Article
Chemistry, Multidisciplinary
Jin Wang, Chen Wang, Jing-Juan Xu, Xing-Hua Xia, Hong-Yuan Chen
Summary: Integrating discrete plasmonic nanoparticles into assemblies can induce plasmonic coupling, leading to stronger electromagnetic field enhancement effects. This enables better performance in plasmon-based applications, such as enhanced fluorescence and Raman effects, holding great potential for trace analyte detection and nanomedicine. The recent advances in various plasmonic nanoassemblies and their applications in biosensing and cell imaging are discussed, along with the fabrication strategies for self-assembled plasmonic nanostructures.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biophysics
Tongtong Tian, Jia Yi, Yujie Liu, Binxiao Li, Yixin Liu, Liang Qiao, Kun Zhang, Baohong Liu
Summary: This study presents the development of highly efficient nanoparticle arrays for simultaneous capture, identification, and differentiation of bacteria using SERS technology, allowing for single-cell analysis of multiple bacterial species. The technology demonstrates high sensitivity, good reproducibility, and stability, with great potential in bacterial detection and phenotyping studies.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Chih-Feng Wang, Patrick Z. El-Khoury
Summary: The study reveals that nonlinear optical processes can be enhanced at plasmonic tip-sample nanojunctions, allowing for high-spatial-resolution chemical analysis through enhanced spectroscopies.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Xiaojun Song, Yueliang Wang, Yan Hao, Qingqing Zhu, Yanjuan Li, Lei Song, Zhaoxiang Deng
Summary: This study successfully built a series of homo/heterodimeric plasmonic nanomolecules with prescribed compositions using DNA-guided, solvo-driven Ag ion soldering method. Strong in-solution electric-dipole coupling was achieved for materials with strong (Au, Ag) or damped (Pt, Pd) plasmonic responses.
Article
Nanoscience & Nanotechnology
Giovanna Palermo, Massimo Rippa, Ylli Conti, Ambra Vestri, Riccardo Castagna, Giovanna Fusco, Elisabetta Suffredini, Jun Zhou, Joseph Zyss, Antonio De Luca, Lucia Petti
Summary: The study aimed at developing a high-flux and high-accuracy surface-enhanced Raman spectroscopy (SERS) nanobiosensor for the detection of pathogens to provide an effective method for early and easy water monitoring, which can be fast and convenient.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Optics
Hui Cheng, Yabin Zhang, Guoqiang Li, Xiaohong Li, Jiahao Fang, Lin Xiao, Xiaoxuan Tang, Zehang Cui, Yi Yang, Yong Cai, Jiangong Zhu, Liang Zhong
Summary: Surface-enhanced Raman scattering (SERS) offers an effective spectroscopic approach for detecting trace molecules with unique vibrational fingerprints, but challenges remain in concentrating target molecules and enhancing sensitivity. Superhydrophobic microcrater arrays as SERS substrates show excellent superhydrophobicity and plasmonic nanostructures, making them a strong candidate for reliable and high-quality SERS applications.
OPTICS AND LASER TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Qingqing Li, Hongqi Huo, Ying Wu, Lanlan Chen, Lichao Su, Xuan Zhang, Jibin Song, Huanghao Yang
Summary: Surface-enhanced Raman scattering (SERS) is a feasible and ultra-sensitive method for biomedical imaging and disease diagnosis. The recent developments in SERS active materials and their in vivo imaging and biosensing applications are overviewed, including various SERS substrates and their successful utilization in in vivo imaging, as well as the role of highly sensitive SERS biosensors in disease detection and prevention. Additionally, the review highlights the use of SERS in the identification and resection of microtumors, as well as its potential as a diagnostic and therapeutic platform.
Review
Nanoscience & Nanotechnology
Yajuan Liu, Mei Li, Haisha Liu, Chao Kang, Xiyong Yu
Summary: Nanoparticle-based drug delivery systems have the potential to enhance the properties of drugs by enabling targeted delivery. Monitoring the intracellular behavior of nanoparticles is crucial but challenging. The recent advancements in Raman techniques provide a versatile tool for noninvasive cellular measurements.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Physical
Yi-Yu Cai, Lawrence J. Tauzin, Behnaz Ostovar, Stephen Lee, Stephan Link
Summary: This article summarizes recent advances in the study of the light emission mechanism of gold nanoparticles, including the impact of changing excitation wavelength and power on the energy distribution of hot carriers and emission spectral lineshape, as well as the role of interband and intraband transitions in the emission lineshape by varying the particle size.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Review
Chemistry, Multidisciplinary
Ilya A. Milekhin, Alexander G. Milekhin, Dietrich R. T. Zahn
Summary: This study presents the optical response of spherical CdSe nanocrystals using SERS and TERS techniques, achieving significant enhancement of optical phonons by selecting appropriate plasmonic substrates. Combining Raman scattering with atomic force microscopy offers nanoscale spatial resolution for investigating phonon properties. Gap-mode TERS further enhances Raman scattering of CdSe NCs' optical phonon modes with nanometer spatial resolution, providing new pathways for optical characterization and phonon spectrum details at the nanometer scale of single semiconductor nanostructures.
Review
Biochemistry & Molecular Biology
Antonio Sasso, Angela Capaccio, Giulia Rusciano
Summary: This review focuses on the recent studies conducted by our group in the past decade, where novel nanofabrication techniques were successfully applied to SERS and TERS experiments for studying bio-systems and molecular species of environmental interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Hui He, Lingli Zhou, Zhanchen Guo, Pengfei Li, Song Gao, Zhen Liu
Summary: A novel dual biomimetic recognition-driven plasmonic nanogap-enhanced Raman scattering strategy was reported for ultrasensitive protein fingerprinting and quantitation. By trapping target proteins into plasmonic nanogaps, ultra-high Raman signal amplification was achieved, along with a ratiometric assay for robust quantitation.
Review
Chemistry, Analytical
Xiaowen Ou, Yuqi Liu, Mingxing Zhang, Li Hua, Shenshan Zhan
Summary: Plasmonic gold nanostructures, with unique optical properties and good biocompatibility, are ideal for developing methods in biosensing and bioimaging. This review summarizes the applications and techniques of biosensing and bioimaging in vitro and in vivo using plasmonic gold nanostructures.
Article
Chemistry, Multidisciplinary
Lei Yao, Qi Hao, Mingze Li, Xingce Fan, Guoqun Li, Xiao Tang, Yunjia Wei, Jiawei Wang, Teng Qiu
Summary: We propose and demonstrate sandwich plasmonic nanocavities as a surface-selection ruler to illustrate molecular orientations using surface-enhanced Raman spectroscopy. The field vector in the nanocavity presents a transverse spinning feature under specific excitations, allowing the selective amplification of Raman modes of target molecules. This method can be extended as a universal ruler for the identification of molecular orientations.
Article
Chemistry, Physical
Felipe Herrera, Marina Litinskaya
Summary: We propose the use of molecular picocavity ensembles as macroscopic coherent nonlinear optical devices enabled by nanoscale strong coupling. We show that strong coupling of the picocavity vacua with a specific vibronic sideband in the molecular emission spectrum can significantly change the effective refractive index of the metamaterial, allowing cross-phase modulation of optical fields. Our work paves the way for the development of plasmonic metamaterials that exploit strong coupling for optical state preparation and quantum control.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Nanoscience & Nanotechnology
Yang Liu, Austin B. Carpenter, Christopher J. Pirozzi, Hsiangkuo Yuan, Matthew S. Waitkus, Zhengyuan Zhou, Landon Hansen, Michelle Seywald, Ren Odion, Paula K. Greer, Thomas Hawk, Bennett B. Chin, Ganesan Vaidyanathan, Michael R. Zalutsky, Hai Yan, Tuan Vo-Dinh
Review
Clinical Neurology
Stephen D. Silberstein, Hsiangkuo Yuan, Umer Najib, Jessica Ailani, Andreia Lopes de Morais, Paul G. Mathew, Eric Liebler, Cristina Tassorelli, Hans-Christoph Diener
Article
Clinical Neurology
Cristina Tassorelli, Hans-Christoph Diener, Stephen D. Silberstein, David W. Dodick, Peter J. Goadsby, Rigmor H. Jensen, Delphine Magis, Patricia Pozo-Rosich, Hsiangkuo Yuan, Daniele Martinelli, Thomas van den Hoek, Marie Deen, Messoud Ashina, Gisela M. Terwindt
Summary: The International Headache Society's Clinical Trials Committee has provided recommendations for optimizing the design and conduct of controlled trials of neuromodulation devices for the acute and/or preventive treatment of migraine. This includes defining key terms, providing recommendations for assessment in different age groups, outlining ethical and administrative responsibilities, and creating a bibliography of previous research in this area. Adopting these recommendations will improve the quality of evidence regarding the use of neuromodulation devices in migraine treatment.
Review
Clinical Neurology
Hsiangkuo Yuan, Tzu-Ying Chuang
Summary: Neuromodulation devices have become an attractive alternative to traditional pharmacotherapy for migraine, especially for patients intolerant to medication or who prefer non-pharmacological options. Studies on the efficacy of these devices in chronic migraine are limited, but show promising results, although more well-designed research is needed for FDA clearance and insurance coverage.
CURRENT PAIN AND HEADACHE REPORTS
(2021)
Article
Clinical Neurology
Hsiangkuo Yuan, John G. Curran, Scott W. Keith, Mary M. Hopkins, Stephen D. Silberstein
Summary: The study evaluated the efficacy and safety of IV ibuprofen for acute migraine treatment. While the primary endpoint was not met, there was significant pain relief within 2 hours post-treatment with IV ibuprofen compared to placebo. Adverse events were minimal, suggesting that IV ibuprofen may be a safe and effective option for acute migraine treatment. Further studies with larger sample sizes are needed for confirmation.
Review
Clinical Neurology
Monica P. Mallampalli, Habib G. Rizk, Amir Kheradmand, Shin C. Beh, Mehdi Abouzari, Alaina M. Bassett, James Buskirk, Claire E. J. Ceriani, Matthew G. Crowson, Hamid Djalilian, Joel A. Goebel, Jeffery J. Kuhn, Anne E. Luebke, Marco Mandala, Magdalena Nowaczewska, Nicole Spare, Roberto Teggi, Maurizio Versino, Hsiangkuo Yuan, Ashley Zaleski-King, Michael Teixido, Frederick Godley
Summary: Vestibular migraine is increasingly recognized as a pathological cause of vestibular disorders, yet it remains underdiagnosed. The pathophysiology of this disorder is still unclear. A multidisciplinary expert workshop identified seven current care gaps that need to be resolved, including a better understanding of symptoms and phenotypes, a lack of diagnostic markers, a better understanding of pathophysiological mechanisms, as well as the need for clear recommendations and outcome measures. Recommendations were made to address these gaps, such as establishing a global registry and conducting trials to validate current treatments.
FRONTIERS IN NEUROLOGY
(2022)
Review
Oncology
Fred Cohen, Hsiangkuo Yuan, Stephen D. Silberstein
Summary: Calcitonin gene-related peptide (CGRP) is believed to be involved in the pathogenesis of migraine, and there are two classes of therapeutic agents targeting CGRP: CGRP-targeted monoclonal antibodies and small-molecule antagonists. Multiple clinical studies have shown the efficacy and tolerability of these treatments.
Article
Clinical Neurology
Yi-Hsien Tu, Yen-Feng Wang, Hsiangkuo Yuan, Shih-Pin Chen, Yi-Shiang Tzeng, Wei-Ta Chen, Kuan-Lin Lai, Yu-Hsiang Ling, Shuu-Jiun Wang
Summary: This study investigated the distribution, clinical associations, and treatment responses for the most bothersome symptoms of migraine in a large sample of patients in Taiwan. Nausea was found to be the most common most bothersome symptom, followed by phonophobia and photophobia. The response rates to previous acute treatments for different most bothersome symptoms were similar.
Review
Clinical Neurology
Fred Cohen, Hsiangkuo Yuan, E. M. G. DePoy, Stephen D. Silberstein
Summary: Remarkable advancements have been made in the field of migraine research and treatment, particularly with the discovery of CGRP functional blocking monoclonal antibodies (mAbs) as an effective preventive therapy for both chronic and episodic migraine. These mAbs offer advantages such as high affinity and selectivity, long-circulating plasma half-lives, and limited risk for side effects and drug-drug interactions. However, long-term safety and use during pregnancy should be further studied.
Review
Health Care Sciences & Services
Fred Cohen, Hsiangkuo Yuan
Summary: Advances in molecular biology and neuroscience have led to the discovery of CGRP and its role in migraine. Gepants, including atogepant, are oral medications that inhibit CGRP receptors to prevent migraine attacks and neurogenic inflammation.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2022)
Review
Clinical Neurology
Rupert D. Smit, Nikolaos Mouchtouris, KiChang Kang, Maikerly Reyes, Anish Sathe, Sarah Collopy, Giyarpuram Prashant, Hsiangkuo Yuan, James J. Evans
Summary: This literature review examines the evidence for interventional therapies in medically intractable SUNCT/SUNA, including occipital nerve stimulation, pulsed radiofrequency, stereotactic radiosurgery, and microvascular decompression. The review finds promising outcomes with these treatments, but emphasizes the need for further research.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Anesthesiology
Hsiangkuo Yuan, Aniket Natekar, Jade Park, Clinton G. Lauritsen, Eugene R. Viscusi, Michael J. Marmura
Summary: This retrospective study assessed the prevalence, harms, and effectiveness of prescription drug misuse and "lean" (cough syrup) in patients with treatment-resistant headaches. The results showed that both prescription drug misuse and "lean" were common among patients with treatment-resistant headaches, but they were not effective in treating headaches.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Anesthesiology
Hsiangkuo Yuan, Samantha Strutner, Clara Yuh, Suwarna Anand, Gaurav Chauhan, Anand Prem, Shalini Shah, Nathaniel M. Schuster
Summary: With headache being a common complaint, accurately diagnosing and treating specific headache disorders requires understanding and differentiating various headache characteristics. This article discusses several myths about common headache disorders and provides a discussion based on the International Classification of Headache Disorders and the latest studies. Understanding the intricacies of headache diagnoses helps providers provide better care for patients.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Meeting Abstract
Clinical Neurology
J. Curran, J. Waters, H. Yuan
Article
Chemistry, Analytical
Andrew M. Fales, Pietro Strobbia, Tuan Vo-Dinh, Ilko K. Ilev, T. Joshua Pfefer
