Article
Immunology
Riguo Lan, Zhixin Wan, Yuanyuan Xu, Zhenglei Wang, Shaodong Fu, Yuanyuan Zhou, Xinguang Lin, Xiangan Han, Zhenhua Luo, Jinfeng Miao, Yulong Yin
Summary: Streptococcus uberis is an important pathogen causing mastitis, and metabolic reprogramming during host immune responses is associated with infection-driven inflammation. The use of taurine can restore metabolic homeostasis and alleviate inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhenglei Wang, Riguo Lan, Yuanyuan Xu, Jiakun Zuo, Xiangan Han, Vanhnaseng Phouthapane, Zhenhua Luo, Jinfeng Miao
Summary: Taurine enhances PTEN activity, inhibits Akt/mTOR signaling, and activates autophagy to degrade intracellular S. uberis, reducing bacterial load, inhibiting over-activation of the NF-kappa B pathway, and alleviating inflammation and damage caused by S. uberis infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhixin Wan, Riguo Lan, Yilin Zhou, Yuanyuan Xu, Zhenglei Wang, Zhenhua Luo, Jinfeng Miao
Summary: In bacterial mastitis, lipid metabolism leads to the synthesis of fatty acids and production of lipid droplets, while taurine can reduce fatty acid synthesis, the abundance of lipid droplets, and the in vitro bacterial load. These changes are mediated, at least partly, by the E3 ubiquitin ligase IDOL associated with the degradation of low-density lipoprotein receptors (LDLRs).
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Ming Li, Zhenglei Wang, Shaodong Fu, Naiyan Sun, Weizhen Li, Yuanyuan Xu, Xiangan Han, Jinqiu Zhang, Jinfeng Miao
Summary: Taurine plays a protective role in mastitis by modulating the immune network, inhibiting inflammation and oxidative damage to alleviate the damage caused by inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Anna Dobrut, Dagmara Wojcik-Grzybek, Agata Mlodzinska, Dorota Pietras-Ozga, Katarzyna Michalak, Aleksander Tabacki, Urszula Mroczkowska, Monika Brzychczy-Wloch
Summary: This study aimed to detect immunoreactive proteins related to bovine mastitis through in silico and in vitro methods. Thirteen proteins were identified, which showed immunoreactivity to antibodies present in serum from cows with diagnosed mastitis. These proteins have the potential to be used as targets in rapid immunodiagnostic assays for bovine mastitis, but further research is needed due to the limited sample size.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Virginia E. Sherwin, Martin J. Green, James A. Leigh, Sharon A. Egan
Summary: Streptococcus uberis is a major causative agent of bovine mastitis worldwide. The prevalence of S. uberis in feces and factors affecting gastrointestinal carriage were investigated in two longitudinal studies. Seasonality and management conditions were found to significantly influence the detection of S. uberis.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Veterinary Sciences
Virginia E. Sherwin, Sharon A. Egan, Martin J. Green, James A. Leigh
Summary: This study demonstrates the importance of bedding type and management on the environmental survival of S. uberis. Bacteria can survive and replicate on bedding materials such as straw and sand for at least 35 days, but not beyond 7 days on sawdust. The addition of feces and urine on used bedding materials promotes the replication of S. uberis.
VETERINARY JOURNAL
(2021)
Article
Immunology
Ming Li, Zhenglei Wang, Yawei Qiu, Shaodong Fu, Yuanyuan Xu, Xiangan Han, Vanhnaseng Phouthapane, Jinfeng Miao
Summary: Taurine was found to protect mammary health under S. uberis infection by reducing inflammatory responses and maintaining the integrity of the blood-milk barrier.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Veterinary Sciences
Zhixin Wan, Shaodong Fu, Zhenglei Wang, Yuanyuan Xu, Yuanyuan Zhou, Xinguang Lin, Riguo Lan, Xiangan Han, Zhenhua Luo, Jinfeng Miao
Summary: Foamy macrophages with lipid droplets play a role in the immune response to Streptococcus uberis-induced mastitis. The fatty acid synthesis pathway is enhanced during infection, leading to increased levels of lipid droplets and an intensified inflammatory response. This process is mediated by FABP4, a subtype of the fatty acid-binding protein family, and gene silencing of FABP4 decreases lipid droplet deposition and reduces inflammatory cytokine expression.
VETERINARY RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Larissa Martins, Juliano L. Goncalves, Renata F. Leite, Tiago Tomazi, Vera L. M. Rall, Marcos Santos
Summary: This study aimed to evaluate the association between antimicrobial use and antimicrobial resistance in relation to Streptococcus uberis causing clinical mastitis in dairy herds. The findings showed high resistance of Strep. uberis isolates to macrolides, tetracycline, and penicillin G, while lower resistance was observed for ceftiofur and enrofloxacin.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Immunology
Ming Li, Yabing Gao, Zhenglei Wang, Binfeng Wu, Jinqiu Zhang, Yuanyuan Xu, Xiangan Han, Vanhnaseng Phouthapane, Jinfeng Miao
Summary: This study investigated the molecular mechanisms of S. uberis-induced NETs formation and the regulatory role of taurine. The results showed that taurine can protect mammary epithelial cells and barriers from damage by reducing S. uberis-induced NETs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Jayedul Hassan, Md. Abdus Sattar Bag, Md. Wohab Ali, Ajran Kabir, M. Nazmul Hoque, Muhammad Maqsud Hossain, Md. Tanvir Rahman, Md. Shafiqul Islam, Md. Shahidur Rahman Khan
Summary: This study aimed to determine the diversity of Streptococcus spp. isolated from clinical mastitis of cattle in Bangladesh. The results showed that out of 105 samples, 59 samples tested positive for Streptococcus, 18 samples tested positive for Staphylococcus, 10 samples tested positive for Enterococcus faecalis, and 24 samples tested positive for E. coli. Through 16S rRNA sequencing, it was identified that approximately 55.6% of the Streptococcus isolates were Streptococcus uberis, 33.3% were Streptococcus agalactiae, 5.6% were Streptococcus hyovaginalis, and 5.6% were Streptococcus urinalis. Additionally, two novel ST types of S. uberis were identified through whole genome sequencing.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Petr Slama, Terezie Zavadilova, Ales Pavlik, Pavel Horky, Sylvie Skalickova, Jiri Skladanka, Shubhadeep Roychoudhury, Simona Baldovska, Adriana Kolesarova, Roman Konecny, Vladimir Tancin, Monika Zouharova
Summary: Bovine mastitis is a significant issue for dairy farmers with antibiotic treatment needing to be minimized due to resistance. Streptococcus uberis is a common pathogen, with research indicating that gamma delta T cells may play a key role in resolving inflammation in mammary glands.
Article
Agriculture, Dairy & Animal Science
B. G. Alves, L. Martins, J. N. Ribeiro, F. M. S. Tavares, M. dos Santos
Summary: Streptococcus uberis is a major cause of environmental mastitis, with potential contagious transmission. The study evaluated the diversity of S. uberis isolates, identifying different hybridization patterns and high prevalence of virulence genes. This suggests diversity within the population and importance of certain virulence factors for intramammary infections.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Infectious Diseases
Valentina Monistero, Antonio Barberio, Paola Cremonesi, Bianca Castiglioni, Stefano Morandi, Desiree C. K. Lassen, Laerke B. Astrup, Clara Locatelli, Renata Piccinini, M. Filippa Addis, Valerio Bronzo, Paolo Moroni
Summary: The study revealed that Strep. uberis is an environmental pathogen responsible for mastitis in dairy cows in Italy, showing resistance to multiple antimicrobials with a low prevalence of beta-lactam resistance. The genotypic variability of the isolates was investigated using multiplex PCR and RAPD-PCR typing, along with phenotypic antimicrobial resistance assessment. The highest resistance rate was observed for lincomycin, with most isolates showing resistance to at least one drug tested.