期刊
ANALYTICA CHIMICA ACTA
卷 635, 期 1, 页码 115-120出版社
ELSEVIER
DOI: 10.1016/j.aca.2009.01.019
关键词
Photoacoustic spectroscopy; Percutaneous penetration; Propolis ointment; Wound healing; Reepithelialisation
资金
- CNPq
- CAPES
- Fundacao Araucaria
The aim of this work is to investigate the dynamics of reepithelialisation and the penetration rate of a propolis ointment formulation during cutaneous wounds healing. The experiments were performed as a function of the treatment time in a well controlled group of rats. We observed that the propolis ointment influenced the healing process stimulating keratinocytes cell proliferation as compared to the control group. It was shown that the propagation of the bee propolis was dependent on the wound healing stages. In addition, the photoacoustic spectroscopy showed that the applied substances reached the deep wound region, highlighting once again the particular characteristic of this technique to evaluate the penetration rate of substances through the skin. (c) 2009 Elsevier B.V. All rights reserved.
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