期刊
ANAEROBE
卷 17, 期 6, 页码 444-447出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.anaerobe.2011.05.008
关键词
SELDI-TOF MS; Phenotyping; Bacteria identification
类别
资金
- Czech Science Foundation [203-08-1680, P502/10/P083]
- European Regional Development Fund (RECAMO) [CZ.1.05/2.1.00/03.0101]
Based on experiments with 10 defined strains of Escherichia coli, we present a new method for bacterial phenotyping using SELDI-TOF mass spectrometry. Changes in bacterial protein profiles in the context of the time of cultivation and the antibiotic environment were minimal. Proteom subprofiling may further distinguish between strains with specific susceptibility to antimicrobials. Mass spec-based methods may become common in the future of bacterial pathogen identification in clinical microbiology diagnostics. (C) 2011 Elsevier Ltd. All rights reserved.
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