Article
Immunology
Jaiprasath Sachithanandham, Ashwin Balagopal, Julia Leep-Lazar, Jeffrey Quinn, Kenneth Bowden, Kathleen Ward, Ruy M. Ribeiro, Mark S. Sulkowski
Summary: Using single-cell methods, the proportion of HCV-infected hepatocytes significantly decreased after initiating direct-acting antivirals (DAAs), proving that the second-phase viral dynamics derive from the loss of infected cells.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Keyla Santos Guedes de Sa, Ednelza da Silva Graca Amoras, Simone Regina Souza da Silva Conde, Maria Alice Freitas Queiroz, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosario Vallinoto
Summary: Inefficient immune response and viral evasion mechanisms contribute to the chronicity of hepatitis C virus infection. The gene expressions of TLR3 and IFN-lambda 3 in liver tissue were investigated as potential biomarkers of HCV infection. The study found that TLR3 expression was higher and IFNL3 expression was lower in chronic HCV carriers, with different levels of expression in early and advanced stages of liver fibrosis and inflammation, showing no correlation with serum viral load.
Article
Biochemistry & Molecular Biology
Mosleh Abomughaid, Enoch S. E. Tay, Russell Pickford, Chandra Malladi, Scott A. Read, Jens R. Coorssen, Brian S. Gloss, Jacob George, Mark W. Douglas
Summary: HCV infection increases neutral lipid and phospholipids in cells and induces the expression of PEMT, a key enzyme promoting lipid accumulation and virus replication. The induction of PEMT may explain the genotype-specific differences in hepatic steatosis caused by the virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Vicky Caponigro, Anna L. Tornesello, Fabrizio Merciai, Danila La Gioia, Emanuela Salviati, Manuela G. Basilicata, Simona Musella, Francesco Izzo, Angelo S. Megna, Luigi Buonaguro, Eduardo Sommella, Franco M. Buonaguro, Maria L. Tornesello, Pietro Campiglia
Summary: This study utilized metabolomics and lipidomics to identify potential biomarkers for hepatocellular carcinoma (HCC). The identified biomarkers showed high diagnostic potential and could assist in the diagnosis of HCC, including in patients with negative AFP results. The predictive accuracy of metabolomics and lipidomics was superior to AFP in distinguishing HCC from chronic HCV conditions.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ting Xie, Chuxiang Lei, Wei Song, Xunyao Wu, Jianqiang Wu, Fangyuan Li, Yanze Lv, Yuexin Chen, Bao Liu, Yuehong Zheng
Summary: Abdominal aortic aneurysm (AAA) is characterized by irreversible dilation of the infrarenal aorta. This study explored the variation of lipids during AAA development and found that lysophosphatidylcholines (lysoPCs) were specifically decreased in AAA patients and mice. The study also identified weakened positive correlations between lysoPCs and HDL-c in AAA patients, suggesting that HDL-lysoPCs may play a role in AAA pathogenesis. These findings suggest that lysoPCs could be promising biomarkers for AAA development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Yi Huang, Jinfeng Liang, Wenjin Hu, Yushan Liang, Xue Xiao, Weilin Zhao, Xuemin Zhong, Yanping Yang, Xinli Pan, Xiaoying Zhou, Zhe Zhang, Yonglin Cai
Summary: Plasma lipidomics can be used to discover biomarkers, and this study found significant differences in lipid metabolism between nasopharyngeal carcinoma (NPC) patients and healthy controls. The study also suggests that Epstein-Barr virus (EBV) infection may influence the risk and prognosis of NPC through modulating lipid metabolism.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Jeffrey R. Quinn, Ashish Goyal, Ruy M. Ribeiro, Guido Massaccesi, Justin R. Bailey, David L. Thomas, Ashwin Balagopal
Summary: This study provides the first evidence that ART reduces the intrahepatic burden of HCV and suggests that HIV affects the pathogenesis of HCV infection through an NK/NK T-cell-mediated mechanism that may involve HLA-E and can be rescued, at least in part, by ART.
Article
Gastroenterology & Hepatology
Noe Rico Montanari, Ricardo Ramirez, Abhishek Aggarwal, Nick van Buuren, Michael Doukas, Christina Moon, Scott Turner, Lauri Diehl, Li Li, Jose D. Debes, Becket Feierbach, Andre Boonstra
Summary: In this study, the immunological composition and transcriptional profiles of liver samples from patients with chronic HBV were compared to healthy controls. The results showed distinct inflammatory profiles and gene expression differences in chronic HBV phases compared to healthy liver, indicating the complex interplay between the immune system and the virus in the liver.
JOURNAL OF HEPATOLOGY
(2022)
Review
Public, Environmental & Occupational Health
S. Mehmandoost, M. Khezri, G. Mousavian, F. Tavakoli, F. Mehrabi, H. Sharifi, K. Dolan, M. Shokoohi
Summary: This study systematically summarized the prevalence of HIV, HBV, and HCV infections among incarcerated people in Iran. The results showed that the prevalences of these infections are relatively high in this population. Meta-analysis and regression analysis found a decrease in HIV and HCV infections over time.
Article
Pharmacology & Pharmacy
Xiaomi Li, Jingyan Wang, Xiaoyan Ding, Yawen Xu, Minghua Yu, Hongxiao Wu, Na Deng, Wei Li, Jinglong Chen
Summary: The clinical efficacy of lenvatinib was compared between hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and hepatitis C virus (HCV)-related HCC. The study found that patients with HBV-HCC had higher objective response rate and disease control rate compared to HCV-HCC, but there were no significant differences in progression-free survival and overall survival between the two groups. Multivariate regression analysis identified HBV infection and antiviral time > 5 years as independent favorable factors for progression-free survival. Overall, lenvatinib seemed to be more effective in HBV-related HCC compared to HCV-related HCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Gastroenterology & Hepatology
Alessandra Mangia, Rosa Cotugno, Giovanna Cocomazzi, Maria Maddalena Squillante, Valeria Piazzolla
Summary: The World Health Organization's goal of eliminating Hepatitis C virus (HCV) by 2030 using direct-acting antiviral treatments has become less attainable post the 2020 pandemic of coronavirus disease 2019. Therefore, a more realistic approach of micro-elimination in population segments where targeted strategies of prevention and treatment are easily attained has been promoted in Europe. Active involvement of stakeholders and community participation are essential components for the success of a micro-elimination project tailored at the geographical level according to HCV epidemiology and individual country's income.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Microbiology
Natsumi Oe, Haruhiko Takeda, Yuji Eso, Atsushi Takai, Hiroyuki Marusawa
Summary: This article reviews the development of HCC after HCV eradication and discusses the current understanding of the molecular mechanisms of tumorigenesis after virus elimination, focusing on the genetic and epigenetic background of chronically damaged liver tissues.
Article
Obstetrics & Gynecology
X. Sun, T. Qu, W. Wang, C. Li, X. Yang, X. He, Y. Wang, G. Xing, X. Xu, L. Yang, H. Zhang
Summary: This study compared plasma lipid profiles in women with normal pregnancies and those with intrahepatic cholestasis of pregnancy (ICP), revealing a link between ICP and disordered sphingolipid metabolism. Abnormal sphingolipid metabolism is involved in the pathogenesis of ICP.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Biophysics
Ru Cheng, Fu Zhu, Min Huang, Qiang Zhang, Hui Hong Yan, Xiao Hui Zhao, Fu Kang Luo, Chun Mei Li, Hui Liu, Gao Lin Liang, Cheng Zhi Huang, Jian Wang
Summary: In this study, a new biosensor named hepatitis virus indicator was developed for the simultaneous detection of HBV and HCV. The biosensor utilized Exo III assisted signal amplification strategy and particle counting technology with a dark-field microscopy, enabling sensitive and selective detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Gastroenterology & Hepatology
Chen-Hua Liu, Jia-Horng Kao
Summary: Acute hepatitis C virus (HCV) infection, with varying incidence rates globally, is most common in individuals who have received unsafe medical procedures, used injection drugs, and lived with human immunodeficiency virus. Diagnosing acute HCV infection is challenging in immunocompromised, reinfected, and superinfected patients due to difficulties in detecting anti-HCV antibody seroconversion and HCV ribonucleic acid. Clinical trials have recently shown the treatment benefits of direct-acting antivirals (DAAs). Early initiation of DAAs is recommended for acute HCV infection before spontaneous viral clearance, and shorter treatment durations can be effective. Standard DAA regimens have similar efficacy in treating HCV-reinfected patients and DAA-naive ones. For specific cases, such as HCV-viremic liver and non-liver solid organ transplant recipients, different treatment durations and courses of DAAs are suggested. Prophylactic HCV vaccines are currently unavailable, so prevention measures, harm reduction, safe sex, and vigilant surveillance after viral clearance are crucial for reducing HCV transmission. (Clin Mol Hepatol 2023;29:623-642)
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yinhuan Zhang, Xiaowei Yang, Zhixin Jia, Jie Liu, Xiaoning Yan, Yihang Dai, Hongbin Xiao
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
Yijun Chen, Hao Wu, Yueting Li, Jie Liu, Zhixin Jia, Wenjuan Xu, Hongbin Xiao, Wei Wang
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Sport Sciences
Sung-Min Kim, Feng Qu, Wing-Kai Lam
Summary: This study compared the effects of analogy learning and explicit learning on balance task performance, finding that explicit learners performed worse in dual-task tests, while analogy learners showed more stable performance across different tests.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2021)
Article
Medicine, Research & Experimental
Hao Wu, Yijun Chen, Beibei Huang, Yingting Yu, Shujun Zhao, Jie Liu, Zhixin Jia, Hongbin Xiao
Summary: The study demonstrated that ethanol extract of Aster tataricus (ATE) could significantly promote small intestinal transit, reduce fecal amount, increase fecal water content, and alleviate colonic pathological damage. In vitro experiments showed that ATE could attenuate constipation by antagonizing acetylcholine binding to muscarinic receptors, inhibiting calcium influx, and anti-inflammatory effects in a concentration-dependent manner.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biophysics
Wei Wang, Feng Qu, Shangxiao Li, Liduan Wang
Summary: This study investigated the effects of motor skill level and running speed on movement variability, particularly focusing on stride length, joint angles, and coordination. Results showed significant interactions between skill level and speed on movement variability, with athletes demonstrating greater angle and coordination variability during sprinting. The relationship between coordination variability and performance was found to be complex, with more longitudinal studies needed to fully understand their connection.
JOURNAL OF BIOMECHANICS
(2021)
Article
Plant Sciences
Meixia Zhu, Zhixin Jia, Xiaoning Yan, Lirong Liu, Cong Fang, Menghan Feng, Yihang Dai, Yinhuan Zhang, Hao Wu, Beibei Huang, Yueting Li, Jie Liu, Hongbin Xiao
Summary: This study evaluated the ameliorative effects of DHG on liver inflammation and fibrosis in a methionine/ choline-deficient (MCD) diet-induced NASH rat model, and its underlying mechanism.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Zhixin Jia, Lirong Liu, Jie Liu, Cong Fang, Mingxia Pan, Jingxuan Zhang, Yueting Li, Zhong Xian, Hongbin Xiao
Summary: Through sphingolipidomics analysis, three potential biomarkers for potential liver injury caused by Polygonum multiflorum Thunb. (PM) were identified, and a new criterion for evaluation was proposed, which may be more sensitive than current indicators.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Plant Sciences
Cong Fang, Jie Liu, Menghan Feng, Zhixin Jia, Yueting Li, Yihang Dai, Meixia Zhu, Beibei Huang, Lirong Liu, Zuying Wei, Xu Wang, Hongbin Xiao
Summary: The study found that Shengyu Decoction (SYD) can improve the cognitive abilities of rats with vascular cognitive impairment (VCI). Its active ingredients improve cognitive impairment by affecting the AKT/HIF-1 alpha/VEGF and p38 MAPK/NF-kappa B signaling pathways, promoting cerebrovascular generation, and ameliorating neuroinflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yinhuan Zhang, Lirong Liu, Menghan Feng, Hao Wu, Yihang Dai, Zhixin Jia, Cong Fang, Mingyan Liu, Xiaoning Yan, Meixia Zhu, Beibei Huang, Biqiong Qu, Hongbin Xiao
Summary: The hepatotoxic equivalent markers (HEMs) of Polygonum multiflorum Thunb. (PMT) were identified as 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG) and emodin-8-O-glucoside (EG). It was found that PMT induced liver injury by interfering with purine metabolism.
Article
Biochemistry & Molecular Biology
Zhixin Jia, Lirong Liu, Cong Fang, Mingxia Pan, Shiyu Cong, Zhonghui Guo, Xiaoqin Yang, Jie Liu, Yueting Li, Hongbin Xiao
Summary: A strategy combining network pharmacological technique with integrated pharmacokinetics was developed to address the potential liver injury caused by Polygonum multiflorum. A HPLC-QQQ-MS method was established for the simultaneous quantification of five effective compounds. Pathway enrichment analysis revealed that potential liver injury is primarily associated with PI3K-Akt, MAPK, Rap1, and Ras signaling pathways.
Meeting Abstract
Sport Sciences
Fangtong Zhang, Mengzi Sun, Kelsey Lewis, Feng Qu, Li Li
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Meeting Abstract
Sport Sciences
Ruiya Ma, Feng Qu
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Meeting Abstract
Sport Sciences
Mengzi Sun, Kelsey Lewis, Jung Hun Chio, Fangtong Zhang, Feng Qu, Li Li
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Meeting Abstract
Sport Sciences
Chen Yang, Bing Yu, Hui Liu, Feng Qu
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Article
Plant Sciences
Xiaoning Yan, Jie Liu, Meixia Zhu, Lirong Liu, Yijun Chen, Yinhuan Zhang, Menghan Feng, Zhixin Jia, Hongbin Xiao
Summary: The study revealed that components of Rhodiola crenulata can induce metabolic reprogramming by regulating the Hif-1 alpha signaling pathway, activating compensatory responses. Microglia sensed low oxygen levels earlier than neurons, accompanied by elevated expression of Hif-1 alpha protein.
PHARMACEUTICAL BIOLOGY
(2021)
