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Biochemistry & Molecular Biology
Maryam H. Al-Zahrani, Maha J. Balgoon, Nagwa M. El-Sawi, Fawzia A. Alshubaily, Ebtihaj J. Jambi, Sohair M. Khojah, Raghad S. Baljoon, Nuha A. Alkhattabi, Lina A. Baz, Asmaa A. Alharbi, Amira M. Ahmed, Ayat M. Abo Elkhair, Mohamed Ismael, Sahar M. Gebril
Summary: Curcumin and taurine were compared as antioxidants against T-2-induced hepatotoxicity. Results showed that both curcumin and taurine significantly ameliorated liver toxicity, with curcumin being more effective.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
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Pharmacology & Pharmacy
Shuxin Li, Hongmin Zhang, Jing Chang, Dongming Li, Pengxiu Cao
Summary: Pulmonary fibrosis is a chronic, progressive lung disease with limited treatment options. Recent research has shown that iron accumulation and mitochondrial damage play key roles in its development, highlighting a promising direction for finding effective therapeutics.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
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Chemistry, Inorganic & Nuclear
Yun-Qiong Gu, Yu-Jun Zhong, Mei-Qi Hu, Huan-Qing Li, Kun Yang, Qi Dong, Hong Liang, Zhen-Feng Chen
Summary: The four copper complexes showed higher cytotoxic activity against various cancer cell lines, especially BEL-7402 cells, with low toxicity to normal human liver cells. Mechanistic studies revealed that they induced apoptosis by inducing G0/G1 arrest and altering the expression of cell cycle-related proteins.
DALTON TRANSACTIONS
(2022)
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Pharmacology & Pharmacy
Serah Kimani, Suparna Chakraborty, Ikponmwosa Irene, Jo de la Mare, Adrienne Edkins, Andre du Toit, Ben Loos, Angelique Blanckenberg, Annick Van Niekerk, Leticia Costa-Lotufo, K. N. ArulJothi, Selwyn Mapolie, Sharon Prince
Summary: The study investigated the anti-cancer activity of a palladium complex, BTC2, in human breast cancer cells, demonstrating its selectivity, inhibition of cancer cell migration, and suppression of cancer stem cell activity. BTC2 also induced DNA double strand breaks, triggered cell cycle arrests, and activated multiple cell death pathways, showing promising anti-breast cancer activity both in vitro and in vivo.
BIOCHEMICAL PHARMACOLOGY
(2021)
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Environmental Sciences
Ruirui Li, Bin Liu, Wenping Xu, Lvnan Yu, Cheng Zhang, Jiagao Cheng, Liming Tao, Zhong Li, Yang Zhang
Summary: The study revealed the cytotoxic effect of fungicide DFC on mouse monocyte macrophage RAW264.7, including inhibiting cell viability, inducing DNA damage, and enhancing apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2022)
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Chemistry, Medicinal
Nataliya Finiuk, Anna Kryshchyshyn-Dylevych, Serhii Holota, Olga Klyuchivska, Andriy Kozytskiy, Olexandr Karpenko, Nazar Manko, Iryna Ivasechko, Rostyslav Stoika, Roman Lesyk
Summary: A series of novel pyrrolidinedione-thiazolidinones were synthesized and evaluated for their anticancer potential. The compounds showed high antiproliferative activity and cytotoxicity against various cancer cell lines, while exhibiting low toxicity towards normal human cells. The compounds also demonstrated selective cytotoxicity towards leukemia, lung, breast, cervical, colon carcinoma, and glioblastoma cells. The mechanism of action involved mitochondria-dependent apoptosis and DNA damage in treated cancer cells. These findings suggest that the novel hybrid pyrrolidinedione-thiazolidinones have potential as anticancer agents with reduced toxicity towards normal cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
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Cell Biology
Ragini Singh, Mohit Rajput, Rana P. Singh
Summary: Simulated microgravity (SMG) results in decreased cell proliferation and viability, increased DNA damage and apoptosis, and altered expression of DNA repair genes, leading to changes in DNA repair capacity. These effects may activate apoptotic cell death pathways mediated by ATM/ATR-Chk1/2 and Ku70/80 and DNA-PK.
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Environmental Sciences
Xin Wang, Hongfei Ni, Wenping Xu, Bing Wu, Te Xie, Cheng Zhang, Jiagao Cheng, Zhong Li, Liming Tao, Yang Zhang
Summary: Difenoconazole exhibits neurotoxicity at the cellular level, causing cell apoptosis and DNA damage, and adversely affecting cell function.
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Medicine, Research & Experimental
Mansurah A. Abdulazeez, Hiba A. Jasim, Musa Bashir, Kehinde Ross, Amos A. Fatokun
Summary: This study investigated the effects of Peristrophe bicalyculata leaf extracts on cancer cells and their mechanisms of action. The extracts showed potential anti-tumor activity by inhibiting cancer cell growth and inducing oxidative stress, mitochondrial damage, and caspase activation. The study identified several constituents of the extracts, suggesting that they could be used as leads for developing novel anti-cancer agents.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
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Biochemistry & Molecular Biology
Beatrice Razmiene, Veronika Vojackova, Eva Reznickova, Lukas Malina, Vaida Dambrauskiene, Martin Kubala, Robert Bajgar, Hana Kolarova, Asta Zukauskaite, Egle Arbaciauskiene, Algirdas Sackus, Vladimir Krystof
Summary: A series of N-aryl-2,6-diphenyl-2H-pyrazolo[4,3-c]pyridin-7-amines were synthesized from easily accessible 1-phenyl-1H-pyrazol-3-ol and used in a Buchwald-Hartwig cross-coupling reaction with various anilines. These compounds showed low cytotoxicity to melanoma cells in the dark, but their activity increased when exposed to visible blue light. The most active compound exhibited potent anticancer activity.
BIOORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Chian Ju Jong, Priyanka Sandal, Stephen W. Schaffer
Summary: Taurine is a naturally occurring sulfur-containing amino acid found abundantly in tissues like the heart and brain, with known benefits in protecting mitochondria function and providing antioxidant effects. Studies suggest that taurine supplementation can help prevent various pathologies.
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Chemistry, Multidisciplinary
Gurunath Sahu, Sushree Aradhana Patra, Sudhir Lima, Sanchita Das, Helmar Goerls, Winfried Plass, Rupam Dinda
Summary: Three new ruthenium complexes were synthesized and characterized, and their cytotoxicity and mechanism of action in cells were investigated.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
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Biochemistry & Molecular Biology
Fang Yuan, Yingying Xu, Kai You, Jiaye Zhang, Fan Yang, Yin-xiong Li
Summary: The study showed that calcitriol can alleviate ethanol-induced hepatocyte damage by enhancing autophagy, providing a convenient preventive and hepatoprotective means for people who occasionally engage in social drinking. Autophagy is significantly enhanced by calcitriol, and the effect is mediated through the AMPK/mTOR signaling pathway and dependent on the Vitamin D receptor (VDR).
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
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Biochemistry & Molecular Biology
Anna Kryshchyshyn-Dylevych, Lidia Radko, Nataliya Finiuk, Myroslav Garazd, Nataliya Kashchak, Andrzej Posyniak, Krzysztof Niemczuk, Rostyslav Stoika, Roman Lesyk
Summary: A series of novel indole-azolidinone hybrids were synthesized and resulted in a compound with high cytotoxicity towards tumor cells and lower toxicity towards non-malignant cells. The compound induced apoptosis and DNA damage in tumor cells, suggesting its potential as a promising anticancer agent for further studies.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Editorial Material
Plant Sciences
Moira Rodriguez, Ana Martinez-Hottovy, Alan C. Christensen
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(2018)
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Baskaran Yogalakshmi, Chandrasekaran Sathiya Priya, Carani Venkatraman Anuradha
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Saravanan Bhuvaneswari, Baskaran Yogalakshmi, S. Sreeja, Carani Venkatraman Anuradha
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MOLECULAR AND CELLULAR BIOCHEMISTRY
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Dipti Nanda, Sathiya Priya Chandrasekaran, Vidhya Ramachandran, Kalpana Kalaivanan, Anuradha Carani Venkatraman
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Rajagopalan Geetha, Chandrasekaran Sathiya Priya, Carani Venkatraman Anuradha
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Radika Mutlur Krishnamoorthy, Anuradha Carani Venkatraman
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(2014)