Article
Chemistry, Analytical
Mohamad Mahani, Maryam Taheri, Faten Divsar, Faeze Khakbaz, Alireza Nomani, Huangxian Ju
Summary: A new turn-on fluorescent assay based on triplex DNA labeled with N-doped carbon dots and gold nanoparticles was established for sensitive and selective detection of transcription factor NF-kB p50.
ANALYTICA CHIMICA ACTA
(2021)
Article
Polymer Science
Elisa Chiodi, Francesco Damin, Laura Sola, Lucia Ferraro, Dario Brambilla, M. Selim Unlu, Marcella Chiari
Summary: A reliable and easy quality control method using the Interferometric Reflectance Imaging Sensor (IRIS) system has been proposed for the evaluation of probe properties in microarray tests. This study demonstrated that IRIS analysis can detect missing probes immediately after immobilization, preventing signal deficiency during testing with clinical relevance.
Article
Materials Science, Multidisciplinary
Fatemeh Baraty, Samaneh Hamedi
Summary: This paper proposes the use of a ring resonator in a two-dimensional photonic crystal biosensor. The biosensor detects changes in the light characteristics caused by binding the sample to the analyte. By forming a periodic array of silicon rods with a refractive index of n = 3.46 in the air background, a cubic lattice structure is created. The resonant wavelength shifts when the refractive index of the analyte changes, resulting in a transmission spectrum shift of approximately 4.47 nm towards higher wavelengths. This mechanism can distinguish between normal and cancerous cells. The designed structure has average values of sensitivity, quality factor, FOM, and transmission of 308.5 (nm/RIU), 3803.55, 848.06 RIU-1, and 98.78%, respectively. It shows promising applications for highly sensitive label-free optical biosensors.
RESULTS IN PHYSICS
(2023)
Article
Optics
Tianwei Wu, Marco Menarini, Zihe Gao, Liang Feng
Summary: Using spatial light modulator-based lithography-free programmable light transmission, we demonstrate optical switching and a basic photonic neural network. Integrated photonics is crucial for handling increasing data traffic due to its high speed, large bandwidth, and unlimited parallelism. This lithography-free paradigm allows for dynamic control of spatial-temporal modulations of the imaginary index, enabling tailored optical-gain distributions for desired photonic functionality. The resulting programmability and multifunctionality can revolutionize integrated photonic signal processing and enhance information-processing speed.
Article
Materials Science, Multidisciplinary
Dipti Chauhan, Ramesh Chandra, Suveen Kumar
Summary: In this study, a nanobiosensing platform was developed for rapid, label free, and minimally invasive electrochemical detection of ANXA2 for early LC diagnosis. The fabricated nanobiosensor showed a linear detection range of 0 to 60 ng mL(-1), sensitivity of 1.805 mu A mL ng(-1) cm(-2), and a selectivity coefficient similar to 1.
Article
Engineering, Electrical & Electronic
Mohammad Houssein Jokar, Alieh Naraghi, Mahmood Seifouri, Saeed Olyaee
Summary: A new design of a bio-sensor using silicon photonic crystal double-elliptical ring resonators is proposed, which has improved sensitivity and capability for cancer detection. Numerical results show that the design achieves high sensitivities of 1170 nm/RIU and 1116.66 nm/RIU, as well as improved quality factors (Q) of 422.36 and 449.16 for skin (Basal) and cervical (HeLa) cancer cells, respectively. Additionally, the design demonstrates a low detection limit value of 3.2 x 10(-3) RIU. The proposed bio-sensor, with its attractive and simple topology, along with its high sensitivity, is a suitable choice for bio-sensing applications.
OPTICAL AND QUANTUM ELECTRONICS
(2023)
Article
Optics
Ibrahim Halil Giden
Summary: Optical sensing devices, particularly photonic crystal (PC) based sensors, have great potential in industrial and biomedical applications. In this study, a new type of Mach-Zehnder Interferometer (MZI) using low-symmetric Si PCs is proposed for efficient optical sensing of toxic gases and liquids. The interference phenomenon in the MZI allows for controlled location of dip and peak frequencies in the transmission spectra, enabling distinct observation of refractive index changes in surrounding media.
Article
Multidisciplinary Sciences
Wen Zhou, Bowei Dong, Nikolaos Farmakidis, Xuan Li, Nathan Youngblood, Kairan Huang, Yuhan He, C. David Wright, Wolfram H. P. Pernice, Harish Bhaskaran
Summary: This paper reports an in-memory photonic-electronic dot-product engine that decouples electronic programming of phase-change memory cells and enables parallel photonic computation with high-bit operation, low energy consumption, and high accuracy. The developed system achieves high inferencing accuracies in image recognition.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Daiki Kawasaki, Hirotaka Yamada, Kenji Sueyoshi, Hideaki Hisamoto, Tatsuro Endo
Summary: A simple, cost-effective, and sensitive plasmonic-photonic hybrid sensor using gold nanorods and a photonic crystal slab (PCS) was developed for label-free DNA detection. The sensitivity of the sensor was assessed experimentally and theoretically, and ultrasensitive detection of DNA was achieved.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Applied
Kuo Zhan, Zhaolong Wang, Yabin Zhu, Jun Yan, Yunlin Chen
Summary: This study proposed a label-free high performance optical refractive index CCl4 vapor sensor based on MIL-101(Cr)/TiO2 one-dimensional photonic crystals (1DPC) with excellent sensitivity, selectivity, and reliability. The sensor demonstrated high sensitivity, good linear relationship, fast optical response and recovery time, exceptional repeatability and reliability for CCl4 vapor detection, making it suitable for practical applications.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Review
Chemistry, Analytical
Ke Ma, Xing Li, Bin Xu, Wenjing Tian
Summary: Bioassays using fluorophore and DNA aptamer have been extensively developed due to the ultra-sensitivity of fluorophores and recognition ability of DNA aptamers. A label-free aptasensing strategy has been introduced, utilizing flexible fluorophore indicators and ssDNA aptamers for various sensing and assay applications. The conformational change of the DNA aptamer in the presence of the target results in dramatic fluorescence recovery and amplification.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Multidisciplinary
Juan Wang, Pepijn W. H. Pinkse, Loes Segerink, Jan C. T. Eijkel
Summary: Photonic crystals are materials that can confine and manipulate incident light, and have been extensively studied for the development of optical sensors with high adsorption and enhanced light-matter interaction. They are mainly utilized through five sensing principles, including sensing of refractive index variations, sensing by lattice spacing variations, enhanced fluorescence spectroscopy, surface-enhanced Raman spectroscopy, and configuration transitions.
Article
Biophysics
G. Zanchetta, T. Carzaniga, L. Vanjur, L. Casiraghi, G. Tagliabue, C. Morasso, T. Bellini, M. Buscaglia
Summary: This study demonstrates a rapid, multiplex detection method for miRNAs based on RPI, achieving sub-pM quantification of different miRNAs in about 1.5 hours without the need for washing steps. The method involves specific capture with surface DNA probes and a 35-fold mass amplification using antibodies, enabled by the characterization of individual interactions through RPI.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemical Research Methods
Hanyuan Zhang, Alanna M. Klose, Benjamin L. Miller
Summary: The study utilized glycan-based receptor analogue microarrays on the AIR platform to achieve label-free, multiplex detection and discrimination of human and avian influenza viruses. The method can be expanded to systematically evaluate influenza virus adaptation in humans, facilitating global influenza surveillance and serving as a new tool enabling quick reactions in the face of a pandemic outbreak for health organizations, governments, research institutes, and laboratories.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Li Li, Zhengbo Chen
Summary: In this study, a high specificity, flexibility, and simplicity aptasensor strategy was designed using a triblock DNA probe. It was found that the polyA fragment could assemble on the gold electrode surface via polyA instead of traditional Au-S bonds, leading to improved hybridization stability. The electrochemical aptasensor showed good repeatability, stability, and specificity.
BIOELECTROCHEMISTRY
(2023)
Article
Electrochemistry
Vicente Compan, Ricardo Diaz-Calleja, Joaquin Diaz-Boils, Jorge Escorihuela
Summary: In this study, we propose an alternative approach to calculate the mobility, diffusivity, and charge density in polyelectrolytes using a distribution of the Debye length (L-D), which provides a more concise way to consider these parameters.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Jianlin Han, Jorge Escorihuela, Santos Fustero, Aitor Landa, Vadim A. Soloshonok, Alexander Sorochinsky
Summary: This review critically discusses the literature data on the preparation of substituted GABA derivatives using the Michael addition reaction. Special attention is paid to asymmetric methods featuring synthetically useful stereochemical outcomes and operational simplicity.
Article
Chemistry, Inorganic & Nuclear
Jorge Escorihuela, Lawrence M. Wolf
Summary: This study investigates the mechanism and reactivity of the Pauson-Khand reaction of fluorinated and asymmetric N-tethered 1,7-enynes using density functional theory calculations. The results reveal that the intramolecular alkene insertion into the carbon-cobalt bond is the rate determining step, and the stereoselectivity is rationalized by different transition states.
Article
Chemistry, Analytical
Luca Tramarin, Rafael Casquel, Jorge Gil-Rostra, Miguel Angel Gonzalez-Martinez, Raquel Herrero-Labrador, Ana Maria M. Murillo, Maria Fe Laguna, Maria-Jose Banuls, Agustin R. Gonzalez-Elipe, Miguel Holgado
Summary: In this study, a dual optical and electrochemical sensor based on resonant nanopillars coated with ITO thin film was developed. The ITO layer acted as an electrode without compromising the optical sensing capability. The experimental results were supported by theoretical simulations.
Review
Chemistry, Applied
Shintaro Kawamura, Pablo Barrio, Santos Fustero, Jorge Escorihuela, Jianlin Han, Vadim A. Soloshonok, Mikiko Sodeoka
Summary: The difunctionalizative trifluoromethylation of unsaturated C-C bonds is a highly useful and efficient method for synthesizing trifluoromethyl compounds. This review focuses on reactions that simultaneously form C-heteroatom and C-H bonds, providing useful CF3 group-containing building blocks. The comprehensive survey categorizes reactions into those that are synthetically mature and those with room for further development.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Jorge Escorihuela, Santos Fustero
Summary: The chemistry of fluorinated compounds has grown significantly in recent decades due to the diverse properties they possess. Among them, fluorinated chiral imines, especially the Ellman's imines, are crucial in the synthesis of enantioenriched carbocycles and heterocycles with exceptional biological and synthetic properties. This personal account highlights the important findings of our research group in the past two decades, focusing on asymmetric tandem reactions, particularly the intramolecular aza-Michael reaction, diversity oriented synthesis, asymmetric tandem reactions involving a p-tolylsulfinyl group, cycloaddition processes, and the use of fluorinated chiral N-sulfinyl imines and their derivatives as starting materials for enyne compounds in Pauson-Khand reactions, [2+2+2]-cycloadditions, and metathesis reactions.
Article
Chemistry, Organic
Melinda Nonn, Jorge Escorihuela, Lorand Kiss
Summary: This article introduces a convenient domino synthetic approach for the construction of the indolizidine core in a high-yield and diastereoselective manner, providing triple functionalization.
Article
Chemistry, Organic
Jorge Escorihuela
Summary: In this study, density functional theory calculations are used to clarify the mechanism and reactivity of enynes containing a vinyl fluoride moiety for the Co2(CO)(8)-mediated intramolecular Pauson-Khand reaction. The results show that alkene insertion is the rate-determining step for this reaction. The effect of substituents on the reaction has also been investigated, with fluorinated enynes having lower reactivity compared to malonate homologues.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Multidisciplinary
Johannes A. M. Damen, Jorge Escorihuela, Han Zuilhof, Floris L. van Delft, Bauke Albada
Summary: The rates of reaction between strained cycloalkynes and cycloalkenes with 1,2-quinone were studied using stopped flow UV-Vis spectroscopy and computational analysis. The results showed that strained alkyne BCN OH 3 reacted over 150 times faster than strained alkene TCO-OH 5, and the introduction of a carbamate derivative reduced the rate constant by almost half. Additionally, the 8-membered strained alkyne BCN OH 3 reacted 16 times faster than the more strained 7-membered THS 2. Thermodynamic activation parameters were determined using the linearized Eyring equation, providing valuable insights into these rapid click reactions.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Lorand Kiss, Jorge Escorihuela
Summary: Density functional theory calculations were used to investigate the reactivity and regioselectivity of 1,3-dipolar cycloaddition reactions. The calculated activation free energies reproduced the experimentally observed product ratios. Both electronic and steric effects influenced the regioselectivities.
Article
Chemistry, Analytical
Paola Zezza, Maria Isabel Lucio, Estrella Fernandez, Angel Maquieira, Maria-Jose Banuls
Summary: The present research aimed to develop a label-free biosensing platform using a biofunctionalized hydrogel with a surface diffractive micropattern. The biosensors were fabricated by holographic recording of polyethylene terephthalate (PET) surface micro-structures and their transfer into a hydrogel material. Two different immobilization approaches, during or after hydrogel synthesis, were demonstrated with the latter showing better loading capacity of the bioreceptor groups. The label-free biosensor showed selective response with a limit of detection of 2.47 μM for the complementary DNA strand, making it a cheap and easy-to-fabricate tool for medical diagnosis.
Article
Chemistry, Organic
Manas Bandyopadhyay, Sayan Bhadra, Swastik Pathak, Anila M. Menon, Deepak Chopra, Snehangshu Patra, Jorge Escorihuela, Souradeep De, Debabani Ganguly, Suman Bhadra, Mrinal K. Bera
Summary: An electrochemical method was developed for the reagentless synthesis of 4,5-disubstituted triazole derivatives using secondary propargyl alcohol and sodium azide. The reaction was conducted at room temperature in an undivided cell with a constant current using a pencil graphite anode and stainless-steel cathode in a MeCN solvent system. The proposed reaction mechanism was convincingly established through control experiments and electrochemical and density functional theory studies.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yumei Zhu, Jorge Escorihuela, Haiying Wang, Andrew C. -H. Sue, Han Zuilhof
Summary: We developed an improved method to synthesize a series of pillar[6]arenes with varying numbers of quinone groups. The strength of host-guest interactions with silver ions depends on the number of quinone groups, with a decrease in electron affinity as the number of quinone groups increases. Furthermore, we found that the macrocycle-Ag(2) complexes exhibit a clear distinction between terminal alkynes and internal alkynes, internal alkenes, and terminal alkenes in terms of binding strength.
Article
Chemistry, Organic
Pablo Garcia-Aznar, Jorge Escorihuela
Summary: The study of reaction rates and mechanisms in click chemistry reactions is still a challenging task. The inverse electron demand Diels-Alder (IEDDA) reaction is a promising metal-free alternative that exhibits enhanced reaction rates compared to other click chemistry reactions. The reaction mechanism of IEDDA reaction using norbornene derivatives was investigated using quantum mechanical calculations. The results provide insights into the factors affecting the reaction rates.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Alberto Llobat, Jorge Escorihuela, Carmen Ramirez de Arellano, Santos Fustero, Mercedes Medio-Simon
Summary: This study describes the preparation of merged symmetrical tetrahydroisoquinolines with central chirality through a rhodium-catalyzed intramolecular [2 + 2 + 2] cycloaddition. The results demonstrate that linear triynes lacking a 3-atom tether can efficiently undergo cyclisation. Additional substitution at the benzene rings can be achieved by employing substituted triynes at the terminal triple bonds, leading to more complex tetrahydroisoquinolines.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
