Article
Chemistry, Multidisciplinary
Han Wang, Xueqi Wang, Jing Cheng
Summary: In this study, a VB12 bionic enzyme-assisted ion-selective amperometric biosensor based on a 3D porous conductive matrix (PCM) was proposed for rapid and accurate monitoring of nitrite in complex biofluids. The biosensor exhibited high sensitivity, a wide linear range, low limit of detection, and excellent stability and repeatability. The results obtained from salivary nitrite detection matched well with those from a commercial nitrite analyzer.
Article
Biochemical Research Methods
Ye Chen, Bin Li, Peng Lyu, Hang Fai Kwok, Lilin Ge, Qinan Wu
Summary: Phenylboronic acid-functionalized nanometer-sized CaCO3 particles (PBA-CaCO3) were designed and utilized for detecting CEA glycoprotein through a boronate ester bond with a portable Ca2+ ion-selective electrode (Ca-ISE). The synthesized PBA-CaCO3 exhibited good conjugation properties for CEA glycoprotein, enabling sensitive detection of CEA at concentrations as low as 7.3 pg mL(-1) under optimal conditions. Additionally, the Ca-ISE-based aptasensing system can be easily extended to detect other disease-related glycoproteins by controlling the corresponding aptamer.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Warangkana Lohcharoenkal, Zareen Abbas, Yon Rojanasakul
Summary: Cytokines are small proteins secreted by immune and non-immune cells in response to external stimuli, with applications in early disease diagnosis and therapeutic response assessment. Various methods are available for cytokine detection, but using wearable biosensors for multiplexed or continuous measurements is highly desirable.
Article
Chemistry, Analytical
Xiao-Yan Yang, Yi-Yan Bai, Yue-Yue Huangfu, Wen-Jing Guo, Yan-Ju Yang, Dai-Wen Pang, Zhi-Ling Zhang
Summary: An ultrasensitive electrochemiluminescence biosensor based on a closed bipolar electrode was proposed for the detection of alkaline phosphatase. The sensitivity of the system was greatly enhanced by utilizing enzyme catalysis for signal amplification and electrodeposition of Au nanoparticles on the cathode surface. This biosensor showed high sensitivity and specificity, with a detection limit as low as 3.7 aM, and successfully realized ALP detection in single cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Multidisciplinary
Nurlely, Musa Ahmad, Lee Yook Heng, Ling Ling Tan
Summary: A membrane-based potentiometric biosensor was developed for rapid and easy detection of formaldehyde, showing a broad linear range and high sensitivity. The sensor exhibited high stability in detecting formaldehyde and was able to avoid interference from potential interferants.
Review
Biotechnology & Applied Microbiology
Zi-Xu Liu, Si-Ling Huang, Jin Hou, Xue-Ping Guo, Feng-Shan Wang, Ju-Zheng Sheng
Summary: Valuable polysaccharides are typically produced through fermentation using wild-type or metabolically-engineered microbial strains, with high-throughput screening techniques being used to identify cells with high levels of polysaccharide synthesis. Strategies such as fluorescence labeling, fluorescence quenching, and biosensors are effective for cell sorting in industrial strains and pathway optimization for polysaccharide synthesis. Additionally, high-throughput screening using individual whole cells is critical in the discovery and evolution of enzymes involved in polysaccharide biosynthesis, with these enzymes and their mutants being valuable catalysts for saccharide synthesis.
MICROBIAL CELL FACTORIES
(2021)
Article
Materials Science, Multidisciplinary
Antonio Ruiz-Gonzalez, Kwang Leong Choy
Summary: A novel approach integrating PVC-functionalised silica nanoparticles in a plasticized PVC film for ion sensors has been developed, resulting in highly specific and mechanically robust systems for the detection of K+ in solution. The system shows exceptional hardness and low signal drift, demonstrating potential applications in healthcare for disease diagnosis and monitoring.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Multidisciplinary
Lanfang Wang, Ruifang Ding, Yanqing Hao, Yujia Li, Wenjiao Liu, Wenbo Lu, Xiaohong Xu
Summary: A novel light-driven non-enzymatic glucose sensor based on AuNi nanodendrites has been successfully developed. The nanodendritic structure provides a large surface area and excellent electron transfer for glucose oxidation. Under visible light illumination, this hierarchical hybrid structure exhibits remarkable photoelectrocatalytic activity.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Electrochemistry
Omer Isildak, Ilyas Yildiz
Summary: A new all-solid-state PVC membrane nitrate electrode was developed and used for potentiometric analysis of nitrate ions. The electrode utilized silver (I) bisdiethyldithiocarbamate ((C2H5)2NCS2)2Ag+) (Ag(dtc)2) compound as the electroactive positive charged carrier (ionophore) in a plasticized PVC membrane structure. The nitrate-ISE exhibited linear potentiometric behavior in the concentration range of nitrate ions with a detection limit of 6.71 x 10-6 mol L-1. It was successfully applied for the determination of nitrate ions in different water samples and fruit juices, although its pH working range is limited to 4 - 9.
ELECTROCHIMICA ACTA
(2023)
Review
Oncology
Rachel M. Morris, Toni O. Mortimer, Kim L. O'Neill
Summary: Cytokines play a crucial role in cancer development, influencing immune function, inflammation, and tumor cell survival. They also have a significant impact on the molecular biology and microbiology of the tumor microenvironment. Therefore, cytokines have become attractive targets for cancer treatment.
Article
Polymer Science
Bongjin Jeong, Jin Seong Oh, Do Yeob Kim, Dong Gyu Kim, Young Il Kim, Jungseok Heo, Hyung-Kun Lee
Summary: Phosphorus is an important nutrient in aquatic habitats, but it can also inhibit growth in aquatic ecosystems and contribute to environmental issues. Rapid phosphorus detection is of growing interest for water resource management and protection. A new ionophore based on a biomimetic nicotinamide functional group, combined with a silicone rubber ion-selective electrode membrane, showed efficient and selective detection of phosphate ions.
Article
Chemistry, Analytical
Miao Liu, Mingxuan Jia, Yifeng E, Donghui Li
Summary: A novel potential sensor based on electrochemical co-reduction of graphene oxide was developed for detecting sarafloxacin hydrochloride by potential response value. The improved electrode showed wider linear range, lower limit of detection, and shorter equilibration time, while exhibiting good performance in the detection of actual samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Niu Feng, Shu Wang, Luyu Wei, Qinyu Wang, Xinrui Cheng, Peng Lu, Xuewen Peng, Xufeng Wang, Chen Zhan, Yiming Dong, Yiping Chen
Summary: In this study, a sensing method called SMART was developed for rapid, sensitive, and multiplex profiling of foodborne pathogens using artificial intelligence transcoding. The method utilizes programmable polystyrene microspheres to encode different pathogens and generate visible signals under conventional microscopy. A customized artificial intelligence-computer vision was trained to decode the microspheres' intrinsic properties and reveal the numbers and types of pathogens. The assay enables the rapid and simultaneous detection of multiple bacteria without DNA amplification, and shows strong consistency with standard microbiologic and genotypic methods. Phage-guided targeting is adopted to discriminate between live and dead bacteria.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yueyuan Zhuang, Han Dong, Tianqing Liu, Yongmei Zhao, Yan Xu, Xiaojuan Zhao, Dan Sun
Summary: A biosensing strategy based on target-induced SERS hot spot formation has been developed for highly sensitive and selective detection of intracellular caspase-3 level. The strategy utilizes gold nanoparticles modified with probe molecules and peptide chains, and achieves high sensitivity detection of caspase-3 through the formation of SERS hot spots.
Article
Chemistry, Analytical
Andrei E. Deller, Ana L. Soares, Jaqueline Volpe, Jean G. A. Ruthes, Denio E. P. Souto, Marcio Vidotti
Summary: In this study, a hybrid material composed of polypyrrole nanotubes and gold nanoparticles was synthesized and used as an electroactive layer for protein attachment in the construction of a high-performance biosensor. The biosensor showed sensitivity and capability in detecting different biological substances, with a wide linear range of detection.
Article
Chemistry, Analytical
Elsayed M. Zahran, Elisabeth M. Fatila, Chun-Hsing Chen, Amar H. Flood, Leonidas G. Bachas
ANALYTICAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Catherine J. Munro, Elise C. Bell, Mary O. Olagunju, Joshua L. Cohn, Elsayed M. Zahran, Leonidas G. Bachas, Marc R. Knecht
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2019)
Article
Environmental Sciences
Jeramy L. R. Baum, Umer Bakali, Chitvan Killawala, Katerina M. Santiago, Emre Dikici, Erin N. Kobetz, Natasha Schaefer Solle, Sapna Deo, Leonidas Bachas, Sylvia Daunert
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Chemistry, Analytical
Elnaz Zeynaloo, Elsayed M. Zahran, Elisabeth M. Fatila, Amar H. Flood, Leonidas G. Bachas
Summary: The study utilized a clamshell-shaped ionophore (ClS) composed of two preorganized cyanostar (CNstar) macrocycles for anion complexation via CH-hydrogen bonding. The optimized electrode displayed an anti-Hofmeister selectivity pattern towards iodide with a nanomolar detection limit. This selectivity could be altered by using an ionophore where the two CNstar macrocycles are linked together with a flexible 12-carbon chain to control the molecularity of the binding event.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Ahmed E. ElMetwally, Mostafa S. Sayed, Elnaz Zeynaloo, Elsayed M. Zahran, Jae-Jin Shim, Marc R. Knecht, Leonidas G. Bachas
Summary: A hierarchical coreshell structure of nanostructured ACOF-1@BiOBr was prepared and its performance in the degradation of organic contaminants under light irradiation was demonstrated. The enhanced photocatalytic activity of the ACOF-1@BiOBr system can be attributed to the synergy between ACOF-1 and BiOBr, which form a Type-II heterostructure that reduces the recombination rate of photogenerated charge carriers. The ACOF-1@BiOBr system also exhibited enhanced generation of superoxide radicals.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Mary O. Olagunju, Elsayed M. Zahran, Elnaz Zeynaloo, Dharmendra Shukla, Joshua L. Cohn, Bapurao Surnar, Shanta Dhar, Leonidas G. Bachas, Marc R. Knecht
Summary: The study presents a direct route for the production of SrTiO3/BiOBr/Pd heterojunction using a low temperature, sustainable method, resulting in a highly integrated composite material. The enhanced reactivity of the materials under visible light, attributed to significant integration between materials facilitating electron transfer, demonstrates potential for sustainable environmental remediation. This research provides key insights for developing new materials with optimized visible-light-driven photocatalytic reactivity.
Article
Chemistry, Multidisciplinary
Edward B. Miller, Elsayed M. Zahran, Marc R. Knecht, Leonidas G. Bachas
Summary: In this study, a nanocomposite catalyst consisting of a m-BiVO4/BiOBr heterojunction surface-decorated with Pd nanoparticles was used for the photocatalytic reductive debromination of PBDEs using visible light. The catalyst showed rapid and complete debromination of BDE-47 with a high reaction rate constant. These findings provide new insights into the degradation of common organic pollutants via sustainable methods.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Nanoscience & Nanotechnology
Ahmed E. ElMetwally, Farnoosh Goodarzi, Katlyn K. Meier, Elsayed M. Zahran, Sundeep Rayat, Soren Kegnaes, Marc R. Knecht, Leonidas G. Bachas
Summary: In this study, a multistage templating approach was used to prepare Cu2S@Bi2S3 double-shelled cages, which exhibited efficient degradation of atrazine in the dark. The synergy between Cu2S and Bi2S3 in activating peroxymonosulfate (PMS) led to enhanced catalytic performance by promoting radical generation. Mechanistic studies revealed hydroxyl radicals and singlet oxygen as the dominant species generated during atrazine degradation.
ACS APPLIED NANO MATERIALS
(2021)
Article
Biophysics
Elnaz Zeynaloo, Elsayed M. Zahran, Yu-Ping Yang, Emre Dikici, Trajen Head, Leonidas G. Bachas, Sylvia Daunert
Summary: This study introduces a new method of using unnatural amino acids as protein labels, which not only changes the local microenvironment but also has minimal impact on the overall structure. By incorporating L-DOPA into the protein, it can be used as an electrochemical label for highly selective and sensitive detection of glucose.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Ahmed E. ElMetwally, Mostafa S. Sayed, Yiqun Zhou, Justin B. Domena, Jae-Jin Shim, Roger M. Leblanc, Marc R. Knecht, Leonidas G. Bachas
Summary: In this study, Pd nanoparticles were deposited over thermally exfoliated gC(3)N(4) to enhance the production of singlet oxygen and promote the synthesis of DFF. The results showed a direct proportionality between Pd content and DFF production, with a decline observed beyond a certain threshold. Trapping experiments and EPR analysis indicated that singlet oxygen is the key species responsible for the selective oxidation of HMF to DFF.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Physical
Edward B. Miller, Marc R. Knecht, Leonidas G. Bachas
Summary: This study presents a sustainable method for olefin hydrogenation and semihydrogenation of alkynes using a solar energy-driven photocatalyst. The catalyst efficiently hydrogenates both terminal and internal double bonds, prioritizing alkynes over alkenes. This system serves as a platform for transitioning critical catalytic processes towards sustainability.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Ahmed E. ElMetwally, Mostafa Saad Sayed, Jae-Jin Shim, Marc R. Knecht, Leonidas G. Bachas
Summary: In this study, plasmonic Au nanoparticles were used to enhance the photocatalytic activity of BiVO4/BiOBr nanosheets through surface plasmonic resonance. The highest conversion of benzyl alcohol (100%) and the maximum yield of benzaldehyde (99%) were achieved using BiVO4/BiOBr/Au 3% after 4 hours of irradiation. Singlet oxygen was identified as the dominant species responsible for the photocatalytic oxidation of benzyl alcohol to benzaldehyde. The proposed mechanism involved the excitation of electrons in BiVO4/BiOBr/Au to singlet states, which eventually produced triplet excitons and reacted with dissolved O2 to generate singlet oxygen. The thermodynamic analysis indicated that the reaction was favorable.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Ahmed E. ElMetwally, Elnaz Zeynaloo, Dharmendra Shukla, Bapurao Surnar, Shanta Dhar, Joshua L. Cohn, Marc R. Knecht, Leonidas G. Bachas
Summary: By loading azine-based COF spheres onto Cu2O cubes and decorating them with palladium nanoparticles, an efficient photocatalytic hybrid material was developed for the degradation of chlorinated biphenyls. The congener with a para chlorine atom was found to be more vulnerable to degradation due to increased conjugation between the phenyl rings induced by the electron-donating effect of the chlorine atom, leading to enhanced planarity and easier removal of the chlorine atom. The data also showed that nucleophilic substitution at the para position had the lowest Gibbs free energy, while substitution at the ortho position had the highest Gibbs free energy.
ACS APPLIED NANO MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Mary O. Olagunju, Elsayed M. Zahran, Jacqueline M. Reed, Elnaz Zeynaloo, Dharmendra Shukla, Joshua L. Cohn, Bapurao Surnar, Shanta Dhar, Leonidas G. Bachas, Marc R. Knecht
Summary: In this study, nanoscale BiVO4/BiOX/Pd materials were successfully synthesized using a single pot approach, and the effect of halide identity on photocatalytic properties was investigated. Results showed that BiOCl and BiOBr structures exhibited enhanced reactivity compared to BiOI, with potential environmental applications demonstrated in degradation experiments using natural water samples.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Analytical
Elsayed M. Zahran, Ki-Jung Paeng, Ibrahim H. A. Badr, David Hume, Bert C. Lynn, R. Daniel Johnson, Leonidas G. Bachas
