In vitro selective inhibitory effect of 8-hydroxyquinoline against bifidobacteria and clostridia

8-Hydroxyguinoline (8HQ) inhibited Clostridium tertium, Clostridium clostridioforme, Clostridium difficile and Clostridium perfringens in vitro with MICs of 8, 16, 32 and 32 mu g/mL, respectively. In contrast, MICs of most bifidobacteria (84%) were 512 mu g/mL or higher. Thus, 8HQ could be used as anti-clostridial agent or in selective media for bifidobacteria isolation. (C) 2013 Elsevier Ltd. All rights reserved.