期刊
AMINO ACIDS
卷 50, 期 12, 页码 1663-1678出版社
SPRINGER WIEN
DOI: 10.1007/s00726-018-2658-8
关键词
Leucine; Glucose homeostasis; Insulin resistance; Obesity; Diabetes
L-Leucine has been used to improve metabolic outcomes in glucose-intolerant rodent models. However, because studies have used different experimental models and conditions it is difficult to establish the best approach for new clinical trials evaluating the potential effects of l-leucine on glucose homeostasis. We performed a systematic review to report the effect of l-leucine supplementation on glucose homeostasis in rodents with glucose intolerance. The search engines MEDLINE and ScienceDirect were applied using MeSH terms. Thirty-four studies were included in this systematic review. Based on the current data, ingestion of 90-140mgday(-1) of isolated l-leucine in diet-induced obesity (DIO) models shows improvement in metabolic markers if offered during the development of the metabolic disorder in almost all the studies, but not after. Branched-chain amino acid supplementation was effective in streptozotocin-induced -cells death but not in DIO models. l-Leucine supplementation seems to have an optimal dose and timing for supplementation to improve glucose homeostasis in DIO.
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