Article
Nutrition & Dietetics
Guangsu Zhu, Min Guo, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: Alzheimer's disease is characterized by global metabolic alterations, leading to cognitive impairment. This study found that B. breve CCFM1025 intervention can restore the metabolic changes induced by Aβ injection, particularly in amino acid metabolism.
Article
Chemistry, Analytical
Fang-Lin Liu, Ying Rong, Hui Zhou, Tong Yu, Luyao Liu, Qianwen Cao, Zhaolong Qin, Lingbo Qu, Xinglin Liao, Qiman Jiang, Nan Zhang, Xia Xu
Summary: In this study, the protective effects of cineole on mice with allergic rhinitis were investigated. The results showed that cineole reduced the levels of inflammatory factors and improved nasal tissue damage, thereby alleviating the symptoms of allergic rhinitis. Cineole achieved its protective effects by regulating arachidonic acid metabolism and inhibiting the production of inflammatory mediators.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Chunlan Tang, Yuqing Tang, Qinwen Wang, Donghui Chu, Jinyue Zhou, Yuping Zhou
Summary: The traditional Chinese prescription, Yangyinqingfei Decoction (YYQFD), has been found to improve pulmonary functions, decrease levels of inflammatory mediators, and regulate fatty acid metabolism and antioxidant systems, thereby providing a potential therapeutic approach for respiratory diseases caused by air pollutants.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Meihe Li, Haixia Yang, Minchao Kang, Peng An, Xili Wu, Huimin Dang, Xin Xu
Summary: The study utilized UPLC-MS/MS metabolomics approach to identify potential biomarkers for recurrent spontaneous abortion (RSA) and found that regulation of the arachidonic acid metabolism pathway could be a promising therapeutic strategy for relieving symptoms in RSA patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Fan Li, Yu Wang, Huahui Yu, Xiaoqian Gao, Linyi Li, Haili Sun, Yanwen Qin
Summary: This study found that plasma concentrations of free arachidonic acid and AA-enriched triglyceride species were significantly associated with plasma low-density lipoprotein-cholesterol, ApoB, and total cholesterol concentrations in individuals with hyperlipidemia, and it was confirmed that AA could increase plasma TC levels in mice, suggesting a potential role of AA in regulating plasma cholesterol and lipoprotein concentrations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Fisheries
Cheng Li, Xuan Xing, Hongqing Qi, Ying Liu, Fanjie Jian, Jihui Wang
Summary: Screening significant differential metabolites during infection of Apostichopus japonicus (A. japonicus) by pathogens can improve immune ability and guide healthy culture. The arachidonic acid (ARA) metabolism pathway was found to play an important role in the immune stress of A. japonicus. Exogenous ARA consumption significantly increased immune-related enzyme activity and survival rate in A. japonicus.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Clinical Neurology
Yumi Watanabe, Kensaku Kasuga, Takayoshi Tokutake, Kaori Kitamura, Takeshi Ikeuchi, Kazutoshi Nakamura
Summary: This study utilized mass spectrometry to analyze urine from AD patients and control groups, identifying 26 molecules with significantly different concentrations between the two groups. The orthogonal partial least-squares discriminant analysis showed significant discrimination between AD patients and controls. Pathway analysis revealed alterations in molecules related to glycerolipid and glycerophospholipid metabolism, thermogenesis, and caffeine metabolism in AD patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Zhubiao Ye, Jianru Chen, Pengran Du, Qingrong Ni, Baizhang Li, Zhe Zhang, Qi Wang, Tingting Cui, Xiuli Yi, Chunying Li, Shuli Li
Summary: This study aimed to determine the differences in specific fatty acids between vitiligo patients and healthy individuals and to investigate their association with clinical features. The results showed that the serological level of alpha-linolenic acid (ALA) was increased in vitiligo patients, while the levels of arachidonic acid (ARA), arachidic acid (AA), and behenic acid were decreased. ALA levels were positively associated with the vitiligo area scoring index (VASI). Supplementation with ARA or nordihydroguaiaretic acid (NDGA) could suppress the function of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tetsuo Sugishita, Masanori Tokunaga, Kenjiro Kami, Kozue Terai, Hiroyuki Yamamoto, Hajime Shinohara, Yusuke Kinugasa
Summary: The minimum sample volume for CE-FTMS analysis of hydrophilic metabolites was investigated using samples from colorectal cancer patients. Different numbers of biopsies were collected from tumor and nontumor parts of surgically removed specimens. The analysis showed that two biopsies could provide sufficient data for metabolomic analysis and distinguish tumor and nontumor samples.
Article
Neurosciences
Pan Liu, Qian Yang, Ning Yu, Yan Cao, Xue Wang, Zhao Wang, Wen-Ying Qiu, Chao Ma
Summary: Metabolomics analysis of postmortem human brain tissues revealed pervasive metabolic dysregulation, including abnormalities in phenylalanine metabolism, valine, leucine, and isoleucine biosynthesis, and other pathways, in the hippocampus of individuals with Alzheimer's disease (AD). The study identified upregulation of specific metabolites and enzymes associated with AD pathology, pointing towards a potential role of phenylalanine metabolism dysregulation in the formation of AD pathology.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Tian-Hoe Tan, Shih-Wen Li, Chih-Wei Chang, Yuan-Chih Chen, Yu-Hsuan Liu, Jui-Ti Ma, Ching-Ping Chang, Pao-Chi Liao
Summary: In this study, hair was found to undergo metabolic changes in rats induced with beta-amyloid, which were associated with cognitive impairments. Furthermore, these changes observed in the hair of beta-amyloid-induced rats showed a similar trend to the metabolites found in the cerebrospinal fluid of Alzheimer's disease patients. Therefore, hair can be a valuable biospecimen for assessing endogenous metabolic disturbances and identifying biomarkers of Alzheimer's disease.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yuxin Hu, Qian Xu, Hongxue Li, Ziyu Meng, Ming Hao, Xuefei Ma, Wenjian Lin, Hongyu Kuang
Summary: The study revealed that dapagliflozin can slow the progression of diabetic retinopathy by reducing apoptosis of retinal cells, and alleviate HRMECs apoptosis induced by high glucose through the ERK/1/2/cPLA2/AA/ROS pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Liming Shen, Xiaoxiao Tang, Huajie Zhang, Hongbin Zhuang, Jing Lin, Yuxi Zhao, Xukun Liu
Summary: This study analyzed the eye tissues of 2- and 6-month-old triple transgenic AD (3 x Tg-AD) male mice and identified differential metabolites associated with various metabolic pathways. The results showed that the eye tissues of 3 x Tg-AD mice underwent changes in the early stages of the disease, and these changes were more pronounced at 6 months of age. The joint analysis with previous hippocampal study revealed similar differential metabolites and mechanisms, but with tissue specificity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Caleigh A. Findley, Samuel A. McFadden, MaKayla F. Cox, Lindsey N. Sime, Mackenzie R. Peck, Kathleen Quinn, Andrzej Bartke, Kevin N. Hascup, Erin R. Hascup
Summary: This study investigates the relationship between Alzheimer's disease and metabolic dysfunction, and finds that modulation of glutamatergic activity can improve glucose metabolism and spatial cognition, providing a new therapeutic approach for cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Pharmacology & Pharmacy
Xuedan Cheng, Jian Chu, Liandong Zhang, Zhirong Suo, Wei Tang
Summary: This study used metabolomics to analyze the effects of uranium exposure on human kidney cells and identified an oxidative stress mechanism caused by uranium exposure, providing new evidence for the study of uranium poisoning.
Article
Chemistry, Physical
Imane Ellouzi, Souad El Hajjaji, Mourad Harir, Philippe Schmitt-Kopplin, Didier Robert, Larbi Laanab
Summary: New multidoped TiO2 nanomaterials with potential photochemical response were synthesized via an uncomplicated sol-gel process. The doped nanomaterials exhibited smaller crystallite size, larger surface area, and visible light absorption compared to undoped TiO2 P-25. Under visible light irradiation, the doped TiO2 nanomaterials showed 2 to 3 times higher photochemical response than TiO2 P-25, and the photocatalytic efficiency depended on the type and dosage of dopants. The synergistic effect of S, N, C, and Fe significantly influenced the crystalline structure, optical properties, pore volume, and surface area.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Siyu Li, Mourad Harir, Philippe Schmitt-Kopplin, Michael Gonsior, Alex Enrich-Prast, David Bastviken, Juliana Valle, Fausto Machado-Silva, Norbert Hertkorn
Summary: This study investigates the processing of dissolved organic matter (DOM) in the Amazon basin using advanced analytical techniques. The study reveals the effects of different processes on the chemical composition and structural characteristics of black, white, and clear water systems. The findings suggest that the sources of DOM and the mechanisms of its transformation vary between different rivers in the Amazon basin.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Philippe Schmitt-Kopplin, Marco Matzka, Alexander Ruf, Benedicte Menez, Hasnaa Chennaoui Aoudjehane, Mourad Harir, Marianna Lucio, Jasmine Hertzog, Norbert Hertkorn, Regis D. Gougeon, Victor Hoffmann, NancyW. Hinman, Ludovic Ferriere, Ansgar Greshake, Zelimir Gabelica, Laszlo Trif, Andrew Steele
Summary: This study reveals a wide range of organic compounds in the Tissint Mars meteorite, showing nonuniform distribution in functionality and abundance. The organics in Tissint meteorite include abundant C3-7 aliphatic branched carboxylic acids and aldehydes, olefins, and polyaromatics with and without heteroatoms, forming a homologous oxidation structural continuum. Organomagnesium compounds are highly abundant in olivine macrocrystals and melt veins, indicating specific organo-synthesis processes in close interaction with magnesium silicates and temperature stresses. The diversity and abundance of complex molecules suggest heterogeneity in organic speciation within the martian mantle and crust over geological time.
Article
Chemistry, Analytical
Peiru Luo, Mengke Bai, Qingyun He, Zifang Peng, Lingyun Wang, Chuan Dong, Zenghua Qi, Wenfen Zhang, Yanhao Zhang, Zongwei Cai
Summary: The widespread use of plastic products has led to a significant release of microplastics (MPs) into the environment. However, the study of MPs in atmospheric fine particulate matter (PM2.5) is limited due to the lack of appropriate analytical methods. This study developed a novel strategy using pyrolysis-gas chromatography-tandem mass spectrometry (Pyr-GC-MS/MS) to accurately quantify polyethylene MPs (PE-MPs) in PM2.5 without sample pretreatment. The results showed relatively serious pollution of PE-MPs in Taiyuan and suggested the widespread occurrence and potential human exposure risks of PM2.5-bound PE-MPs.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Hongli Tan, Liu Yang, Xiaolin Liang, Diedie Huang, Xinhang Qiao, Qingyuan Dai, Da Chen, Zongwei Cai
Summary: With the tightening restrictions on phthalate esters (PAEs), nonphthalate plasticizers (NPPs) are increasingly used. However, there is limited knowledge on the environmental occurrences, fate, and human exposure risks of many emerging NPPs. This study investigated the presence of NPPs and major PAEs in house dust, finding widespread occurrences of NPPs, such as ATBC, TCTM, TOTM, GMO, MO, and DiBA. Although current exposure may not pose significant health risks, potential hazards cannot be overlooked due to the lack of toxic threshold data and possible cocktail effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Philippe Diederich, Thomas Geisberger, Yingfei Yan, Christian Seitz, Alexander Ruf, Claudia Huber, Norbert Hertkorn, Philippe Schmitt-Kopplin
Summary: The authors report the formation of acetaldehydes and higher condensation products from a reaction between acetylene and carbon monoxide catalyzed by nickel sulfide under hydrothermal conditions. This finding is important for understanding the synthesis of aldehydes in the early Earth.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Archaeology
Jasmine Hertzog, Hitomi Fujii, Rugile Zostautaite, Agnes Lattuati-Derieux, Pascale Richardin, Vincent Carre, Frederic Aubriet, Philippe Schmitt-Kopplin
Summary: Deciphering the biomolecular composition of archaeological organic materials is important for understanding ancient civilizations. This study used FTICR MS in combination with GC-MS and infrared spectroscopy to analyze embalming materials from Egyptian crocodile mummies. FTICR MS provided complementary information and advantages over GC-MS, such as easier sample preparation and detection of higher-mass compounds. The results confirmed the use of pine resin, beeswax, and animal and vegetal fat in the embalming process, and also assessed the oxidation of the samples. FTICR MS is a valuable tool for quickly analyzing biomolecular fingerprints and assessing sample degradation in archaeological materials.
JOURNAL OF ARCHAEOLOGICAL SCIENCE-REPORTS
(2023)
Article
Environmental Sciences
Siyu Li, Mourad Harir, Philippe Schmitt-Kopplin, Fausto Machado-Silva, Michael Gonsior, David Bastviken, Alex Enrich-Prast, Juliana Valle, Norbert Hertkorn
Summary: Positive and negative electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and H-1 NMR were used to investigate the compositional and structural changes of dissolved organic matter (DOM) at Amazon confluence sites. Major structural transformations were observed in the case of mixing water from the Solimoes and Negro Rivers (S + N), while minor alterations were found in the case of mixing water from the Amazon and Tapajo's Rivers (A + T). The results also showed that the structural changes were dependent on incubation time, with reversing alterations observed after 1-day to 5-day incubation.
Article
Engineering, Environmental
Jing Chen, Peisi Xie, Pengfei Wu, Zian Lin, Yu He, Zongwei Cai
Summary: This study used metabolomics and lipidomics combined with mass spectrometry imaging to reveal the mechanisms of enhanced growth of MCF-7 breast cancer cell spheroids exposed to triclosan (TCS). The results showed that TCS and TCS sulfate penetrated the entire area of the cell spheroids initially, but localized in the inner area later. Metabolomics data indicated that TCS exposure induced alterations in energy metabolism and the biosynthesis of glycerophospholipids and glycerolipids. Mass spectrometry imaging revealed enhanced energy supply in the peripheral area and increased energy storage in the inner area as potential contributors to the enhanced growth of MCF-7 breast cancer cell spheroids exposed to TCS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Xuemei Wang, Chin Wai Leung, Zongwei Cai, Di Hu
Summary: Organophosphate flame retardants (OPFRs) were found in PM2.5 in Hong Kong, with chlorinated OPFRs being the dominant component. Plastic processing and waste disposal were identified as the main emission sources. Health risk assessment revealed a low-risk level for PM2.5-bound OPFRs, but relatively high noncarcinogenic and carcinogenic risks were associated with chlorinated OPFRs emitted from plastic processing and waste disposal.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Guodong Cao, Wei Wang, Jing Zhang, Pengfei Wu, Han Qiao, Huankai Li, Gefei Huang, Zhu Yang, Zongwei Cai
Summary: para-Phenylenediamine quinones (PPD-Qs) are newly discovered transformation products derived from para-phenylenediamine (PPD) antioxidants. Their occurrence and fate in wastewater treatment plants (WWTPs) need further investigation to improve pollutant removal efficiency.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anna Hau-Yee Kong, Aston Jiaxi Wu, Olivia Ka-Yi Ho, Maggie Ming-Ki Leung, Alexis Shiying Huang, Yuanyuan Yu, Ge Zhang, Aiping Lyu, Min Li, King-Ho Cheung
Summary: Neuroinflammation is a precursor to neurodegenerative diseases, and targeting it with aptamers offers potential diagnostic and therapeutic applications. This review summarizes the use of aptamers for diagnosing and treating inflammatory biomolecules and cells associated with neurodegenerative diseases. It also discusses the potential of short nucleotides for targeted brain delivery and the challenges of using aptamers as therapeutic agents. Overall, this review assesses the potential of aptamers as a pioneering approach for CNS target delivery and the treatment of neuroinflammation and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Philippe Diederich, Alexander Ruf, Thomas Geisberger, Leopold Weidner, Christian Seitz, Wolfgang Eisenreich, Claudia Huber, Philippe Schmitt-Kopplin
Summary: Chemical complexity is crucial for the origin of life and biological evolution. The chemical evolution of a complex prebiotic mixture containing acetylene, carbon monoxide, and nickel sulfide has been analyzed using mass spectrometry. Isotopic labeling reveals the presence of diverse compounds within the reaction mixture. Different degrees of labeling enable robust characterization of functional groups. The study also reveals a characteristic addition pattern and a high diversity of sulfur-containing compounds. The temporal analysis provides insights into the role of sulfur in the origin of life.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Liesa Salzer, Philippe Schmitt-Kopplin, Michael Witting
Summary: This study compared the application of capillary electrophoresis coupled to mass spectrometry (CE-MS) and hydrophilic interaction liquid chromatography coupled to mass spectrometry (HILIC-MS) for the analysis of polar metabolites in C. elegans. The results showed that CE-MS exhibited better performance in terms of separation, peak width, and linearity, and provided complementary information compared to HILIC-MS. CE-MS was successfully applied to recover known metabolites and identify novel putative biomarkers of longevity in C. elegans.
Article
Biochemical Research Methods
Leopold Weidner, Daniel Hemmler, Michael Rychlik, Philippe Schmitt-Kopplin
Summary: We developed DBDIpy, a Python library for processing and analyzing untargeted, time-sensitive plasma ionization MS datasets. It is capable of identifying in-source fragments and rivaling ionization pathways of the same analytes in time-sensitive datasets. DBDIpy also includes basic functions for processing untargeted metabolomics data and interfaces to existing tools for MS data analysis in Python.