Article
Chemistry, Analytical
Yongjuan Jia, Xingli Liu, Li Xu, Jinbao Zhao, Junjun Ni, Yuanyuan Zhang
Summary: A high-throughput solid-phase extraction method was developed for the analysis of 26 steroids in human serum and plasma samples by liquid chromatography-tandem mass spectrometry in this study. The method showed good linearities and sensitivity for each steroid hormone within the quantitative range. It has been successfully applied to series of samples from clinical trials with no significant difference between serum and ethylenediaminetetraacetic acid plasma samples.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Engineering, Environmental
Meiping Tian, Shuangshan Wu, Yi-Xin Wang, Liangpo Liu, Jie Zhang, Heqing Shen, Yanyang Lu, Huaqiong Bao, Qingyu Huang
Summary: This study examined the association between urinary phthalate metabolites and altered male steroid hormone synthesis and metabolism. The results showed that DEHP metabolites were the main contributor to the decline in hormone synthesis, and environmentally relevant phthalate exposures were associated with both altered steroid synthesis and excretion, providing insights into the endocrine-disrupting potential of phthalates.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Zhong-Min Li, Kurunthachalam Kannan
Summary: This paper describes a methodology for simultaneous determination of 19 steroid hormones and validates its accuracy and sensitivity through experiments. The method will facilitate the analysis of steroid hormones in population-based biomonitoring studies.
Article
Environmental Sciences
Javier Lopez-Vazquez, Rosario Rodil, Maria J. Trujillo-Rodriguez, Jose Benito Quintana, Rafael Cela, Manuel Miro
Summary: Little effort has been made to study the impact of chemical additives in microplastics on human health. This study investigated the oral bioaccessibility of plastic additives and monomers in low-density polyethylene (LDPE) and polyvinyl chloride (PVC) microplastics using standardized bioaccessibility tests. It was found that the gastric and gastrointestinal bioaccessibility of certain additives and monomers was highest under fed-state gastrointestinal extraction conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Analytical
E. V. Dmitrieva, A. Z. Temerdashev, M. O. Zorina, Yu-Qi Feng, P. N. Nesterenko
Summary: The possibility of applying solid-phase analytical derivatization (SPAD) for quantifying seven steroid hormones in human urine was investigated. The proposed method involved enzymatic hydrolysis, followed by SPAD with hydroxylamine. The method was optimized to achieve high recovery values and demonstrated applicability for routine analysis of real urine samples using reversed-phase ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Food Science & Technology
Rayco Guedes-Alonso, Zoraida Sosa-Ferrera, Jose J. Santana-Rodriguez, Abuzar Kabir, Kenneth G. Furton
Summary: In this study, the FPSE technique was used for the extraction of hormones from raw milk, achieving simplified sample handling and green alternative to traditional extraction methods. Through optimization, 15 hormones were successfully analyzed with low detection limits in the samples. The presence of lactose was found to affect the efficiency of hormone extraction in the experiment.
Article
Environmental Sciences
Hannah Gardener, Vivian Nguyen, Lori A. Hoepner
Summary: Maternal exposure to phthalates and BPA during pregnancy can have adverse effects on offspring health. The study found that phthalate metabolite concentrations were highest among Hispanic women, while education level was associated with higher phthalate concentrations. These disparities were not explained by diet.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
R. Wang, M. F. Hartmann, S. A. Wudy
Summary: A LC-MS/MS method was developed and validated for quantifying 15 glucuronides of urinary steroid hormones in human urine, showing good accuracy and recovery.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Hannah Collden, Maria E. Nilsson, Anna-Karin Norlen, Andreas Landin, Sara H. Windahl, Jianyao Wu, Karin L. Gustafsson, Matti Poutanen, Henrik Ryberg, Liesbeth Vandenput, Claes Ohlsson
Summary: This study established a comprehensive atlas of sex hormone concentrations in tissues and serum of male mice, revealing the distribution characteristics of sex hormones. Brain sex hormone levels are well correlated with serum levels, and white adipose tissue serves as a major reservoir of sex hormones in mice. Progesterone is the most abundant sex hormone in castrated mice.
Article
Biochemical Research Methods
Jufang Li, Aiping Xu, Jianyou Xue, Wei Qian, Ping Xu, Zhineng Hu, Chen Chen, Chaochao Wu
Summary: The paper proposes a novel method of deep eutectic solvent (DES)-assisted liquid-liquid extraction (LLE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for extracting steroid hormones from serum. The method has good linear calibration ranges, high extraction recoveries, and low limits of quantification, making it a simple and environmentally-friendly method.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemistry & Molecular Biology
Adamantios Krokos, Olga Deda, Christina Virgiliou, Helen Gika, Nikolaos Raikos, Eleni Aggelidou, Aristeidis Kritis, Georgios Theodoridis
Summary: This study evaluated the effect of cocaine on human liver cancer cell lines and revealed the predominant impact of cocaine on the metabolic pathways of alanine, aspartate, and glutamate. Targeted metabolomics identified changes in metabolites upon cocaine administration, but deciphering the exact cocaine cytotoxic mechanism remains challenging.
Article
Medicine, General & Internal
Elena Tessitore, Kevin Dobretz, Nasser Abdalla Dhayat, Ilse Kern, Belen Ponte, Menno Pruijm, Daniel Ackermann, Sandrine Estoppey, Michel Burnier, Pierre-Yves Martin, Bruno Vogt, Nicolas Vuilleumier, Murielle Bochud, Francois Mach, Georg Ehret
Summary: The study assessed the effect of endogenous steroid hormone metabolites on Lp(a) levels and found that the impact of endogenous hormone levels on Lp(a) variability was small at best, suggesting a negligible influence on the wide range of Lp(a) variability.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemical Research Methods
Hui Li, Guolei Zhang, Wei Wang, Li-Li Jiao, Chang-Bao Chen, Jing-Rui Huo, Wei Wu
Summary: A rapid quantitative method using ultra-performance liquid chromatography-tandem mass spectrometry was developed to determine catecholamine metabolites in urine. The study found that the excretion content of VMA and HVA in urine was higher than that of MHPG and DOPAC.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Biochemistry & Molecular Biology
Alexandra Robciuc, Hanna Savolainen-Peltonen, Mikko Haanpaa, Jukka A. O. Moilanen, Tomi S. Mikkola
Summary: The sexual dimorphism in inflammatory/autoimmune diseases is mainly caused by sex hormone actions. Dry eye, a common eye disease, disproportionately affects women. The hormone levels in tears are correlated with serum levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Clarissa Daniela Voegel, Markus R. Baumgartner, Thomas Kraemer, Stefan Wuest, Tina Maria Binz
Summary: Endogenous steroid hormones and endocannabinoids were quantified in hair samples using a sensitive LC-MS/MS method. The study found no significant differences in steroid and EC concentration levels between males and females in hair, except for testosterone and androstenedione. The concentrations of cortisol to cortisone and testosterone to androstenedione were positively correlated, and there were significant intercorrelations between endocannabinoids.
Article
Environmental Sciences
Jiaqi Yang, Hexing Wang, Hongyi Du, Hongji Fang, Minghui Han, Linji Xu, Shuping Liu, Jianping Yi, Yue Chen, Qingwu Jiang, Gengsheng He
Summary: Laboratory and epidemiologic studies have shown that exposure to perfluoroalkyl substances (PFASs) may affect lipid metabolism in pregnant women, with specific PFASs being positively or negatively associated with cholesterol and lipoprotein levels.
Article
Environmental Sciences
Jiaqi Yang, Hexing Wang, Hongyi Du, Hongji Fang, Minghui Han, Yuanping Wang, Linji Xu, Shuping Liu, Jianping Yi, Yue Chen, Qingwu Jiang, Gengsheng He
Summary: This study found that exposure to PFASs can disrupt estrogen homeostasis in pregnant women, with different PFASs showing varying effects on estrogen levels at different stages of pregnancy.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Neurosciences
Haojie Zhang, Bin Wang, Chi Chen, Ying Sun, Jie Chen, Xiao Tan, Fangzhen Xia, Jihui Zhang, Yingli Lu, Ningjian Wang
Summary: In this large prospective study, a healthy sleep pattern was associated with a significant reduction in incident CKD risk regardless of participants' high, intermediate, or low genetic risk.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Ying Sun, Yuefeng Yu, Haojie Zhang, Bin Wang, Chi Chen, Yuying Wang, Xiao Tan, Jihui Zhang, Yi Chen, Fangzhen Xia, Yingli Lu, Ningjian Wang
Summary: This study analyzed data from the UK Biobank and found a significant association between psychological wellbeing status and type 2 diabetes. The risk of type 2 diabetes increased with worse psychological wellbeing, regardless of genetic predisposition.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Haojie Zhang, Yuying Wang, Chi Chen, Bin Wang, Jie Chen, Xiao Tan, Fangzhen Xia, Jihui Zhang, Yingli Lu, Ningjian Wang
Summary: The study showed that both sleep behaviors and NAFLD were risk factors for type 2 diabetes. Insomnia may modify the relationship between NAFLD and type 2 diabetes.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Environmental Sciences
Juan Li, Bin Wang, Shijian Liu, Yue Zhang, Chen Chen, Yihui Jin, Zhemin Shen, Tao Yuan, Xiaodan Yu
Summary: This study investigated the associations between urinary concentrations of multiple antibiotics and adiposity risk in school children, revealing a link between exposure to veterinary antibiotics and increased risk of adipogenesis in children, particularly in boys. Further studies are needed to confirm these findings and clarify the underlying mechanisms.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Shenghan Cai, Na Wang, Like Xu, Fei Yan, Qingwu Jiang, Xinping Zhao, Wei Wang, Hexing Wang, Lufang Jiang, Wenjuan Cong, Samuel K. Sheppard, Jason Weeks, Barbara Kasprzyk-Hordern, Chaowei Fu, Helen Lambert
Summary: This paper presents a study protocol aiming to comprehensively understand the factors influencing antibiotic resistance and antibiotic use in rural Eastern China. The study utilizes a multidisciplinary approach, including microbiology, genomics, epidemiology, geospatial analysis, anthropology, and sociology, to assess human exposure to antibiotics and its potential health outcomes. The research will provide insights into optimizing and monitoring antibiotic use through the analysis of national and local policy contexts.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Infectious Diseases
Wenjuan Cong, Beth Stuart, Nour AIhusein, Binjuan Liu, Yunyi Tang, Hexing Wang, Yi Wang, Amit Manchundiya, Helen Lambert
Summary: This scoping review explored the prevalence and patterns of global antibiotic use and bacterial infection in COVID-19 patients. The study found a decline in antibiotic prescribing rates for COVID-19 patients compared to previous periods, and identified the need to closely monitor the resistance data for commonly used antibiotics.
Article
Environmental Sciences
Minghui Han, Yuanping Wang, Zichen Yang, Yi Wang, Min Huang, Baozhang Luo, Hexing Wang, Yue Chen, Qingwu Jiang
Summary: China, the largest beekeeping and honey consumption country globally, has extensive residues of neonicotinoids in honey, which may affect bee health but show no detectable effect on human health.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Environmental
Yuanping Wang, Xiaolian Dong, Minghui Han, Zichen Yang, Yi Wang, Lu Qian, Min Huang, Baozhang Luo, Hexing Wang, Yue Chen, Qingwu Jiang
Summary: This study collected 94 honey samples from the Chinese market and assessed the presence of 20 common antibiotics and their potential health risks. The results showed widespread antibiotic residues in Chinese honey, which varied with production place, sale price, and commercial category of nectariferous plants, but posed a low health risk.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Hexing Wang, Wenyun Li, Jiaqi Yang, Yuanping Wang, Hongyi Du, Minghui Han, Linji Xu, Shuping Liu, Jianping Yi, Yue Chen, Qingwu Jiang, Gengsheng He
Summary: This study investigated the effects of gestational exposure to PFASs on fetal growth by examining DNA methylation in placenta tissue of pregnant women. The results showed that PFOS was negatively associated with LINE-1 methylation, and the mixture of PFASs was negatively associated with LINE-1 methylation and NR3C1 methylation. PFOA, PFNA, PFDA, and the PFASs mixture were negatively associated with head circumference. Stratified analysis by newborns' sex found that PFOA, PFNA, and the PFASs mixture were negatively associated with LINE-1 methylation in males, and LINE-1 methylation was negatively associated with ponderal index in females. Interactions between newborns' sex and PFOS/PFOA on IGF2 and LINE-1 methylation were statistically significant. These findings suggest that intrauterine exposure to PFASs affects placental DNA methylation and reduces fetal growth, which may be modified by sex.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Nutrition & Dietetics
Lei Chu, Hexing Wang, Deqi Su, Huanwen Zhang, Bahegu Yimingniyazi, Dilihumaer Aili, Tao Luo, Zewen Zhang, Jianghong Dai, Qingwu Jiang
Summary: The study found that adults in Xinjiang are extensively exposed to multiple antibiotics, and some types of food may be potential sources of exposure. Future attention should be paid to the health effects of antibiotic exposure in humans.
Article
Environmental Sciences
Yuanping Wang, Yue Chen, Yangzong Gesang, Zichen Yang, Yi Wang, Ke Zhao, Minghui Han, Chunxia Li, Luobu Ouzhu, Jiwei Wang, Hexing Wang, Qingwu Jiang
Summary: The study found that Tibetan pregnant women in Lhasa were exposed to various antibiotics, with animal-derived food items such as poultry meat and fish being the main sources of exposure. The exposure to antibiotics was associated with microbiological disruption of gut microbiota, posing health risks for some pregnant women.
ENVIRONMENTAL POLLUTION
(2023)
Article
Nutrition & Dietetics
Lei Chu, Deqi Su, Hexing Wang, Dilihumaer Aili, Bahegu Yimingniyazi, Qingwu Jiang, Jianghong Dai
Summary: This study aimed to explore the relationship between antibiotic exposures from different sources and type 2 diabetes in middle-aged and older people through urinary antibiotic biomonitoring. The results showed that antibiotic exposure from sources associated with food and drinking water significantly increased the risk of developing type 2 diabetes in middle-aged and older adults.
Article
Multidisciplinary Sciences
Nan Jiang, Lu Qian, Guankai Lin, Yuxin Zhang, Sumiao Hong, Baochang Sun, Hexing Wang, Min Huang, Jiwei Wang, Qingwu Jiang
Summary: This study investigates the relationship between maternal blood parameters and the risk of neonatal pathological jaundice. The results suggest that neonates born to mothers with high white blood cell count and mean corpuscular volume are at an increased risk of developing pathological jaundice. Regular obstetric examinations and routine blood tests are crucial for providing appropriate care.
SCIENTIFIC REPORTS
(2023)