期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 393, 期 4, 页码 1209-1216出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-008-2399-8
关键词
Lab-on-a-chip; Microfluidics; Optical waveguides; Capillary electrophoresis; Laser-induced fluorescence
资金
- European Commission [IST-2005-034562]
We use direct femtosecond laser writing to integrate optical waveguides into a commercial fused silica capillary electrophoresis chip. High-quality waveguides crossing the microfluidic channels are fabricated and used to optically address, with high spatial selectivity, their content. Fluorescence from the optically excited volume is efficiently collected at a 90 angle by a high numerical aperture fiber, resulting in a highly compact and portable device. To test the platform we performed electrophoresis and detection of a 23-mer oligonucleotide plug. Our approach is quite powerful because it allows the integration of photonic functionalities, by simple post-processing, into commercial LOCs fabricated with standard techniques.
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