期刊
ANALYTICA CHIMICA ACTA
卷 808, 期 -, 页码 56-69出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2013.10.027
关键词
Polymeromics; Mass spectrometry; Polymer science; Polymer sequencing
资金
- Dutch Polymer Institute (DPI technology area HTE) [667]
- Thuringer Kultusministerium [B715-07011]
Mass spectrometry (MS) is the most versatile and comprehensive method in OMICS sciences (i.e. in proteomics, genomics, metabolomics and lipidomics). The applications of MS and tandem MS (MS/MS or MSn) provide sequence information of the full complement of biological samples in order to understand the importance of the sequences on their precise and specific functions. Nowadays, the control of polymer sequences and their accurate characterization is one of the significant challenges of current polymer science. Therefore, a similar approach can be very beneficial for characterizing and understanding the complex structures of synthetic macromolecules. MS-based strategies allow a relatively precise examination of polymeric structures (e. g. their molar mass distributions, monomer units, side chain substituents, end-group functionalities, and copolymer compositions). Moreover, tandem MS offer accurate structural information from intricate macromolecular structures; however, it produces vast amount of data to interpret. In OMICS sciences, the software application to interpret the obtained data has developed satisfyingly (e. g. in proteomics), because it is not possible to handle the amount of data acquired via (tandem) MS studies on the biological samples manually. It can be expected that special software tools will improve the interpretation of (tandem) MS output from the investigations of synthetic polymers as well. Eventually, the MS/MS field will also open up for polymer scientists who are not MS-specialists. In this review, we dissect the overall framework of the MS and MS/MS analysis of synthetic polymers into its key components. We discuss the fundamentals of polymer analyses as well as recent advances in the areas of tandem mass spectrometry, software developments, and the overall future perspectives on the way to polymer sequencing, one of the last Holy Grail in polymer science. (C) 2013 Elsevier B. V. All rights reserved.
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