Article
Chemistry, Multidisciplinary
Yui Sasaki, Kohei Ohshiro, Qi Zhou, Xiaojun Lyu, Wei Tang, Kiyosumi Okabe, Shin-ya Takizawa, Tsuyoshi Minami
Summary: A self-assembled chemosensor made of readily available materials exhibits various fluorescence responses, such as ratiometric and simple ON-OFF switching, upon the addition of different toxic metal ions. The distinct fingerprint-like responses have been utilized for pattern recognition of metal ions in river water, aiding in environmental analysis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Wanling Huang, Yi Qu, Ying Zhu, Na Jiang, Wenling Huang
Summary: A fluorescent sensor based on triphenylamine (TPAI) was designed for monitoring battery pollution. The sensor showed a low detection limit and high binding constants towards Zn2+, with excellent selectivity over other metal ions.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Analytical
Hong Dinh Duong, Jong Il Rhee
Summary: Ratiometric fluorescent glucose and lactate biosensors were developed with high sensitivity, selectivity, fast reversibility, and long-term stability for reliable detection of glucose and lactate in artificial human serum.
Article
Chemistry, Applied
Xiaojun Zhao, Zhishuai Ren, Qiang Zhang, Wenjing Zhang, Mingming Yu, Yuqi Guo, Zhanxian Li
Summary: Abnormal levels of SO2 derivatives can cause mitochondrial and lysosomal dysfunction, leading to various diseases. Therefore, the development of fluorescent probes for the detection of SO2 derivatives in biological systems is crucial. In this study, two new ratiometric fluorescent probes, MByn and HByn, were developed to accurately and rapidly respond to HSO3- in PBS buffer solution through a Michael addition reaction. The probes showed a 5-fold increase in ratiometric response signal and a macroscopic change in fluorescence color upon addition of HSO3-. Additionally, MByn and HByn exhibited low detection limit (LOD = 0.96/0.79 μM), good photostability, and low cytotoxicity. Cell imaging experiments demonstrated that MByn and HByn accurately localized mitochondria and lysosomes and detected both exogenous and endogenous SO2 derivatives in living cells.
Article
Chemistry, Analytical
Meiting Hou, Liangfei Fan, Xia Fan, Xin Liang, Weihua Zhang, Yubin Ding
Summary: A ratiometric sensor array Py-PP was constructed to discriminate GAGs, showing excellent discrimination ability towards Hep, HA, Chs, and DS. The sensor array was effective in both PBS and 5% serum media, and could detect trace GAG contaminants in Hep with 100% accuracy. The Py-PP sensor array proved to be a powerful tool for accurate discrimination of GAGs.
ANALYTICA CHIMICA ACTA
(2021)
Article
Materials Science, Multidisciplinary
Denghui Li, Jie Ma, Huiling Wang, Lian Liu, Honggao Yang
Summary: A new tetraphenylethylene-based barbituric acid derivative, TPEB, exhibits aggregation induced emission effect and can serve as a fluorescent probe for CN-. The probe shows high selectivity and anti-interference towards CN(-) in a DMSO-H2O system, with a limit of detection reaching 0.767 x 10(-6) mol L-1. The probe operates via intramolecular charge transfer mechanism and can be used for qualitative detection of solution acidity and basicity.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Engineering, Environmental
Pramod Kumar Mehta, Jongyong Jeon, Ki Ryu, See-Hyoung Park, Keun-Hyeung Lee
Summary: Ratiometric fluorescent peptidyl probe was synthesized and used for quantifying Pb(II) in aquatic environment and live cells. The probe displayed high selectivity and sensitivity towards Pb(II), with cell-permeability and rapid response. The study revealed that the probe formed a complex with Pb(II) and formed red-emissive nanoparticles and fibrils.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Spectroscopy
Junying Zhang, Ruochen Li, Yiling Bei, Xing-Dong Xu, Wenbing Kang
Summary: This study reports a ClO-ratio fluorescence sensor with large Stokes shift, which exhibits excellent detection performance and selectivity, and achieves encryption and anti-counterfeiting functions through inkjet printing technology.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Jianwen Qiu, Chunli Zhong, Meng Liu, Yaofeng Yuan, Hu Zhu, Yong Gao
Summary: Two water-soluble fluorescent probes, T1 and T2, have been designed and synthesized. T1 shows excellent selectivity for Fe3+ detection, while T2 performs poorly in Fe3+ detection. This indicates that different substituents at the bottom ring have different effects on the performance of xanthene-based probes.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Applied
Ting Cao, Liang Zhang, Yun Liu, Hong Ma
Summary: This study developed the first near-infrared ratiometric fluorescence sensor (TMNF) for monitoring and imaging neutrophil elastase (NE) in vivo and in vitro. Cell imaging results showed that NE was highly expressed in cells treated with pro-inflammatory factors, and NE activity was significantly reduced after pretreatment with the enzyme inhibitor. Relevant experiments demonstrated that inflammation can lead to increased expression of NE in vivo. The imaging of the probe in inflammation mice demonstrated excellent practicality, making it an effective tool for the early diagnosis and treatment of diseases related to inflammatory lesions.
Review
Polymer Science
Yanan Zhang, Dajun Hou, Zelong Wang, Ning Cai, Chaktong Au
Summary: This review systematically summarizes the recent progress in nanomaterial-based dual-emission ratiometric fluorescent biosensors, which play an essential role in biosensing and cell imaging applications. It introduces general design approaches and typical examples, while also discussing potential challenges and future outlook for dual-emission ratiometric fluorescent nanosensors.
Article
Chemistry, Analytical
Moumi Mandal, Dibyendu Sain, Md. Majharul Islam, Dipanjan Banik, Muthaimanoj Periyasamy, Sukhendu Mandal, Ajit Kumar Mahapatra, Arik Kar
Summary: New ratiometric probes based on 1,3,5-triazine have been introduced for selective detection of Zn2+ ions, with one probe showing strong interaction with lung cancer cells. These probes exhibit high selectivity with detection limits of 1.22 x 10(-7) M and 1.13 x 10(-7) M, respectively, and could serve as portable Zn2+ sensors with color changes in absorption and fluorescence.
ANALYTICAL METHODS
(2021)
Article
Materials Science, Multidisciplinary
Changfang Lu, Dongxu Chen, Yuanyuan Duan, Wei Zhang, Yue Xie, Yinyin Chen, Xianxiang Wang
Summary: The study demonstrates that carbon nanomaterials (CNMs) synthesized with ethanolamine and doped with zinc can improve their optical properties, especially when coupled with ZnCdS quantum dots (QDs) as a dual emission system. This system shows a good linear relationship and low detection limit when used as a ratiometric fluorescence pH sensor for detecting ascorbic acid.
MATERIALS RESEARCH BULLETIN
(2021)
Article
Chemistry, Analytical
Qin Tan, Xuanxuan An, Shuang Pan, Shujun Zhen, Yongmei Hu, Xiaoli Hu
Summary: A novel ratiometric fluorescent sensor for gallic acid was developed using carbon dots, CoOOH nanoflakes, and o-phenylenediamine, showing high sensitivity with a linear response range of 2.0-60.0 μmol L-1 and a detection limit of 1.2 μmol L-1. The sensor was successfully applied to detect gallic acid in green tea.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Yunsu Ma, Yuan Wang, Yongjie Liu, Lujia Shi, Dongzhi Yang
Summary: A cascade-triggered ratiometric fluorescent sensor based on nanocomposites was developed for lactate detection, with a LOD of 0.12 mu M. The sensor showed promising results in detecting lactate in human serum, indicating its potential for clinical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Applied
Dibyendu Satapathi, Manik Das, Karunamoy Rajak, Soumik Laha, Md Maidul Islam, Indranil Choudhuri, Nandan Bhattacharyya, Sinjan Das, Bidhan Chandra Samanta, Tithi Maity
Summary: Two novel Cu(II) complexes and one Ni(II) complex have been developed and characterized for their structure and properties, including their binding ability with DNA and human serum albumin. Experimental methods and molecular docking studies confirmed the binding potential of these complexes with DNA and HSA, as well as their anticancer properties. The nuclear staining study revealed the nuclear morphological changes in cancer cells and suggested the activation of apoptotic pathways.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Pranabendu Das, Swati Singh Rajput, Manik Das, Soumik Laha, Indranil Choudhuri, Nandan Bhattacharyya, Arindam Das, Bidhan Chandra Samanta, Md. Mehboob Alam, Tithi Maity
Summary: A Schiff base chemosensor with moderate fluorescence activity has been developed for the selective and colorimetric detection of Cu(II), Zn(II), and F- ions. The sensor showed enhanced luminance under UV light after the introduction of Zn(II) and formed a deep green color after the addition of F-. Interestingly, the luminescence color of the sensor became colorless after the addition of Cu(II). The binding constant values and spectroscopic analysis confirmed the formation of bonds between the sensor and the recognized ions. The sensor's bio sensing activity for Zn(II) was confirmed through fluorescence live cell imaging. The sensor's detection of F- ions in drinking water was also successful.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Oncology
Anutosh Patra, Anish Nag, Anindita Chakraborty, Nandan Bhattacharyya
Summary: The study found that Pol beta Delta cells with a 97 amino acid deletion were more sensitive to gamma radiation and exhibited a higher rate of apoptosis compared to normal cells. In silico docking experiments also revealed that Pol beta Delta had a stronger binding potential to dsDNA, potentially leading to cell death.
RADIATION ONCOLOGY JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Manik Das, Somali Mukherjee, Md. Maidul Islam, Indranil Choudhuri, Nandan Bhattacharyya, Bidhan Chandra Samanta, Basudeb Dutta, Tithi Maity
Summary: A new versatile azide-bridged polymeric Cu(II) complex was synthesized and its biomedical potential was evaluated. The complex demonstrated the ability to effectively bind with macromolecules such as DNA and HSA, and showed antiproliferative and anticancer activity.
Article
Chemistry, Physical
Sibaprasad Maity, Annada C. Maity, Avijit Kumar Das, Gourisankar Roymahapatra, Shyamaprosad Goswami, Tarun Kanti Mandal
Summary: Sensor 1 based on coumarin has been designed and synthesized for visual recognition of fluoride ions in acetonitrile, showing high selectivity and sensitivity. Experimental and theoretical calculations have supported its strong binding affinity towards fluoride ions.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Susmita Das, Manik Das, Soumik Laha, Karunamoy Rajak, Indranil Choudhuri, Nandan Bhattacharyya, Bidhan Chandra Samanta, Tithi Maity
Summary: A Salen type Schiff base probe H3L was developed for selective and easy detection of Zn(II), Al(III), and SO4= ions. The probe exhibited moderate luminescent properties and showed fluorescence enhancement and diminution during the detection of Al(III)/Zn(II) and SO4=, respectively. The binding mechanisms between the probe and ions were analyzed through experimental and theoretical methods, and the probe was successfully applied for ion detection in tap water. Additionally, fluorescence live cell imaging study confirmed the effective sensing of intracellular Zn(II) by the chemosensor.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Engineering, Environmental
Francis Joy, K. P. Chaithra, Aatika Nizam, Ayswaria Deepti, P. S. Baby Chakrapani, Avijit Kumar Das, T. P. Vinod, Yamuna Nair
Summary: A novel Schiff base molecule, DHN, was found to exhibit reversible fluorescence switching and selective binding propensity towards zinc in aqueous media, with a limit of detection of 9.135 nM. DHN showed weak fluorescence in polar solvents, but strong fluorescence in solid state due to aggregation induced emission (AIE). The ESIPT Schiff base DHN was utilized for the development of multiresponsive fluorescent materials for selective sensing of metal ions in both solid and solution states, and demonstrated practical applicability in on-site detection of Zn2+ and fluorescent imaging of intracellular zinc.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Manjushree Bera, Manik Das, Malay Dolai, Soumik Laha, Md Maidul Islam, Bidhan Chandra Samanta, Arindam Das, Indranil Choudhuri, Nandan Bhattacharyya, Tithi Maity
Summary: A new quercetin-based iron(III) cationic complex, [Fe(Qr)-Cl(H2O)(MeO)] (complex 1), was synthesized in this study through condensation of quercetin with ferric chloride in the presence of Et3N. Spectroscopic analysis, conductometric measurement, and electron paramagnetic resonance (EPR) research confirmed the existence and +3-oxidation state of complex 1. Biophysical studies demonstrated the strong affinity of complex 1 for DNA and human serum albumin (HSA) protein. The potential of complex 1 as an anticancer drug was evaluated using the MTT assay technique on HeLa cancer cell lines and HEK-293 normal cell lines, and significant anticancer properties were observed. Apoptotic-induced cell-killing mechanism and cell morphological changes were confirmed using AO/PI staining approach.
Article
Microbiology
Palash Pan, Nandan Bhattacharyya
Summary: Microbial fuel cells (MFCs) use microorganisms to decompose the substrate, generating electrons and protons which are then converted to electricity at the cathode. MFCs have potential for practical applications in addressing energy shortages and environmental pollution. This study focused on the power production potential of a newly identified bacterial strain, Lysinibacillus xylanilyticus nbpp1, in an H-type MFC setup. The MFC produced a high open circuit voltage and achieved a maximum power density, demonstrating its promising electrochemical performance.
CURRENT MICROBIOLOGY
(2023)
Article
Chemistry, Physical
Gopal C. Das, Avijit Kumar Das, Debsankar Das, Tilak Raj Maity, Aveek Samanta, Fatmah Ali Alasmary, Amani Salem Almalki, Amjad Iqbal, Malay Dolai
Summary: The ligand (E)-N'-(2-hydroxy-3-methoxybenzylidene) acetohydrazide (HL) has been synthesized for selective sensing of Al3+ and Zn2+ ions. In the presence of these ions, HL shows a significant increase in fluorescence intensity due to chelation-enhanced fluorescence. HL exhibits high selectivity and sensitivity with LOD of 0.836 x 10-6 M for Al3+ and 1.01 x 10-6 M for Zn2+. DFT calculation is used to study the binding of HL with metal ions. The cytotoxicity and cell biology of the probe and Al3+ sensing are also observed.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Engineering, Environmental
P. Keerthana, Avijit Kumar Das, M. Bharath, Munmun Ghosh, Anitha Varghese
Summary: A fluorescent ratiometric nanosensor was developed using biomass-derived carbon quantum dots with surface modification for highly selective identification of cadmium ions.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Review
Chemistry, Analytical
Nidhi P. Rao, C. M. C. Vaishnavi, Malavika S. Kumar, S. Vishnu, Bimalendu Mukherjee, N. Karthik, Gorachand Dutta, Avijit Kumar Das
Summary: This review discusses the recent advancements in chemosensors for the selective detection of essential amino acids. Different sensing techniques, such as reaction-based approach, DNA-based sensors, nanoparticle formation, coordination ligand binding, host-guest chemistry, fluorescence indicator displacement (FID) approach, electrochemical sensors, carbon dot-based sensors, MOF-based sensors and metal-based techniques, are described.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Multidisciplinary
Biman Ari, Manik Das, Paola Brandao, Somali Mukherjee, Atish Dipankar Jana, Biplab Koley, Soumik Laha, Md. Maidul Islam, Indranil Choudhuri, Nandan Bhattacharya, Bidhan Chandra Samanta, Nitin Chattopadhyay, Tithi Maity
Summary: In this study, a mono-nuclear Ni(II) complex and a di-nuclear Cu(II) complex were synthesized and characterized. Both complexes showed affinity for binding with DNA and HSA. The binding mode with DNA was found to be intercalative for complex 1 and groove binding for complex 2. The MTT assay revealed that complex 2 exhibited superior anticancer properties with low toxicity to normal cells. Furthermore, a nuclear staining study confirmed an apoptotic cell-killing pathway for the complexes.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Analytical
Sibaprasad Maity, Annada C. Maity, Avijit Kumar Das, Nandan Bhattacharyya
Summary: A fluorescent chemosensor, FAD, was developed for the selective detection of Zn2+ and OCl- simultaneously by employing a metal coordination and analyte-induced chemodosimetric approach. The binding constant and detection limits for Zn2+ were determined, and the potential application of FAD in fluorescence imaging inside HeLa cells was demonstrated.
ANALYTICAL METHODS
(2022)
