Article
Engineering, Environmental
Kang Mao, Zhugen Yang, Hua Zhang, Xiqing Li, Jonathan M. Cooper
Summary: Wastewater-based epidemiology is a powerful technique for monitoring illicit drugs, and a surface-enhanced Raman spectroscopy sensor assembled with noble metal core-shell nanoparticles on a custom-made glassy nanofibrous electrospun paper matrix enables sensitive and selective detection of methamphetamine. The study shows that higher drug mass loads are generally found in sewage influent from urban areas, suggesting more local methamphetamine usage compared to less populated areas.
Article
Nanoscience & Nanotechnology
Hee-Kyung Na, Jisun Ki, Minh-Uyen Le, Kyoung-Shim Kim, Chul-Ho Lee, Tae Geol Lee, Jung-Sub Wi
Summary: The study developed a new type of SERS probe formed by enzyme reactions in the presence of Raman reporters, which achieved uniform and stable signal generation for biomolecule detection on chips over long periods. By applying this approach to a SERS-based immunohistochemistry assay, successful multiplexed protein detection was achieved in brain tissue from transgenic mice.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Analytical
Caterina Serafinelli, Alessandro Fantoni, Elisabete C. B. A. Alegria, Manuela Vieira
Summary: SERS analysis is an attractive tool for detecting molecules in trace amounts, combining the specificity of molecular fingerprints with potential single-molecule sensitivity. With the development of nanotechnology, there has been increasing interest in hybridizing plasmonic metal nanoparticles with (2D) nanomaterials to improve the drawbacks of SERS platforms and create systems with outstanding properties.
Article
Chemistry, Analytical
Tingting Zhang, Gongying Wang, Juan Bao, Chang Liu, Weihua Li, Zhe Kong, Xiuyun Sun, Jiansheng Li, Rui Lu
Summary: A highly sensitive method for detecting histamine using surface-enhanced Raman spectroscopy (SERS) was developed by combining Fe3O4 and Ag-based SERS nanotags. The method showed good sensitivity and reliability in detecting histamine in fish samples.
Review
Optics
Moram Sree Satya Bharati, Venugopal Rao Soma
Summary: Flexible substrates used as SERS platforms for detecting hazardous materials offer advantages of low cost and easy sampling, making them potentially valuable for trace detection of hazardous materials.
OPTO-ELECTRONIC ADVANCES
(2021)
Article
Chemistry, Analytical
Tianao Li, Tao Sui, Binyu Wang, Kun Xu, Sheng Zhang, Xiaojian Cao, Yi Wang, Weiping Qian, Jian Dong
Summary: In this study, a highly sensitive method for detecting Acetylcholinesterase (AchE) is developed using surface-enhanced Raman scattering (SERS) lever strategy. By adjusting the absorbance of Rhodamine B and using SERS-active microneedles, the method can accurately discriminate samples with different enzyme activity. This method meets the requirements for identifying motor and sensory fibers in clinic.
Article
Chemistry, Physical
Juan Li, Yanru Li, Shuai Chen, Weili Duan, Xue Kong, Yunshan Wang, Lianqun Zhou, Peilong Li, Chengpeng Zhang, Lutao Du, Chuanxin Wang
Summary: In this study, a highly sensitive detection system was developed for the direct quantitation of specific exosomes in pancreatic cancer. The detection system showed improved diagnostic efficiency for pancreatic cancer and potential for early diagnosis.
Article
Nanoscience & Nanotechnology
Jae-Eul Shim, Young Jun Kim, Jong-Ho Choe, Tae Geol Lee, Eun-Ah You
Summary: This study presents a sensing platform based on bumpy core-shell surface-enhanced Raman spectroscopy (SERS) nanoprobe and single-nanoparticle (SNP)-based digital SERS analysis for the ultrasensitive and quantitative detection of SARS-CoV-2. The platform outperforms conventional methods and can detect mutated spike proteins from the virus variants.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Jae-Eul Shim, Young Jun Kim, Jong -Ho Choe, Tae Geol Lee, Eun-Ah You
Summary: This study presents a bumpy core-shell SERS nanoprobe-based sensing platform with SNP-based digital SERS analysis for the ultrasensitive and quantitative detection of SARS-CoV-2. It can also detect mutated spike proteins from the SARS-CoV-2 variants and has the potential for detecting other highly infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Analytical
Feng Gao, Fang Li, Jianhao Wang, Hang Yu, Xiang Li, Hongyu Chen, Jiabei Wang, Dongdong Qin, Yiyi Li, Songyan Liu, Xi Zhang, Zhi-Hao Wang
Summary: This review focuses on the application of surface-enhanced Raman scattering (SERS)-based biosensors in the diagnosis of Alzheimer's disease (AD). These biosensors leverage the optical properties of nanomaterials to enhance detection performance, offering high sensitivity and noninvasiveness. Different types of SERS sensors targeting AD biomarkers are discussed, and specific details regarding nanomaterials and AD biomarkers are provided. The future research directions and challenges for improving AD marker detection using SERS sensors are also outlined.
Article
Chemistry, Analytical
Junjie Wang, Chunxiang Xu, Milan Lei, Yi Ma, Xiaoxuan Wang, Ru Wang, Jianli Sun, Ru Wang
Summary: The study developed a microcavity-based sandwich immune chip for ultrasensitive detection of cardiac markers utilizing the SERS method, demonstrating sensitivity, specificity, and stability, making it an effective diagnostic tool for cardiac biomarkers detection.
MICROCHEMICAL JOURNAL
(2021)
Article
Food Science & Technology
Qing Yang, Da-Wen Sun, Hongbin Pu
Summary: Porous materials nanohybridized with metal nanoparticles (PSM/MNPs) have shown significant potential in enhancing SERS detection for various food contaminants. The high porosity and large surface specific area of porous materials prevent aggregation of MNPs, increase adsorption of target analytes, and improve stability and sensitivity of SERS substrates. Future challenges and potential solutions in this area are also discussed, highlighting the promising prospect of PSM/MNPs for sustainable and large-scale detection to ensure food safety.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Physical
M. Chen, P. L. Burn, P. E. Shaw
Summary: Luminescence-based sensing enables sensitive and rapid detection of chemicals, and can be incorporated into portable detectors. While commercially available for explosive detection, there are fewer examples of luminescence-based detection of illicit drugs, requiring further research, particularly in thin film detection.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Biophysics
Xudong Zhao, Huijing Shen, Bingyang Huo, Yu Wang, Zhixian Gao
Summary: In this study, a novel bionic magnetic SERS aptasensor based on dual antennae nano-silver was designed for efficient, sensitive and selective detection of deoxynivalenol (DON). The specific recognition and competitive binding of DON and aptamer, combined with magnetic separation and enhanced Raman scattering techniques, resulted in a lower SERS intensity, with a good linear relationship between the SERS intensity and the logarithm of DON concentration. The SERS aptasensor exhibited good selectivity, repeatability and practicability, showing great application potential in toxin detection and biochemical analysis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Nasurullah Mahar, Amir Al -Ahmed, Abdulaziz A. Al-Saadi
Summary: The development of rapid and efficient spectroanalytical protocols is closely related to the evolution of new generations of nanostructured materials. In this work, the synthesis and characterization of vanadium carbide sheets using a soft condition approach were reported. The synthesized highly stable MXene was treated with self-assembled silver nanoparticles (AgNPs) to fabricate a hybrid material as a potential surface-enhanced Raman scattering (SERS) substrate for the detection of ultra-trace quantities of anti-cancer drug gemcitabine (GMC). The MXene-based SERS sensor achieved a Raman signal amplification corresponding to an enhancement factor of 109, with high sensitivity and reproducibility.
APPLIED SURFACE SCIENCE
(2023)
Article
Respiratory System
Pouline M. P. van Oort, Tamara M. Nijsen, Iain R. White, Hugo H. Knobel, Timothy Felton, Nicholas Rattray, Oluwasola Lawal, Murtaza Bulut, Waqar Ahmed, Antonio Artigas, Pedro R. Povoa, Ignacio Martin-Loeches, Hans Weda, Royston Goodacre, Marcus J. Schultz, Paul M. Dark, Stephen J. Fowler, Lieuwe D. Bos
Summary: The study found that exhaled breath analysis can effectively distinguish patients suspected of ventilator-associated lower respiratory tract infections, with high sensitivity and negative predictive value.
Article
Anatomy & Morphology
Abigail J. Clevenger, Logan Z. Crawford, Dillon Noltensmeyer, Hamed Babaei, Samuel B. Mabbott, Reza Avazmohammadi, Shreya Raghavan
Summary: Peristalsis is a complex mechanical stimulus involving multi-axial strain and shear stress. A bioreactor that mimics peristalsis was designed to deliver these stimuli to a PDMS membrane wall. Experimental and modeling results showed that the bioreactor successfully generated multi-axial strain and shear stress on the wall. Human mesenchymal stem cells (hMSCs) responded differently to peristalsis compared to static controls, perfusion, or strain, resulting in changes in proliferation, actin filament alignment, smooth muscle actin expression, and genetic markers of differentiation. The peristalsis bioreactor device has broad utility in studying development and disease in various organ systems.
CELLS TISSUES ORGANS
(2023)
Article
Immunology
Waqar M. Ahmed, Dominic Fenn, Iain R. White, Breanna Dixon, Tamara M. E. Nijsen, Hugo H. Knobel, Paul Brinkman, Pouline M. P. Van Oort, Marcus J. Schultz, Paul Dark, Royston Goodacre, Timothy Felton, Lieuwe D. J. Bos, Stephen J. Fowler
Summary: Microbial volatiles were detected in the exhaled breath of mechanically ventilated patients with bacterial lung infection. Concentration of isovaleric acid and isovaleraldehyde were higher in patients with Staphylococcus aureus. Indole was higher in patients with bacteria known to metabolize tryptophan.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Sahand Shams, Cassio Lima, Yun Xu, Shwan Ahmed, Royston Goodacre, Howbeer Muhamadali
Summary: The rise and extensive spread of antimicrobial resistance (AMR) has become a global concern and threat to the environment and human health. Traditional AMR identification methods are time-consuming or expensive, and thus culture-independent and single-cell technologies are needed for rapid detection and identification of antimicrobial-resistant bacteria. In this study, a non-destructive phenotyping method using optical photothermal infrared (O-PTIR) spectroscopy was employed for the first time to detect AMR in Uropathogenic Escherichia coli (UPEC) at both single-cell and population levels.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Analytical
Georgios Theodoridis, Helen Gika, Daniel Raftery, Royston Goodacre, Robert S. Plumb, Ian D. Wilson
Summary: Metabolite identification is a major challenge in contemporary metabolomics research, particularly in liquid chromatography-mass spectrometry technology. This article categorizes the errors into two types: biologically implausible identities and identities that do not match the chromatographic and physicochemical properties of the proposed molecule. It discusses the issue, presents examples, and proposes measures for improvement.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Sarir Sarmad, Mark R. Viant, Warwick B. Dunn, Royston Goodacre, Ian D. Wilson, Katie E. Chappell, Julian L. Griffin, Valerie B. O'Donnell, Brendon Naicker, Matthew R. Lewis, Toru Suzuki
Summary: In this Perspective, the authors propose a four-tiered framework to evaluate the reliability of targeted metabolomics analyses. They discuss the need for community-accepted, harmonized guidelines and summarize the regulatory guidance provided by various authorities. The framework includes levels for discovery, screening, qualification, and validation.
Article
Multidisciplinary Sciences
Ashton G. Theakstone, Paul M. Brennan, Michael D. Jenkinson, Royston Goodacre, Matthew J. Baker
Summary: Discrimination between brain cancer and non-cancer patients was achieved using serum-based ATR-FTIR spectroscopy with a sensitivity of 92.8% and specificity of 91.5%. Further research stratified between different brain tumor types with a sensitivity of 90.1% and specificity of 86.3%. The study highlighted the importance of high molecular weight components in discriminating between cancer and non-cancer cases and different tumor types.
Editorial Material
Multidisciplinary Sciences
Asaph Aharoni, Royston Goodacre, Alisdair R. Fernie
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Spectroscopy
Douglas Carvalho Caixeta, Cassio Lima, Yun Xu, Marco Guevara-Vega, Foued Salmen Espindola, Royston Goodacre, Denise Maria Zezell, Robinson Sabino-Silva
Summary: This study used ATR-FTIR spectroscopy to evaluate the differences in urinary components among non-diabetic, diabetic, and diabetic insulin-treated rats. ATR-FTIR combined with univariate and multivariate chemometric analyses provides an innovative, non-invasive, and sustainable approach to diabetes surveillance.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Biochemistry & Molecular Biology
Howbeer Muhamadali, Catherine L. Winder, Warwick B. Dunn, Royston Goodacre
Summary: Metabolomics is a powerful research tool that can measure hundreds to thousands of metabolites. This review discusses the use of GC-MS and LC-MS in discovery-based metabolomics research, defines metabolomics workflows, and highlights considerations for generating robust and reproducible data. It emphasizes the routine application of metabolomics across various biological species and systems, including the study of microbial interactions and their impact on human health. The review also discusses the challenges and potential applications of metabolomics in synthetic biology and gut microbial interactions with the human host.
BIOCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Antonio Valle, Maria Elena de la Calle, Howbeer Muhamadali, Katherine A. Hollywood, Yun Xu, Jonathan R. Lloyd, Royston Goodacre, Domingo Cantero, Jorge Bolivar
Summary: Metabolic engineering can enhance the production of hydrogen and ethanol by modifying Escherichia coli. Metabolomics platforms can identify metabolic bottlenecks, and various strategies can increase hydrogen production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Paul I. C. Richardson, Adam Burke, Nigel Gotts, Royston Goodacre
Summary: Electronic cigarettes have gained popularity as an alternative to traditional cigarettes. This study introduces a complementary technology based on Raman spectroscopy and chemometrics to detect and quantify the PG:VG ratio and nicotine content of e-cigarette liquids. Results showed accurate quantification of PG:VG ratio and nicotine content for most commercial samples, without the need for accurate knowledge of flavonoid composition. The limitations of Raman spectroscopy are discussed, along with potential solutions.
Article
Chemistry, Analytical
Najla AlMasoud, Taghrid S. Alomar, Yun Xu, Cassio Lima, Royston Goodacre
Summary: Paracetamol (acetaminophen) is commonly used as an OTC drug for mild pain, headache, cold and flu. However, it is also used for suicide attempts in young adults, making rapid detection of overdose crucial to limit liver damage. In this study, a surface-enhanced Raman scattering (SERS) methodology was developed to accurately quantify paracetamol and its metabolites in water and artificial urine.
Article
Polymer Science
Liam J. Dodd, Cassio Lima, David Costa-Milan, Alex R. Neale, Benedict Saunders, Bowen Zhang, Andrei Sarua, Royston Goodacre, Laurence J. Hardwick, Martin Kuball, Tom Hasell
Summary: Inverse vulcanised polymers have been studied due to their easy and cheap synthesis from elemental sulfur, resulting in a wide range of valuable properties. However, the high sulfur content makes the polymers difficult to analyze. This study presents the use of Raman spectroscopy to better understand the structure and properties of these polymers. It was found that Raman spectroscopy can provide key information about the elemental sulfur content, homogeneity, reactions, and proportions of different sulfur ranks in the polymer.
Meeting Abstract
Ophthalmology
Neeru Amrita Vallabh, Cassio Lima, Hannah Levis, Hussameddin Muntasser, Stephen Kaye, Royston Goodacre
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)