期刊
ANALYST
卷 139, 期 1, 页码 157-164出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an01794j
关键词
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资金
- EU-FEDER
- Interreg IV, project Plasmobio
- Centre National de la Recherche Scientifique (CNRS)
- Institut Universitaire de France (IUF)
- Nord-Pas-de Calais region
We show in this article that doxorubicin-modified gold nanoparticles (Au NP-DOX) can be used for the post-amplification of the wavelength shift of localized surface plasmon resonance (LSPR) signals after DNA hybridization events. We take advantage of the intercalation properties of DOX with guanine-rich oligonucleotides and the plasmon coupling between surface-linked gold nanostructures and Au NP-DOX in solution to detect in a sensitive manner DNA hybridisation events. Post-treatment of double-stranded DNA with Au NP-DOX resulted in a detection limit of approximate to 600 pM, several times lower than that without post-incubation (LOD approximate to 40 nM).
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