期刊
ANALYST
卷 138, 期 21, 页码 6511-6516出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an01267k
关键词
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资金
- Ministry of Science and Technology of China [2012CB825800, 2012CB932600, 2012CB825805]
- National Natural Science Foundation of China [11179004, 11275251, U1232113, U1232114, 31170077]
- K. C. Wong Education Foundation
- Youth Innovation Promotion Association CAS
Using synchrotron radiation X-ray fluorescence (SRXRF), we have examined the biodistribution and pulmonary toxicity of nanoscale titanium dioxide (nanoTiO(2)) in mice at the elemental level. Notably, nanoTiO(2) particles were mainly retained in lungs after intratracheal instillation, slowly cleared and were still present at 3 months. Different methods of intratracheal instillation influenced the clearance of nanoTiO(2) from lungs. NanoTiO(2) interfered with the natural distribution of K, Ca, Fe, Cu and Zn in lungs. We have thus demonstrated that SRXRF provides an effective approach to investigate the distribution of metal nanomaterials and native metal elements in tissues and organs, which offers new opportunities for revealing nanotoxic mechanisms of nanomaterials.
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