Review
Chemistry, Multidisciplinary
Vasiliki Tsampasian, Ioannis Merinopoulos, Donnie Cameron, Pankaj Garg, Vassilios S. Vassiliou
Summary: Myocardial inflammation is proposed as a common mechanism underlying the development and progression of cardiovascular diseases. Cardiac magnetic resonance (CMR) is a non-invasive technique that allows direct visualization of the myocardium. The use of ultrasmall superparamagnetic particles of iron oxide (USPIO) in CMR is gaining research interest and can provide valuable information for identifying active inflammation in the myocardium, which is hypothesized to be the substrate for adverse remodeling and heart failure.
APPLIED SCIENCES-BASEL
(2022)
Article
Nanoscience & Nanotechnology
Jinling Gao, Huige Zhou, Yanjie Zhao, Lin Lu, Jianzhong Zhang, Wenting Cheng, Xuxia Song, Yuxin Zheng, Chunying Chen, Jinglong Tang
Summary: The metabolism of ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) in cells can induce ferroptosis, characterized by the transformation of iron oxide to ferritin, down-regulation of intracellular GPX4, and accumulation of lipid peroxide. These findings provide insight into the time-dependent process of ferroptosis activation involving iron overload and lipid peroxidation in the cell membrane.
Article
Biotechnology & Applied Microbiology
Qinmin Liu, Lijuan Liu, Chunwei Mo, Xiao Zhou, Dongming Chen, Yu He, Hailu He, Wei Kang, Yongfeng Zhao, Guanqiao Jin
Summary: The synthesized USPIO-PEG-sLe(x) nanoparticles demonstrate excellent photothermal conversion properties and showed significant cytotoxic effects on NPC cells in vitro. Additionally, they could target the tumor area and reduce the T2* value of tumor tissue. This nanotheranostic platform may serve as a new strategy for treating NPC.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Oncology
Svenja Engels, Bianca Michalik, Luca-Marie Meyer, Lena Nemitz, Friedhelm Wawroschek, Alexander Winter
Summary: Magnetometer-guided sentinel lymph node dissection in prostate cancer patients detected more sentinel lymph nodes per patient and predicted lymph node involvement rates equally well compared to the standard technique. This study confirmed the reliability of magnetometer-guided sentinel lymph node dissection and emphasized the importance of the sentinel technique in detecting lymph node metastases in prostate cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Caroline M. Colbert, Zhengyang Ming, Arutyun Pogosyan, J. Paul Finn, Kim-Lien Nguyen
Summary: This study compares the in vitro and in vivo MRI relaxometry and enhancement of Feraheme, generic ferumoxytol, and MoldayION. The results demonstrate that MoldayION has minor differences in in vitro relaxometry and comparable in vivo MRI characteristics compared to clinically approved ferumoxytol formulations.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
B. H. E. Jansen, Y. J. L. Bodar, G. J. C. Zwezerijnen, D. Meijer, J. P. van der Voorn, J. A. Nieuwenhuijzen, M. Wondergem, T. A. Roeleveld, R. Boellaard, O. S. Hoekstra, R. J. A. van Moorselaar, D. E. Oprea-Lager, A. N. Vis
Summary: The study found that F-18-DCFPyL PET/CT has high specificity but limited sensitivity for detecting pelvic lymph-node metastases in primary prostate cancer patients. Therefore, current PSMA PET/CT imaging cannot fully replace diagnostic ePLND. Further research is needed to determine the exact role of PSMA PET/CT imaging in the primary staging of prostate cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Computer Science, Artificial Intelligence
Iam Palatnik de Sousa, Marley M. B. R. Vellasco, Eduardo Costa da Silva
Summary: This study presents a novel evolutionary approach for Explainable Artificial Intelligence, combining Local Interpretable Model Agnostic Explanations (LIME) with Multi-Objective Genetic Algorithms. The results show that this methodology can find high quality explanations and has the advantage of automated parameter fine tuning.
Article
Obstetrics & Gynecology
Tanja Ignatov, Johannes Gassner, Mihaela Bozukova, Stylianos Ivros, Jozsef Meszaros, Olaf Ortmann, Holm Eggemann, Atanas Ignatov
Summary: The risk of contralateral non-SLN metastases in patients with unilateral SLN metastases in vulvar cancer is low, suggesting a need for further investigation into the impact of contralateral lymphadenectomy on patient survival.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rutger C. H. Stijns, Bart W. J. Philips, Iris D. Nagtegaal, Fatih Polat, Johannes H. W. de Wilt, Carla A. P. Wauters, Patrik Zamecnik, Jurgen J. Fritterer, Tom W. J. Scheenen
Summary: The study evaluated the initial results of predicting lymph node metastasis in rectal cancer patients using USPIO-enhanced MRI at 3 T. High-resolution MRI visualized a large number of mesorectal lymph nodes, but USPIO-enhanced MRI was not accurate in differentiating small benign from small tumoral lymph nodes in rectal cancer patients. Suspicious nodes on in-vivo MRI were found to be both inflammatory and metastatic nodes.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Zhenyu Yang, Xingliang Tan, Yanjun Wang, Yuantao Zou, Dong Chen, Zhiming Wu, Zhuowei Liu, Yonghong Li, Zike Qin, Hui Han, Fangjian Zhou, Kai Yao
Summary: The study evaluated the relationship between deep inguinal lymph node metastasis and pelvic lymph node metastasis in PSCC, finding that deep ILNM is the most accurate factor for predicting PLNM. Patients with deep ILNM should be referred for pelvic lymph node dissection, as it indicates poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Bo Chen, Guochun Zhang, Jianguo Lai, Weikai Xiao, Xuerui Li, Cheukfai Li, Hsiaopei Mok, Kai Li, Yulei Wang, Li Cao, Minghan Jia, Chongyang Ren, Lingzhu Wen, Guangnan Wei, Jiali Lin, Yingzi Li, Yuchen Zhang, Xiaoqing Chen, Xueying Wu, Henghui Zhang, Min Li, Jing Liu, Charles M. Balch, Ning Liao
Summary: This study revealed significant differences in molecular and immune profiles between single lymph node metastases and multiple lymph node metastases in breast cancer patients. Single lymph node metastases were associated with more aggressive tumor characteristics and more favorable immune characteristics compared to multiple lymph node metastases.
Article
Oncology
Nushin Mirzaei, Fredrik Waernberg, Pontus Zaar, Henrik Leonhardt, Roger Olofsson Bagge
Summary: This study aimed to determine the feasibility of detecting sentinel lymph nodes (SLNs) in breast cancer patients using an ultra-low dose of superparamagnetic iron oxide nanoparticles (SPIO). SPIO was injected intradermally 4 days before surgery, and SLNs were detected using a handheld magnetometer during surgery. The results showed that SLNs were successfully detected in all patients using the ultra-low dose of SPIO.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Guiling Lu, Liang Chen
Summary: This study compared the diagnostic performance of ultrasound and computed tomography in screening for cervical lymph node metastasis in patients with papillary thyroid cancer before thyroidectomy. The results showed that computed tomography had higher sensitivity and accuracy compared to ultrasound, making it a complementary imaging method for detecting lymph node metastasis.
Article
Oncology
Qiufang Liu, Jiaru Li, Bowen Xin, Yuyun Sun, Dagan Feng, Michael J. J. Fulham, Xiuying Wang, Shaoli Song
Summary: This study developed and validated two machine learning models based on preoperative F-18-FDG PET/CT images that have predictive value for LNMs and the N stage in gastric cancer. These predictive models show promise as a potentially useful adjunct to current staging approaches for patients with gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Doris Mangiaracina Benbrook, James Randolph Sanders Hocker, Katherine Marie Moxley, Jay S. Hanas
Summary: This study analyzed serum samples from endometrial cancer patients and benign gynecology surgical patients using electron spray ionization mass spectrometry (ES-MS), and evaluated the differences in serum proteins through leave one out cross validation (LOOCV). The study found that serum proteins could distinguish between different groups and predict positive lymph node metastases. Pathways related to metastases include loss of PTEN activation, calcium signaling activation, and estrogen receptor-induced transcription. These findings provide new insights for treatment decisions in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Otorhinolaryngology
Andrew B. DeAtkine, Jessica W. Grayson, Nikhi P. Singh, Alexander P. Nocera, Soroush Rais-Bahrami, Benjamin J. Greene
ENT-EAR NOSE & THROAT JOURNAL
(2023)
Editorial Material
Oncology
Andrew M. Fang, Soroush Rais-Bahrami
Article
Pathology
Jennifer B. Gordetsky, Kathleen W. Montgomery, Giovanna A. Giannico, Soroush Rais-Bahrami, Prabin Thapa, Stephen Boorjian, Igor Frank, John Cheville
Summary: UC, UCSD, and SCC exhibit differences in gender distribution, risk factors, and clinical outcomes. PD-L1 22C3 and SP142 scores can predict CSS in SCC cases. Women are more likely to be nonsmokers, and patients with SCC and UCSD are typically at higher pathologic stages at the time of cystectomy.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Surgery
Zachary A. Glaser, Zachary R. Burns, Andrew M. Fang, Ava Saidian, Cristina Magi-Galluzzi, Jeffrey W. Nix, Soroush Rais-Bahrami
Summary: This study compared the perioperative outcomes of robotic assisted single-port and multi-port partial nephrectomy procedures, finding similar short-term outcomes between the two approaches. The single-port robotic approach did not reduce the postoperative opioid analgesic requirements.
JOURNAL OF ROBOTIC SURGERY
(2022)
Article
Medicine, General & Internal
Samuel J. Galgano, John C. Norton, Kristin K. Porter, Janelle T. West, Soroush Rais-Bahrami
Summary: Penile squamous cell carcinoma has a higher incidence worldwide, and clinical examination is crucial for initial diagnosis. Imaging plays a vital role in staging, restaging, and follow-up of penile cancer patients.
Article
Urology & Nephrology
Hiten D. Patel, Elizabeth L. Koehne, Steven M. Shea, Andrew M. Fang, Marielia Gerena, Alex Gorbonos, Marcus L. Quek, Robert C. Flanigan, Ari Goldberg, Soroush Rais-Bahrami, Gopal N. Gupta
Summary: A prostate cancer risk calculator incorporating multiparametric magnetic resonance imaging (mpMRI) has been developed and validated, outperforming other risk calculators in diagnosing high-risk prostate cancer and potentially reducing unnecessary biopsies.
Review
Oncology
Samuel J. Galgano, Andrew M. McDonald, Janelle T. West, Soroush Rais-Bahrami
Summary: With the development and application of PSMA-PET imaging, we are able to detect oligometastatic prostate cancer more accurately. However, there is currently a lack of data guiding the best treatment course for these cases. Moreover, the definition of oligometastatic disease is facing problems and challenges due to advancements in imaging modalities.
Article
Medicine, Research & Experimental
James L. Tatum, Joseph D. Kalen, Paula M. Jacobs, Lisa A. Riffle, Amy James, Lai Thang, Chelsea Sanders, Melinda G. Hollingshead, Falguni Basuli, Jianfeng Shi, James H. Doroshow
Summary: The study evaluated [F-18]FLT PET imaging as an in vivo biomarker for palbociclib efficacy in a non-breast cancer model. Results showed that the biomarker accurately predicted treatment response in the tumor as early as 3 days post initiation of therapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Letter
Oncology
Andrew M. M. Fang, Luke A. A. Shumaker, Soroush Rais-Bahrami
Editorial Material
Oncology
Soroush Rais-Bahrami, Yao Zhu
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Review
Medicine, General & Internal
Carli E. Calderone, Eric M. Turner, Omar E. Hayek, David Summerlin, Janelle T. West, Soroush Rais-Bahrami, Samuel J. Galgano
Summary: Tissue changes and enlargement of the prostate, both benign and malignant, are common diseases that have significant impacts on men's length and quality of life. Benign prostatic hyperplasia (BPH) is highly prevalent with age, affecting almost all older men. Prostate cancer, except for skin cancer, is the most common cancer among men in the US. Imaging plays a crucial role in diagnosing and managing these conditions, with various modalities available, including novel imaging techniques that have revolutionized prostate imaging. This review covers standard-of-care prostate imaging modalities, advancements in newer technologies, and emerging standards impacting prostate gland imaging.
Article
Oncology
Taraswi Mitra Ghosh, Suman Mazumder, Joshua Davis, Jyoti Yadav, Ayuba Akinpelu, Ahmed Alnaim, Harish Kumar, Razan Waliagha, Allison E. Church Bird, Soroush Rais-Bahrami, R. Curtis Bird, Panagiotis Mistriotis, Amarjit Mishra, Clayton C. Yates, Amit K. Mitra, Robert D. Arnold
Summary: This study found that the use of topotecan and other drugs can inhibit the growth of prostate cancer and reduce the number of cancer stem cells. By analyzing RNA sequencing and single-cell omics data, the study also identified potential biomarkers for monitoring treatment efficacy and disease progression response.
CANCER RESEARCH COMMUNICATIONS
(2023)
Review
Urology & Nephrology
Samuel J. Galgano, Janelle T. West, Soroush Rais-Bahrami
Summary: The potential role of molecular imaging in the detection of localized prostate cancer has not been fully established yet, although it has been widely used for systemic staging and restaging in prostate cancer patients.
THERAPEUTIC ADVANCES IN UROLOGY
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Christopher Drake, Paula Jacobs, James Tatum, Joseph Kalen, Lisa Riffle, Ling Wei, Falguni Basuli, Jianfeng Shi, Keita Saito, Nimit Patel, Lilia Ileva, Patricia Gonzalez Pagan, Melinda Hollingshead, Yvonne Evrard, Michelle Gottholm-Ahalt, Chelsea Sanders, Amy James, Simone Difilippantonio, Elijah Edmondson, James Doroshow
NUCLEAR MEDICINE AND BIOLOGY
(2022)
Review
Urology & Nephrology
Garrett J. Brinkley, Andrew M. Fang, Soroush Rais-Bahrami
Summary: Inclusion of multiparametric magnetic resonance imaging (mpMRI) findings into prostate cancer nomograms has significantly improved accuracy, helping both doctors and patients make reliable clinical decisions and reduce unnecessary procedures.
THERAPEUTIC ADVANCES IN UROLOGY
(2022)