期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 393, 期 1, 页码 31-35出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-008-2367-3
关键词
Mass spectrometry imaging; Lipids; Cluster ion source; TOF-SIMS
资金
- European Union [LSHG-CT-2005-518194]
This brief article provides an overview of the current state of the art in biological imaging mass spectrometry using cluster time-of-flight secondary ion mass spectrometry (TOF-SIMS). Recent and spectacular improvements in terms of sensitivity of TOF-SIMS imaging methods have allowed many biological applications to recently be successfully tested, such as mapping of lipid disorders in human muscles of a patient suffering from dystrophy, localization of surfactins after the swarming of bacteria on a surface, or lipid mapping over whole-body animal sections.
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