期刊
AMINO ACIDS
卷 46, 期 5, 页码 1403-1407出版社
SPRINGER WIEN
DOI: 10.1007/s00726-014-1686-2
关键词
Antimicrobial peptides; Branched peptides; Pegylation; Peg; Elastase; Peptide stability
资金
- Italian Foundation for Cystic Fibrosis (FFC) [12/2013]
M33 is a branched peptide currently under preclinical characterization for the development of a new antibacterial drug against gram-negative bacteria. Here, we report its pegylation at the C-terminus of the three-lysine-branching core and the resulting increase in stability to Pseudomonas aeruginosa elastase. This protease is a virulence factor that acts by destroying peptides of the native immune system. Peptide resistance to this protease is an important feature for M33-Peg activity against Pseudomonas.
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