Article
Chemistry, Analytical
Dexin Du, Jue Wang, Mingquan Guo, Jiangnan Shu, Wei Nie, Zhiping Bian, Di Yang, Hua Cui
Summary: Label-free electrochemiluminescence (ECL) immunoassays (lf-ECLIA) have become an attractive method for biomarker detection due to their simplicity, speed, and cost-effectiveness. This study investigated the interaction between biomarkers and analytical interfaces constructed using a nanoluminophore and antibody-functionalized gold nanoparticles. The results showed that positively charged biomarkers increased the ECL intensity, while negatively charged biomarkers decreased the ECL intensity. A charge-dependent lf-ECLIA method was established based on the ECL signal changes, which exhibited different responses to positively charged and negatively charged biomarkers.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Malik Saddam Khan, Hafsa Ameer, Yuwu Chi
Summary: A novel and simple label-free electrochemiluminescence immunosensor was proposed using Ce2Sn2O7 nanocubes as ECL emitters, which were functionalized with gold nanoparticles to enhance ECL emission. The immunosensor showed improved ECL performance for detecting CEA concentrations, with outstanding stability, reproducibility, and specificity, making it an innovative method for sensitive analysis of biomarkers in real samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Rocco Cancelliere, Alessio Di Tinno, Andrea Maria Di Lellis, Giorgio Contini, Laura Micheli, Emanuela Signori
Summary: This study presents two novel label-free voltammetric immunosensors for rapid and accurate detection of IL-6 in human serum. The immunosensors showed good analytical performances and outperformed a commercial ELISA kit in terms of sensitivity, reproducibility, and detection time. They were also successfully applied in blood samples, demonstrating good sensitivity and reproducibility.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Applied
Karutha Pandian Divya, Venkataraman Dharuman
Summary: A novel and rapid electrochemical immunosensing platform was developed for directly sensing antibody interactions with a virulence factor, utilizing various techniques to study molecular interactions and sensor performance.
Article
Materials Science, Ceramics
Yuanting Wu, Senmao Ren, Xiaojing Chang, Jingyue Hu, Xiaoying Wang
Summary: In this study, a multi-heterojunction inverse opal structure photocatalyst with a multi-level branched pore structure was prepared by the sol-gel method. The special three-dimensional dendritic porous structure solved the problem of poor pollutant solution penetration in traditional ordered inverse opal photocatalysts. The structure also led to nanocrystallization of TZS powders, promoting the formation of ZrTiO4 and optimizing the heterogeneous interface, resulting in improved redox ability. By adjusting the loading amount of TZS, the matching of heterojunction and inverse opal structure could be effectively controlled to enhance degradation efficiency. This study provides a new idea for effective collaboration between multi-heterogeneous interfaces and 3D branch fractal structures.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Jairo Pinto de Oliveira, Francisco Burgos-Florez, Isabella Sampaio, Pedro Villalba, Valtencir Zucolotto
Summary: In this study, a label-free impedimetric immunosensor was developed to detect OTA in coffee. The biosensor showed high selectivity and was not affected by matrix interference in coffee samples. It has the advantages of small sample volume, short analysis time, and potential miniaturization.
Article
Chemistry, Physical
Jie Yu, Angel Caravaca, Chantal Guillard, Philippe Vernoux, Liang Zhou, Lingzhi Wang, Juying Lei, Jinlong Zhang, Yongdi Liu
Summary: A highly efficient photocatalyst for degrading toluene has been developed, capable of converting 93% of toluene into non-toxic products. This enhanced performance is attributed to the inverse opal structure and the incorporation of carbon nitride quantum dots.
Article
Nanoscience & Nanotechnology
Mariana Bras, Julia Zanoni, Bruno P. Falcao, Joaquim P. Leitao, Florinda M. Costa, Teresa Monteiro, Sonia O. Pereira, Joana Rodrigues
Summary: Antibiotic pollution is a global concern, so it is important to develop cost-effective and reliable devices for detecting these contaminants. In this study, zinc oxide nanostructures were used as transducers in a fluorescent immunosensor to detect tetracycline. The nanostructures had a high surface area and could interact with antibodies and tetracycline molecules, providing a sensing mechanism. The sensor could quantitatively detect tetracycline in the range of 0.001 to 1 μg/L with a low limit of detection, indicating its advanced performance in this field.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Analytical
Zhenqiang Ning, Erli Yang, Yongjun Zheng, Mengyuan Chen, Guoqiu Wu, Yuanjian Zhang, Yanfei Shen
Summary: This study proposed a facile synthesis strategy to prepare a self-enhanced ECL emitter DEAMTES@RuSiO2, which exhibited improved ECL properties and film-forming ability critical for ECL biosensors. By combining catalytic hairpin assembly and signal amplification, a label-free ECL biosensor was constructed for highly sensitive detection of miRNA-21 with a detection limit of 8.19 fM, showing superior reliability in detecting miRNA-21 in human serum samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Baha Ondes, Sinem Evli, Murat Uygun, Deniz Aktas Uygun
Summary: A new label-free electrochemical immunosensor modified with boron nitride nanosheets was developed for early detection of CA125 in this study. The immunosensor showed good detection properties and stability, successfully detecting CA125 in artificial serum samples. The prepared immunosensor has potential for point-of-care diagnosis in real cases.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Multidisciplinary Sciences
S. Reza Mahmoodi, Pengfei Xie, Daniel P. Zachs, Erik J. Peterson, Rachel S. Graham, Claire R. W. Kaiser, Hubert H. Lim, Mark G. Allen, Mehdi Javanmard
Summary: A non-faradaic label-free cortisol sensing platform was developed using a nanowell array design, allowing for rapid and low volume sensing. The sensor, built on a glass substrate, showed a good response to cortisol concentrations and compared well with results from standard ELISA. Nanowell array sensors have potential to be a promising platform for point-of-care testing.
Article
Multidisciplinary Sciences
Jantima Upan, Napaporn Youngvises, Adisorn Tuantranont, Chanpen Karuwan, Philippe Banet, Pierre-Henri Aubert, Jaroon Jakmunee
Summary: A label-free electrochemical aptamer-based sensor was developed for AFP detection, utilizing a PtNPs/GO-COOH modified platform with an AFP aptamer as the recognition element. The sensor demonstrated good sensitivity, selectivity, and stability for sensitive detection of AFP in serum samples.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Anthony Maho, Michael Lobet, Nathan Daem, Pierre Piron, Gilles Spronck, Jerome Loicq, Rudi Cloots, Pierre Colson, Catherine Henrist, Jennifer Dewalque
Summary: Photonically structured TiO2 is used in perovskite solar cells to enhance light absorption and charge collection efficiency, with optimum light absorption shown with approximately 400nm diameter TiO2 hollow spheres filled with CH3NH3PbI3. Solar cells composed of approximately 220nm diameter large TiO2 pores filled with CH3NH3PbI3 achieve the highest conversion efficiency.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Chemistry, Analytical
Viviana Vasquez, Jahir Orozco
Summary: Cases of SARS-CoV-2 are still widespread due to the emergence of new variants worldwide. The severity and infectiousness of the virus are still not fully understood. Therefore, there is an urgent need for improved viral detection and diagnosis tools.
MICROCHEMICAL JOURNAL
(2023)
Article
Engineering, Environmental
Jing Zhang, Yipeng Qin, Oliver J. Pambos, Jingjing Zhang, Su Chen, Ziyi Yu, Chris Abell
Summary: The confinement-mediated self-assembly of colloidal crystals in dynamic borate ester-based networks was demonstrated to produce spherical opal composites using a microfluidic device. The resulting optical beads are flowable and injectable, facilitating injection molding of three-dimensional well-defined macroscopic opals. Furthermore, the opal composites formed in semi-spherical sessile microdroplets can serve as individual pixels for two-dimensional patterns integrating angle-independent structural colors and self-healing characteristics.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Erteng Jia, Yuqi Sheng, Huajuan Shi, Ying Wang, Ying Zhou, Zhiyu Liu, Ting Qi, Min Pan, Yunfei Bai, Xiangwei Zhao, Qinyu Ge
Summary: This study analyzed the gene expression features of single cells in different spatial locations of the mouse hippocampus and explored the effects of gene expression regulation on learning and memory mechanisms. The expressions of Sv2b, Neurod6, Grp, and Stk32b genes varied significantly in single cells at different locations in the hippocampus, and marker genes for CA1, CA3, and DG subregions were identified. The up-regulated genes were mainly involved in neuron to neuron synapse, vesicle-mediated transport in synapse, calcium signaling pathway, and neurodegenerative disease pathways, affecting learning and memory function. These findings are crucial for understanding the pathogenesis of Parkinson's disease and developing precise treatment plans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Ruimin Xu, Shijie Dai, Menghua Dou, Jing Yang, Xiu Wang, Xiaomeng Liu, Chenhong Wei, Qianjin Li, Jianlin Li
Summary: A SERS-based array assay for multiple pesticides was developed using colloidal silver nanoparticles loaded three-dimensional silica photonic microspheres (SPMs) array as the analytical platform. The method showed high sensitivity and low cost, making it suitable for high-throughput screening of multiple pesticide residues in real samples.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Physical
Siyu Kang, Muhammad Shemyal Nisar, Yu Lu, Ning Chang, Yan Huang, Haibin Ni, Sergey M. M. Novikov, Yi Wang, Qiannan Cui, Xiangwei Zhao
Summary: This study introduces a new 3D biocompatible plasmonic tweezer for single living cell manipulation in solution. The key design involves a tapered tip with a three-layer surface structure, which enables reversible binding between functionalized surface and cell membrane through surface plasmon polaritons and thermally driven phase transition of the thermosensitive hydrogel. The 3D biocompatible plasmonic tweezer achieves selective capture, 3D pathway free transport, and position-controlled release of target cells, with excellent biocompatibility, low energy consumption, and high operational flexibility.
Article
Chemistry, Applied
Tingting Wang, Qianjin Li, Meng Wang, Jianhong Xu, Jianlin Li, Fenying Wang
Summary: Development of multiple detection methods is crucial for monitoring non-steroidal anti-inflammatory drugs (NSAIDs) in food to protect human health. In this study, fluorescent artificial receptors were synthesized using molecular imprinting technique to establish a simultaneous detection system for NSAIDs. The obtained fluorescent molecularly imprinted polymers (FMIPs) showed high specificity, rapid response time, and high sensitivity. The constructed simultaneous detection system demonstrated comparable performance to HPLC methods in real sample testing. Overall, using different FMIPs to construct simultaneous detection systems is practicable for sensing multiple hazards in food samples.
Article
Chemistry, Applied
Xin Wan, Danyang Li, Jiayan Lu, Yan Yan, Zhiyong He, Jie Chen, Ye Jiao, Jianlin Li, Weiwei Li
Summary: Garlic diallyl disulfide (DAD) nano-emulsions made of soy proteins were used to investigate their effects on physicochemical properties and heterocyclic aromatic amines (HAAs) formation in roasted pork. The encapsulated DAD in soy proteins had a particle size ranging from 400-700 nm. Application of DAD nano-emulsions to pork patties resulted in changes in color and texture, with increased brightness and decreased redness and yellowness. Flavor determination showed a significant reduction in sulfur-containing compound levels in encapsulated DAD, especially 7S group compounds, indicating a successful masking effect on the pungent odor of garlic oil by proteins. Exposure to DAD nano-emulsions significantly reduced the levels of three HAAs (MeIQx, PhIP, and Harman) by 51.84%, 76.80%, and 48.70%, respectively. This study presents a novel method for inhibiting HAA formation and improving the sensory qualities of meat products.
Article
Biochemistry & Molecular Biology
Meng Wang, Jun Qiu, Chennuo Zhu, Yunyan Hua, Jie Yu, Lulu Jia, Jianhong Xu, Jianlin Li, Qianjin Li
Summary: Due to the extensive use and misuse of pesticides, the research community needs to develop rapid on-site detection technology to ensure food safety. In this study, a fluorescent sensor based on paper, integrated with molecularly imprinted polymer (MIP) targeting glyphosate, was successfully prepared. The MIP-coated paper sensor exhibited high selectivity and had a low detection limit of 0.29 μmol for glyphosate. It also had a short detection time of about 5 minutes and showed good accuracy with a spiked recovery rate of 92-117% in real samples. The fluorescent MIP-coated paper sensor has the advantages of specificity, stability, low cost, ease of operation, and portability, making it highly suitable for the on-site and rapid detection of glyphosate for food safety.
Article
Chemistry, Analytical
Yunxia Guo, Junjie Ma, Zhengyue Li, Kaitong Dang, Qinyu Ge, Yan Huang, Guang-zhong Wang, Xiangwei Zhao
Summary: This study investigates the effects of fixation and storage time on the nuclear transcriptome signatures of the brain. The fixation time has a greater impact on the transcriptomic profiles than the retention time of FFPE samples. The findings will guide the preparation of FFPE samples for single-nucleus RNA-seq, especially in transcriptomic studies of brain diseases.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Applied
Xiu Wang, Wei Li, Shijie Dai, Menghua Dou, Saisai Jiao, Jing Yang, Weiwei Li, Ya Su, Qianjin Li, Jianlin Li
Summary: The aim of this research was to develop a simple, rapid, sensitive, high-throughput detection method for foodborne Escherichia coli (E. coli) O157:H7 based on the aptamer-modified gold nanoparticles@macroporous magnetic silica photonic microsphere (Au@MMSPM). The established SERS assay platform provided a new high-throughput, highly sensitive and fast detection technology for monitoring E. coli O157:H7 in real samples from the fields of food industry, medicine and environment.
Article
Chemistry, Applied
Qianjin Li, Meng Wang, Yu Jin, Yongling Lu, Shuqing Xiong, Mengdi Wang, Jianhong Xu, Chenhong Wei, Jianlin Li
Summary: Fluorescent artificial antibodies for detecting ovalbumin in food were synthesized using molecular imprinting technique. The functional monomer used in this study had pH-responsive property. Both FITC-based and RB-based FMIPs showed specific recognition towards ovalbumin. FITC-based FMIP had an imprinting factor of 2.5 and cross-reactivity factors with ovotransferrin, β-lactoglobulin, and bovine serum albumin of 2.7, 2.8, and 3.4, respectively. The FMIP was successfully applied for ovalbumin detection in milk powder with good recovery rates. Moreover, the FMIP can be reused multiple times.
Article
Chemistry, Applied
Xiaomeng Liu, Wei Li, Jialong Sun, Shijie Dai, Xiu Wang, Jing Yang, Qianjin Li, Yao Li, Hongyu Ge, Jianning Zhao, Jianlin Li
Summary: A smartphone-based detection platform for Escherichia coli O157: H7 was developed, which is sensitive, rapid, label-free and high-throughput. The platform utilized a specific aptamer modified on silica photonic microspheres (SPM) and gold nanoparticles for improved sensitivity. It exhibited a wide linear detection range of 102 -108 CFU/mL with a low limit of detection (LOD) of 68 CFU/mL and high specificity for Escherichia coli O157:H7. The platform had potential applications in food safety, environmental monitoring, and disease diagnosis due to its easy manipulation and lack of complex sample pretreatment.
Review
Biochemistry & Molecular Biology
Yunxia Guo, Wenjia Wang, Kaiqiang Ye, Liyong He, Qinyu Ge, Yan Huang, Xiangwei Zhao
Summary: Single-cell sequencing and single-nucleus RNA sequencing have revolutionized the study of cellular heterogeneity and genetic variations. Recent advancements in single-nucleus RNA sequencing have shown improved performance in reducing transcription bias and handling formalin-fixed paraffin-embedded samples compared to traditional single-cell sequencing. The development of single-nucleus RNA sequencing technologies for formalin-fixed paraffin-embedded samples will provide a crucial foundation for transcriptomic studies in clinical medicine and human sample banks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Ying Zhou, Ting Qi, Min Pan, Jing Tu, Xiangwei Zhao, Qinyu Ge, Zuhong Lu
Summary: A new approach called Deep-Cloud, based on deep learning algorithm and cloud model, is developed to extract gene expression information from RNA-seq data and estimate differentially expressed genes. It combines convolutional neural network and long short-term memory to extract features and quantifies the uncertainty using statistical method of the cloud model for in-depth analysis of DEGs.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Medicine, General & Internal
Wen-Jia Wang, Liu-Xi Chu, Li-Yong He, Ming-Jing Zhang, Kai-Tong Dang, Chen Gao, Qin-Yu Ge, Zhou-Guang Wang, Xiang-Wei Zhao
Summary: The complexity of cellular heterogeneity in the respiratory system presents challenges to researchers. While bulk RNA sequencing and single cell RNA sequencing have provided insights into cell types and heterogeneity, spatial transcriptomics has been used to study the spatial localization and cellular interactions in the respiratory system. This review discusses the application of spatial transcriptomics in respiratory studies, with a focus on the lungs, and proposes potential directions for further development in this field.
MILITARY MEDICAL RESEARCH
(2023)
Review
Nanoscience & Nanotechnology
Liyong He, Wenjia Wang, Kaitong Dang, Qinyu Ge, Xiangwei Zhao
Summary: Cells are basic building blocks of life with vast heterogeneity. Rapid development of single-cell multiomics has facilitated comprehensive understanding of gene regulatory networks, cellular characteristics, and temporal dynamics. However, simultaneous analysis of transcriptome and proteome at single-cell level still faces challenges.
Article
Chemistry, Analytical
Yu Lu, Ruihua Fei, Jiahe Zhang, Geng Zhu, Xiufang Mo, Yu Wan, Yan Huang, Qingjiang Sun, Dianhuai Meng, Xiangwei Zhao
Summary: A new vertical flow assay device has been proposed in this study, which can simultaneously diagnose and distinguish between SARS-CoV-2 and influenza A. The device allows for fast and sensitive detection, and its clinical feasibility has been validated.
SENSORS & DIAGNOSTICS
(2023)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
