期刊
AMINO ACIDS
卷 39, 期 3, 页码 713-726出版社
SPRINGER WIEN
DOI: 10.1007/s00726-010-0506-6
关键词
Domain boundary prediction; Support vector regression; AAindex; Principal component analysis
资金
- RCMI [2 G12 RR003048]
- Division of Research Infrastructure
- National Center for Research Resources
- NIH
- Howard University
- Singapore MOE ARC Tier-2 [T208B2203]
- National Science Foundation of China [60803107, CCF-0845888]
Protein domains are structural and fundamental functional units of proteins. The information of protein domain boundaries is helpful in understanding the evolution, structures and functions of proteins, and also plays an important role in protein classification. In this paper, we propose a support vector regression-based method to address the problem of protein domain boundary identification based on novel input profiles extracted from AAindex database. As a result, our method achieves an average sensitivity of similar to 36.5% and an average specificity of similar to 81% for multi-domain protein chains, which is overall better than the performance of published approaches to identify domain boundary. As our method used sequence information alone, our method is simpler and faster.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据