Article
Medicine, General & Internal
Anna Welz, Marcin Koba, Piotr Koslinski, Joanna Siodmiak
Summary: Recreational use of piperazine designer drugs poses a serious threat to human health. These compounds have similar effects to illegal drugs and can induce psychostimulatory effects and hallucinations. The presence of multiple psychoactive substances, including piperazine derivatives, has been found in many poisoning cases, which presents challenges in their identification. This article compares the methods of detecting abused piperazine designer drugs using liquid chromatography with a diode-array detector (LC-DAD) or mass spectrometer (LC-MS). Both methods can be used independently or complement each other to provide reliable results for qualitative and quantitative confirmation. The proposed methods can aid in toxicological diagnostics and analytical confirmation of poisonings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Anna Welz, Marcin Koba, Piotr Koslinski, Joanna Siodmiak
Summary: Piperazine derivatives are popular psychostimulating compounds sought by consumers for recreational use due to their stimulating effects. Despite being found in NPS-related poisonings and deaths, confirming the involvement of piperazine derivatives in poisoning can be challenging. A new rapid detection method using LC-MS has been proposed to provide analytical confirmation of poisoning with piperazine designer drugs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Manal A. Alhefeiti, James Barker, Iltaf Shah
Summary: This review presents an overview of roadside drug testing, driving enforcement, and drunk/drug driving detection worldwide. It highlights the implications of drunk or drug driving on road safety, the introduction of mobile roadside drug testing devices, and the use of oral fluid by law enforcement agencies. The article also discusses the types of drugs abused by drivers, behavioral testing methods, and sample collection and analysis procedures.
Article
Chemistry, Analytical
Fabio Vaiano, Elisabetta Bertol, Maria Mineo, Laura Pietrosemoli, Jolanda Rubicondo, Claudiu T. Supuran, Fabrizio Carta
Summary: Liquid chromatography coupled with mass spectrometry (LC/MS) has been increasingly utilized in forensic toxicology for screening purposes, offering high sensitivity and reliability for simultaneous detection of NPS and other drugs. The dynamic multiple reaction monitoring analysis method described in this study allows for effective identification and quantification of various substances, making it suitable for routine analytical activities in forensic caseworks.
Article
Chemistry, Analytical
Hsiu-Chuan Chen, Pin-Duo Lee, Yan-Zin Chang
Summary: A high-throughput method using microwave-assisted extraction, chemical derivatization, and liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS) was developed for the simultaneous analysis of illicit drugs and their metabolites in a micro-segment of a single hair. The method showed high throughput, high sensitivity, and short analysis time.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Medicine, Legal
Martin M. Kimani, Skyler W. Smith, Adam Lanzarotta, Jana L. Brueggemeyer, JaCinta S. Batson
Summary: The emergence of illicit designer benzodiazepines without approved clinical use is a great concern for public health in the US. This study developed robust analytical methods using Raman spectroscopy, SERS, FT-IR spectroscopy, and LC-MS to rapidly detect these chemicals. Micro-extraction procedures were also developed for sample preparation. The developed SERS and FT-IR procedures could be used in satellite laboratories to screen suspect packages and prioritize samples for additional laboratory-based analyses.
FORENSIC SCIENCE INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Anna Roszkowska, Natalia Treder, Alina Plenis, Natalia Miekus, Ilona Oledzka, Piotr Kowalski, Tomasz Baczek
Summary: This study compared and optimized two microextraction strategies for the extraction of four immunosuppressants in biofluids. The results showed that one strategy exhibited better performance for the extraction of a novel immunosuppressive drug.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Chemistry, Analytical
Pin-Chuan Chen, Wei-Zhe Zhang, Wei-Ru Chen, Yung-Cheng Jair, Yi-Hsin Wu, Yi-Hsin Liu, Pei-Zhen Chen, Lian-Yu Chen, Pai-Shan Chen
Summary: A novel high-pressure resistant microfluidic chip was successfully fabricated and coupled with an LC-MS system for efficient and precise bioanalysis. The experimental results demonstrated significant reproducibility, stability and durability of the chip, making it an effective tool for biological sample analysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Medicine, Research & Experimental
Claudia Gioe-Gallo, Sandra Ortigueira, Jose Brea, Iu Raich, Jhonny Azuaje, M. Rita Paleo, Maria Majellaro, Maria Isabel Loza, Cristian O. Salas, Xerardo Garcia-Mera, Gemma Navarro, Eddy Sotelo
Summary: Synthetic cannabinoid receptor agonists (SCRAs) are the largest and most defiant group of abuse designer drugs, with potent effects and severe consequences. Due to their ever-changing structure, limited information is available to the scientific community and law enforcement. This study provides new insights into the synthesis, pharmacology, and toxicity of SCRAs, identifying potential illegal psychoactive substances and their neurotoxicity on neuronal cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Multidisciplinary
Myriam Bustamante-Rangel, Maria Milagros Delgado-Zamarreno, Encarnacion Rodriguez-Gonzalo
Summary: A simple and sensitive method has been developed for the analysis of anthelmintic drugs in milk, involving extraction using QuEChERS method and separation and determination by LC-MS/MS. This method provides high sensitivity for the determination of anthelmintics in milk samples and can be successfully used for routine analysis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Medicinal
Pablo Estevez, David Castro, Jose Manuel Leao-Martins, Manoella Sibat, Angels Tudo, Robert Dickey, Jorge Diogene, Philipp Hess, Ana Gago-Martinez
Summary: This study focused on the identification of toxic compounds produced by a G. australes strain from the Mediterranean Sea, revealing the presence of a novel MTX analogue named MTX5 and the absence of CTX precursors, highlighting the complexity of identifying CTX precursors in these regions.
Article
Environmental Sciences
Marina Bellot, Carlos Barata, Cristian Gomez-Canela
Summary: The study evaluated the stability of 17 neuroactive compounds in water and found that most compounds did not degrade, except for apomorphine and 6-hydroxydopamine which degraded completely within 24 hours. Most compounds altered motile responses to light in the crustacean Daphnia magna.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Analytical
Yanping Zhu, Qian Zhang, Jun Lu, Kai Wang, Ruina Zhang, Quan Yu
Summary: With its advantages of rapid analysis, high sensitivity, and multicomponent identification, mass spectrometry (MS) is an appealing choice for high-throughput screening (HTS) analysis. Over the last 2 decades, the development of miniature mass spectrometers has made great progress, providing not only the essential analytical performance, but also simple operation and HTS capability.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Nadia Arbouche, Jean-Sebastin Raul, Pascal Kintz
Summary: Oral antidiabetics are drugs used to control blood sugar in diabetic subjects. The greatest risk of using these drugs is hypoglycemia, especially in individuals with no history of exposure to these medications. Hair testing for oral antidiabetics can help differentiate the cause of hypoglycemia and has a large detection window with long-term stability. A liquid-chromatography coupled to tandem mass spectrometry method has been developed and successfully applied to analyze 13 oral antidiabetics in hair samples from diabetic patients.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sunyeong Jang, Hyungju Seo, Hojin Kim, Hyoyoung Kim, Jongsung Ahn, Hyunjeong Cho, Sunghie Hong, Seunghwa Lee, Taewoong Na
Summary: A method for the rapid and quantitative analysis of 30 veterinary drugs in feed samples was developed and validated. The method showed good linearity and recovery rates, and can be used for screening residual multiclass veterinary drugs in feed samples.