期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 405, 期 11, 页码 3431-3448出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-012-6606-2
关键词
Amperometric biosensors; Functional nanomaterials; Graphene; Carbon nanotubes; Metal and metal oxide nanoparticles; Clinical metabolites; Immunosensors; Cancer biomarkers; DNA; Genosensors
资金
- Department of Science and Technology
- Council of Scientific and Industrial Research, New Delhi
- Indian Institute of Technology Kharagpur
Functional nanomaterials have emerged as promising candidates in the development of an amperometric sensing platform for the detection and quantification of bioanalytes. The remarkable characteristics of nanomaterials based on metal and metal oxide nanoparticles, carbon nanotubes, and graphene ensure enhanced performance of the sensors in terms of sensitivity, selectivity, detection limit, response time, and multiplexing capability. The electrocatalytic properties of these functional materials can be combined with the biocatalytic activity of redox enzymes to develop integrated biosensing platforms. Highly sensitive and stable miniaturized amperometric sensors have been developed by integrating the nanomaterials and biocatalyst with the transducers. This review provides an update on recent progress in the development of amperometric sensors/biosensors using functional nanomaterials for the sensing of clinically important metabolites such as glucose, cholesterol, lactate, and glutamate, immunosensing of cancer biomarkers, and genosensing.
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