Article
Environmental Sciences
Mingxuan Jia, Boyu Jia, Xiaofang Liao, Linchun Shi, Zheng Zhang, Miao Liu, Lidong Zhou, Donghui Li, Weijun Kong
Summary: A CdSe@CdS quantum dots-based label-free ECL aptasensor was developed for specific and sensitive detection of OTA, with excellent stability and strong ECL intensity. The sensor showed superior sensitivity for OTA with a wide linear concentration range after optimizing crucial conditions, demonstrating potential for various applications.
Article
Chemistry, Analytical
Shu-Han Chang, Hanene Salmi-Mani, Philippe Roger, Sue-min Chang
Summary: A fluorescent microgel for BPA detection was developed by crosslinking poly(styrene-co-glycidyl methacrylate) with CdSe quantum dots. The microgel demonstrated high sensitivity and selectivity towards BPA molecules through specific binding sites. It had a wide dynamic detection range and low detection limit, and outperformed other structural analogues.
Article
Food Science & Technology
Shasha Feng, Wei Hu, Fubin Pei, Zhiwei Liu, Bin Du, Xihui Mu, Bing Liu, Qingli Hao, Wu Lei, Zhaoyang Tong
Summary: A sensitive dual-readout immunosensor combining fluorescence and electrochemiluminescence (ECL) detection was developed for ricin detection. The sensor utilized CdSe/ZnS quantum dots as dual-signal function probes and a streptavidin-biotin signal amplification system. The sensor exhibited high sensitivity and could successfully detect ricin in complex matrices.
Article
Chemistry, Analytical
Xiang Hu, Ying Wang, Xiong Zuping, Pei Song, Ai-Jun Wang, Zhaosheng Qian, Pei-Xin Yuan, Tiejun Zhao, Jiu-Ju Feng
Summary: In this study, an aggregation-enhanced PEC photosensitizer PPIX-[BMIm] was prepared by electrostatic bonding, and its PEC performance in a binary solvent of water and DMSO was studied. A label-free PEC cytosensor was built using PPIX-[BMIm], which showed a wide linear range and low limit of detection for detecting leukemia cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhi Jian Zheng, Li Zhang, Li Zhi Wang, Zu Qi Zhong, Yu Tian Xiong, Jing Guo, Zhi Bin Zhang, Xiao Hong Cao, Sai Jin Xiao
Summary: Rapid, sensitive, and portable uranium detection is essential for effectively controlling and monitoring uranium contamination caused by increasing amounts of uranium-containing waste from nuclear power. The introduction of abundant oxygen- and nitrogen-containing groups to molybdenum oxide quantum dots with dopamine modification significantly increased detection sensitivity and binding affinity for uranium. The DA-functionalized MoOx quantum dots showed a 1000-fold increase in sensitivity compared to MoOx QDs alone, with a detection limit of 3.85 nM, making it a promising method for uranium contamination control and monitoring.
Article
Chemistry, Physical
Shaomei Linghu, Ziyong Wu, Yuan Zhu, Huaju Song, Ying Wang, Zhiping Zhou, Yun Shan
Summary: This study reports the strong and stable anodic electrochemiluminescence (ECL) generated from Mn2+ doped CdS nanocrystal films on an indium tin oxide (ITO) electrode. The Mn2+ doping significantly enhances the anodic ECL intensity due to efficient Mn excitation via nonradiative recombination energy transfer. This anodic ECL can be used for the detection of dopamine with a wide linear range and low detection limit. This work provides new insights into ECL generation in doped semiconductor nanocrystals, showing the potential of Mn2+ doped CdS nanocrystals in the development of biosensors.
SURFACES AND INTERFACES
(2022)
Article
Biophysics
Zhuoxin Ye, Yibing Liu, Meichen Pan, Xiuli Tao, Yuxuan Chen, Pinyi Ma, Ying Zhuo, Daqian Song
Summary: In this study, low-toxic quaternary AgInZnS quantum dots were synthesized and used as novel anodic electrochemiluminescence (ECL) emitters. These QDs exhibited strong and stable ECL emission, a low excitation potential, and high ECL efficiency. An on-off-on ECL biosensor for detecting microRNA-141 was designed based on a dual isothermal enzyme-free strand displacement reaction, achieving cyclic amplification of the target and ECL signal, as well as a switch function. The ECL biosensor showed a wide linear range and low detection limit, making it a promising tool for rapid and accurate diagnosis of clinical diseases.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Yongjuan Meng, Jinling Pu, Jiamei Gan, Jianping Li
Summary: A composite of ZIF-8 doped with CdSe quantum dots was synthesized, and a molecularly imprinted electrochemiluminescence sensor was constructed. The sensor showed high sensitivity and specificity for the detection of estriol, with a detection limit of 8.9 x 10(-16) mol L-1. It was successfully applied in the determination of estriol in serum samples.
Article
Chemistry, Multidisciplinary
Zheng Yanyan, Jing Lin, Liuhong Xie, Hongliang Tang, Kailong Wang, Jiyang Liu
Summary: A simple and efficient synthesis method for graphene quantum dots (GQDs) with anodic electrochemiluminescence (ECL) has been a challenge. The study presents an anodic ECL-sensing platform based on nitrogen-doped GQDs (N-GQDs) for sensitive detection of hydrogen peroxide (H2O2) and glucose, with a simple and green synthesis approach yielding high production. The N-GQDs exhibit high ECL activity for H2O2 detection and can also be used for sensitive glucose detection due to the production of H2O2 during glucose oxidation.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Arun Ashokan, Paul Mulvaney
Summary: Solution-phase spectroelectrochemistry was used to study electron injection into colloidal CdSe quantum dots in THF. The results showed reversible optical changes on a time-scale of minutes, with the injection of electrons leading to quenching of photoluminescence. The number of electrons injected into the QDs depended on the electrode potential and QD size, with most injection occurring below the band edge.
CHEMISTRY OF MATERIALS
(2021)
Article
Spectroscopy
Xin Liu, Wei Yu, Xiaowei Mu, Wei Zhang, Xinghua Wang, Qiang Gu
Summary: A rapid and sensitive strategy for sensing dopamine (DA) was proposed based on the fluorescence quenching effects of polydopamine (PDA) on carbon dots (CDs). The green-emission fluorescence CDs were synthesized via a facile one-pot hydrothermal approach. The proposed fluorescence probe exhibits good selectivity and sensitivity to DA in a wide concentration range, making it a potential tool for diagnosing DA-related diseases.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Li Wang, Wei-Jia Zeng, Xia Yang, Ruo Yuan, Wen-Bin Liang, Ying Zhuo
Summary: In this work, luminescent groups rich carbon dots (Lu-CDs) were synthesized by incorporating luminol into the CDs, resulting in a significantly enhanced electrochemiluminescent (ECL) performance. The ECL emission of Lu-CDs showed excellent consistency with its fluorescence emission, unlike other surface state-dominated CDs. Furthermore, Lu-CDs were used to develop an ECL biosensor for tumor cell analysis, demonstrating a wide detection range and low detection limit.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ali Firoozbakhtian, Morteza Hosseini, Mahsa Naghavi Sheikholeslami, Foad Salehnia, Guobao Xu, Hodjattallah Rabbani, Ebtesam Sobhanie
Summary: The rapid spread of SARS-CoV-2 has raised the need for efficient and rapid diagnostic tools. In this study, an electrochemiluminescence (ECL)-based detection system was developed and trained using machine learning algorithms to accurately diagnose COVID-19 with over 90% accuracy. The system provides a cost-effective and time-saving alternative to traditional testing methods.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Quanxiu Zhou, Zhaofa Li, Qunfang Wang, Liang Peng, Shihe Luo, Feng Long Gu
Summary: In this study, poly(styrene-co-maleic anhydride)-capped CdSe/ZnS quantum dots aminolyzed with ethanolamine were proposed as fluorescent probes for the detection of Cu2+ and Hg2+, with different quenching mechanisms discussed. The coordination abilities of the surface polymer of CdSe/ZnS QDs and the two metal ions were calculated using density functional theory. The probes showed high sensitivity to both Cu2+ and Hg2+, with fast response times and the ability to detect the ions within minutes.
ANALYTICAL METHODS
(2021)
Article
Spectroscopy
Chaoshuai Hu, Yaming Zhu, Xuefei Zhao
Summary: Novel nitrogen-doped carbon quantum dots (N-CQDs) were synthesized for highly sensitive fluorescent on-off-on switch sensor to selectively and simultaneously detect Cu2+ and Fe3+. The N-CQDs exhibited outstanding optical properties and high optical stability within the pH range of 4-10, with detection limits for Cu2+ and Fe3+ at 0.16 µM and 0.173 µM, respectively.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Yu Du, Xiaoyue Zhang, Yue Jia, Rui Feng, Tingting Wu, Nuo Zhang, Huangxian Ju
Summary: The researchers proposed a host-guest recognition strategy to enhance the electrochemiluminescence (ECL) efficiency and stability of gold nanoclusters (AuNCs). The prepared AuNCs showed improved ECL emission efficiency and stability, and exhibited excellent sensing results for D-dimer.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chao Wang, Songqin Liu, Huangxian Ju
Summary: This article reviews the origin and development of electrochemiluminescent nanoemitters and their application in sensitive detection of protein biomarkers. It specifically focuses on metal-organic frameworks (MOFs)-based nanoemitters and discusses effective strategies to enhance the electrochemiluminescent response and improve immunosensing sensitivity. The article comprehensively presents the application of electrochemiluminescent nanoemitters in the diagnosis of cancers and other diseases, particularly lung cancer and heart diseases. The recent advancement of electrochemiluminescent imaging with nanoemitters for the detection of multiplex protein biomarkers on single cell membranes is also highlighted. Finally, the future opportunities and challenges in the field of electrochemiluminescent biosensing are discussed.
BIOELECTROCHEMISTRY
(2023)
Article
Chemistry, Analytical
Ze-Rui Zhou, Da-Wei Li, Ruo-Can Qian, Huangxian Ju
Summary: We developed a DNAzyme-powered DNA walker to visualize the cooperative expression of mutant p53 and telomerase in living cells. The DNA walker allows for real-time monitoring of mutant p53 and active telomerase expression in cancer cells, providing new insights into the study of cancer pathway-relevant biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Lele Li, Siqi Yu, Jie Wu, Huangxian Ju
Summary: We developed a sensitive electrochemiluminescence (ECL) biosensing strategy for the detection of activated CRISPR/Cas12a using polymer dots (Pdots) as emitters. The strategy involves the regulation of binding between Pdots-DNA and a biosensor, and the enhancement of ECL emission through the local surface plasmon resonance (LSPR) effect of electrochemically deposited Au nanoparticles (depAuNPs). The integration of target DNA-triggered catalysis and the LSPR effect greatly improves the sensitivity of ECL analysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Weisu Kong, Da Zhu, Yong Zhang, Rengan Luo, Jing Ma, Jianping Lei, Huangxian Ju
Summary: To improve the photoelectrochemical performance, an additional electron donor/acceptor is typically needed to suppress electron-hole recombination. However, the enhancement is limited due to long-distance diffusion. In this study, a self-supplying electron strategy is designed by coordinating an electron donor 1.4-diazabicyclo[2.2.2]octane (Dabco) in a metal-organic framework (MOF) to enhance PEC performance. The presence of Dabco effectively inhibits electron-hole recombination and leads to a 23.2-fold enhancement in photocurrent. This work provides a new approach for improving the PEC performance of nanomaterials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Shiyi Bi, Wei Chen, Yanyun Fang, Yingfei Wang, Qing Zhang, Hongqian Guo, Huangxian Ju, Ying Liu
Summary: Clustering of cell membrane receptors can regulate cell behaviors. This study presents a Raji cell Selective MAnipulation of Receptor Clustering (SMARC) strategy for CD20, which is driven by endogenous secretion of Raji cells. The strategy utilizes retractable DNA nanostrings anchored to the cell membrane CD20, which contract in response to Raji cell-secreted VEGF with corresponding CD20 clustering. The SMARC strategy selectively induces apoptosis in Raji cells with minimal interference to normal B cells, and shows promising in vivo therapeutic efficacy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Nan Feng, Yiran Li, Jiahui Sun, Haiqi Wang, Qiulin Ma, Jingxing Guo, Huangxian Ju
Summary: We developed a mass spectrometric protocol for in situ biosensing of multiple enzyme secretions by inserting tentacle-like nanoprobes on live cells. This technique allows for rapid detection of secreted enzymes and has promising applications.
Review
Chemistry, Multidisciplinary
Rengan Luo, Da Zhu, Huangxian Ju, Jianping Lei
Summary: Electrochemiluminescence (ECL) is a powerful technique that relies on charge transfer between electrochemical intermediates and co-reactants/emitters to form excited emitters. The development of molecular nanocrystals, such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), has allowed for the exploration of ECL mechanisms and enhancement strategies. Reticular crystalline nanoemitters with different topologies provide a platform for understanding ECL fundamentals and designing next-generation ECL devices.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Analytical
Xue Wang, Dongquan Leng, Faying Li, Lei Liu, Xiang Ren, Jin Yong Lee, Huangxian Ju, Qin Wei
Summary: An efficient photoelectrochemical (PEC) split-type sensor based on a controlled release strategy was successfully established for ultrasensitive and accurate physiological monitoring, with improved visible light absorption efficiency and stability. The sensor separated the immune reaction from the photoelectrochemical conversion process, eliminating interference. The use of Cu2O nanocubes as labels and acid etching improved the sensitivity of the sensor. Under optimized conditions, the PEC sensor showed a wide concentration linear range and a low detection limit for CYFRA21-1 target detection.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Shiya Zhao, Yuanjiao Yang, Yuru Wang, Huipu Liu, Huangxian Ju, Yunlong Chen
Summary: This study presents a functional dendrimer probe that can conveniently detect newly generated sialic acid groups in vivo using a dual-color imaging strategy. It enables the in situ semiquantitative evaluation of sialylation differences between tumor and normal tissues, allowing the investigation of sialylation-related biological events and facilitating clinical tumor diagnosis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jun Sun, Jie Wu, Huangxian Ju
Summary: The motion ability of enzyme-powered micro/nanomotors is primarily determined by the size of the silica rather than the asymmetric coating of the enzyme. Silica micro/nanomotors at sizes of 500 nm and 2 μm show significant increases in diffusion coefficient, while those larger than 5 μm do not exhibit self-propulsion behavior at all. Although asymmetry enhances the diffusion of the micro/nanomotors, only those at a size of 2 μm are sensitive to the level of asymmetry.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Analytical
Xue Dong, Xiaoyue Zhang, Xiang Ren, Hongmin Ma, Nuo Zhang, Faying Li, Huangxian Ju, Qin Wei
Summary: In this study, a bandgap-regulated ECL enhancement strategy was developed to improve the ECL efficiency of ZrO2. Through the synthesis of ZrCuO3, which exhibited a narrower bandgap and higher electron transfer efficiency, the ECL efficiency of ZrO2 was enhanced. This strategy provides a novel approach for the sensitive detection of target substances.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Yuanjiao Yang, Shan Wu, Yunlong Chen, Huangxian Ju
Summary: The detection and mapping of cellular biomarkers is crucial for understanding physiological and pathological processes. SERS technology, with its high sensitivity and multiplex detection capabilities, has emerged as a powerful tool for this purpose.
Article
Chemistry, Multidisciplinary
Farukh Mansoor, Huangxian Ju, Madiha Saeed, Shamsa Kanwal
Summary: This work explores a new precursor for the facile synthesis of gold nanocubes by controlling the morphology of silver nanocubes. The Ag@4MBA@AuNCs nanostructure exhibits a 1010-times enhancement in surface enhanced Raman scattering (SERS) signal, making it a highly sensitive imaging probe for the detection of breast cancer cells. Additionally, this study achieves the catalytic reduction of toxic chemicals through the incorporation of alloy nanoparticles.
Article
Chemistry, Analytical
Jiajun Liu, Yu Du, Aiping Guo, Nuo Zhang, Lei Liu, Dawei Fan, Xue Dong, Qin Wei, Huangxian Ju
Summary: In this study, a sandwich sensing platform was developed using silica-coated silver nanoparticles as a luminescent material and cerium dioxide as a signal quencher for sensitive neuro-specific enolase detection. The core-shell structure protected the silver nanoparticles and improved their luminescence properties. Amino-functionalized cerium dioxide efficiently diminished the luminescence signal, resulting in a highly sensitive and accurate detection mode. This detection strategy showed a powerful capability for biomolecule detection.
