期刊
ANAEROBE
卷 17, 期 4, 页码 180-185出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.anaerobe.2011.02.004
关键词
Probiotics; Neonatal necrotizing enterocolitis; Immature intestine; Premature infant
类别
资金
- National Institute of Child Health and Human Development [R21 AT004044, R01 HD059123]
- March of Dimes Foundation [5-FY09-91]
Neonatal necrotizing enterocolitis (NEC) is one of few diseases for which probiotics have appeared to have clear benefit in clinical trials, however safety concerns persist. Clinical trials of probiotics have preceded our understanding of the effect of probiotics on the developing gut and microbial colonization patterns of the preterm infant. Colonization of the preterm intestine begins with the birthing process and is then influenced by the neonatal intensive care unit and iatrogenic manipulations. Resulting altered microbiota may have significant implications for the immature preterm gut and susceptibility to NEC. (C) 2011 Published by Elsevier Ltd.
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