Article
Multidisciplinary Sciences
Madhuradhar Chegondi, Jose F. Hernandez Rivera, Fuad Alkhoury, Balagangadhar R. Totapally
Summary: This study aims to evaluate the effect of blood transfusion therapy on mortality in children with severe traumatic brain injury. The analysis of two years of inpatient databases revealed a higher mortality rate associated with blood transfusion therapy.
Review
Biochemistry & Molecular Biology
Manuel Serrano, Gerard Espinosa, Antonio Serrano, Ricard Cervera
Summary: The prevalence of both criteria and extra-criteria antiphospholipid antibodies in COVID-19 patients may be influenced by age, while coagulopathy associated with the onset of the disease is likely independent of aPL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yuhui Chen, Jun Tian, Bin Chi, Shangming Zhang, Liangfeng Wei, Shousen Wang
Summary: The incidence of coagulopathy after open traumatic brain injury (TBI) is high. Patients with a low GCS score, high NLR, low PLR, and hyperglycemia at admission are at greater risk of coagulopathy and poor prognosis. The efficacy of TXA in open TBI patients with coagulopathy is unclear. PLR may be a novel indicator for predicting coagulopathy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Gael B. Morrow, Molly S. A. Carlier, Sruti Dasgupta, Fiona B. Craigen, Nicola J. Mutch, Nicola Curry
Summary: This study compared the effects of cryoprecipitate and fibrinogen concentrate added to fibrinogen-deficient plasma, finding that cryoprecipitate may be a superior source of fibrinogen for controlling bleeding in trauma coagulopathy. However, further evaluation of these different products in a clinical setting is needed to validate these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Zhimin Zou, Li Li, Nadine Schafer, Qiaobing Huang, Marc Maegele, Zhengtao Gu
Summary: TBI, a leading cause of death and disability worldwide, has been associated with damage to the endothelial glycocalyx which plays a crucial role in maintaining the balance between blood coagulation and anticoagulation. Recent advances in analytical techniques have made it possible to conduct biochemical, visual, and computational investigations on this vascular component.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Sebastiaan M. Bossers, Stephan A. Loer, Frank W. Bloemers, Dennis Den Hartog, Esther M. M. Van Lieshout, Nico Hoogerwerf, Joukje van der Naalt, Anthony R. Absalom, Saskia M. Peerdeman, Lothar A. Schwarte, Christa Boer, Patrick Schober
Summary: The study suggests that prehospital administration of tranexamic acid is associated with increased mortality in patients with isolated severe traumatic brain injury, indicating caution in its use when there is no evidence of extracranial hemorrhage.
Review
Medicine, Research & Experimental
Marie Hanscom, David J. Loane, Terez Shea-Donohue
Summary: Traumatic brain injury (TBI) is a chronic and progressive disease that not only affects neurological function, but also impacts peripheral organs like the gastrointestinal tract. The brain-gut axis plays a crucial role in shaping post-TBI gastrointestinal issues, with dysautonomia and systemic inflammation contributing to dysmotility and increased mucosal permeability. Understanding this communication is key in developing therapeutic strategies for TBI.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Jing Li, Bin Liu
Summary: Emerging evidence suggests a strong association between multisystem organ failure in COVID-19 patients and various coagulopathies, presenting a clinical challenge for treatment. Understanding the mechanisms of complement cascade activation in the genesis of COVID-19-associated coagulopathy could lead to the development of novel anticoagulant drugs targeting C5a/C5aRs signaling.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Emergency Medicine
Gaku Fujiwara, Yohei Okada, Wataru Ishii, Ryoji Iizuka, Mamoru Murakami, Takehiko Sakakibara, Tarumi Yamaki, Naoya Hashimoto
Summary: The study found that skull fracture is associated with in-hospital mortality among patients with severe traumatic brain injury, and patients with both skull base and skull vault fractures have a higher mortality rate.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Liam Barrett, Nicola Curry, Jeries Abu-Hanna
Summary: Trauma-induced coagulopathy (TIC) is a major cause of morbidity and mortality in traumatic injury patients, ranging from bleeding to widespread clot formation. The endotheliopathy of trauma (EoT) is believed to underlie TIC, but our understanding of it is still limited due to the lack of experimental research. This review discusses the mechanisms of haemostasis regulation by the vascular endothelium and their dysregulation in traumatic injury, as well as available in vitro and in vivo models for studying EoT and its contribution to TIC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Marc Maegele
Summary: TBI can lead to hemorrhagic progression and coagulopathy, affecting morbidity and mortality, with potential associations with preinjury use of antithrombotic agents and changes in coagulation function. Further research suggests the presence of both hyper- and hypocoagulable states after TBI, requiring more comprehensive hemostatic analysis.
Article
Medicine, General & Internal
Ross Davenport, Nicola Curry, Erin E. Fox, Helen Thomas, Joanne Lucas, Amy Evans, Shaminie Shanmugaranjan, Rupa Sharma, Alison Deary, Antoinette Edwards, Laura Green, Charles E. Wade, Jonathan R. Benger, Bryan A. Cotton, Simon J. Stanworth, Karim Brohi
Summary: This study aimed to assess whether administering an early and empirical high dose of cryoprecipitate could improve survival in patients with trauma and bleeding. The results showed that this treatment method did not reduce all-cause mortality at 28 days in patients who required activation of a major hemorrhage protocol.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Hematology
Carlos A. Canas, Felipe Canas, Mario Bautista-Vargas, Fabio Bonilla-Abadia
Summary: COVID-19 is a highly contagious infection with high mortality rates, especially in elderly, heart failure patients, hypertension patients, diabetes patients, and smokers. It is associated with increased expression of ACE-2, leading to severe lung involvement and microvascular thrombosis. Therapeutic strategies are being developed to target TF for COVID-19-associated coagulopathy.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Review
Medicine, General & Internal
Fabian Kockelmann, Marc Maegele
Summary: Due to the aging population, the number of low falls in elderly people with pre-existing anticoagulation is increasing, leading to traumatic brain injury (TBI) with a social and economic burden. Hemostatic disorders and imbalances seem to play a significant role in bleeding progression. The interrelationships between anticoagulation medication, coagulopathy, and bleeding progression show promise for therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Masaki Takahashi, Takeshi Wada, Ryuta Nakae, Yu Fujiki, Takahiro Kanaya, Yasuhiro Takayama, Go Suzuki, Yasutaka Naoe, Shoji Yokobori
Summary: This study aimed to investigate the relationship between antithrombin (AT) activity levels and long-term outcomes in patients with traumatic brain injury (TBI). The study found that low AT activity levels within 1 hour after injury were associated with poor outcomes, and AT activity levels 1 hour after injury had a strong predictive value for long-term outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)