Review
Plant Sciences
Katya Carbone, Fabio Gervasi
Summary: The medicinal potential of hop is well-known and its active compounds have anti-inflammatory, antioxidant, antimicrobial, and phytoestrogen activities. The presence of xanthohumol and 8-prenyl naringenin in hop contributes to its anticancer and estrogenic properties. Hop compounds have been found to inhibit various signaling pathways involved in cell proliferation. This review aims to provide an up-to-date overview of the active compounds in hop and their applications in human health and disease prevention.
Article
Biochemistry & Molecular Biology
Raimo Pohjanvirta, Atefeh Nasri
Summary: 8-prenylnaringenin (8-PN) is a potent phytoestrogen with potential benefits and adverse effects. High concentrations may require pharmacological intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Md. Mahfuzur Rob, Kawsar Hossen, Mst. Rokeya Khatun, Keitaro Iwasaki, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi
Summary: The allelopathic potential of Garcinia xanthochymus extracts was evaluated against various test plant species, inhibiting their growth in a concentration- and species-specific manner. Two allelopathic compounds, methyl phloretate and vanillic acid, were identified in the extracts, with methyl phloretate being more effective in inhibiting cress and timothy seedlings growth compared to vanillic acid. These findings suggest the involvement of methyl phloretate and vanillic acid in the phytotoxicity of G. xanthochymus extracts.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Dino Grgic, Elisabeth Varga, Barbara Novak, Anneliese Mueller, Doris Marko
Summary: This review summarizes the metabolization of isoflavones in animals and their distribution in tissues, as well as the effects of isoflavones on livestock species. It also discusses the occurrence of isoflavones in feed materials and their co-occurrence with zearalenone.
Article
Food Science & Technology
Arthur Zastepa, Todd R. Miller, L. Cynthia Watson, Hedy Kling, Susan B. Watson
Summary: The study documents the formation of annual DCLs in two meso-oligotrophic embayments in Lake Huron, Canada, dominated by the potentially toxic cyanobacteria Planktothrix cf. isothrix. The contribution of P. cf. isothrix to total biomass increases as thermal stratification progresses. The presence of microbial activity and allelopathy, particularly related to potentially toxigenic species, plays a key role in supporting DCLs in the studied embayments.
Review
Pharmacology & Pharmacy
Qinfang Zheng, Ye Wang, Shuihan Zhang
Summary: This work reviews the progress in the phytochemical and biological investigations of bioactive components from Lobelia species, highlighting the shift in research focus towards novel chemical classes and molecular mechanisms of these components.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Celeste de Jesus Pereira Franco, Oberdan Oliveira Ferreira, Jorddy Neves Cruz, Everton Luiz Pompeu Varela, Angelo Antonio Barbosa de Moraes, Lidiane Diniz do Nascimento, Marcia Moraes Cascaes, Antonio Pedro da Silva Souza Filho, Rafael Rodrigues Lima, Sandro Percario, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade
Summary: This study analyzed the chemical composition of Calycolpus goetheanus specimens' essential oils and evaluated their phytotoxic and antioxidant activities, as well as the interaction mode with a molecular binding protein through molecular docking.
Review
Microbiology
Sushma Mishra, Priyanka, Shilpi Sharma
Summary: Endophytes have a specific association with host plants and can influence plant responses and produce bioactive compounds with potential applications.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Meiby Fernandez-Rojas, Lyanne Rodriguez, Andres Trostchansky, Eduardo Fuentes
Summary: Cardiovascular diseases are the leading cause of death worldwide. Platelet hyperactivation can lead to thrombus formation and blood vessel obstruction, while a diet rich in bioactive compounds can help prevent cardiovascular diseases. This review collects the latest research on the cardioprotective and antiplatelet activities of different compounds extracted from natural products.
Article
Food Science & Technology
Xiumei Han, Leonid Akhov, Paula Ashe, Courteney Lewis, Leah Deibert, L. Irina Zaharia, Lily Forseille, Daoquan Xiang, Raju Datla, Matthew Nosworthy, Carol Henry, Jitao Zou, Bianyun Yu, Nii Patterson
Summary: In this study, an improved method for simultaneous analysis of multiple phytoestrogens among 100 pea accessions was developed. The variability of isoflavones and other bioactive compounds in pea seeds was profiled, providing an immense resource for research, breeding, and selection of genotypes for various applications.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Chemistry, Medicinal
Antia G. Pereira, Paz Otero, Javier Echave, Anxo Carreira-Casais, Franklin Chamorro, Nicolas Collazo, Amira Jaboui, Catarina Lourenco-Lopes, Jesus Simal-Gandara, Miguel A. Prieto
Summary: Xanthophylls in algae are a type of carotenoids with anti-tumor and anti-inflammatory activities, protecting other molecules from oxidative stress through their antioxidant properties. Different algae species contain varying amounts of xanthophylls, primarily extracted from brown seaweeds, microalgae, and other algae species.
Review
Nutrition & Dietetics
Nasreddine El Omari, Saad Bakrim, Mohamed Bakha, Jose M. Lorenzo, Maksim Rebezov, Mohammad Ali Shariati, Sara Aboulaghras, Abdelaali Balahbib, Mars Khayrullin, Abdelhakim Bouyahya
Summary: Cancer is a complex disease with genetic and epigenetic disturbances playing major roles in tumor formation. Research is currently focused on the involvement of epigenetic disturbances in cancer, as well as the effects of drugs on different epigenetic pathways.
Review
Biochemistry & Molecular Biology
Priscila Schilrreff, Ulrike Alexiev
Summary: This review discusses the crucial role of chronic inflammation in chronic wounds and its close association with immune regulation. The dysregulation of the immune system leads to persistent inflammation and impaired wound healing, resulting in chronic skin wounds. Furthermore, it explores the potential of natural bioactive compounds in wound treatment, particularly focusing on compounds with antioxidant, anti-inflammatory, and antibacterial activities, as well as recent advancements in wound treatments utilizing nanotechnology or new biomaterial platforms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Mariana Novo Belchor, Caroline Ramos da Cruz Costa, Airam Roggero, Laila L. F. Moraes, Ricardo Samelo, Isabelly Annunciato, Marcos Antonio de Oliveira, Sergio F. Sousa, Marcos Hikari Toyama
Summary: In this study, in silico tools were used to evaluate the potential of quercetin methylated derivatives in inhibiting snake venom toxins and phospholipase A2. The results showed that certain residues, including Leu2, Phe5, Tyr28, glycine in the calcium-binding loop, His48, and Asp49, were the main targets for inhibition. These findings are important for further research on the anti-inflammatory effects of quercetin derivatives.
Review
Biochemistry & Molecular Biology
Rodion Khotimchenko, Igor Bryukhovetskiy, Maksim Khotimchenko, Yuri Khotimchenko
Summary: The study reviews the outcomes of screening studies of natural compounds with high anti-glioma activity, emphasizing the potential for greater diversity of marine compounds and likelihood of finding effective molecules. It covers the main problems of glioma chemotherapy and provides information on at least 15 classes of organic compounds with their chemical formulas and pharmacokinetic profiles. The taxonomic diversity of marine species containing bioactives with antiglioma activity is analyzed, noting cytotoxicity indicators and comparing them to similar indicators of antitumor agents for clinical use.
Article
Environmental Sciences
Jane S. Wu, Frederik Clauson-Kaas, Dan Nybro Lindqvist, Lars Holm Rasmussen, Bjarne W. Strobel, Hans Christian Bruun Hansen
Summary: The degradation of PTA in groundwater is influenced by pH and temperature, with PTA persisting for months under slightly acidic to neutral pH conditions. The existing laboratory-based model for PTA hydrolysis is generally accurate for groundwater, but further validation is needed at extremes of pH. Formation of other products besides PTB was observed under slightly acidic conditions, indicating complexities in the degradation process.
ENVIRONMENTAL SCIENCES EUROPE
(2021)
Article
Chemistry, Multidisciplinary
Jannis Grafmueller, Alexandra Boehm, Yiling Zhuang, Stephanie Spahr, Pascale Mueller, Thomas N. Otto, Thomas D. Bucheli, Jens Leifeld, Robin Giger, Michael Tobler, Hans-Peter Schmidt, Nicolaus Dahmen, Nikolas Hagemann
Summary: The addition of wood ash as an additive in biochar production can increase biochar yield and improve the recycling of ash-derived nutrients. Experimental pyrolysis showed that the increase in yield is linearly correlated with ash concentration up to a certain point, and higher concentrations do not significantly increase yield. Ash addition has no effect on the content of polycyclic aromatic hydrocarbons in biochar, but increases the content of polychlorinated organic pollutants. Furthermore, ash addition increases the electron exchange capacity of biochar but decreases the micropore specific surface area and thermal stability.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Engineering, Environmental
Gabriel Sigmund, Hans Peter H. Arp, Benedikt M. Aumeier, Thomas D. Bucheli, Benny Chefetz, Wei Chen, Steven T. J. Droge, Satoshi Endo, Beate I. Escher, Sarah E. Hale, Thilo Hofmann, Joseph Pignatello, Thorsten Reemtsma, Torsten C. Schmidt, Carina D. Schonsee, Martin Scheringer
Summary: Permanently charged and ionizable organic compounds (IOC) are a diverse group of contaminants. Existing models for neutral compounds are inadequate for describing the sorption and mobility of IOC. Better models and monitoring data are needed to assess the mobility of IOC and guide further research.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Correction
Engineering, Environmental
Gabriel Sigmund, Hans Peter H. Arp, Benedikt M. Aumeier, Thomas D. Bucheli, Benny Chefetz, Wei Chen, Steven T. J. Droge, Satoshi Endo, Beate I. Escher, Sarah E. Hale, Thilo Hofmann, Joseph Pignatello, Thorsten Reemtsma, Torsten C. Schmidt, Carina D. Schonsee, Martin Scheringer
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Jawameer R. Hama, Daniel Bernardo Garcia Jorgensen, Efstathios Diamantopoulos, Thomas D. Bucheli, Hans Chr Bruun Hansen, Bjarne W. Strobel
Summary: This study investigated the presence of alkaloids in lupin plants, soil, and water in cultivated areas. The findings suggest that alkaloids are transported preferentially through macropores and contribute to surface water contamination.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Isabel Hilber, Franziska Blum, Thomas D. Bucheli, Hans-Peter Schmidt
Summary: Pyrogenic carbonaceous materials (PCM) are widely used in consumer products, containing polycyclic aromatic hydrocarbons (PAHs) that need to be monitored and regulated. Current legal methods for quantifying PAHs in such products may not be suitable, leading to potential safety risks and compliance issues.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Environmental
Judith Riedo, Chantal Herzog, Samiran Banerjee, Kathrin Fenner, Florian Walder, Marcel G. A. Van der Heijden, Thomas D. Bucheli
Summary: Pesticides are widely present in soils, even in untreated areas like grasslands. It takes up to 20 years for organic fields to reach pesticide levels as low as those of grassland sites. Different pesticide composition patterns in grassland sites and organically managed fields help differentiate between long-term persistence of residues and diffuse contamination processes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Agronomy
Laerke Daverkosen, Alena Holzknecht, Jurgen K. Friedel, Thomas Keller, Bjarne W. Strobel, Annelie Wendeberg, Sabine Jordan
Summary: This study aims to investigate the impact of regenerative management practices on soil health indicators in Gotland, Sweden. The results show that the application of organic matter has a positive effect on soil indicators, while reduced tillage and increased share of perennials have a positive impact on vegetation density and root abundance. Additionally, cluster analysis reveals significant differences in soil indicators among different management types.
JOURNAL OF PLANT NUTRITION AND SOIL SCIENCE
(2022)
Article
Soil Science
Florian Walder, Marc W. Schmid, Judith Riedo, Alain Y. Valzano-Held, Samiran Banerjee, Lucie Buchi, Thomas D. Bucheli, Marcel G. A. van Der Heijden
Summary: Pesticide residues have long-lasting effects on the soil microbiome. Environmental factors are the main drivers of the soil microbiome, but pesticide residues are strongly associated with soil microbiome traits. Pesticide residues are positively correlated with the relative abundance of certain bacterial and fungal taxa, while negatively correlated with other bacterial taxa and the abundance of the nifH gene.
SOIL BIOLOGY & BIOCHEMISTRY
(2022)
Article
Engineering, Environmental
Xiaomeng Liang, Jan H. Christensen, Thomas D. Bucheli, Nikoline Juul Nielsen
Summary: A new method called source-supported suspect screening (4S) was used to discover plant toxins in different environments, investigate their occurrences, identify their sources, and understand their leaching mechanisms. This method was demonstrated in a five-month crop field experiment with Lupinus angustifolius L. (L. angustifolius).
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Andrea Rosch, Felix E. E. Wettstein, Daniel Wachter, Vanessa Reininger, Reto G. G. Meuli, Thomas D. D. Bucheli
Summary: A multi-residue trace analytical method is proposed for accurately quantifying 146 pesticides in agricultural soils with varying properties. The method employs an optimized quick, easy, cheap, effective, rugged, and safe (QuEChERS) approach for extraction and liquid chromatography coupled to tandem mass spectrometry for analysis. The method is validated using both aged soil with target pesticides and field soils with native pesticide residues, and it shows high sensitivity, precision, and accuracy. The method has been applied to Swiss agricultural soils, revealing the presence of 77 different pesticides, and is now used for routine soil monitoring as part of the Swiss Action Plan.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Judith Riedo, Daniel Wachter, Andreas Gubler, Felix E. Wettstein, Reto G. Meuli, Thomas D. Bucheli
Summary: The application of synthetic pesticides in agricultural fields results in the formation of residues in soils. Long-term soil monitoring programs are necessary to understand the fate of pesticide residues and provide complementary retrospective exposure assessment. The study found that pesticide residues could be detected in soils even years or decades after their last application, highlighting the importance of comprehensive long-term recording and monitoring.
ENVIRONMENTAL POLLUTION
(2023)
Article
Soil Science
Walter W. Wenzel, Frederik Nygaard Philipsen, Lauren Herold, Alya Kingsland-Mengi, Monika Laux, Alireza Golestanifard, Bjarne W. Strobel, Olivier Duboc
Summary: Hedgerows can act as a relevant carbon sink for climate change mitigation in agricultural landscapes. Our study in Eastern Austria investigated carbon sequestration in hedgerow soils after 1-70 years of planting. We found that total SOC stocks increased significantly beneath hedgerows, with carbon sequestration mainly occurring in the topsoil layer and declining with hedgerow age in both soil layers.
Article
Engineering, Environmental
Xiaomeng Liang, Jan H. Christensen, Thomas D. Bucheli, Nikoline Juul Nielsen
Summary: Through sample collection and analysis of terrestrial and aquatic environments, it was found that 72 phytotoxins were identified, with 10 confirmed to originate from L. angustifolius. Among them, 26 were consistently detected in soil, drainage water, and surface water. Soil served as an intermediary for phytotoxin leaching from L. angustifolius to drainage water, and the occurrence in the aquatic environment depended on soil and water physico-chemical properties.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)