Review
Chemistry, Analytical
Daniel Rojas, Juan F. Hernandez-Rodriguez, Flavio Della Pelle, Alberto Escarpa, Dario Compagnone
Summary: The ubiquity and importance of ROS and RNS in cellular signaling, disease development, and death have led to a significant interest in their detection and quantification. Electrochemical sensors are particularly suitable for the detection of ROS/RNS due to their high sensitivity and miniaturization, allowing for in situ and real-time detection. Nanomaterial-based enzyme-free electrochemical sensors have superior sensitivity, selectivity, stability, and catalytic activities. Moreover, their integration into nanoelectrodes, lab-on-chips, microfluidic systems, and stretchable electrodes enables the determination of ROS/RNS in individual cells, cell organelles, or cell populations under different experimental conditions that are difficult to achieve using classical detection methods.
Article
Chemistry, Analytical
Zahra Nasri, Giuliana Bruno, Sander Bekeschus, Klaus-Dieter Weltmann, Thomas von Woedtke, Kristian Wende
Summary: The study presented the development of an electrochemical sensor for in-situ assessment of reactive species in redox-based therapies, enabling the detection of the production of reactive oxygen and nitrogen species like hydrogen peroxide through chronoamperometry at different potentials.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Article
Plant Sciences
Chan Liu, Weibiao Liao
Summary: Potassium ion is an essential signaling molecule in plant growth and development. It interacts with calcium, reactive oxygen species, and reactive nitrogen species to regulate plant growth, development, and abiotic stress responses.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Keke Hu, Emily Relton, Nicolas Locker, Nhu T. N. Phan, Andrew G. Ewing
Summary: SGs encapsulate ROS, predominantly H2O2, and may act as communicators of cellular stress, regulating cellular metabolism and stress responses to provide cytoprotection in pathological conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Chemistry, Analytical
Surachet Duanghathaipornsuk, Eveline J. Farrell, Ana C. Alba-Rubio, Piotr Zelenay, Dong-Shik Kim
Summary: Reactive oxygen species (ROS) are widely distributed and related to various diseases, with common ROS in human health being superoxide, hydrogen peroxide, and hydroxyl radicals. Fluorescence and electrochemical methods are effective techniques recently developed for ROS detection.
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Analytical
Nina Wang, Dongni Wang, Rongrong Pan, Dengchao Wang, Dechen Jiang, Hong-Yuan Chen
Summary: By using a self-referenced nanopipette, researchers were able to measure hydrogen peroxide inside living cells under oxidative stress and found an uneven distribution of this substance between the nucleus and the cytoplasm, providing valuable insights into the chemical environment within living cells.
ANALYTICAL CHEMISTRY
(2021)
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Chemistry, Multidisciplinary
Jia Liu, Lin Shi, Yang Wang, Mingyi Li, Cheng Zhou, Lifang Zhang, Chundong Yao, Ye Yuan, Daan Fu, Yan Deng, Miaodeng Liu, Guobin Wang, Lin Wang, Zheng Wang
Summary: A nanosized ruthenium-based metal-organic framework (Ru-MOF) with high porosity and versatile reactive oxygen and nitrogen species (RONS) scavenging activities has been developed for treating inflammatory diseases.
Review
Biochemistry & Molecular Biology
Massimo Malerba, Raffaella Cerana
Summary: Programmed cell death (PCD) is a genetically controlled suicide process present in all living beings, playing a crucial role in plant development and stress responses. Studying PCD in whole plants or complex tissues is challenging due to its occurrence in a small group of inaccessible cells. Cultured cells provide a useful tool with their uniformity, accessibility, and reproducibility for investigating various aspects of plant PCD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Renkai Li, Chengwen Zheng, Polly Ho-Ting Shiu, Panthakarn Rangsinth, Wen Wang, Yiu-Wa Kwan, Emily Sze-Wan Wong, Yanbo Zhang, Jingjing Li, George Pak-Heng Leung
Summary: Despite various therapeutic approaches, developing novel and more effective methods for colorectal cancer treatment is crucial due to its high fatality rate. The recent study explored the anticancer effects of GAR E, a bioactive xanthone found in mangosteen, and identified the involvement of the ROS/JNK signaling pathway in its mechanism of action. The experiments demonstrated that GAR E inhibited colony formation and wound healing in cancer cells, triggered ROS production, induced mitochondrial dysfunction and apoptosis, and caused cell cycle arrest. In vivo experiments also confirmed the antitumor effect of GAR E in a xenograft mouse model. These findings suggest that GAR E could be a potential chemotherapeutic agent for colorectal cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
