Article
Engineering, Electrical & Electronic
Yujia Wang, Hao Zhang, Shaoxiang Duan, Wei Lin, Bo Liu, Jixuan Wu
Summary: The proposed WGM microresonator biosensor utilizes grapefruit MOFs to enhance interaction with microfluidic samples, functionalized with poly-L-lysine monolayer for label-free binding of ssDNA, and allows real-time monitoring of DNA processes. The sensor demonstrates linear fitting for DNA concentration detection from 0.01 fmol/µL to 100 fmol/µL, with ease of operation, fast response, label-free method, and high specificity, making it promising for in-situ DNA detection and biosensing applications.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Catarina R. F. Caneira, Denis R. Santos, Virginia Chu, Joao P. Conde
Summary: Recently, there has been a growing demand for rapid diagnosis of diseases, which has led to the development of new DNA detection platforms. However, the potential risk of misdiagnosis has hindered their market acceptance. In this study, a regenerable bead-based microfluidic device with integrated thin-film photodiodes was developed for real-time monitoring of DNA molecular recognition. The system demonstrated high sensitivity and the potential for reusability, which can reduce costs and improve the accuracy of diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Sundar Hengoju, Oksana Shvydkiv, Miguel Tovar, Martin Roth, Miriam A. Rosenbaum
Summary: Droplet microfluidics using optical fiber as a light guiding medium has revolutionized analytical possibilities by providing a simpler, more flexible, lower-cost, and sensitive setup for the detection of various parameters. This technology has great potential in biochemistry and biotechnology research.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Ruiyun Zhou, Chen Wang, Yuxin Huang, Kang Huang, Yingli Wang, Wendao Xu, Lijuan Xie, Yibin Ying
Summary: This study investigates the integration of graphene with THz metasurface into a microfluidic cell for sensitive biosensing in liquid environment, demonstrating high sensitivity in detecting DNA sequences of Escherichia coli O157:H7. The results suggest the potential of the proposed graphene-metasurface microfluidic biosensor for label-free biosensing applications.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Chemistry, Analytical
Zhen Li, Houfang Liu, Dongqing Wang, Miao Zhang, Yi Yang, Tian-ling Ren
Summary: This article extensively explains the latest improvements in microfluidic sensors for monitoring nutrients in water. It addresses the various substrate materials and current microfluidic technologies, and describes in detail the microfluidic approaches for the determination of different nutrients and their detection performance.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Hiromi Takahashi, Takao Yasui, Hiromu Kashida, Koki Makino, Keiko Shinjo, Quanli Liu, Taisuke Shimada, Sakon Rahong, Noritada Kaji, Hiroyuki Asanuma, Yoshinobu Baba
Summary: A device integrated with a microheater and zinc oxide nanowires was developed for non-invasive and rapid detection of target DNA. This device can detect target single-stranded DNA through DNA probe hybridization, offering broad potential applications in fundamental research.
Article
Biophysics
Yuxin Bayinqiaoge, Yuxin Zhang, Tim Cole, Jiahao Zheng, Jinhong Guo, Shi-Yang Tang
Summary: The effective analysis of bioparticles is important for early disease diagnosis. Optical microfluidic platforms have limitations in practical point-of-care testing due to their expensive components and bulky devices. Therefore, cost-effective non-optical microfluidic platforms are urgently needed. This review summarizes passive and active methods for bioparticle manipulation and surveys the latest progress in non-optical microfluidic strategies based on electrical, magnetic, and acoustic techniques for bioparticle detection. The challenges faced by current non-optical platforms in practical point-of-care testing and clinical applications are also discussed.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Like Li, Ya-nan Zhang, Wanlu Zheng, Xuegang Li, Yong Zhao
Summary: This study proposes an optical fiber SPR biosensor based on a sandwich model with gold nanoparticles amplification for high sensitivity DNA hybridization detection. The experimental results show a log-linear response in the DNA concentration range of 1 pM-10 nM with high sensitivity and detection limit.
Article
Multidisciplinary Sciences
Pierre-Alexandre Goyette, Etienne Boulais, Maude Tremblay, Thomas Gervais
Summary: The article introduces the pixelated chemical display (PCD) for highly parallel and reconfigurable liquid handling on open surfaces. It creates microfluidic pixels to display dynamic chemical images on surfaces without the need for physical barriers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Islam Seder, Dong-Min Kim, Sang-Hyun Hwang, Heungsup Sung, Dong-Eun Kim, Sung-Jin Kim
Summary: The article discusses a microfluidic platform for the sample-to-answer detection of viral RNA from clinical swab samples in a fully automated and highly sensitive manner. This platform allows for accurate diagnosis of infectious diseases in point-of-care settings.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Yang Xiao, Nicolas Martino, Klaudia Wagner, Geoffrey M. Spinks, David L. Officer, Pawel Wagner
Summary: The research achieved the isothermal light-directed movement of water droplets in organic media through photoisomerization, allowing controlled chemical transport and site-directed chemistry. The application of this new photoactive delivery system was demonstrated by inducing a chemical reaction through merging two reactive droplets.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Xiaowei Chen, A. Ghorbani, Long Quan, D. Toghraie
Summary: Sports injuries are a common problem for athletes, ranging from minor sprains to severe fractures and concussions. Microfluidic devices have shown promise in sports medicine by analyzing small samples of sweat, blood, or urine to provide real-time data on an athlete's physiological status. This information can optimize training, prevent injuries, and also contribute to the development of diagnostic and therapeutic methods for cancer and other diseases.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Analytical
Supratim Divya, Supratim Mahapatra, Pranjal Chandra
Summary: Creatinine is a common and specific biomarker for renal diseases. Researchers have developed an optical sensing device that can quantitatively detect creatinine through a change in color. The sensor has been integrated with a smartphone to create a palm-sized device for personalized creatinine analysis. The fabricated biosensor has been thoroughly characterized and shown to have excellent sensitivity and selectivity, with no cross-reactivity from interfering molecules. The system has been validated for quantifying creatinine in spiked serum samples, showing high reproducibility and stability.
Article
Materials Science, Multidisciplinary
Daniel C. Rabe, Uyen K. Ho, Adarsh Choudhury, Jessica C. Wallace, Evelyn G. Luciani, Dasol Lee, Elizabeth A. Flynn, Shannon L. Stott
Summary: This work demonstrates a method of depositing biotin onto the surface of a plastic microfluidic chip using aryl-diazonium, which chemically bonds biotin to the surface and allows for the addition of streptavidin nanoparticles. The nanoparticles increase the chip's surface area and improve the orientation of capture moieties. This method offers faster, cost-effective, and scalable production of devices, including those used for diagnostic testing.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Biochemical Research Methods
Jingui Qian, Huaize Lan, Liang Huang, Shaohui Zheng, Xuefeng Hu, Minghui Chen, Joshua E. -Y. Lee, Wei Zhang
Summary: Trace biological sample detection is crucial in biomedical pathology analysis. An orthogonal tunable acoustic tweezer allows simultaneous droplet transport and centrifugation, enhancing sensitivity for biomarker detection.
Article
Optics
Camiel Op de Beeck, Bahawal Haq, Lukas Elsinger, Agnieszka Gocalinska, Emanuele Pelucchi, Brian Corbett, Gunther Roelkens, Bart Kuyken
Article
Engineering, Biomedical
Kjeld Laursen, Amin Rashidi, Seyedsina Hosseini, Tanmay Mondal, Brian Corbett, Farshad Moradi
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2020)
Article
Acoustics
Seyedsina Hosseini, Kjeld Laursen, Amin Rashidi, Tanmay Mondal, Brian Corbett, Farshad Moradi
Summary: The study introduces a Sectored-Multiring Ultrasonic Transducer (S-MRUT) as a straightforward solution for selectively powering brain implants, avoiding the complexity of conventional phased arrays.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Chemistry, Multidisciplinary
Enrica E. Mura, Agnieszka M. Gocalinska, Megan O'Brien, Ruggero Loi, Gediminas Juska, Stefano T. Moroni, James O'Callaghan, Miryam Arredondo, Brian Corbett, Emanuele Pelucchi
Summary: Researchers demonstrated a 1.3 μm band laser grown by MOVPE on a GaAs substrate with a specially engineered metamorphic parabolic-graded buffer to overcome surface epitaxial dynamics and instabilities. By using a combination of AlInGaAs and InGaP alloys for cladding layers, they achieved efficient compressively strained In0.4Ga0.6As quantum wells with low lasing threshold and high slope efficiency in the active layer.
CRYSTAL GROWTH & DESIGN
(2021)
Review
Optics
Peter J. Parbrook, Brian Corbett, Jung Han, Tae-Yeon Seong, Hiroshi Amano
Summary: The article presents the principles and applications of micro-LED technology, discussing the implications of reduced LED size in necessitating mitigation strategies for nonradiative device edge damage and the potential for higher drive current densities.
LASER & PHOTONICS REVIEWS
(2021)
Article
Optics
Brendan Roycroft, Meena Baskaran, David McMahon, Brian Corbett
Summary: The study demonstrates laser power conversion using an edge-coupled waveguide configuration, achieving high power conversion efficiency. This technology can be applied to power conversion from fiber to devices and enable power-free data transmission, opening new possibilities for medical interventions and remote photonics applications.
Article
Optics
Stijn Cuyvers, Bahawal Haq, Camiel Op de Beeck, Stijn Poelman, Artur Hermans, Zheng Wang, Agnieszka Gocalinska, Emanuele Pelucchi, Brian Corbett, Gunther Roelkens, Kasper Van Gasse, Bart Kuyken
Summary: Research shows that leveraging ultra-low losses of silicon-nitride waveguides to manufacture a III-V-on-silicon-nitride integrated optical comb laser leads to superior performance, high efficiency, and low manufacturing costs.
LASER & PHOTONICS REVIEWS
(2021)
Article
Chemistry, Analytical
Desmond Brennan, Louise O'Connor, Martin Cormican, James Kileen, Eoin Clancy, Terry J. Smith, Paul Galvin
Summary: A PCR assay was developed to screen Chlamydia trachomatis directly from urine with high sensitivity and specificity, suitable for implementation on a disposable cartridge system. The assay protocol involved heating urine samples to 85°C for ten minutes and performing a duplex realtime PCR on resulting urine lysate.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Optics
Ida Izadi, Vanessa Dusend, Abdulaziz Takrouni, Noreen Nudds, Kamil Gradkowski, Peter O'Brien, Philipp Sasse, Brian Corbett
Summary: Control of heart rhythm is crucial in cases of arrhythmia. Cardiac optogenetics is a promising technique that may replace electrical stimulation, but further research on optimizing light delivery methods is necessary. A 2 x 2 blue LED optoelectronic module demonstrates high illumination homogeneity and irradiance for cardiac muscle illumination, enabling successful optogenetic pacing with reduced phototoxicity.
Article
Chemistry, Analytical
Julia Madden, Eoghan Vaughan, Michael Thompson, Alan O' Riordan, Paul Galvin, Daniela Iacopino, Sofia Rodrigues Teixeira
Summary: We developed a flexible laser scribed graphitic carbon based lactate biosensor with good working and storage stability for lactate detection.
Editorial Material
Optics
Fatima Gunning, Brian Corbett
Summary: The use of on-chip nonlinear waveguides can convert 1.5-mu m wavelength signals into the 2-mu m region, opening up new opportunities for expanding the bandwidth of optical communications.
Proceedings Paper
Engineering, Electrical & Electronic
Jing Zhang, Clemens J. Kruckel, Bahawal Haq, Bozena Matuskova, Johanna Rimbock, Stefan Ertl, Agnieszka Gocalinska, Emanuele Pelucchi, Brian Corbett, Joris Van Campenhout, Guy Lepage, Peter Verheyen, Dries Van Thourhout, Roel Baets, Gunther Roelkens
Summary: We presented an array of C-band high-speed silicon MZI switches with integrated III-V amplifiers on the imec iSiPP50G platform using micro-transfer printing. The integrated amplifiers have 10 dB optical gain, allowing lossless switching and improved cross-talk suppression of the switches.
IEEE 72ND ELECTRONIC COMPONENTS AND TECHNOLOGY CONFERENCE (ECTC 2022)
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Zeinab Shaban, Mehrdad Saei, Brian Corbett, Zhi Li
Summary: This study presents a method of micro-transfer printing GaN-on-Si LEDs into miniature reflective cavities to enhance their forward directed optical power. The power is further increased by using polymeric lenses in the cavities. Compared to LEDs on the original substrate, a 9-fold enhancement in collected light is achieved after transfer printing. Additionally, the printed LEDs demonstrate potential applications in visible light communication.
IEEE 72ND ELECTRONIC COMPONENTS AND TECHNOLOGY CONFERENCE (ECTC 2022)
(2022)
Proceedings Paper
Optics
Carlos Reyes, Brian Corbett, Brendan Roycroft
Summary: The system utilizes a fiber-based swept-source optical coherence tomography system to scan sections of ex-vivo tissue samples using a translation stage, achieving a scanning range of 5x5mm(2) with a minimum scanning step resolution of 0.5 μm.
OPTICAL COHERENCE IMAGING TECHNIQUES AND IMAGING IN SCATTERING MEDIA IV
(2021)
