Article
Biochemistry & Molecular Biology
Haiyang Wu, Osmond Rebello, Emmanuelle H. Crost, C. David Owen, Samuel Walpole, Chloe Bennati-Granier, Didier Ndeh, Serena Monaco, Thomas Hicks, Anna Colvile, Paulina A. Urbanowicz, Martin A. Walsh, Jesus Angulo, Daniel I. R. Spencer, Nathalie Juge
Summary: The study focuses on how gut bacteria adapt to ecological niches by utilizing fucosylated glycans, identifying a fucosidase enzyme with specific substrate and linkage preferences. This enzyme has the ability to recognize and hydrolyze specific fucosyl linkages, potentially contributing to the adaptation of R. gnavus strains in the infant and adult gut microbiome.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Yoshiki Teramoto, Shohei Akagawa, Shin-ichiro Hori, Shoji Tsuji, Koichiro Higasa, Kazunari Kaneko
Summary: This study found that children with a history of acute Kawasaki disease (KD) have an imbalance in their gut microbiota, characterized by increased microbial diversity and changes in the relative abundance of certain microbial genera. This imbalance may increase susceptibility to acute Kawasaki disease in children.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Colin Buttimer, Ekaterina V. Khokhlova, Lisa Stein, Cara M. Hueston, Bianca Govi, Lorraine A. Draper, R. Paul Ross, Andrey N. Shkoporov, Colin Hill
Summary: This study isolates and characterizes six bacteriophages that can infect Ruminococcus gnavus, a gut microbe associated with inflammatory bowel disease. The phages have a temperate lifestyle and can coexist with the host bacterium without causing a significant reduction in its abundance. Analysis of gut virome data reveals a high abundance of these phages in individuals with IBD. This work provides insight into the interaction between phages and R. gnavus in the human gut microbiome.
Article
Multidisciplinary Sciences
Matthew T. Henke, Eric M. Brown, Chelsi D. Cassilly, Hera Vlamakis, Ramnik J. Xavier, Jon Clardy
Summary: Research has shown that some isolates of R. gnavus produce a capsular polysaccharide that promotes tolerogenic immune responses, while isolates lacking a capsule trigger robust proinflammatory responses. In mouse experiments, it was also found that mice colonized with an isolate of R. gnavus lacking a capsule showed increased gut inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Conor J. McGrath, Edgaras Laveckis, Andrew Bell, Emmanuelle Crost, Nathalie Juge, Stephanie Schuller
Summary: The gut microbiota plays a crucial role in protecting against enteric infection, but the underlying mechanisms are largely unknown. Researchers developed a new experimental model and optimized the culture medium to study bacterial growth in mucus-producing intestinal cells. They found that L. reuteri and R. gnavus have different effects on EPEC infection and can reduce the secretion of inflammatory factors.
DISEASE MODELS & MECHANISMS
(2022)
Article
Microbiology
Claudia Saralegui, Carmen Garcia-Duran, Eduardo Romeu, Maria Luisa Hernaez-Sanchez, Ainhize Maruri, Natalia Baston-Paz, Adelaida Lamas, Saioa Vicente, Estela Perez-Ruiz, Isabel Delgado, Carmen Luna-Paredes, Juan de Dios Caballero, Javier Zamora, Lucia Monteoliva, Concepcion Gil, Rosa del Campo
Summary: In recent years, various techniques have been used to study microbial ecosystems, with 16S rRNA gene sequencing being the most common method. Metaproteomics can identify the interaction between microorganisms and human cells, but the available databases are limited and imprecise. This study compares the differences between 16S rRNA amplicon sequencing and metaproteomics in identifying microorganisms and analyzing alpha diversity. Additionally, the study explores the establishment of intestinal ecosystems in newborns with cystic fibrosis, characterized by host inflammation and enrichment of Ruminococcus gnavus.
MICROBIOLOGY SPECTRUM
(2022)
Article
Genetics & Heredity
Rashidin Abdugheni, Chang Liu, Feng-Lan Liu, Nan Zhou, Cheng-Ying Jiang, Yonghong Liu, Li Li, Wen-Jun Li, Shuang-Jiang Liu
Summary: This study investigates the genomic features and health relevance of Ruminococcus gnavus. The findings suggest that strain-level genomic variability may contribute to the ambiguities regarding its function and impact on host well-being. The study identifies certain genes with health benefits and potential health risks, as well as the presence of antibiotic resistance and virulence-related genes. These results provide new insights into R. gnavus and raise concerns about its pathogenicity and antibiotic resistance.
MICROBIAL GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Rong Li, Sheng Xu, Bei Li, Bo Zhang, Weihua Chen, Die Dai, Zhi Liu
Summary: Refractory constipation is a severe form of constipation with unknown etiology. Accumulating studies have shown significant dysbiosis of the gut microbiota in constipation patients. This study analyzed the gut microbiota composition of fresh and accumulated feces of refractory constipation patients and found a significant difference between them.
Article
Gastroenterology & Hepatology
Erika Coletto, Dimitrios Latousakis, Matthew G. Pontifex, Emmanuelle H. Crost, Laura Vaux, Estella Perez Santamarina, Andrew Goldson, Arlaine Brion, Mohammad K. Hajihosseini, David Vauzour, George M. Savva, Nathalie Juge
Summary: Ruminococcus gnavus (R. gnavus) is found in excessive amounts in inflammatory bowel disease and neurological disorders. This study found that mice colonized with R. gnavus displayed changes in sialic acid derivatives and metabolites associated with brain function. Furthermore, the colonization of R. gnavus resulted in improved spatial working memory in the mice. These findings provide important insights into the role of R. gnavus in neurological disorders.
Article
Medicine, Research & Experimental
Upasana Gupta, Priyankar Dey
Summary: This review comprehensively discusses the impact of gut microbiota modulation on opportunistic bacterial infections. It covers mechanisms such as colonization resistance, nutrient and metabolite-associated factors, mucosal immune response, and commensal-pathogen reciprocal interactions. The review highlights the importance of altered intestinal immuno-metabolic and metabolomic homeostasis in the promotion or prevention of infections, and suggests gut microbiota-centered strategies, like probiotics and fecal microbiota transplantation, as potential interventions to attenuate opportunistic bacterial infections.
Article
Genetics & Heredity
Armin Rashidi, Motoko Koyama, Neelendu Dey, Jeffrey S. McLean, Geoffrey R. Hill
Summary: The presence of oral bacteria in the gut is not due to impaired colonization resistance, as even in extreme cases of antibiotic pressure and gut microbiota disruption, only a small number of oral bacteria colonize the gut.
BMC MEDICAL GENOMICS
(2023)
Article
Microbiology
Vita Rozman, Tomaz Accetto, Sylvia H. Duncan, Harry J. Flint, Masa Vodovnik
Summary: The study analyzed genome sequences of 118 taxonomically diverse bacterial strains isolated mainly from anaerobic environments, revealing that T4P systems with diverse genetic organization are widespread among Gram-positive anaerobic non-pathogenic bacteria belonging to the phyla Firmicutes and Actinobacteria. The analysis also included the study of Carbohydrate Active enZYmes (CAZymes) consortia to predict carbohydrate utilization abilities of selected strains, which was confirmed by experimental assessment of substrate-related growth patterns.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Immunology
Giovanny Herrera, Laura Vega, Anny Camargo, Manuel Alfonso Patarroyo, Juan David Ramirez, Marina Munoz
Summary: This study found that the coexistence of Clostridium perfringens and Clostridium difficile can lead to minor differences in the composition and diversity of gut bacterial communities, particularly in patients with hospital-acquired diarrhea. These alterations suggest a need for a comprehensive understanding of gut microbiota.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2023)
Review
Gastroenterology & Hepatology
Yucheng Zhang, Peng Tan, Ying Zhao, Xi Ma
Summary: This review focuses on recent discoveries about the etiology, pathogenesis, and clinical manifestation of enterotoxigenic Escherichia coli (ETEC), as well as the colonization resistances mediated by gut microbiota and preventative strategies against ETEC.
Article
Microbiology
Evgenii Olekhnovich, Artem B. Ivanov, Vladimir Ulyantsev, Elena N. Ilina
Summary: Fecal microbiota transplantation (FMT) is used to treat intestinal diseases, but its therapeutic mechanism and donor bacteria colonization in the recipient's intestine remain unclear. Metagenomic analysis of FMT experiments can provide insights into the relationship between the host and gut microbiota. The enrichment of successful gut microbes with antibiotic resistance genes may play a key role in the colonization and redistribution of recipient gut microbiota during FMT.
Article
Biotechnology & Applied Microbiology
F. Graziani, A. Pujol, C. Nicoletti, S. Dou, M. Maresca, T. Giardina, M. Fons, J. Perrier
JOURNAL OF APPLIED MICROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Sophie Bouillet, Olivier Genest, Cecile Jourlin-Castelli, Michel Fons, Vincent Mejean, Chantal Iobbi-Nivol
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Microbiology
Olivier N. Lemaire, Flora A. Honore, Cecile Jourlin-Castelli, Vincent Mejean, Michel Fons, Chantal Iobbi-Nivol
RESEARCH IN MICROBIOLOGY
(2016)
Article
Multidisciplinary Sciences
Hiba Baaziz, Cyril Gambari, Anne Boyeldieu, Amine Ali Chaouche, Radia Alatou, Vincent Mejean, Cecile Jourlin-Castelli, Michel Fons
Article
Biotechnology & Applied Microbiology
M. Cervera-Tison, L. E. Tailford, C. Fuell, L. Bruel, G. Sulzenbacher, B. Henrissat, J. G. Berrin, M. Fons, T. Giardina, N. Juge
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2012)
Article
Environmental Sciences
Dallel Arabet, Sebastien Tempel, Michel Fons, Yann Denis, Cecile Jourlin-Castelli, Joshua Armitano, David Redelberger, Chantal Iobbi-Nivol, Abderrahmane Boulahrouf, Vincent Mejean
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Laetitia Bruel, Gerlind Sulzenbacher, Marine Cervera Tison, Ange Pujol, Cendrine Nicoletti, Josette Perrier, Anne Galinier, David Ropartz, Michel Fons, Frederique Pompeo, Thierry Giardina
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Multidisciplinary Sciences
Emmanuelle H. Crost, Louise E. Tailford, Gwenaelle Le Gall, Michel Fons, Bernard Henrissat, Nathalie Juge
Article
Microbiology
Margarita Aguilera, Harivony Rakotoarivonina, Alexandre Brutus, Thierry Giardina, Gwenola Simon, Michel Fons
RESEARCH IN MICROBIOLOGY
(2012)
Article
Biotechnology & Applied Microbiology
Kamel Bendjeddou, Michel Fons, Pierre Strocker, Djamila Sadoun
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2012)
Article
Microbiology
Elvis L. Ongey, Robert T. Giessmann, Michel Fons, Juri Rappsilber, Lorenz Adrian, Peter Neubauer
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Steve Chiumento, Clarisse Roblin, Sylvie Kieffer-Jaquinod, Sybille Tachon, Chloe Lepretre, Christian Basset, Dwi Aditiyarini, Hamza Olleik, Cendrine Nicoletti, Olivier Bornet, Olga Iranzo, Marc Maresca, Renaud Hardre, Michel Fons, Thierry Giardina, Estelle Devillard, Francoise Guerlesquin, Yohann Coute, Mohamed Atta, Josette Perrier, Mickael Lafond, Victor Duarte
Article
Multidisciplinary Sciences
Clarisse Roblin, Steve Chiumento, Olivier Bornet, Matthieu Nouailler, Christina S. Mueller, Katy Jeannot, Christian Basset, Sylvie Kieffer-Jaquinod, Yohann Coute, Stephane Torelli, Laurent Le Pape, Volker Schuenemann, Hamza Olleik, Bruno De La Villeon, Philippe Sockeel, Eric Di Pasquale, Cendrine Nicoletti, Nicolas Vidal, Leonora Poljak, Olga Iranzo, Thierry Giardina, Michel Fons, Estelle Devillard, Patrice Polard, Marc Maresca, Josette Perrier, Mohamed Atta, Francoise Guerlesquin, Mickael Lafond, Victor Duarte
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Microbiology
Mickael Lafond, Alexandra S. Tauzin, Laetitia Bruel, Elisabeth Laville, Vincent Lombard, Jeremy Esque, Isabelle Andre, Nicolas Vidal, Frederique Pompeo, Nathalie Quinson, Josette Perrier, Michel Fons, Gabrielle Potocki-Veronese, Thierry Giardina
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Microbiology
Hiba Baaziz, Olivier N. Lemaire, Cecile Jourlin-Castelli, Chantal Iobbi-Nivol, Vincent Mejean, Radia Alatou, Michel Fons
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2018)