Article
Environmental Sciences
Yi Zhang, Pai Zheng, Jiaqi Shi, Ying Ma, Zhangjian Chen, Tiancheng Wang, Guang Jia
Summary: This study aimed to investigate the association of ambient temperature with creatine kinase MB (CK-MB) and creatine kinase (CK). The results showed a V-shaped relationship between CK-MB and ambient temperature, and a linear relationship between CK and ambient temperature. Cold exposure was associated with increased levels of CK-MB and CK, while no heat-related elevation was observed. These findings suggest a possible adverse effect of cold exposure on myocardial injury.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Physical
Andre L. Ferreira, Lucas F. de Lima, Ariana S. Moraes, Rafael J. G. Rubira, Carlos J. L. Constantino, Fabio L. Leite, Adriana O. Delgado-Silva, Marystela Ferreira
Summary: This paper presents a new biosensor for detecting the cardiac biomarker CK-MB using SPR technique, showing increased sensitivity and accuracy in detecting CK-MB in saliva and urine samples. The enhanced interaction between the functionalized substrate and CK-MB demonstrates a high affinity, indicating potential for accurate diagnosis of AMI.
APPLIED SURFACE SCIENCE
(2021)
Article
Psychiatry
Ping Rong, Shuyi Zhao, Qianfang Fu, Mengrui Chen, Libin Yang, Yifei Song, Xilian Zhang, Rong Ma
Summary: This article discusses a 5-year-old girl with autism spectrum disorder (ASD) whose serum creatine kinase and creatine kinase MB isoenzyme levels have been rising for nearly 2 years. After treatment with traditional Chinese medicine, the creatine kinase MB isoenzyme level decreased dramatically. This indicates that patients with ASD may experience long-term increases in serum creatine kinase levels, and traditional Chinese medicine can temporarily reduce the creatine kinase MB isoenzyme level.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Medicine, Research & Experimental
Angelo Zinellu, Salvatore Sotgia, Alessandro G. Fois, Arduino A. Mangoni
Summary: The meta-analysis found that higher levels of CK-MB were significantly associated with severe disease and mortality in COVID-19 patients. This biomarker may be useful for risk stratification in this group. Extreme between-study heterogeneity was observed, but sensitivity analysis did not modify the effect size.
ADVANCES IN MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Johann Zwirner, Sven Anders, Simone Bohnert, Ralph Burkhardt, Ugo Da Broi, Niels Hammer, Dirk Pohlers, Rexson Tse, Enjamin Ondruschka
Summary: The study suggests that using creatine kinase (CK) immunoassays in postmortem cerebrospinal fluid can serve as an adjunct quantitative test aid in diagnosing acute TBI-related fatalities. TBI cases showed a significant increase in CK and CK-MB, with moderate to high diagnostic accuracy.
Article
Infectious Diseases
Paulin N. Essone, Bayode R. Adegbite, Marien J. M. Mbadinga, Armel Mbouna, Fabrice Lotola-Mougeni, Ayodele Alabi, Jean R. Edoa, Bertrand Lell, Abraham S. Alabi, Ayola A. Adegnika, Michael Ramharter, Joel F. D. Siawaya, Martin P. Grobusch, Peter G. Kremsner, Selidji T. Agnandji
Summary: This study evaluated the diagnostic utility of creatine kinase-MB (CK-MB) and hepcidin (HEPC) for tuberculosis (TB) and found that their levels were statistically different between confirmed TB cases and non-TB cases. Combining them with two other biomarkers can improve the diagnostic accuracy.
Article
Computer Science, Interdisciplinary Applications
Kevser Kubra Kirboga, Ecir Ugur Kucuksille, Muhammet Emin Naldan, Mesut Isik, Oktay Gulcu, Emrah Aksakal
Summary: This study used explainable white box algorithms to diagnose Troponin levels in the COVID-19 process in order to provide a clear explanation. The SHAP algorithm was applied to analyze the model and determine the highest importance of features such as DDimer mean, mortality, CKMB, and Glucose.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Shengwei Wu, Yufang Zhou, Zhengzheng Xuan, Linghui Xiong, Xinyu Ge, Junrong Ye, Yun Liu, Lexin Yuan, Yan Xu, Guoan Ding, Aixiang Xiao, Jianxiong Guo, Lin Yu
Summary: This study found that patients, especially females, who had previously used SSRI antidepressants were more likely to have elevated CK and CK-MB levels, indicators of myocardial muscle injury.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Cong Chen, Xianchao Lin, Ronggui Lin, Heguang Huang, Fengchun Lu
Summary: This study aimed to explore the potential value of the CK-MB-to-total-CK ratio (CK ratio) in differentiating pancreatic cancer (PC) from benign masses when combined with carbohydrate antigen 19-9 (CA19-9). The CK ratio was significantly elevated in patients with pancreatic adenocarcinoma and is an independent factor predicting pancreatic adenocarcinoma. Combined detection of CA19-9 and the CK ratio improves the diagnostic accuracy of pancreatic cancer.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Ze Chen, Thea Laurentius, Yvonne Fait, Aline Mueller, Eva Mueckter, Leo Cornelius Bollheimer, Mahtab Nourbakhsh
Summary: Sarcopenia, characterized by muscle loss, can be diagnosed by measuring appendicular skeletal muscle index (ASMI). A study on older adults found positive correlations between ASMI and nutritional status (p = 0.001) and serum creatine kinase (CK) (p = 0.019), but negative correlations with serum CXCL12a (p = 0.023) and interleukin (IL)-7 (p = 0.024). The study identified advanced age, malnutrition, low CK levels, and high CXCL12a levels as risk factors for sarcopenia. Combining low CK and high CXCL12a levels can be used as serum markers for sarcopenia. The linear correlation between ASMI and CXCL12a levels may aid future studies on sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Mengmeng Chen, Yu Wang, Xudong Zhao, Jingyang Zhang, Yuan Peng, Jialei Bai, Shuang Li, Dianpeng Han, Shuyue Ren, Kang Qin, Sen Li, Tie Han, Zhixian Gao
Summary: A portable visual quantitative assay for CK-MB was developed by combining target-responsive DNA hydrogel and a microfluidic chip. This method has the potential for quantitative point-of-care testing in resource-constrained settings.
Article
Food Science & Technology
Simone Balbinot, Anand Mohan Srivastav, Jasmina Vidic, Ibrahim Abdulhalim, Marisa Manzano
Summary: This article highlights the importance and advantages of optical biosensors in food safety, comparing them with traditional methods and showcasing the applications of different technologies and future trends.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Veterinary Sciences
Vitor Bruno Bianconi Rosa, Ivan Felismino Charas dos Santos, Leticia Gondim Souto, Emilia de Paiva Porto, Dietrich Pizzigatti, Bruno Fornitano Cholfe, Breno Fernando Martins de Almeida, Thais Helena Constantino Patelli, Regina Kiomi Takahira
Summary: This study aimed to evaluate the effects of acupuncture on rodeo bulls in training by measuring hematological variables, CK, AST, fibrinogen, and plasma lactate levels. The results showed that bulls treated with acupuncture had smaller variations in hemogram, increased eosinophils levels, and lower plasma lactate levels after exercise compared to the control group. The findings suggest that acupuncture treatment can have positive effects on the physiological response to exercise in rodeo bulls.
RESEARCH IN VETERINARY SCIENCE
(2023)
Review
Chemistry, Analytical
Jingjing Jiang, Jili Xia, Yang Zang, Guowang Diao
Summary: Electrochemistry- and photoelectrochemistry-based biosensors have been recognized as powerful tools for trace monitoring of carcinoembryonic antigen (CEA) due to their high sensitivity, excellent selectivity, and low cost. They are classified into two main categories: immunosensors and aptasensors. This review presents recent examples and discusses signaling strategies, advanced materials, and detection modes.
Article
Chemistry, Analytical
Shi-Yun Cen, Yi-Ge Feng, Jian-Hong Zhu, Xiao-Yu Wang, Ai-Jun Wang, Xiliang Luo, Jiu-Ju Feng
Summary: Advanced nanomaterials, particularly ultra-thin AuPdCu alloyed nanowire networks, have been successfully synthesized and utilized as signal amplifiers in label-free electrochemical immunosensors for CK-MB detection. The efficient catalytic performance of AuPdCu NWNs in reducing H2O2 enhances detection responses, leading to wide linear detection range and low LOD for CK-MB assay. This research provides valuable guidelines for monitoring cardiac markers in clinical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Fernando Garay
SENSORS AND ACTUATORS B-CHEMICAL
(2015)
Article
Chemistry, Analytical
Lucas Colombo, Ana Maria Baruzzi, Fernando Sebastian Garay
SENSORS AND ACTUATORS B-CHEMICAL
(2015)
Article
Electrochemistry
Mariela Cuellar, Sabrina N. Vettorelo, Patricia I. Ortiz, Fernando Garay
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2016)
Article
Electrochemistry
Sabrina N. Vettorelo, Fernando Garay
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2016)
Article
Electrochemistry
Angelica C. Heredia, Jenny Gomez Avila, Fernando Garay, Monica E. Crivello
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2017)
Article
Chemistry, Analytical
Marcelo R. Romero, Damian Peralta, Cecilia I. Alvarez Igarzabal, Ana M. Baruzzi, Miriam C. Strumia, Fernando Garay
SENSORS AND ACTUATORS B-CHEMICAL
(2017)
Article
Biochemical Research Methods
Fausto N. Comba, Marcelo R. Romero, Fernando S. Garay, Ana M. Baruzzi
ANALYTICAL BIOCHEMISTRY
(2018)
Article
Chemistry, Analytical
Lucas Colombo, Fernando Garay
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Chemistry, Analytical
Sabrina N. Vettorelo, Fernando Garay
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2018)
Article
Chemistry, Analytical
Jenny Gomez Avila, Angelica C. Heredia, Monica E. Crivello, Fernando Garay
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Physical
Angelica Heredia, Jenny Gomez Avila, Ariel Vinuesa, Clara Saux, Sandra M. Mendoza, Fernando Garay, Monica Crivello
ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY
(2019)
Article
Chemistry, Analytical
Sabrina N. Vettorelo, Mariela Cuellar, Patricia I. Ortiz, Fernando Garay
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Analytical
Jenny Gomez Avila, Jhan Carlos Burgos Gomez, Angelica C. Heredia, Monica E. Crivello, Fernando Garay
Summary: This study presents a mechanistic analysis of the cathodic stripping square-wave voltammetric response of the copper-arsenic system, where a mathematical model is used to evaluate the stability constant of arsenide formation and other parameters. Simulation results indicate the reduction of copper instead of arsenic during the cathodic stripping scan, and the formation of a metal complex in the presence of copper.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Fernando Garay, Sabrina N. Vettorelo
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2020)
Article
Electrochemistry
Alicia D. Robles, Sabrina N. Vettorelo, Marcela Gerpe, Fernando Garay
ELECTROCHIMICA ACTA
(2017)