Review
Chemistry, Analytical
Changdong Chen, Ming La, Xinyao Yi, Mengjie Huang, Ning Xia, Yanbiao Zhou
Summary: Electrochemical immunosensors with alkaline phosphatase (ALP) as the signal reporter have shown great potential in various fields. This work summarizes the achievements of these immunosensors, focusing on detection principles, signal amplification strategies, and challenges for improving the performance of ALP-based immunoassays.
Review
Biotechnology & Applied Microbiology
Yanna Shao, Huan Zhou, Qingping Wu, Yonghua Xiong, Juan Wang, Yu Ding
Summary: This study systematically discusses the importance of enzyme-based signal transduction patterns in immunoassay, as well as different strategies for enhancing the output signals of enzymes to significantly improve the sensitivity of enzyme-based immunosensors. The article categorizes these strategies into three categories and discusses the current focus and future direction of enzyme-based immunoassays.
BIOTECHNOLOGY ADVANCES
(2021)
Review
Chemistry, Analytical
JeeYoung Kim, Min Park
Summary: This paper reviews the recent progress in electrochemical immunosensors, focusing on the immobilization methods using antibodies for voltammetric, amperometric, impedimetric, and electrochemiluminescent immunosensors. The use of antibodies as molecular recognition molecules and the introduction of electrochemistry for quantitative signals are highlighted in the detection of biomarkers.
Review
Chemistry, Multidisciplinary
Chunyi Zhang, Ziyan Zhou, Shengnan Fu, Changyuan Yu, Muhammad Irfan, Xin Su
Summary: Aberrant glycoforms of glycoproteins, resulting from changes in their post-translational modification patterns, are often linked to the onset of various disorders. Early detection and identification of these glycoforms are crucial for timely diagnosis, prognosis, and drug treatment. This article addresses the gap in knowledge by providing a detailed discussion on the utilization of DNA nanoprobes for detecting and imaging glycoproteins, highlighting their potential as a powerful tool in this field.
Article
Biochemistry & Molecular Biology
Li Li, Zhengbo Chen
Summary: In this study, a high specificity, flexibility, and simplicity aptasensor strategy was designed using a triblock DNA probe. It was found that the polyA fragment could assemble on the gold electrode surface via polyA instead of traditional Au-S bonds, leading to improved hybridization stability. The electrochemical aptasensor showed good repeatability, stability, and specificity.
BIOELECTROCHEMISTRY
(2023)
Article
Chemistry, Analytical
Yihan Wang, Jinfeng Quan, Jialei Zhang, Kejing Huang, Xuemei Wang, Hui Jiang
Summary: This study reports a DNA walker driven by endonuclease Nt.BbvC I for highly sensitive detection of tumor cells. By modifying the electrode surface and using magnetic beads, an ultra-high sensitivity electrochemical cell analysis is achieved.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Xinyi Zhong, Yuan Deng, Qiling Yang, Sirui Yi, Haiyan Qiu, Lanlan Chen, Shanwen Hu
Summary: Based on the electrochemical activity characteristics of Escherichia coli, an enhanced electrochemiluminescence aptasensor was developed for accurate identification. The use of a double aptamer recognition system improved the accuracy of the identification process. The application of an electrode potential facilitated continuous electron transfer between the electrode and the microorganisms, resulting in an enhanced electroluminescence signal. This strategy demonstrates better sensitivity, accuracy, and stability, showing potential for E. coli analysis.
Review
Chemistry, Analytical
Andrea Gabriela Ochoa-Ruiz, Guillermo Parra, Diego Lopez-Espinoza, Pablo Astudillo, Dmitry Galyamin, Neus Sabate, Juan Pablo Esquivel, Alba Adriana Vallejo-Cardona
Summary: Electrochemical immunosensors combine molecular biology and electrochemistry. This review discusses the main components of electrochemical immunosensors and how they have been integrated into lab-on-a-chip and point-of-care devices using enzyme-linked immunosorbent assay (ELISA). It also explores the use of nanotechnology for lower detection limits and label-free devices. Finally, it explores new perspectives on integrating electrochemical immunosensors into novel paper microfluidic devices called E mu PADs.
Article
Biophysics
Ssu-Chia Chen, Kuan-Ting Chen, Amily Fang-Ju Jou
Summary: The novel dual-amplification-boosted electrochemical biosensor was developed for detecting pancreatic cancer-associated miR-196b, showing a detection limit of 0.26 pM and nice analytical reproducibility. The biosensor offers great promise as a complementary tool for real sample detection in the clinic.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Yao Shi, Jie Wu, Wenxin Wu, Nini Luo, Hao Huang, Yuhui Chen, Jun Sun, Qian Yu, Hang Ao, Qiqi Xu, Xiaotian Wu, Qianfeng Xia, Huangxian Ju
Summary: Electrocheluminescence analysis using coreaction accelerators has achieved breakthroughs in ultrasensitive biomarker detection. The proposed strategy utilizes AuNPs@MoSe2 heterostructure to enhance the ECL efficiency of the Ru(bpy)(2+)(3)/TPrA system. This coreaction accelerator successfully enhances ECL intensity by accelerating the generation of TPrA(circle+) radicals. The developed immunosensor based on this strategy demonstrates excellent selectivity, stability, and reproducibility, making it promising for clinical diagnosis.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Analytical
Mingdi Xu, Dianping Tang
Summary: DNA walkers, as dynamic nanomachines, move along multiple dimensional tracks powered by various driving forces, with characteristics of high efficiency, flexibility, and directionality, widely applied in biosensing, material assembly, and early cancer diagnosis. Furthermore, DNA walkers can be combined with different amplification approaches to enhance signal transduction and amplify biosensor sensing signals.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Multidisciplinary
Li-Dan Zhao, Xia Yang, Xia Zhong, Ying Zhuo
Summary: DNA walkers, composed of driving power, walking strands and tracks, are programmable molecular machines with diverse structures. They can generate and amplify signals under specific external stimuli, such as strand displacement strategies, enzymatic reactions, and environmental condition stimulus. DNA walker-based ECL biosensors combine ECL technology and bio-identification strategies to achieve ultrasensitive detection for diverse targets through multiple identification and recycling methods.
Article
Chemistry, Multidisciplinary
Xingcheng Zhou, Daena A. Schuh, Lauren M. Castle, Ariel L. Furst
Summary: In the field of infectious disease diagnostics, access to healthcare resources is unequal. Point-of-care (POC) diagnostics, especially those that can be used in non-laboratory settings, are appealing for disease control in resource-limited environments. To improve the sensitivity and specificity, signal amplification strategies have been developed for electrochemical biosensors. This perspective reviews recent advances in signal amplification strategies, specifically for biosensors that detect nucleic acids and pathogenic microbes. These strategies are classified into target-based amplification and signal-based amplification. The authors also emphasize the importance of designing signal amplification strategies that are tailored to the application location and disease target, and that take into account the resources required for production and operation of the sensor, particularly when the sensor is intended for use in low-resource settings. It is anticipated that incorporating signal-based amplification strategies will expand the usage of electrochemical POC devices for diagnosing infectious diseases in various settings.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Jianhao Hu, Zhipeng Shen, Lei Tan, Jun Yuan, Ning Gan
Summary: In this study, a double stirring bars-based signal amplification strategy was demonstrated for simultaneous electrochemical detection of Vibrio parahaemolyticus and Salmonella typhimurium, achieving high sensitivity and cost savings through in-situ amplification and electrochemical detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yina Sun, Chuan Huang, Xiujin Sun, Qian Wang, Peini Zhao, Shenguang Ge, Jinghua Yu
Summary: By utilizing MoS2-GQDs nanocomposite and enzyme-assisted DNA signal amplification, a novel on-off switch ECL biosensor was developed for sensitive detection of specific DNA sequences. The biosensor showed a good linear relationship in the range from 1 nM to 100 aM with a detection limit of 25.1 aM, providing a powerful strategy for biomedical research and clinical analysis.
Review
Chemistry, Multidisciplinary
Si-Xuan Guo, Cameron L. Bentley, Minkyung Kang, Alan M. Bond, Patrick R. Unwin, Jie Zhang
Summary: This article introduces two advanced spatiotemporal voltammetric techniques for electrocatalytic studies, which provide important insights into the electrochemical reduction of CO2. Fourier transformed large-amplitude alternating current voltammetry allows the resolution of rapid electron-transfer processes, while scanning electrochemical cell microscopy provides high-resolution activity maps and potentiodynamic movies of catalyst surfaces.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Laura Garcia-Quintana, Nagore Ortiz-Vitoriano, Haijin Zhu, Gene M. Nolis, Javier Herrero-Martin, Maria Echeverria, Juan Miguel Lopez del Amo, Maria Forsyth, Alan M. Bond, Patrick C. Howlett, Cristina Pozo-Gonzalo
Summary: A series of hybrid electrolytes composed of diglyme and ionic liquids have been investigated for Na-O-2 batteries. Different chemical compositions of the ILs affect the size, purity, and distribution of the discharge products. By controlling the physicochemical properties of the electrolyte and the speciation of Na+ and superoxide radical anion, the nucleation and growth phenomena, as well as electrolyte stability, can be optimized to improve battery performance.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Linbo Li, Jun Chen, Venkata Sai Sriram Mosali, Yan Liang, Alan M. Bond, Qinfen Gu, Jie Zhang
Summary: In this study, a novel hydrophobicity-graded hydrophobic GDL (HGGDL) was developed to control the hydrophobicity and gas transport over the GDL during electroreduction of CO2. The HGGDL, achieved by coating PTFE binders and sintering PTFE macroporous layer on a hydrophilic GDL, showed superior performance compared to commercial GDLs, with a CO faradaic efficiency of over 83% after 103 hours of operation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Physical
Alan M. Bond, Jie Zhang, Luke Gundry, Gareth F. Kennedy
Summary: Voltammetry is a powerful tool for obtaining quantitative mechanistic information in important electron transfer processes. Machine learning methods have emerged as a powerful tool in voltammetry data analysis, offering opportunities for rapid identification of the best fitting mechanism through data comparison and automated methods.
CURRENT OPINION IN ELECTROCHEMISTRY
(2022)
Article
Chemistry, Applied
Dilini Bopitiya, Milton T. W. Hearn, Jie Zhang, Louise E. Bennett
Summary: This study reports the levels of H2O2 in commercially manufactured orange juice (OJ) products. It found that the concentrations of H2O2 were significantly higher in processed OJ compared to fresh OJ. The levels of H2O2 were uncorrelated with storage time post-manufacture, and increased after opening, followed by a significant decrease after 24 hours. Ascorbic acid, total reducible substances, and total sugar were positively correlated with H2O2 levels, whereas total protein, fiber, and unsaturated fats were negatively correlated.
Article
Chemistry, Applied
Dilini Bopitiya, Sixuan Guo, Milton T. W. Hearn, Jie Zhang, Louise E. Bennett
Summary: Recently, it has been discovered that autoxidation mediated by ascorbic acid (AA) and other ingredients in energy beverages can generate hydrogen peroxide (H2O2). In this study, cyclic voltammetry and the FOX assay were used to monitor the production and stability of H2O2 generated by AA and redox-active ingredients at short and long incubation times, respectively. The levels of H2O2 in energy drinks were found to be stable or increased upon vessel opening. A predictive model showed that H2O2 peaked after 1 day and declined over time. This research highlights the importance of monitoring H2O2 levels and modifying formulations to avoid AA autoxidation in beverages.
Article
Chemistry, Multidisciplinary
Peng Zhou, Si-Xuan Guo, Linbo Li, Tadaharu Ueda, Yoshinori Nishiwaki, Liang Huang, Zehui Zhang, Jie Zhang
Summary: In this study, highly efficient carbon supported Ni-MoO2 heterostructured catalysts were reported for the electrochemical hydrogenation (ECH) of phenol in 0.10 M aqueous sulfuric acid (pH 0.7) at 60 degrees C. Catalysts with high and low densities of oxygen vacancy (O-v) sites achieved the highest yields of cyclohexanol and cyclohexanone, 95% and 86%, respectively, with faradaic efficiencies of approximately 50%. The enhanced phenol adsorption strength attributed to the O-v density was found to be responsible for the superior catalytic efficiency. This work provides a promising avenue for the rational design of advanced electrocatalysts for the upgrading of phenolic compounds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Dilini Bopitiya, Milton T. W. Hearn, Jie Zhang, Louise E. Bennett
Summary: This study aimed to demonstrate the ultimate antioxidant effects of protein extract from mustard seed in suppressing hydrogen peroxide (H2O2). The results showed that the mustard seed protein isolate (MPI) could completely suppress the production of H2O2 in orange juice, with slightly higher antioxidant efficacy than the reference protein thaumatin. The thiol-rich amino acid-containing proteins and other antioxidants in MPI were highly effective in inhibiting the autoxidation-mediated production of H2O2 in orange juice and could be useful for other manufactured beverages.
Article
Chemistry, Physical
Anbrah E. Alzubidi, Alan M. Bond, Lisandra L. Martin
Summary: Published data suggests that sparingly soluble metal complexes of TCNQF1-n, where n=0, 1, 2, 4, can act as heterogeneous catalysts for the slow [Fe(CN)6]3- =4- -S2O2-3/S4O2-6 reaction in water. However, this study shows that the coordination polymer CuTCNQF4 can participate as a homogeneous catalyst through a small concentration of dissolved TCNQF1-4. UV-visible spectrophotometry was used to study the catalysis of the redox reaction in the presence of various catalysts. The findings suggest the need to reevaluate the mechanism of catalysis by TCNQF4 based solids.
Review
Chemistry, Multidisciplinary
Peng Zhou, Jie Zhang
Summary: Replacing conventional fossil resources with renewable raw materials is crucial for achieving carbon neutrality and alleviating the energy crisis. Biomass, due to its natural abundance and ability to fix CO2, is considered a promising candidate for this purpose. Electrochemical conversion of biomass offers advantages such as operating at ambient conditions, scalability, and green generation of equivalents. This review discusses recent progress in electrochemical transformation of biomass, including catalysts, strategies for enhancing efficiency, and mechanistic understanding.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Chemistry, Physical
Madhurima Barman, Venkata Sai Sriram Mosali, Alan M. Bond, Jie Zhang, A. Sarkar
Summary: This study investigates the effects of morphology, specific surface area, and relative content of Cu/Cu-oxide in CuO-derived Cu electrocatalysts on the current density and product formation during electrochemical carbon dioxide reduction reaction (eCO(2)RR). The results show that the Cu-content of the CuO-derived Cu electrocatalysts determines the type of products and their corresponding faradic efficiencies, with higher initial Cu-content resulting in higher faradic efficiencies at lower negative potentials. Furthermore, it is found that high Cu-content, regardless of morphology, is particularly important for the formation of methane and formate. Therefore, this study reveals the relative roles of specific surface area and Cu/CuO-content of CuO-derived Cu electrocatalysts on the current densities, product formation, and associated faradic efficiencies in eCO(2)RR.
Article
Chemistry, Physical
Anbrah E. Alzubidi, Alan M. Bond, Lisandra L. Martin
Summary: Mechanistic variation in catalysis through substituent-based redox tuning is well established. Fluorination of TCNQ provides a significant variation in the redox potentials of the TCNQF(n)(0/1-) and TCNQF(n)(1/2-) processes. The catalysis of the ferrocyanide-thiosulfate redox reaction in aqueous solution occurs via different mechanisms depending on the presence of fluorinated or non-fluorinated catalysts. Thermodynamic data explain the observed differences in the catalytic mechanisms for the two systems. CuTCNQF(n) coordination polymers, previously considered as insoluble and heterogeneous catalysts, are shown to act as homogeneous catalysts in the ferricyanide-thiosulfate reaction.
Article
Biochemistry & Molecular Biology
Ruchika Ojha, Peter C. Junk, Alan M. Bond, Glen B. Deacon
Summary: Pt-IV coordination complexes were synthesized by oxidizing the antitumor agent [Pt-II(p-BrC6F4)NCH2CH2NEt2}Cl(py)]. Experimental data showed that excess H2O2 and elevated temperature favored the oxidation of the ligand, while a smaller amount of H2O2 at room temperature favored the oxidation of the metal, resulting in the formation of platinum(IV) complexes.
Article
Materials Science, Multidisciplinary
Thom R. Harris-Lee, Enrico Della Gaspera, Frank Marken, Jie Zhang, Cameron L. Bentley, Andrew L. Johnson
Summary: Aerosol-assisted chemical vapor deposition (AACVD) was used to fabricate highly nanostructured mixed anatase-rutile phase TiO2 using new and bespoke precursors. The precursor syntheses involved two steps and the suitability for AACVD was assessed using thermogravimetric analysis. The resulting TiO2 films showed exceptional OH- oxidation performance and promise for use in photoanodes for water splitting applications.
MATERIALS ADVANCES
(2023)
Review
Chemistry, Multidisciplinary
Venkata Sai Sriram Mosali, Alan M. Bond, Jie Zhang
Summary: Excessive reliance on fossil fuels has caused CO2 emissions, leading to environmental pollution and global warming. The electrochemical conversion of CO2 to valuable chemicals or fuels using alloy catalysts can mitigate this problem. Alloying copper with other metals can enhance the selectivity of copper catalysts, enabling the production of desired products.
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
