Article
Biology
Filip Kukic, Vladimir Mrdakovic, Aleksandar Stankovic, Dusko Ilic
Summary: This study investigated the effects of knee joint angle on muscle activation, exerted torque, and whether the knee angle affects the muscle activation-torque ratio. The results showed that knee joint angle had an effect on torque, while muscle activation remained unaffected. Significant effects were not observed in the muscle activation-torque ratio for lateral and medial quadriceps heads. The investigated range of knee joint angles seems to provide optimal conditions for maximal muscle activation but not for torque output, ligament loading, and joint contact forces. Clinicians and sports coaches should carefully consider training goals and choose knee joint angles accordingly.
Article
Physiology
Everett C. Minchew, Nicholas C. Williamson, Andrew T. Readyoff, Joseph M. McClung, Espen E. Spangenburg
Summary: Assessing contractile function of skeletal muscle in murine models is commonly employed in laboratory research. This study aimed to characterize the functional properties of hindlimb muscles in different mouse strains. The data reveals both unique differences and similarities between the muscles in different genetic backgrounds. Additionally, the strain of the mouse could potentially influence the measured biological outcome and interact with any genetic manipulation or therapeutic intervention. Therefore, careful consideration of the genetic background and documentation of the strain of mouse is critical in experimental design and publication.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Masakazu Minetama, Mamoru Kawakami, Masatoshi Teraguchi, Yoshio Enyo, Masafumi Nakagawa, Yoshio Yamamoto, Nana Sakon, Sachika Matsuo, Tomohiro Nakatani, Ryota Nakagawa, Wakana Nagata, Yukihiro Nakagawa
Summary: A randomized controlled trial found that supplementation with branched-chain amino acids (BCAA) and vitamin D did not improve postoperative recovery in patients with lumbar spinal stenosis (LSS).
Article
Physiology
Javier Rodriguez-Falces, Armando Malanda, Javier Navallas, Nicolas Place
Summary: This study aimed to experimentally assess the changes in the compound muscle action potential (M-wave) caused by brief voluntary and stimulated isometric contractions. Two methods of inducing muscle shortening were used under isometric condition, and the amplitude and duration of the M-wave phases were measured. The results showed that muscle shortening led to a decrease in the amplitude of the first phase and an increase in the amplitude of the second phase of the M-wave.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Neurosciences
Alessandro Del Vecchio, Carina Marconi Germer, Thomas M. Kinfe, Stefano Nuccio, Francois Hug, Bjoern Eskofier, Dario Farina, Roger M. Enoka
Summary: The purpose of this study was to identify the low-dimensional latent components, called motor unit modes, underlying the discharge rates of motor units in knee extensors and hand muscles during submaximal isometric contractions. Factor analysis identified two independent motor unit modes that captured most of the covariance of the motor unit discharge rates. The distribution of motor unit modes was different between hand and knee muscles, with a continuous distribution found for the knee muscles.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Cecilia Leijding, Ida Viken, Joseph D. D. Bruton, Daniel C. C. Andersson, Arthur J. J. Cheng, Hakan Westerblad
Summary: During the initial phase of fatigue, tetanic force decreases despite increasing tetanic cytosolic calcium concentration. However, the increase in calcium concentration has positive effects on force in early fatigue.
Article
Health Care Sciences & Services
Jung Hae Yun, Du Hwan Kim, Min Cheol Chang
Summary: This study demonstrated that simple bedside exercise training for moderate-degree AD patients can significantly increase maximal voluntary contraction for hip flexion and knee extension, helping to maintain and enhance lower extremity muscle strength.
Article
Multidisciplinary Sciences
Meiwand Bedar, Tiam M. Saffari, Patricia F. Friedrich, Guilherme Giusti, Allen T. Bishop, Alexander Y. Shin
Summary: This article discusses the focus of research in nerve regeneration and the experimental methods used to assess functional recovery in a rat sciatic nerve model. The technique of isometric force measurement of tetanic muscle contraction is crucial for evaluating motor recovery after nerve injury or repair.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Review
Biochemistry & Molecular Biology
Heitor O. Santos, Henrique S. Cerqueira, Grant M. Tinsley
Summary: This article reviews the effects of dietary supplements, nutraceutical agents, and physical exercise on myostatin levels and cautions against accepting clinical conclusions based solely on randomized clinical trials. Despite inconsistent findings, research suggests that supplements or functional foods do not clearly outperform placebos in modulating myostatin levels.
Article
Multidisciplinary Sciences
Keisuke Yunoki, Tatsunori Watanabe, Takuya Matsumoto, Takayuki Kuwabara, Takayuki Horinouchi, Kanami Ito, Haruki Ishida, Hikari Kirimoto
Summary: This study aimed to investigate the difference in cutaneous information processing between position and force tasks during static muscle contraction. The results demonstrated that the reduction of somatosensory evoked potentials (SEPs) amplitude was significantly larger in the force task, and the amplitude of cutaneomuscular reflex (CMR) was greater in the force task as well.
Article
Nutrition & Dietetics
M. S. Brook, P. Scaife, J. J. Bass, J. Cegielski, S. Watanabe, D. J. Wilkinson, K. Smith, B. E. Phillips, P. J. Atherton
Summary: The study showed that a blend of collagen protein hydrolysate + milk protein supplement had equivalent effects on muscle protein synthesis compared to milk protein alone in older adults, indicating its potential as an alternative for improving muscle mass and patient adherence.
CLINICAL NUTRITION
(2021)
Article
Sport Sciences
Daniel M. Over, Nicola Arjomandkhah, Jordan D. Beaumont, Stuart Goodall, Martin J. Barwood
Summary: The study found that menthol applied topically to the skin improves perception and increases force generation. Nine trained male subjects were tested after spraying menthol on their legs during different weightlifting tasks. The results showed an improved performance in the isometric and dynamic lifting tasks after the application of menthol.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2023)
Article
Neurosciences
Laura Schaefer, Silas Dech, Lara L. Wolff, Frank N. Bittmann
Summary: The link between emotions and motor function is still unclear. This study found that unpleasant imagery significantly reduced the neuromuscular capability to adapt to increasing forces, potentially related to negative emotions. These findings provide insights into the understanding of the causal chain of linked musculoskeletal pain and mental stress.
Review
Nutrition & Dietetics
Joshua L. Hudson, Jamie I. Baum, Eva C. Diaz, Elisabet Borsheim
Summary: Current estimates of protein requirements in children are largely based on the nitrogen balance technique, which may underestimate protein needs. Recent advances in stable isotope techniques suggest protein requirements may be up to 60% higher, especially in children engaging in higher levels of physical activity.
Article
Cell Biology
Hind Albadrani, Tarek Ammar, Rashida Rajgara, Michael Bader, Nadine Wiper-Bergeron, Jean-Marc Renaud
Summary: Recent studies have shown that angiotensin 1-7 (Ang 1-7), through its receptor Mas (MasR), can prevent muscle atrophy and improve muscle integrity and function. This study demonstrates that Ang 1-7 has a hypertrophic effect on muscle mass and fiber cross-sectional area, and enhances muscle contractile function. These effects are mediated by the MasR receptor.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Arnaud F. Klein, Miguel A. Varela, Ludovic Arandel, Ashling Holland, Naira Naouar, Andrey Arzumanov, David Seoane, Lucile Revillod, Guillaume Bassez, Arnaud Ferry, Dominic Jauvin, Genevieve Gourdon, Jack Puymirat, Michael J. Gait, Denis Furling, Matthew J. A. Wood
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Meeting Abstract
Clinical Neurology
M. Traore, C. Gentil, C. Benedetto, J. -Y. Hogrel, P. De la Grange, S. Benkhelifa-Ziyyat, L. Julien, M. Lemaitre, A. Ferry, S. Falcone
NEUROMUSCULAR DISORDERS
(2019)
Article
Cell Biology
Massire Traore, Christel Gentil, Chiara Benedetto, Jean-Yves Hogrel, Pierre De la Grange, Bruno Cadot, Sofia Benkhelifa-Ziyyat, Laura Julien, Megane Lemaitre, Arnaud Ferry, France Pietri-Rouxel, Sestina Falcone
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Neurosciences
Arnaud Ferry, Julien Messeant, Ara Parlakian, Megane Lemaitre, Pauline Roy, Clement Delacroix, Alain Lilienbaum, Yeranuhi Hovhannisyan, Denis Furling, Arnaud Klein, Zhenlin Li, Onnik Agbulut
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Cell Biology
Ivana Prokic, Belinda S. Cowling, Candice Kutchukian, Christine Kretz, Hichen Tasfaout, Vincent Gache, Josiane Hergueux, Olivia Wendling, Arnaud Ferry, Anne Toussaint, Christos Gavriilidis, Vasugi Nattarayan, Catherine Koch, Jeanne Laine, Roy Combe, Laurent Tirent, Vincent Jacquemond, Fanny Pilot-Storck, Jocelyn Laporte
DISEASE MODELS & MECHANISMS
(2020)
Article
Biochemistry & Molecular Biology
Daniel J. Owens, Julien Messeant, Sophie Moog, Mark Viggars, Arnaud Ferry, Kamel Mamchaoui, Emmanuelle Lacene, Norma Romero, Astrid Brull, Gisele Bonne, Gillian Butler-Browne, Catherine Coirault
Summary: Laminopathies are a group of disorders caused by mutations in the LMNA gene, particularly affecting skeletal and cardiac muscles. Mutations in LMNA-CMD lead to impaired myogenic fusion, defective protein synthesis, and neuromuscular junction remodeling. This study suggests that A-type lamins play a role in mechanosignaling pathways in skeletal muscle growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Daniela Rovito, Anna-Isavella Rerra, Vanessa Ueberschlag-Pitiot, Shilpy Joshi, Nezih Karasu, Vanessa Dacleu-Siewe, Khalil Ben Rayana, Kamar Ghaibour, Maxime Parisotto, Arnaud Ferry, Scott A. Jelinsky, Gilles Laverny, Bruno P. Klaholz, Tom Sexton, Isabelle M. L. Billas, Delphine Duteil, Daniel Metzger
Summary: Skeletal muscle size can be remodeled through various cues, with Myod1, GR, and Nrf1 identified as key players in muscle-specific enhancer-promoter communication. The study reveals that these factors control gene expression through direct contacts, transcription factor Nrf1 regulation, and Ctcf-anchored chromatin loops, orchestrating myofiber size regulation in a myofiber-specific manner. Additionally, GR negatively regulates muscle mass and strength in mice by down-regulating anabolic pathways.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Pierre Joanne, Yeranuhi Hovhannisyan, Maximilien Bencze, Marie-Therese Daher, Ara Parlakian, Geraldine Toutirais, Jacqueline Gao-Li, Alain Lilienbaum, Zhenlin Li, Ekaterini Kordeli, Arnaud Ferry, Onnik Agbulut
Summary: Desmin plays a crucial role in muscle remodeling and performance gain induced by mechanical overloading, impacting fatigue resistance and myofibril organization. The lack of desmin affects the functional response to overloading, leading to compromised repair activity of autophagy and altered proteolysis pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Ludovic Arandel, Magdalena Matloka, Arnaud F. Klein, Frederique Rau, Alain Sureau, Michel Ney, Aurelien Cordier, Maria Kondili, Micaela Polay-Espinoza, Naira Naouar, Arnaud Ferry, Megane Lemaitre, Severine Begard, Morvane Colin, Chloe Lamarre, Helene Tran, Luc Buee, Joelle Marie, Nicolas Sergeant, Denis Furling
Summary: Decoy RNA-binding proteins effectively reverse the toxicity of mutant CUG RNA repeats in myotonic dystrophy, restoring normal RNA splicing and improving disease pathology in cell and mouse models.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Medicine, General & Internal
Narjes Baati, Nathalie Mougenot, Megane Lemaitre, Marine Kirsch, Onnik Agbulut, Arnaud Ferry, Damien Vitiello
Summary: Duchenne muscular dystrophy (DMD) is a recessive hereditary myopathy caused by deficiency of functional dystrophin. Current therapeutic interventions need further research to slow down muscle weakness. In this study, male and female D2-mdx mice showed significant muscle function alterations compared to control groups, and high intensity interval training (HIIT) may delay muscle force loss especially in male D2-mdx mice.
INTRACTABLE & RARE DISEASES RESEARCH
(2021)
Article
Multidisciplinary Sciences
Alexandra Monceau, Clement Delacroix, Megane Lemaitre, Gaelle Revet, Denis Furling, Onnik Agbulut, Arnaud Klein, Arnaud Ferry
Summary: Prox1 transfer reduced muscle fragility in exercised mdx mice but not in sedentary mice. Additionally, it increased the expression of specific muscle proteins while decreasing others.
Article
Biochemistry & Molecular Biology
Myriam Boex, Steve Cottin, Marius Halliez, Stephanie Bauche, Celine Buon, Nathalie Sans, Mireille Montcouquiol, Jordi Molgo, Muriel Amar, Arnaud Ferry, Megane Lemaitre, Andree Rouche, Dominique Langui, Asha Baskaran, Bertrand Fontaine, Julien Messeant, Laure Strochlic
Summary: Investigating the function of Vangl2 protein in the Wnt signaling pathway, a study found that it plays a crucial role in the development and assembly of neuromuscular junctions (NMJs). Loss of Vangl2 protein leads to disorganized distribution of acetylcholine receptors (AChRs) in NMJs, resulting in impaired neurotransmission and motor function.
Article
Pathology
Alexandra Monceau, Dylan Moutachi, Megane Lemaitre, Luis Garcia, Capucine Trollet, Denis Furling, Arnaud Klein, Arnaud Ferry
Summary: This study evaluated the impact of voluntary exercise on gene therapy exon skipping approach in a severe DMD murine model. The results showed that voluntary running did not induce muscle damage and did not have a drastic detrimental effect on the gene therapy method. Moreover, these findings suggest considering exercise as an additional factor in future therapeutic approaches for DMD.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dylan Moutachi, Megane Lemaitre, Clement Delacroix, Onnik Agbulut, Denis Furling, Arnaud Ferry
Summary: Valproic acid (VPA) reduces susceptibility to contraction-induced functional loss but increases muscle weakness in murine models of DMD.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
M. Matloka, L. Arandel, F. Rau, J. Marie, M. Ney, A. Klein, A. Sureau, N. Naouar, A. Ferry, N. Sergeant, D. Furling
HUMAN GENE THERAPY
(2019)