Article
Genetics & Heredity
Chi Kin Law, Anne E. Cust, Amelia K. Smit, Lyndal Trevena, Pablo Fernandez-Penas, Omgo E. Nieweg, Alexander M. Menzies, Sarah Wordsworth, Managing Your Risk Study Grp
Summary: This study evaluates the long-term cost-effectiveness of a melanoma prevention program using personalized genomic risk provision and genetic counseling. The results show that targeting high-risk individuals with genomic risk provision is a cost-effective strategy for reducing sunburns.
GENETICS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Eliana L. Fernandez-Quiroz, Lizeth Gonzales-Chachapoyas, Ana L. Alcantara-Diaz, Binz Bulnes-Villalta, Zulmy Ayala-Porras, Carlos J. Toro-Huamanchumo
Summary: Three out of five beachgoers in the northern coast of Peru had one or more sunburns last summer. Factors associated with a higher sunburn frequency include prolonged sun exposure at the beach and irregular use of a hat or cap. Skin Phototypes III-IV were associated with a lower frequency of sunburns.
Article
Health Care Sciences & Services
Raimund Winter, Alexandru Tuca, Paul Wurzer, Caroline Schaunig, Isabelle Sawetz, Judith C. J. Holzer-Geissler, Daniel Georg Gmainer, Hanna Luze, Herwig Friedl, Erika Richtig, Lars-Peter Kamolz, David Benjamin Lumenta
Summary: For patients undergoing completion axillary lymph node dissection for melanoma, removing drains around the 8th postoperative day can reduce the risk of seroma formation and related complications. Most complications can be managed conservatively, with only a small percentage requiring revision surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nutrition & Dietetics
Hee Yul Lee, Eun-Jin Kim, Du Yong Cho, Jea Gack Jung, Min Ju Kim, Jin Hwan Lee, Wanil Kim, Sang Soo Kang, Kye Man Cho, Dawon Kang
Summary: This study assessed the efficacy of fermented and aged mountain-cultivated ginseng sprouts (FAMCGSs) as an inner beauty enhancing food. Results showed that FAMCGSs significantly reduced UVB-induced skin aging in mice, suggesting their potential as a food that promotes inner beauty and protects against UVB-induced photoaging.
Review
Dermatology
Megan H. Trager, Larisa J. Geskin, Faramarz H. Samie, Liang Liu
Summary: The rates of melanoma and non-melanoma skin cancer in the United States have been increasing due to increased ultraviolet radiation exposure. However, skin cancer prevention remains challenging due to the lack of reliable risk assessment methods. There has been significant interest in developing biomarkers for UV exposure in order to improve early detection of skin malignancies.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Oncology
Marie Fournier, Laurent Mortier, Olivier Dereure, Sophie Dalac, Bastien Oriano, Stephane Dalle, Celeste Lebbe
Summary: This study suggests that HPD may be a subtype of disease characterized by rapid deterioration, and can be alleviated by strong-acting treatments.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
Dimitri Kasakovski, Marina Skrygan, Thilo Gambichler, Laura Susok
Summary: Cutaneous Melanoma (CM) is an aggressive cancer originating from pigment-producing melanocytes in the skin, with high metastatic potential. Although it represents a small fraction of skin cancers, it accounts for most skin-cancer-related deaths globally. Immune checkpoint inhibition has been a significant therapeutic approach, but challenges such as the immunosuppressive tumor microenvironment and treatment resistance persist. Combining local and systemic treatments can enhance therapeutic response and overcome resistance, yet complex drug combinations may increase the risk of immune-related adverse events.
Review
Oncology
Lin Li, Baoqiang Pei, Yanyan Feng
Summary: This study found that the use of exogenous hormones is associated with an increased risk of keratinocyte carcinoma (KC), specifically squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), among women. Oral contraceptives (OC) were found to increase the risk of SCC, while no significant association was observed between hormonal replacement therapy (HRT) and SCC risk. Both OC and HRT use were linked to an increased risk of BCC.
Review
Oncology
Anna Fateeva, Kevinn Eddy, Suzie Chen
Summary: This review discusses the available therapeutic options for melanoma, including current treatment modalities and exploring the potential of exploiting glutamatergic signaling for developing new treatments.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Article
Dermatology
Katsuhiko Tsuchida, Natsuki Sakiyama, Yuki Ogura, Masaki Kobayashi
Summary: Human skin is exposed to UVA in sunlight, which leads to oxidative stress associated with skin disorders and aging. This study investigated the effects of skin color on UVA-induced oxidative stress using ultraweak photon emission. The results showed that lighter skin exhibited higher oxidative stress and the stress persisted for a longer time compared to darker skin.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Smitha Sivapragasam, Bastian Stark, Amanda Albrecht, Kaitlynne A. Bohm, Peng Mao, Raymond G. Emehiser, Steven A. Roberts, Patrick J. Hrdlicka, Gregory M. K. Poon, John J. Wyrick
Summary: Somatic mutations in DNA-binding sites for CTCF are elevated in many cancers, possibly due to its role in inhibiting repair of UV damage and modulating the formation of UV-induced DNA damage, leading to mutation hot spots. Analysis demonstrates that CTCF interacts with damaged DNA and hinders repair, providing insights into the molecular mechanisms of how CTCF binding influences CPD formation.
Review
Oncology
Ronan Talty, Marcus Rosenberg
Summary: Melanoma is a deadly form of skin cancer with current treatments not benefiting all patients. Ferroptosis, a newly identified iron-dependent cell death form, is linked to the development of several cancers including melanoma. Future directions in melanoma treatment may involve targeting ferroptosis to improve outcomes.
PIGMENT CELL & MELANOMA RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Thayane Soares Lima, Monalisa Sthefani Silva de Oliveira, Alice Vitoria Frota Reis, Raquel Petrilli, Josimar O. Eloy
Summary: This study reports the encapsulation of methylene blue (MB) in poly-epsilon-caprolactone (PCL) nanoparticles for photodynamic therapy (PDT) in skin cancer treatment. The optimized nanoparticles showed small size, high encapsulation efficiency, and stable surface potential, leading to enhanced penetration and therapeutic effect. The nanoparticles demonstrated efficient release of reactive oxygen species, high cellular uptake, and improved skin penetration. This is the first report of MB encapsulation in PCL nanoparticles for PDT in skin cancer, showing promising application prospects.
Article
Multidisciplinary Sciences
Carolina Morgado-Aguila, Guadalupe Gil-Fernandez, Orlando Rafael Davila-Villalobos, Jesus Perez-Rey, Purificacion Rey-Sanchez, Francisco Jose Rodriguez-Velasco
Summary: This study investigated the association between serum vitamin D levels and non-melanoma skin cancers. Despite all subjects having normal or low levels of vitamin D, it was found that higher vitamin D levels may increase the risk of non-melanoma skin cancer. Further research is needed to fully understand the relationship between vitamin D and skin cancer risk.
Article
Multidisciplinary Sciences
Mike Climstein, Brendan Doyle, Michael Stapelberg, Nedeljka Rosic, Isolde Hertess, James Furness, Vini Simas, Joe Walsh
Summary: The prevalence of pre-skin cancer, non-melanoma skin cancers, and melanoma skin cancers in Australian surfers and swimmers was found to be higher than the general population. These findings emphasize the importance of regular skin cancer screenings for individuals who engage in surfing or swimming activities, as well as the need for sun protection strategies to reduce the risk of skin cancer.
Article
Dermatology
Marcelo de Paula Correa
ANAIS BRASILEIROS DE DERMATOLOGIA
(2015)
Article
Dermatology
E. Mahe, M. de Paula Correa, I. Vouldoukis, S. Godin-Beekmann, M. -L. Sigal, A. Beauchet
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
(2016)
Article
Environmental Sciences
Admir Creso Targino, Mark David Gibson, Patricia Krecl, Marcos Vinicius Costa Rodrigues, Mauricio Moreira dos Santos, Marcelo de Paula Correa
ENVIRONMENTAL POLLUTION
(2016)
Article
Clinical Neurology
Jefferson Becker, Dagoberto Callegaro, Marco Aurelio Lana-Peixoto, Natalia Talim, Tamara Vidaletti, Marcelo de Paula Correa, Irenio Gomes
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2016)
Article
Environmental Sciences
Patricia Krecl, Admir Creso Targino, Luiz Wiese, Matthias Ketzel, Marcelo de Paula Correa
ATMOSPHERIC POLLUTION RESEARCH
(2016)
Article
Oncology
Miguel Rivas, Elisa Rojas, Gloria M. Calaf, Marcela Barberan, Claudio Liberman, Marcelo De Paula Correa
Article
Biochemistry & Molecular Biology
Abel A. Silva, Ana L. C. Yamamoto, Marcelo P. Correa
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Abel A. Silva, Ana L. C. Yamamoto, Marcelo P. Correa
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Rodrigo De Vecchi, Julia da Silveira Carvalho Ripper, Daniel Roy, Lionel Breton, Alexandre Germano Marciano, Plinio Marcos Bernardo de Souza, Marcelo de Paula Correa
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Angela C. G. B. Leal, Marcelo P. Correa, Michael F. Holick, Enaldo V. Melo, Marise Lazaretti-Castro
Summary: This study evaluated the differences in vitamin D-3 synthesis at different latitudes over the course of a year, finding a strong correlation between vitamin D-3 production and UV-B radiation and solar zenith angle. Vitamin D-3 synthesis was found to be higher at lower latitudes, starting later in winter.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2021)
Article
Environmental Sciences
Marcelo de Paula Correa, Alexandre Germano Marciano, Vanessa Silveira Barreto Carvalho, Plinio Marcos Bernardo de Souza, Julia da Silveira Carvalho Ripper, Daniel Roy, Lionel Breton, Rodrigo De Vecchi
Summary: This study aimed to quantify human exposure to environmental factors during routine daily activities and investigate the relationship between environmental factors and skin health. The study found that in most areas of Brazilian cities, people may be exposed to environmental factors such as UV radiation, temperature, and humidity, which could lead to skin damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Optics
Marcelo De Paula Correa
Summary: This article introduces UVBoost, a UV radiation estimator based on a Supervised Machine Learning regression model. It utilizes a conventional Radiative Transfer Model for high precision calculations. The proposed model is efficient, accurate and user-friendly, making it suitable for various applications like disseminating UVR data and climatological projection studies. UVBoost outperforms other regression tools in terms of accuracy and computational cost. It has been validated through global and local scale studies, showing promising results for simulating UVR and its impact on human health. The future plan for UVBoost includes incorporating more geophysical parameters and extending its use to other parts of the electromagnetic spectrum.
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
(2023)
Article
Medicine, General & Internal
Tiago Oselame Fontanive, Nidea Rita Michels Dick, Mariana Costa Silva Valente, Vani dos Santos Laranjeira, Marina Venzon Antunes, Marcelo de Paula Correa, Rita de Cassia Marques Alves, Rafael Linden, Tania Weber Furlanetto
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2020)
Article
Biochemistry & Molecular Biology
M. P. Correa, A. L. C. Yamamoto, G. R. Moraes, S. Godin-Beekmann, E. Mahe
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2019)
Article
Dermatology
Sergio Schalka, Marcelo de Paula Correa, Leticia Yumi Sawada, Camila C. Canale, Thayna N. de Andrade
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2019)
