Review
Engineering, Chemical
Jingjing Wang, Baozheng Xu, Libo Shi, Longyang Zhu, Xi Wei
Summary: This paper focuses on the use of AI in various MEMS biosensors, particularly microcantilever biosensors. It discusses the advantages of microcantilever biosensors over conventional ones and their potential applications in automation, consumer electronics, industrial manufacturing, defense, and medical equipment. The paper explores the fundamentals of neural algorithms and the principal component analysis approach and anticipates the application of AI in microcantilever biosensors. This research is valuable as there are currently limited reports on the use of AI with microcantilever sensors, and it promotes the development of intelligent sensing systems and the potential applications of neural networks in this field.
Review
Biotechnology & Applied Microbiology
Muhammad Musaddiq Shah, Khurshid Ahmad, Sonia Boota, Tor Jensen, Michael R. La Frano, Joseph Irudayaraj
Summary: Endocrine-disrupting chemicals (EDCs) are man-made substances that can disrupt the standard function of the endocrine system. They are widespread in the environment and pose a potential threat to human health, aquatics, and wildlife. Traditional instrument-based analytical techniques are not suitable for onsite detection, while sensor/biosensor-based approaches are more attractive due to their rapid, portable, equally sensitive, and eco-friendly characteristics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Marica Erminia Schiano, Avazbek Abduvakhidov, Michela Varra, Stefania Albrizio
Summary: This review focuses on the application of aptasensors in detecting bisphenol A (BPA) in food matrices, highlighting their significance in assessing the risk of BPA exposure through diet.
APPLIED SCIENCES-BASEL
(2022)
Review
Pharmacology & Pharmacy
Aya Takesono, Tetsuhiro Kudoh, Charles R. Tyler
Summary: Exposure to estrogenic endocrine disrupting chemicals has been found to have negative impacts on neurodevelopment. Transgenic zebrafish models offer new approaches to study the effects of these chemicals on brain development, function, and behavior.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Optics
Anup M. Upadhyaya, Maneesh C. Srivastava, Preeta Sharan
Summary: This paper presents a novel microcantilever sensor for early cancer detection using an integrated optical micro ring resonator. By investigating the effect of geometrical modification on the microcantilever, it was found that the triangular profile has higher resolution and pressure sensitivity, while the regular rectangular profile has lower sensitivity and quality factor. Both sensor configurations showed transmission efficiency above 90%, demonstrating promising linear characteristics as MOEMS sensors.
Article
Physics, Multidisciplinary
Ankur Saxena, Mahesh Kumar, Dhaneshwar Mishra, Kulwant Singh
Summary: This study analyzes an integrated microfluidic pressure sensing mechanism in a microfluidic device, which consists of a poly dimethyl siloxane (PDMS) based material with a microcantilever integrated on one side of the microchannel. The pressure of fluid in the microchannel is measured by the deflection of the PDMS microcantilever. The results show that the Pi-shaped microcantilever achieved the maximum deflection in fluid plasma (37.05 μm) and water (30.98 μm) at a fluid inlet velocity of 8000 μm/s.
Review
Biochemical Research Methods
Rajesh Pradhan, Siddhanth Hejmady, Rajeev Taliyan, Gautam Singhvi, Rajesh Khadgawat, Garima Kachhawa, Sunil Kumar Dubey
Summary: Endocrine-disrupting chemicals (EDCs) are xenobiotics that disrupt the endocrine system in humans at ecologically significant concentrations. Detection methodologies for EDCs require advancements, with hyphenated MS-based chromatograph and biosensors being widely employed for accurate toxicological tests. This article provides a revision of various bioanalytical detection methods and technologies for clinical estimation of EDCs.
Review
Chemistry, Multidisciplinary
Liping Song, Jing Chen, Ben Bin Xu, Youju Huang
Summary: This study provides a comprehensive review of the recent advances in flexible plasmonic biosensors for the healthcare sector, covering design, integration, exploration, and applications. The research indicates the critical importance of flexible plasmonic biosensors in monitoring human health indicators.
Review
Chemistry, Multidisciplinary
Saqer Al Abdullah, Lubna Najm, Liane Ladouceur, Farbod Ebrahimi, Amid Shakeri, Nadine Al-Jabouri, Tohid F. F. Didar, Kristen Dellinger
Summary: Alzheimer's disease (AD) is a significant cause of dementia worldwide, and current diagnostic methods only detect the disease after clinical symptoms appear. However, research suggests that AD pathology may begin before symptoms manifest, such as the formation of amyloid beta plaques and neurofibrillary tangles. Biomarkers like Aβ(40), Aβ(42), and tau protein show promise for early AD diagnosis. This review summarizes the emerging nanobiosensor approaches for detecting these AD biomarkers and discusses the application of electrochemical, optical, and colorimetric biosensors using nanoparticle-based and nanostructure-based materials. The criteria for incorporating these nanomaterials in clinical settings are also presented.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Saeed Sharif Azadeh, Jason C. C. Mak, Hong Chen, Xianshu Luo, Fu-Der Chen, Hongyao Chua, Frank Weiss, Christopher Alexiev, Andrei Stalmashonak, Youngho Jung, John N. Straguzzi, Guo-Qiang Lo, Wesley D. Sacher, Joyce K. S. Poon
Summary: Laser beam scanning is crucial in many applications and the miniaturization of scanners into microchips has driven the development of photonic integrated circuits. However, achieving a compact size, broad wavelength operation, and low power consumption remains a challenge. In this study, we present a laser beam scanner that meets these requirements using microcantilevers embedded with silicon nitride nanophotonic circuitry. These microcantilevers demonstrate broadband, one- and two-dimensional steering of light with a wide range of wavelengths. The microcantilevers have a small area, consume low power, are easy to control, and emit a single light beam. They are integrated on silicon wafers, enabling versatile, power-efficient, and broadband laser scanner microchips.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Electrical & Electronic
Tian Wu, Liyun Ding, Yumei Zhang, Wu Fang
Summary: Cortisol plays a crucial role in maintaining human life, regulating body metabolism, and ensuring normal biological function. We have developed a highly selective biosensor, using AuNPs-DNA conjugates, that can quantitatively detect cortisol at the nanomolar level.
IEEE SENSORS JOURNAL
(2022)
Review
Chemistry, Analytical
Yangwon Jeon, Yejin Lee, Keugtae Kim, Geupil Jang, Youngdae Yoon
Summary: Microorganisms are omnipresent and have a significant impact on human health and safety. New methods have been developed to detect microorganisms and toxins, compensating for the limitations of traditional techniques.
Review
Chemistry, Analytical
Rodica Elena Ionescu
Summary: Several biosensors are currently available to detect abnormal levels of specific human biomarkers in research laboratories. Unfortunately, many bodily fluid biomarkers are not yet accessible for public marketing or pharmacy. This overview summarizes the pre-functionalization of solid/flexible supports with cysteamine and glutaraldehyde chemicals for protein immobilization and biomarker detection in body fluids. The study also compares the use of piezoelectrical, electrochemical, and optical transductions for detection. Cys/GA chemistry is widely used in electrochemical sensing applications, while piezoelectric and optical detection show promise for future miniaturized medical devices.
Article
Chemistry, Analytical
Neda Bagheri, Vincenzo Mazzaracchio, Stefano Cinti, Noemi Colozza, Concetta Di Natale, Paolo Antonio Netti, Mohammad Saraji, Simona Roggero, Danila Moscone, Fabiana Arduini
Summary: The research utilizes a paper-based sensor to detect copper ions in bodily fluids, making full use of the environmentally friendly characteristics of filter paper to achieve highly sensitive detection of copper ions. The application in biological matrices demonstrates good accuracy of the novel eco-designed analytical tool.
ANALYTICAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Rossana E. Madrid, Fernando Ashur Ramallo, Daniela E. Barraza, Roberto E. Chaile
Summary: Smart biosensors play an important role in modern healthcare, but the number of patent applications has decreased in recent years. This review presents the latest developments of smartphone-based biosensors and critically analyzes the reasons why many technologies fail to reach the market. Despite significant advancements, commercialized smart biosensors are still rare, indicating a need to strengthen technology transfer, application, and end-user adoption stages.
BIOENGINEERING-BASEL
(2022)
Article
Nanoscience & Nanotechnology
Ujwal K. Thakur, Pawan Kumar, Sergey Gusarov, Alexander E. Kobryn, Saralyn Riddell, Ankur Goswami, Kazi M. Alam, Spencer Savela, Piyush Kar, Thomas Thundat, Alkiviathes Meldrum, Karthik Shankar
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Nanoscience & Nanotechnology
Kazi M. Alam, Pawan Kumar, Sergey Gusarov, Alexander E. Kobryn, Aarat P. Kalra, Sheng Zeng, Ankur Goswami, Thomas Thundat, Karthik Shankar
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Mohammad Moein Mohammadi, Abhishek Kumar, Jun Liu, Yang Liu, Thomas Thundat, Mark T. Swihart
Article
Nanoscience & Nanotechnology
Abhishek Kumar, Mohammad Moein Mohammadi, Yaoli Zhao, Yang Liu, Jun Liu, Thomas Thundat, Mark T. Swihart
Summary: A hydrogen (H-2) sensor based on a Pd NWs @ rGO @ ZIF-8 nanocomposite has been developed, showing high sensitivity and rapid response to 1% H-2 in air through optimized design.
ACS APPLIED NANO MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Syed A. Bukhari, Ryan McGee, Amirhossein Mahdavi, Farid Bensebaa, Liang Zhou, Hyun-Joong Chung, Thomas Thundat, Ankur Goswami
Summary: Vanadium dioxide (VO2) exhibits an insulator to metal transition at 68 degrees C, displaying significant changes in multiple physical properties. By precise strain engineering, the transition temperature can be reduced. A noncontact, all-optical platform is demonstrated to study macroscopic dynamics related to localized structural rearrangements. Multiple stable frequencies of the resonator can be activated at different optical powers and wavelengths, showing potential applications in ultrafast optical switching and intelligent temperature sensors.
ADVANCED ELECTRONIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Abhishek Kumar, Yaoli Zhao, Mohammad Moein Mohammadi, Jun Liu, Thomas Thundat, Mark T. Swihart
Summary: Palladium nanosheets (PdNS) show promising performance in gas sensing applications, especially for detecting H-2 and CO at room temperature. Compared to pure Pd-based sensors, using multiwalled carbon nanotube@PdNS (MWCNT@PdNS) composites can enhance sensor performance.
Article
Chemistry, Multidisciplinary
Abhishek Kumar, Yaoli Zhao, Shema Rachel Abraham, Thomas Thundat, Mark T. Swihart
Summary: A low-cost sensor using Pd alloy nanosheets on paper is developed for sensitive detection of hydrogen gas. The sensor exhibits improved stability and lower detection limit compared to conventional interdigitated electrode-based sensors. This simple manufacturing method opens up possibilities for widespread use in fuel-cell vehicles and related infrastructure.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Abhishek Kumar, Thomas Thundat, Mark T. Swihart
Summary: One-dimensional nanomaterials are widely studied for gas-sensing applications due to their high surface-to-volume ratio and efficient electron transport pathways. In this study, ultrathin PdNWs were synthesized using colloidal solvothermal synthesis and a sensor with fast response, recovery times, stability, and high selectivity for H-2 was fabricated.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Abhishek Kumar, Kaiwen Chen, Thomas Thundat, Mark T. Swihart
Summary: This paper presents a paper-based sensor using ultrathin palladium nanowires for room-temperature hydrogen detection. The polycrystalline PdNWs showed a response of 4.3% and the quasi-single-crystalline PdNWs showed a response of 8% to 1 vol% H2. The sensor demonstrates excellent selectivity, stability, and sensitivity, and has the potential to be a low-cost alternative to current H2-sensing solutions.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yaoli Zhao, Patatri Chakraborty, Ali Passian, Thomas Thundat
Summary: Molecular-level spectroscopy is essential for sensing and imaging applications, but the detection and quantification of minuscule quantities of chemicals are challenging, particularly when they adsorb in low numbers. In this study, a photothermal spectroscopic technique utilizing a microfabricated nanoscale thermocouple junction integrated into a microcantilever was introduced for high selectivity sensing of adsorbates with an attogram detection limit. The temperature variation driving the thermoelectric junction is caused by the nonradiative decay of molecular adsorbates' vibrational states on the tip. The detection of photothermal spectra of physisorbed trinitrotoluene (TNT) and dimethyl methylphosphonate (DMMP) molecules, as well as representative polymers, with an estimated mass of 10^(-18) g was demonstrated.
Article
Engineering, Electrical & Electronic
Sheng-Joue Young, Yi-Hsing Liu, M. D. Nahin Islam Shiblee, Kumkum Ahmed, Lin-Tzu Lai, Larry Nagahara, Thomas Thundat, Tsukasa Yoshida, Sandeep Arya, Hidemitsu Furukawa, Ajit Khosla
ACS APPLIED ELECTRONIC MATERIALS
(2020)
Article
Engineering, Electrical & Electronic
Anuj Kumar, Ankur Goswami, Kirandeep Singh, Ryan McGee, Thomas Thundat, Davinder Kaur
ACS APPLIED ELECTRONIC MATERIALS
(2019)
Article
Electrochemistry
Seonghwan Kim, Thomas Thundat
ELECTROCHEMICAL SOCIETY INTERFACE
(2019)
Article
Chemistry, Multidisciplinary
Jun Liu, Keren Jiang, Lan Nguyen, Zhi Li, Thomas Thundat
MATERIALS HORIZONS
(2019)
Article
Chemistry, Multidisciplinary
Kamalesh Chaudhari, Tripti Ahuja, Vasanthanarayan Murugesan, Vidhya Subramanian, Mohd Azhardin Ganayee, Thomas Thundat, Thalappil Pradeep