4.6 Article

N-Acetylglucosamine biofunctionalized CdSeTe quantum dots as fluorescence probe for specific protein recognition

期刊

ANALYST
卷 138, 期 2, 页码 666-670

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2an36434d

关键词

-

资金

  1. National Basic Research Program of China [2011CB933502]
  2. National Natural Science Foundation of China [50972058, 21121091]

向作者/读者索取更多资源

Hsp70 proteins are implicated in resistance to chemotherapy in cancers, the detection of which is important for cancer treatment and prognosis. In this work, we report the study on the detection of specific intracellular target protein in fixed cells using GlcNAc-conjugated CdSeTe QDs. The QDs were coupled with Con A via a carbodiimide reaction and then were further assembled with GlcNAc by lectin-carbohydrate interaction between Con A and GlcNAc. The obtained QDs-Con A-GlcNAc conjugates have an emission wavelength at 650 nm that is close to the near-infrared (NIR) regions and a specific recognition for Hsp70. These results show that the QDs-Con A-GlcNAc probe can be a promising tool for direct localization of the Hsp70 protein.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据