期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 405, 期 15, 页码 5119-5131出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-013-6732-5
关键词
Mass spectrometry; Host-pathogen interactions; Liquid chromatography
资金
- ERA-NET PathoGenoMics [0315442C]
Infections with Chlamydia pneumoniae cause several respiratory diseases, such as community-acquired pneumonia, bronchitis or sinusitis. Here, we present an integrated non-targeted metabolomics analysis applying ultra-high-resolution mass spectrometry and ultra-performance liquid chromatography mass spectrometry to determine metabolite alterations in C. pneumoniae-infected HEp-2 cells. Most important permutations are elaborated using uni- and multivariate statistical analysis, logD retention time regression and mass defect-based network analysis. Classes of metabolites showing high variations upon infection are lipids, carbohydrates and amino acids. Moreover, we observed several non-annotated compounds as predominantly abundant after infection, which are promising biomarker candidates for drug-target and diagnostic research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据