Review
Chemistry, Analytical
William R. Heineman, Nicholas Winograd, William B. Jensen
Summary: The article reviews the central role played by Theodore Ted Kuwana and his research group in the invention and early development of spectroelectrochemistry at optically transparent electrodes (OTEs), as well as topics including rapid scan spectrometer development and applications to kinetics of chemical reactions and redox active biological compounds. Relevant work of other contemporary research groups is also presented.
Article
Chemistry, Analytical
Koichiro Takao, Taro Tsubomura
Summary: An optically transparent thin-layer electrode (OTTLE) cell compatible with both absorption and luminescence spectroelectrochemistry was developed and its effectiveness was demonstrated through experiments in both absorption and luminescence spectroelectrochemistry.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Instruments & Instrumentation
Luis G. Vieira
Summary: Comprehensive modeling of non-polarized infrared attenuated total reflection spectrum based on Fresnel equations and wavenumber-dependent dielectric function models is proven to be an effective method to retrieve optical functions. The method is validated and its reliability is demonstrated by comparing the computed refractive index of water with literature data.
APPLIED SPECTROSCOPY
(2023)
Article
Instruments & Instrumentation
Polina Fomina, Antoni Femenias, Michael Hlavatsch, Julian Scheuermann, Nicolas Schaefer, Stephan Freitag, Nageshvar Patel, Achim Kohler, Rudolf Krska, Johannes Koeth, Boris Mizaikoff
Summary: The analytical performance of a compact infrared attenuated total reflection spectrometer using a pyroelectric detector array has been evaluated and compared to a conventional laboratory Fourier transform infrared system for applications in food analysis. Analytical characteristics including sensitivity, repeatability, linearity of the calibration functions, signal-to-noise ratio, and spectral resolution have been derived for both approaches. Representative analytes of relevance in food industries (i.e., organic solvents, fatty acids, and mycotoxins) have been used for the assessment of the performance of the device and to discuss the potential of this technology in food and feed analysis.
APPLIED SPECTROSCOPY
(2023)
Article
Biochemical Research Methods
Rimante Bandzeviciute, Gerald Steiner, Katja Liedel, Jonas Golde, Edmund Koch, Thilo Welsch, Christoph Kahlert, Daniel E. Stange, Marius Distler, Jurgen Weitz, Justinas Ceponkus, Valdas Sablinskas, Christian Teske
Summary: This study demonstrates the application of fiber-based attenuated total reflection infrared (ATR IR) spectroscopy for label-free discrimination of normal pancreatic, tumorous, and pancreatitis tissue. A classification model was established for differentiating between the distinct tissue classes using unprocessed freshly resected tissue samples of 58 patients. The method was further translated into intraoperative application, obtaining fiber optic ATR IR spectra directly in the operating room from freshly resected pancreatic tissue.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Instruments & Instrumentation
Thulya Chakkumpulakkal Puthan Veettil, Kamila Kochan, Karen J. Edler, Paul De Bank, Philip Heraud, Bayden R. Wood
Summary: Malaria is a significant global health concern, and vibrational spectroscopy shows promise as a rapid and cost-effective tool for early detection. Improvements are needed in the measurement procedures and sample preparation to enhance the efficiency of screening for parasitic infections.
APPLIED SPECTROSCOPY
(2022)
Article
Food Science & Technology
Christopher Karim Akhgar, Vanessa Nuernberger, Marlene Nadvornik, Margit Velik, Andreas Schwaighofer, Erwin Rosenberg, Bernhard Lendl
Summary: A novel approach for mid-IR based prediction of bovine milk fatty acid composition was introduced in this study using a rapid, solvent-free two-step centrifugation method along with ATR-FT-IR spectroscopy. The PLS regression models showed good predictions for fatty acid sum parameters and individual fatty acids, with significantly better performance compared to literature using whole milk transmission spectra. This combination of solvent-free lipid separation and ATR-FT-IR spectroscopy represents a fast and high-throughput method for fatty acid prediction.
Article
Materials Science, Multidisciplinary
Kai Shi, Junhong Su, Haifeng Liang, Kai Hu, Junqi Xu
Summary: A transparent electromagnetic shielding method based on graphene mesh structure is proposed, which maintains high optical transmittance while having good electromagnetic shielding effectiveness.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Instruments & Instrumentation
Luis G. Vieira
Summary: This article presents a method for measuring the optical functions of a flat sample made of homogeneous and isotropic material using attenuated total reflection spectroscopy when there is poor contact between the sample and the internal reflection element. The method treats the spacing between the internal reflection element and the sample as an adjustable parameter in the fitting of s- and p-polarized spectra obtained when the gap distance is unknown. The method's ability to accurately determine the optical functions is demonstrated through testing with synthetic and experimental spectra (polystyrene).
APPLIED SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Ryo Hosoda, Naoki Kamoshida, Nagahiro Hoshi, Yasuaki Einaga, Masashi Nakamura
Summary: The oxidation of dopamine on a boron-doped diamond electrode was investigated using in situ attenuated total reflection infrared spectroscopy and infrared reflection absorption spectroscopy. The study revealed that dopamine oxidation led to polymerization and the continuous deposition of polymerized dopamine on the electrode, resulting in irreversible behavior of the voltammogram.
Article
Chemistry, Multidisciplinary
Umberto Celano, Hai Zhong, Florin Ciubotaru, Laurentiu Stoleriu, Alexander Stark, Peter Rickhaus, Felipe Favaro de Oliveira, Mathieu Munsch, Paola Favia, Maxim Korytov, Patricia Van Marcke, Patrick Maletinsky, Christoph Adelmann, Paul van der Heide
Summary: In this study, nonperturbative field distribution mapping in ultra-scaled magnetic nanowires with diameters down to 6 nm was achieved using scanning nitrogen-vacancy magnetometry, enabling localized, minimally invasive magnetic imaging with sensitivity down to 3 μT Hz(-1/2). The imaging revealed the presence of weak magnetic inhomogeneities inside in-plane magnetized nanowires, largely undetectable with standard metrology. The strong magnetic field confinement in the nanowires allowed for the study of the interaction between the stray magnetic field and the nitrogen-vacancy sensor, clarifying the formation mechanisms for technologically relevant magnetic nanostructures.
Article
Instruments & Instrumentation
Md S. Azam, Malcolm D. Ranson, Dennis K. Hore
Summary: This paper demonstrates a simple method to calibrate attenuated total internal reflection infrared absorbance measurement using a commonly available reference sample such as water. The calibration takes into consideration the polarization of the incident beam and the spread of angles about the nominal angle of incidence. The calibrated measurements enable quantitative comparison with spectra calculated from optical constants, and the method is applied to temperature-dependent absorption spectra of a polydimethylsiloxane sample, showing better correlation between the extracted optical constants and temperature-dependent changes in polymer density than the raw absorbance values on vibrational resonance.
APPLIED SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Andrea Teuber, Boris Mizaikoff
Summary: The RobustATR is a compact and robust infrared attenuated total reflectance (IR-ATR) accessory, which uniquely integrates substrate-integrated hollow waveguides (iHWG) for efficient coupling to quantum cascade laser (QCL) light sources. It is particularly suitable for real-world application scenarios.
APPLIED SCIENCES-BASEL
(2022)
Article
Instruments & Instrumentation
Christopher K. Akhgar, Vanessa Nuernberger, Marlene Nadvornik, Victoria Ramos-Garcia, Isabel Ten-Domenech, Julia Kuligowski, Andreas Schwaighofer, Erwin Rosenberg, Bernhard Lendl
Summary: This study presents a novel method for determining the fatty acid composition of human milk using mid-infrared spectroscopy. By analyzing the absorbance spectra of pure milk fat recorded via attenuated total reflection Fourier transform infrared spectroscopy and combining the results with gas chromatography-mass spectrometry measurements, multivariate regression equations were established to predict fatty acid concentrations. The method achieved good predictions for various important fatty acid parameters, demonstrating its high accuracy.
APPLIED SPECTROSCOPY
(2022)
Article
Instruments & Instrumentation
Linying Zhong, Mingshan Xu, Suqin Sun, Qun Zhou, Ling Dong, Jianbo Chen
Summary: Herbal powder preparations (HPPs) are commonly used in traditional medicine, and their safety and efficacy can be ensured through the use of attenuated total reflection Fourier transform infrared spectroscopy (ATR FT-IR) imaging or mapping. This method allows for the individual measurement of different ingredients in an HPP sample, increasing the specificity and sensitivity of infrared spectral identification. The ATR FT-IR mapping method has been successfully used to identify prescribed and abnormal ingredients in oral ulcer pulvis, demonstrating its feasibility and effectiveness in the identification of HPPs.
APPLIED SPECTROSCOPY
(2023)
Review
Chemistry, Analytical
Maria Chiara Sportelli, Christine Kranz, Boris Mizaikoff, Nicola Ciof
Summary: Biofilms are a major cause of health and environmental issues, with bacteria in biofilms showing greater resistance to biocides. Spectroscopic techniques play a crucial role in understanding biofilm formation. This review discusses recent progress and advantages/disadvantages of spectroscopic approaches for studying biofilms.
ANALYTICA CHIMICA ACTA
(2022)
Article
Instruments & Instrumentation
Andrea Teuber, Robert Stach, Julian Haas, Boris Mizaikoff
Summary: The innovative mid-infrared spectroscopic sensor system developed based on quantum cascade lasers combines the versatility of substrate-integrated hollow waveguides with the robustness of attenuated total reflection crystals. This novel assembly enables evanescent field absorption measurements under unprecedented harsh conditions, making it ideal for field applications where robustness and optical alignment are essential.
APPLIED SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Anele Mpupa, Azile Nqombolo, Boris Mizaikoff, Philiswa Nosizo Nomngongo
Summary: A magnetic activated carbon adsorbent decorated with beta-cyclodextrin was prepared and used in the preconcentration of hormones in wastewater samples. The method was optimized and demonstrated high potential for efficient quantification of multiple hormones.
Article
Chemistry, Multidisciplinary
Alex D. Batista, Soumya Rajpal, Benedikt Keitel, Sandra Dietl, Beatriz Fresco-Cala, Mehmet Dinc, Rudiger Gross, Harald Sobek, Jan Munch, Boris Mizaikoff
Summary: This study developed epitope-imprinted polymers for selective binding of SARS-CoV-2, demonstrating high selectivity and potential applications in chem/biosensing and antiviral delivery.
ADVANCED MATERIALS INTERFACES
(2022)
Review
Chemistry, Analytical
Polina S. Fomina, Mikhail A. Proskurnin, Boris Mizaikoff, Dmitry S. Volkov
Summary: This review discusses the analytical capabilities of Fourier-transform infrared spectroscopic techniques for analyzing aqueous solutions and provides examples.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Giada Caniglia, Andrea Teuber, Holger Barth, Boris Mizaikoff, Christine Kranz
Summary: This study investigates the relationship between the adhesion properties of polydopamine films and their surface charge density and pH using atomic force microscopy and attenuated total reflection-Fourier transform infrared spectroscopy. The study also explores the impact of polydopamine surface charge density on bacterial adhesion and biofilm formation.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Optics
Dominik Theiner, Benedikt Limbacher, Michael Jaidl, Marie Ertl, Michael Hlavatsch, Karl Unterrainer, Boris Mizaikoff, Juraj Darmo
Summary: We present a flexible molecular sensing platform in the terahertz range, achieved by merging near-infrared electro-optic modulation and photomixing technologies. The platform utilizes a new generation of compact gas cells called substrate-integrated hollow waveguides (iHWGs), which have been developed for the mid-infrared. We demonstrate the suitability of iHWGs for the terahertz domain by showcasing their low propagation losses and measuring rotational transitions of nitrous oxide (N2O). A fast frequency sideband modulation technique is employed, resulting in significantly reduced measurement times and increased accuracy compared to a standard wavelength tuning method.
Article
Chemistry, Multidisciplinary
Andrea Teuber, Giada Caniglia, Michael Wild, Matthias Godejohann, Christine Kranz, Boris Mizaikoff
Summary: Diamond thin-film waveguides with a nanocrystalline diamond layer were used to detect the IR signature of caffeine in the mid-infrared regime. The morphological properties of the waveguides were characterized using AFM and SEM, and theoretical simulations confirmed the feasibility of using a larger sensing area compared to strip waveguides. A comparative analysis confirmed the performance of the diamond thin-film-waveguide-based sensing system, indicating its potential for various applications.
Article
Chemistry, Analytical
Andrea Teuber, Giada Caniglia, Holger Barth, Christine Kranz, Boris Mizaikoff
Summary: Bacterial sensing based on quantum cascade laser spectroscopy coupled with diamond or gallium arsenide thin-film waveguides is a novel approach for obtaining high-resolution infrared spectroscopic information of bacteria. In this study, Escherichia coli was used as an example, and the laser spectroscopy was compared to conventional Fourier transform infrared spectroscopy. The proliferation behavior of E. coli on the surfaces was also investigated using atomic force microscopy and scanning electron microscopy.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sarah Klingler, Benedikt Bagemihl, Alexander K. Mengele, Simon Kaufhold, Pasi Myllyperkioe, Jussi Ahokas, Mika Pettersson, Sven Rau, Boris Mizaikoff
Summary: Currently, the efficient and economical utilization of photosensitizers and catalysts based on rare earth metals in artificial photosynthesis is a major concern. Although repairing inactivated catalysts is a potential solution, it remains a challenge. The study introduces an innovative in situ technique using non-invasive rotational Raman spectroscopy to accurately monitor initially evolved hydrogen and gas reaction products after active repair, providing valuable insights into the mechanism of active repair during light-driven catalysis and enabling the identification of relevant mechanistic details and innovative repair strategies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Analytical
Michael Hlavatsch, Andrea Teuber, Max Eisele, Boris Mizaikoff
Summary: In this study, the combination of a tunable broadband mid-infrared femtosecond laser source with different sensors for liquid and gas samples is demonstrated. The light source is highly sensitive and suitable for quantitative analysis.
ACS MEASUREMENT SCIENCE AU
(2023)
Article
Chemistry, Analytical
Tingting Zhang, Rui Lu, Gongying Wang, Xiuyun Sun, Jiansheng Li, Boris Mizaikoff
Summary: A facile and sensitive glucose sandwich assay using surface-enhanced Raman scattering (SERS) was developed. Glucose was captured by 3-aminopheyonyl boronic acid (APBA) modified Ag nanoparticles decorated onto a polyamide surface. APBA forms specific cis-diol compounds with glucose molecules avoiding interference by other saccharides and biomolecules in urine enabling its selective detection. AEPO exhibited a distinctive SERS peak in the Raman silent region, thus increasing the sensitivity of the glucose detection to 10(-11) M. The developed SERS assay was reusable and showed potential as a diagnostic tool for glucose sensing in clinical applications.
Article
Chemistry, Analytical
Andrea Teuber, Giada Caniglia, Christine Kranz, Boris Mizaikoff
Summary: Diamond thin-film waveguides combined with quantum cascade lasers augmented by drop-casted graphene enable surface-enhanced infrared absorption spectroscopy, enhancing the signal for analytical scenarios with small sample volumes and low analyte concentration levels.
Article
Chemistry, Analytical
Igor J. G. da Silva, Ivo M. Raimundo, Boris Mizaikoff
Summary: In this study, a THz-TDS spectrometer with ASOPS technology was used to explore the potential of this technique for the identification of saccharides. Linear analytical curves were obtained in the concentration range of 1.7 to 11.7 (w/w). Gaussian peak fitting was employed to aid in the identification of saccharide components in mixtures. The results showed that the region between 0.5 and 2.0 THz is more suitable for analysis and scattering is less evident within this range.
ANALYTICAL METHODS
(2022)
Article
Materials Science, Biomaterials
Soumya Rajpal, Boris Mizaikoff
Summary: In this study, a molecular mechanics based multi-monomer simultaneous docking approach (MMSD) was introduced to computationally screen monomer combinations for selective molecular imprints. The predictive potential of the MMSD approach for peptide imprinting was validated experimentally, and the predicted scores were obtained for polymer combinations.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)