期刊
ANAEROBE
卷 18, 期 5, 页码 546-552出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.anaerobe.2012.09.001
关键词
Clostridium perfringens; Epsilon toxin; Toxin proteolytic processing
类别
资金
- NIAID through MARCE grant [2U54AI057168-08, R01 AI056177-08]
Clostridium perfringens type B and D strains produce epsilon toxin (ETX), which is one of the most potent clostridial toxins and is involved in enteritis and enterotoxemias of domestic animals. ETX is produced initially as an inactive prototoxin that is typically then secreted and processed by intestinal proteases or possibly, for some strains, lambda toxin. During the current work a unique C perfringens strain was identified that intracellularly processes epsilon prototoxin to an active form capable of killing MDCK cells. This activated toxin is not secreted but instead is apparently released upon lysis of bacterial cells entering stationary phase. These findings broaden understanding of the pathogenesis of type B and D infections by identifying a new mechanism of ETX activation. (C) 2012 Elsevier Ltd. All rights reserved.
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