Article
Chemistry, Multidisciplinary
Jinli Li, Yu Wu, Ying Qin, Mingwang Liu, Guojuan Chen, Liuyong Hu, Wenling Gu, Chengzhou Zhu
Summary: An innovative AgCu@CuO aerogel-based photoelectrode material with both remarkable enzyme-like activities and outstanding photoelectric properties was designed and synthesized for the evaluation of xanthine oxidase activity, showing a wide linear detection range and low detection limit in PEC enzymatic biosensors.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Thomas Soranzo, Awatef Ben Tahar, Ayman Chmayssem, Marc Zelsmann, Pankaj Vadgama, Jean-Luc Lenormand, Phillipe Cinquin, Donald K. Martin, Abdelkader Zebda
Summary: In this study, the enzyme aldehyde reductase was synthesized and cloned from a human gene. Spectrophotometric and electrochemical measurements demonstrated that aldehyde reductase can catalyze the reduction of glucose to sorbitol and significantly decrease the electrocatalytic oxidation current of NADPH after glucose addition. This work provides insights into the construction of an efficient electrochemical glucose biosensor.
Article
Chemistry, Multidisciplinary
Cristina Tortolini, Eliana Capecchi, Federico Tasca, Riccardo Pofi, Mary Anna Venneri, Raffaele Saladino, Riccarda Antiochia
Summary: Nanocomposites based on lignin nanoparticles were designed for electrochemical biosensing, showing strong inhibition effect on electron transfer reaction. The modified electrodes assembled with biosensors successfully demonstrated sensitivity towards glucose, with the three-layered structure exhibiting the best analytical performance.
Article
Chemistry, Physical
Monique Levien, Zdenek Farka, Matej Pastucha, Petr Skladal, Zahra Nasri, Klaus-Dieter Weltmann, Katja Fricke
Summary: Acrylate-based hydrogels have been proven to be excellent materials for sensor systems. In this study, hydrogels made of hydroxyethyl methacrylate and 2-(diethylamino)ethyl methacrylate were generated by atmospheric pressure plasma jet. The interaction capability of these hydrogels with biomolecules and their application in electrochemical biosensing were investigated.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Analytical
Ping-hua Ling, Xiao-na Zang, Cai-hua Qian, Feng Gao
Summary: A Metal-Organic Framework with specific characteristics has been used as an artificial enzyme for nonenzymatic electrochemical sensors, demonstrating excellent catalytic performance. The nano-metalloporphyrinic metal-organic framework serves as an effective electrode material for the detection of NO and H2O2, displaying high sensing ability and selectivity towards the analytes, showcasing potential for biosensors.
Article
Chemistry, Analytical
Weixiang Huang, Chunli Yang, Jiaxi Gao, Jingjing Ye, Ruo Yuan, Wenju Xu
Summary: This study presents the design of an electrochemical biosensor based on your mimicking Au@FeCo nanozymes and bicycled hairpin assembly (BHA) for synergistic signal amplification. By immobilizing the enzyme-like FeCo alloy in Au nanoparticles, the resulting Au@FeCo hybrids exhibit improved electronic conductivity and active surface area, as well as excellent mimic catalase activity. The combination of Au@FeCo mimic catalase activity and BHA leads to a significantly increased current signal, enabling the creation of a highly sensitive electrochemical biosensor with potential applications in actual samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xiaoqian Wei, Shaojia Song, Weiyu Song, Weiqing Xu, Lei Jiao, Xin Luo, Nannan Wu, Hongye Yan, Xiaosi Wang, Wenling Gu, Lirong Zheng, Chengzhou Zhu
Summary: The rational construction of advanced sensing platforms to sensitively detect H2O2 produced by living cells is a challenge in both physiological and pathological fields. Single atomic site catalysts (SASCs) with intrinsic peroxidase (POD)-like activity have shown great promise for H2O2 detection, but there is still a gap between them and natural enzymes. A new design of synergistically enhanced single atomic sites for electrochemical sensing applications is proposed in this work.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yuanmeng Zhao, Yunhao Jiang, Yan Mo, Yueming Zhai, Juejing Liu, Andrew C. C. Strzelecki, Xiaofeng Guo, Changsheng Shan
Summary: It is critical to develop high-performance electrocatalysts for electrochemical nonenzymatic glucose sensing. In this work, a single-atom Pt supported on Cu@CuO core-shell nanowires (Pt-1/Cu@CuO NWs) for electrochemical nonenzymatic glucose sensor is designed. The Pt-1/Cu@CuO NWs exhibit outstanding electrocatalytic performance towards glucose, with lower onset potential and higher response current compared to Cu NWs. Sensors fabricated using Pt-1/Cu@CuO NWs also show high sensitivity, low detection limit, wide linear range, excellent selectivity, and great long-term stability. The work provides a new pathway for exploring highly active single-atom catalysts for electrochemical nonenzymatic glucose sensing.
Article
Multidisciplinary Sciences
Jiaru Fang, Dong Liu, Dongxin Xu, Qianni Wu, Hongbo Li, Ying Li, Ning Hu
Summary: This study developed an integrated Au-nanoroded biosensing and regulating platform for investigating the photothermal therapy of cardiac bradyarrhythmia. The platform allows real-time monitoring of the electrophysiological state of cardiomyocytes and restoration of normal rhythm. Compared to conventional strategies, the photothermal strategy is more effective and convenient.
Article
Biochemical Research Methods
Gulcin Bolat, Ernesto De la Paz, Nathalia F. Azeredo, Michael Kartolo, Jayoung Kim, Andre Neirdert de Loyola e Silva, Ricardo Rueda, Christopher Brown, Lucio Angnes, Joseph Wang, Juliane R. Sempionatto
Summary: A soft and flexible wearable sweat microfluidic device capable of stimulating, collecting, and analyzing sweat simultaneously is demonstrated. This device represents an important advancement in non-invasive monitoring of biomarkers.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Andrew Piper, Ingrid Oberg Mansson, Shirin Khaliliazar, Roman Landin, Mahiar Max Hamedi
Summary: Wearable sensors have the potential to revolutionize biomarker detection, with the ability to produce cheap and disposable sensors that can be easily functionalized for a broad range of biomarkers. These sensors are stretchable and have shown promising results in detecting glucose in human sweat, making them ideal for point-of-care sensing applications. The sensors have a high sensitivity and low detection limit, demonstrating their potential for biomarker detection.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemical Research Methods
Razieh Salahandish, Mohsen Hassani, Azam Zare, Fatemeh Haghayegh, Amir Sanati-Nezhad
Summary: The study explores the integration of electrochemical biosensors into fluid handling units to develop point-of-care platforms for quantitative detection of bodily fluid markers. However, current device designs lack full assay automation and require manual loading of reagents or external devices for liquid manipulation. The proposed microfluidic platform addresses challenges by automating steps of electrochemical biosensing assays and optimizing design components for high reproducibility and minimal noise-induced to the biosensor.
Article
Biochemical Research Methods
Lokman Liv, Melisa Yener, Gizem Coban, Sevval Arzu Can
Summary: The study developed an electrochemical biosensing platform capable of detecting the SARS-CoV-2 spike antibody quickly and accurately, with samples including synthetic media and saliva or oropharyngeal swab samples. The method showed high sensitivity, linear response, and excellent selectivity when compared to other diagnostic methods.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Ruhani Singh, Mustafa Musameh, Yuan Gao, Berkay Ozcelik, Xavier Mulet, Cara M. Doherty
Summary: Naturally occurring enzymes are highly efficient catalysts, but their fragile structure limits their industrial and biomedical applications. Researchers successfully mineralized industrial enzymes using metal-organic frameworks, demonstrating their potential in various fields. Additionally, the thermal stability and electrochemical operational stability of these enzyme composites were analyzed, showing promise for applications in electrochemical devices.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Analytical
Dan Li, Xiao-Long Zhang, Ya-Qin Chai, Ruo Yuan
Summary: A high-efficiency controllable three-dimensional DNA nanomachine (CDNM) was developed by regulating the core diameter and DNAzyme cantilever length, which exhibited greater amplification efficiency and faster walking rate compared to traditional 3D DNA nanomachines. The CDNM could be activated by enzyme-free-target-recycling amplification (EFTRA) to achieve fast cleavage and walking on the biosensor surface under the interaction of Mg2+ when the target miRNA-21 was present. The designed electrochemical biosensor successfully detected target miRNA-21 at an ultrasensitive level with a wide response range and low detection limit.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Niamh Creedon, Pierre Lovera, Julio Gutierrez Moreno, Michael Nolan, Alan O'Riordan
JOURNAL OF PHYSICAL CHEMISTRY A
(2020)
Article
Chemistry, Analytical
Luiza A. Wasiewska, Ian Seymour, Bernardo Patella, Rosalinda Inguanta, Catherine M. Burgess, Geraldine Duffy, Alan O'Riordan
Summary: In this study, an electrochemical sensor was developed for silver ion detection in tap water using anodic sweep voltammetry with in-situ pH control. The sensor, enabled by closely spaced interdigitated electrode arrays, allowed for rapid and accurate detection of silver ions in tap water through a combination of complexation with chloride ions and in-situ pH control.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Ian Seymour, Benjamin O'Sullivan, Pierre Lovera, James F. Rohan, Alan O'Riordan
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Analytical
B. Patella, R. R. Russo, A. O'Riordan, G. Aiello, C. Sunseri, R. Inguanta
Summary: The study introduced a nanostructured sensor based on copper nanowires, with rapid response time and easy in-field usability, for monitoring nitrate ions in water.
Article
Chemistry, Multidisciplinary
Ian Seymour, Benjamin O'Sullivan, Pierre Lovera, James F. Rohan, Alan O'Riordan
Summary: The study utilized in-situ pH control to eliminate oxygen interference for monochloramine sensors by converting it to dichloramine, resulting in improved accuracy and efficiency of analysis.
Article
Chemistry, Analytical
Ian Seymour, Tarun Narayan, Niamh Creedon, Kathleen Kennedy, Aidan Murphy, Riona Sayers, Emer Kennedy, Ivan O'Connell, James F. Rohan, Alan O'Riordan
Summary: The development of micro- and nano-scale electrode devices and electrochemical sensing platforms can improve production efficiency and resource utilization in the agri-food sector. These technologies can be applied to monitor water quality, animal health, and chemical substances in agricultural products, reducing resource wastage and enhancing the sustainability of agricultural production.
Article
Chemistry, Analytical
Zhongzheng Wang, Aidan Murphy, Alan O'Riordan, Ivan O'Connell
Summary: This paper reviews the working mechanism of electrochemical sensors, proposes a general model suitable for nanosensors, and discusses the explanation of scan rate in cyclic voltammetry.
Article
Chemistry, Analytical
Niharika Gupta, Shine Augustine, Tarun Narayan, Alan O'Riordan, Asmita Das, D. Kumar, John H. T. Luong, Bansi D. Malhotra
Summary: Molecular diagnostics, including RT-PCR and qRT-PCR, have been vital in the global response to the COVID-19 pandemic. In addition to these gold standards, faster antigen tests and other point-of-care devices have also played a crucial role in containing the spread of the virus. The development of miniaturized, high-throughput PCR systems, digital PCR, electrochemical PCR, and CRISPR/Cas technology for POC diagnostics are areas of increasing interest and research focus. Commercial RT-PCR POC systems approved for COVID-19 detection by various agencies have also been discussed.
Article
Chemistry, Analytical
Julia Madden, Colm Barrett, Fathima R. Laffir, Michael Thompson, Paul Galvin, Alan O' Riordan
Summary: This study focused on the microfabrication and characterization of gold microband electrodes on silicon using standard methods. A two-step electrodeposition process was applied to successfully incorporate glucose oxidase onto the electrodes, resulting in linear glucose detection. Utilizing various microscopy techniques, the biosensor exhibited promising performance in buffer-based solutions.
Article
Chemistry, Analytical
Francesca Mazzara, Bernardo Patella, Chiara D'Agostino, Maria Giuseppina Bruno, Sonia Carbone, Francesco Lopresti, Giuseppe Aiello, Claudia Torino, Antonio Vilasi, Alan O'Riordan, Rosalinda Inguanta
Summary: This study focuses on developing electrochemical sensors for detecting sweat pH by modifying electronic substrate and depositing polyaniline thin films. The sensors showed good performance in the pH range of 2 to 8, with a sensitivity of 62.3 mV/pH and reproducibility of 3.8%.Tests with interference ions demonstrated the sensors' selectivity, and real sweat sample analysis proved excellent agreement with a commercial pH meter.
Article
Optics
Yuqing Yang, Niamh Creedon, Alan O'Riordan, Pierre Lovera
Summary: Recent global warming has resulted in shifting weather patterns, intensification of natural disasters, and pressure on global food systems. Pesticides, while effective in addressing these challenges, pose harm to humans and the environment, necessitating enhanced monitoring. The emergence of Surface Enhanced Raman Scattering (SERS) offers rapid, sensitive, and selective detection of contaminants in agriculture and environmental sectors, making it a promising tool for food safety and environmental monitoring.
Article
Chemistry, Analytical
Francesco Lopresti, Bernardo Patella, Vito Divita, Claudio Zanca, Luigi Botta, Norbert Radacsi, Alan O'Riordan, Giuseppe Aiello, Maiwenn Kersaudy-Kerhoas, Rosalinda Inguanta, Vincenzo La Carrubba
Summary: A green wearable sensor for sweat absorption and chloride sensing is presented in this study. The sensor, made from polylactic acid and upcycled compact discs, showed sensitive and reproducible detection of chloride ions in sweat samples. The results demonstrate the feasibility of applying this integrated sweat sensor directly on human skin.
Article
Engineering, Electrical & Electronic
Aidan Murphy, Ian Seymour, James Rohan, Alan O'Riordan, Ivan O'Connell
Summary: This work presents a flexible and portable data acquisition system for nano and ultra-micro scale electrochemical sensors, which can perform various voltammetric tests. It interfaces to a smartphone, runs on a rechargeable battery, and is designed to be fully portable. By using commercial components, this system aims to lower the barrier to entry for emerging portable electrochemical sensing technologies at micro and nano scale.
IEEE SENSORS JOURNAL
(2021)
Review
Chemistry, Analytical
Julia Madden, Conor O'Mahony, Michael Thompson, Alan O'Riordan, Paul Galvin
SENSING AND BIO-SENSING RESEARCH
(2020)
Article
Chemistry, Analytical
Caoimhe Robinson, Niamh Creedon, Riona Sayers, Emer Kennedy, Alan O'Riordan
ANALYTICAL METHODS
(2020)