期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 305, 期 2, 页码 217-223出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2014.12.019
关键词
Peptidoglycan; PAMP; Immune defence; Muropeptide signalling; PGN hydrolases
资金
- Deutsche Forschungs-gemeinschaft (DFG) (SFB: Collaborative Research Consortium) [Sonderforschungsbereich 766]
Most Eubacteria possess peptidoglycan (PGN) or murein that surrounds the cytoplasmic membrane. While on the one hand this PGN sacculus is a very protective shield that provides resistance to the internal turgor and adverse effects of the environment, it serves on the other hand as a major pattern of recognition due to its unique structure. Eukaryotes harness this particular bacterial macromolecule to perceive (pathogenic) microorganisms and initiate their immune defence. PGN fragments are generated by bacteria as turnover products during bacterial cell wall growth and these fragments can be sensed by plants and animals to assess a potential bacterial threat. To increase the sensitivity the concentration of PGN fragments can be amplified by host hydrolytic enzymes such as lysozyine or amidase. But also bacteria themselves are able to perceive information about the state of their cell wall by sensing small soluble fragments released from its PGN, which eventually leads to the induction of antibiotic responses or cell differentiation. How PGN is sensed by bacteria, plants and animals, and how the antibacterial defence is modulated by PGN perception is the issue of this review. (C) 2015 Elsevier GmbH. All rights reserved.
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