slices and tissue measurements showed high selectivity and low fouling.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)